Jacob Kitzman

Jacob Kitzman

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Jacob Kitzman

Jacob Kitzman

Publications by authors named "Jacob Kitzman"

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45Publications

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Clinical Implications of Identifying Pathogenic Variants in Individuals With Thoracic Aortic Dissection.

Circ Genom Precis Med 2019 Jun 18;12(6):e002476. Epub 2019 Jun 18.

University of Michigan (B.N.W., W.E.H., L.F., J.M., A.D., X.W., M.R.M., S.K.G., N.J.D., C.M.B., J.K., Y.E.C., K.K., G.M.D., H.P., K.A.E., C.J.W., B.Y.), Michigan Medicine, University of Michigan, Ann Arbor.

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http://dx.doi.org/10.1161/CIRCGEN.118.002476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582991PMC
June 2019

Genomic annotation of disease-associated variants reveals shared functional contexts.

Diabetologia 2019 05 12;62(5):735-743. Epub 2019 Feb 12.

Department of Computational Medicine and Bioinformatics, University of Michigan, 100 Washtenaw Avenue, 2049 Palmer Commons Building, Ann Arbor, MI, 48109, USA.

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http://dx.doi.org/10.1007/s00125-019-4823-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451673PMC
May 2019

Genome-wide Study of Atrial Fibrillation Identifies Seven Risk Loci and Highlights Biological Pathways and Regulatory Elements Involved in Cardiac Development.

Am J Hum Genet 2018 01 28;102(1):103-115. Epub 2017 Dec 28.

Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48109, USA; Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health, Norwegian University of Science and Technology, Trondheim 7491, Norway; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2017.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777936PMC
January 2018

Variant Interpretation: Functional Assays to the Rescue.

Am J Hum Genet 2017 Sep;101(3):315-325

Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA; Department of Bioengineering, University of Washington, Seattle, WA 98195, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2017.07.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590843PMC
September 2017

Genetics of Combined Pituitary Hormone Deficiency: Roadmap into the Genome Era.

Endocr Rev 2016 12 9;37(6):636-675. Epub 2016 Nov 9.

Department of Human Genetics (Q.F., A.S.G., M.L.B., A.H.M., P.G., L.Y.M.C., A.Z.D., M.I.P.M., A.B.O., J.O.K., R.E.M., J.Z.L., S.A.C.), Graduate Program in Bioinformatics (A.S.G.), Endocrine Division, Department of Internal Medicine (A.A.), and Department of Computational Medicine and Bioinformatics (J.O.K., R.E.M., J.Z.L.), University of Michigan, Ann Arbor, Michigan 48109.

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http://dx.doi.org/10.1210/er.2016-1101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155665PMC
December 2016

Genome evolution in the allotetraploid frog Xenopus laevis.

Nature 2016 10;538(7625):336-343

University of California, Berkeley, Department of Molecular and Cell Biology and Center for Integrative Genomics, Life Sciences Addition #3200, Berkeley, California 94720-3200, USA.

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http://dx.doi.org/10.1038/nature19840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5313049PMC
October 2016

Fragment Length of Circulating Tumor DNA.

PLoS Genet 2016 07 18;12(7):e1006162. Epub 2016 Jul 18.

Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1006162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948782PMC
July 2016

Haplotypes drop by drop.

Authors:
Jacob O Kitzman

Nat Biotechnol 2016 Mar;34(3):296-8

Department of Human Genetics and Department of Computational Medicine &Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.1038/nbt.3500DOI Listing
March 2016

An essential cell cycle regulation gene causes hybrid inviability in Drosophila.

Science 2015 Dec;350(6267):1552-5

Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

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http://dx.doi.org/10.1126/science.aac7504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703311PMC
December 2015

Experimental Evolution Identifies Vaccinia Virus Mutations in A24R and A35R That Antagonize the Protein Kinase R Pathway and Accompany Collapse of an Extragenic Gene Amplification.

J Virol 2015 Oct 22;89(19):9986-97. Epub 2015 Jul 22.

Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA Departments of Microbiology and Medicine, University of Washington, Seattle, Washington, USA

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http://jvi.asm.org/content/early/2015/07/16/JVI.01233-15.ful
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http://jvi.asm.org/content/89/19/9986.full.pdf
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http://jvi.asm.org/lookup/doi/10.1128/JVI.01233-15
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http://dx.doi.org/10.1128/JVI.01233-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577882PMC
October 2015

Massively Parallel Functional Analysis of BRCA1 RING Domain Variants.

Genetics 2015 Jun 30;200(2):413-22. Epub 2015 Mar 30.

Department of Genome Sciences, University of Washington, Seattle, Washington 98195 Department of Medicine, University of Washington, Seattle, Washington 98195 Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195

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http://dx.doi.org/10.1534/genetics.115.175802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492368PMC
June 2015

Haplotype-resolved genome sequencing: experimental methods and applications.

Nat Rev Genet 2015 Jun 7;16(6):344-58. Epub 2015 May 7.

Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA.

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http://dx.doi.org/10.1038/nrg3903DOI Listing
June 2015

Copy-number variation and false positive prenatal aneuploidy screening results.

N Engl J Med 2015 Apr 1;372(17):1639-45. Epub 2015 Apr 1.

From the Department of Genome Sciences (M.W.S., J.O.K., B.P.C., R.M.D., E.E.E., J.S.), Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology (L.E.S., J.M.H., H.S.G.), and Howard Hughes Medical Institute (E.E.E.), University of Washington, and the Clinical Research Division, Fred Hutchinson Cancer Research Center (H.S.G.) - both in Seattle.

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http://dx.doi.org/10.1056/NEJMoa1408408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411081PMC
April 2015

Massively parallel single-amino-acid mutagenesis.

Nat Methods 2015 Mar 5;12(3):203-6, 4 p following 206. Epub 2015 Jan 5.

Department of Genome Sciences, University of Washington, Seattle, Washington, USA.

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http://dx.doi.org/10.1038/nmeth.3223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344410PMC
March 2015

Adaptive gene amplification as an intermediate step in the expansion of virus host range.

PLoS Pathog 2014 Mar 13;10(3):e1004002. Epub 2014 Mar 13.

Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America; Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America; Departments of Microbiology and Medicine, University of Washington, Seattle, Washington, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1004002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953438PMC
March 2014

Chromosome-scale scaffolding of de novo genome assemblies based on chromatin interactions.

Nat Biotechnol 2013 Dec 3;31(12):1119-25. Epub 2013 Nov 3.

Department of Genome Sciences, University of Washington, Seattle, Washington, USA.

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http://dx.doi.org/10.1038/nbt.2727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117202PMC
December 2013

Assemblathon 2: evaluating de novo methods of genome assembly in three vertebrate species.

Gigascience 2013 Jul 22;2(1):10. Epub 2013 Jul 22.

Genome Center, UC, Davis, CA 95616, USA.

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http://dx.doi.org/10.1186/2047-217X-2-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844414PMC
July 2013

Noninvasive fetal genome sequencing: a primer.

Prenat Diagn 2013 Jun 1;33(6):547-54. Epub 2013 Apr 1.

Department of Genome Sciences, University of Washington, Seattle, WA, USA.

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http://doi.wiley.com/10.1002/pd.4097
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http://dx.doi.org/10.1002/pd.4097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727971PMC
June 2013

Haplotype-resolved genome sequencing of a Gujarati Indian individual.

Nat Biotechnol 2011 Jan 19;29(1):59-63. Epub 2010 Dec 19.

Department of Genome Sciences, University of Washington School of Medicine, Seattle, Washington, USA.

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http://dx.doi.org/10.1038/nbt.1740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116788PMC
January 2011