Publications by authors named "Jacob M Lambert"

2 Publications

  • Page 1 of 1

Anti-cancer Evaluation of Depsides Isolated from Indonesian Folious Lichens: , and .

Biomolecules 2020 10 8;10(10). Epub 2020 Oct 8.

School of Chemistry & Molecular Bioscience and Molecular Horizons, University of Wollongong, and Illawarra Health & Medical Research Institute, Wollongong, NSW 2522, Australia.

Cancer is a serious health burden on global societies. The discovery and development of new anti-cancer therapies remains a challenging objective. Although it has been shown that lichen secondary metabolites may be potent sources for new anti-cancer agents, the Indonesian- grown folious lichens, and have not yet been explored. In this study exhaustive preparative high-performance liquid chromatography was employed to isolate the lichen constituents with spectroscopic and spectrometric protocols identifying nine depsides -, including the new methyl 4-formyl-2,3-dihydroxy-6-methylbenzoate . The cytotoxicity of the depsides towards cancer cells was assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The results indicated lowest toxicity of the depsides towards human A549 lung cancer cells. Importantly, the di-depsides (, and ) showed greatest toxicity, indicating that these structures are biologically more active than the mono-depsides against the HepG2 liver cancer, A549 lung cancer and HL-60 leukemia cell lines.
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http://dx.doi.org/10.3390/biom10101420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600581PMC
October 2020

Alkaloids from the root of Indonesian L.

Nat Prod Res 2021 Feb 8;35(3):481-489. Epub 2019 Jul 8.

School of Chemistry & Molecular Bioscience and Molecular Horizons, University of Wollongong, and Illawarra Health & Medical Research Institute, Wollongong, NSW, Australia.

L. has been used traditionally in Indonesia to treat disease. Phytochemical studies on the alkaloid fractions from the root of L. from Malang-Indonesia resulted in the isolation of an unreported benzylisoquinoline alkaloid (+)-xylopine as well as four known alkaloids (-). The crude methanol extract and alkaloid fractions were tested against K1 and against bacteria (, , , , Methicillin-resistant ) with insignificant activities (MIC > 32 µg/mL). Individual alkaloids were tested against a human suspension cancer cell line (HL-60 leukemia cells) and two human fibroblastic cancer cell lines (A549 lung cancer cells and HepG2 liver cancer cells) in which compound as the most toxic alkaloid with IC values ranging from 20 to 80 µM.
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http://dx.doi.org/10.1080/14786419.2019.1638380DOI Listing
February 2021
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