Jacob D Estes

Jacob D Estes

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Jacob D Estes

Jacob D Estes

Publications by authors named "Jacob D Estes"

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Fingolimod retains cytolytic T cells and limits T follicular helper cell infection in lymphoid sites of SIV persistence.

PLoS Pathog 2019 Oct 18;15(10):e1008081. Epub 2019 Oct 18.

Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1008081DOI Listing
October 2019

Intestinal proteomic analysis of a novel non-human primate model of experimental colitis reveals signatures of mitochondrial and metabolic dysfunction.

Mucosal Immunol 2019 Sep 3. Epub 2019 Sep 3.

Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB, Canada.

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http://dx.doi.org/10.1038/s41385-019-0200-2DOI Listing
September 2019

Autologous, Gene-Modified Hematopoietic Stem and Progenitor Cells Repopulate the Central Nervous System with Distinct Clonal Variants.

Stem Cell Reports 2019 Jul 13;13(1):91-104. Epub 2019 Jun 13.

Division of Clinical Research, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Mail Stop D1-100, PO Box 19024, Seattle, WA 98109-1024, USA; Department of Medicine, University of Washington, Seattle WA 98195, USA; Department of Pathology, University of Washington, Seattle, WA 98195, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2019.05.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6626873PMC
July 2019

Visualizing the Immune System: Providing Key Insights into HIV/SIV Infections.

Front Immunol 2018 2;9:423. Epub 2018 Mar 2.

Tissue Analysis Core, Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID) National Institutes of Health (NIH), Bethesda, MD, United States.

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http://dx.doi.org/10.3389/fimmu.2018.00423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840205PMC
June 2019

Experimental microbial dysbiosis does not promote disease progression in SIV-infected macaques.

Nat Med 2018 09 30;24(9):1313-1316. Epub 2018 Jul 30.

Barrier Immunity Section, Laboratory of Viral Diseases, National Institutes of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.

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http://dx.doi.org/10.1038/s41591-018-0132-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129204PMC
September 2018

Hallmarks of primate lentiviral immunodeficiency infection recapitulate loss of innate lymphoid cells.

Nat Commun 2018 09 27;9(1):3967. Epub 2018 Sep 27.

Barrier Immunity Section, Lab of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 4 Center Drive, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1038/s41467-018-05528-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160474PMC
September 2018

Nonhuman primate models of human viral infections.

Nat Rev Immunol 2018 06;18(6):390-404

Barrier Immunity Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA.

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http://dx.doi.org/10.1038/s41577-018-0005-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5970954PMC
June 2018

Next-generation in situ hybridization approaches to define and quantify HIV and SIV reservoirs in tissue microenvironments.

Retrovirology 2018 01 9;15(1). Epub 2018 Jan 9.

AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD, 21702, USA.

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http://dx.doi.org/10.1186/s12977-017-0387-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5761108PMC
January 2018

CTLA-4PD-1 Memory CD4 T Cells Critically Contribute to Viral Persistence in Antiretroviral Therapy-Suppressed, SIV-Infected Rhesus Macaques.

Immunity 2017 10;47(4):776-788.e5

Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Medicine, Emory University School of Medicine, Atlanta, GA 30329, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2017.09.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679306PMC
October 2017

CXCR5-Dependent Entry of CD8 T Cells into Rhesus Macaque B-Cell Follicles Achieved through T-Cell Engineering.

J Virol 2017 06 12;91(11). Epub 2017 May 12.

AIDS and Cancer Virus Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA

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http://dx.doi.org/10.1128/JVI.02507-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432868PMC
June 2017

Cytotoxic T Cell Functions Accumulate When CD4 Is Downregulated by CD4 T Cells in African Green Monkeys.

J Immunol 2017 06 24;198(11):4403-4412. Epub 2017 Apr 24.

Barrier Immunity Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892;

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http://dx.doi.org/10.4049/jimmunol.1700136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502537PMC
June 2017

Effect of Anti-IL-15 Administration on T Cell and NK Cell Homeostasis in Rhesus Macaques.

J Immunol 2016 08 18;197(4):1183-98. Epub 2016 Jul 18.

Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006;

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http://dx.doi.org/10.4049/jimmunol.1600065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976006PMC
August 2016

Imaging lymphoid tissues in nonhuman primates to understand SIV pathogenesis and persistence.

Curr Opin Virol 2016 08 1;19:77-84. Epub 2016 Aug 1.

AIDS and Cancer Virus Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, BG 535, Post Office Box B, Frederick, MD 21702, USA. Electronic address:

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http://dx.doi.org/10.1016/j.coviro.2016.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021606PMC
August 2016

MRSA Infections in HIV-Infected People Are Associated with Decreased MRSA-Specific Th1 Immunity.

PLoS Pathog 2016 Apr 19;12(4):e1005580. Epub 2016 Apr 19.

Human Immunology Section, Vaccine Research Center, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1005580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836670PMC
April 2016

SIV-induced Translocation of Bacterial Products in the Liver Mobilizes Myeloid Dendritic and Natural Killer Cells Associated With Liver Damage.

J Infect Dis 2016 Feb 3;213(3):361-9. Epub 2015 Aug 3.

Division of Immunology, New England Primate Research Center, Harvard Medical School, Southborough Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts.

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http://dx.doi.org/10.1093/infdis/jiv404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704667PMC
February 2016

Novel Imaging Methods for Analysis of Tissue Resident Cells in HIV/SIV.

Curr HIV/AIDS Rep 2016 Feb;13(1):38-43

Immunology Laboratory, Vaccine Research Center, NIAID, National Institutes of Health, Building 40, 40 Convent Drive, Bethesda, MD, 20892-3005, USA.

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http://dx.doi.org/10.1007/s11904-016-0300-5DOI Listing
February 2016

Defining HIV and SIV Reservoirs in Lymphoid Tissues.

Pathog Immun 2016 ;1(1):68-106

AIDS and Cancer Virus Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943335PMC
January 2016

Accumulation of Cytotoxic CD16+ NK Cells in Simian Immunodeficiency Virus-Infected Lymph Nodes Associated with In Situ Differentiation and Functional Anergy.

J Virol 2015 Jul 22;89(13):6887-94. Epub 2015 Apr 22.

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts, USA

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http://dx.doi.org/10.1128/JVI.00660-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468491PMC
July 2015

Generation and characterization of a SIVmac239 clone corrected at four suboptimal nucleotides.

Retrovirology 2015 Jun 16;12:49. Epub 2015 Jun 16.

Retroviral Evolution Section, AIDS and Cancer Virus Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Building 535, Rm. 408, Frederick, MD, 21702-1201, USA.

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http://dx.doi.org/10.1186/s12977-015-0175-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4469405PMC
June 2015

Gut epithelial barrier and systemic inflammation during chronic HIV infection.

AIDS 2015 Jan;29(1):43-51

aDivision of Gastroenterology, Department of Medicine, University of California, San Francisco (UCSF), San Francisco, California bAIDS and Cancer Virus Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland cDivision of Experimental Medicine, Department of Medicine, UCSF, San Francisco, California dDivision of Gastroenterology, Department of Medicine, University of Washington, Washington eDepartment of Epidemiology and Biostatistics fHIV/AIDS Division, Department of Medicine, UCSF, San Francisco, California, USA.

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http://dx.doi.org/10.1097/QAD.0000000000000511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444362PMC
January 2015

Initiation of ART during early acute HIV infection preserves mucosal Th17 function and reverses HIV-related immune activation.

PLoS Pathog 2014 Dec 11;10(12):e1004543. Epub 2014 Dec 11.

Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America; SEARCH, Bangkok, Thailand; The Thai Red Cross AIDS Research Centre, Bangkok, Thailand; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1004543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263756PMC
December 2014

Hypercytotoxicity and rapid loss of NKp44+ innate lymphoid cells during acute SIV infection.

PLoS Pathog 2014 Dec 11;10(12):e1004551. Epub 2014 Dec 11.

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America; Division of Immunology, New England Primate Research Center, Harvard Medical School, Southborough Campus, Southborough, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1004551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263758PMC
December 2014

CD4 depletion in SIV-infected macaques results in macrophage and microglia infection with rapid turnover of infected cells.

PLoS Pathog 2014 Oct 30;10(10):e1004467. Epub 2014 Oct 30.

Division of Microbiology & Immunology, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, Georgia, United States of America; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1004467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214815PMC
October 2014

HIV-1-induced AIDS in monkeys.

Science 2014 Jun;344(6190):1401-5

Aaron Diamond AIDS Research Center, 455 First Avenue, New York, NY 10016, USA. Laboratory of Retrovirology, The Rockefeller University, 455 First Avenue, New York, NY 10016, USA. Howard Hughes Medical Institute, 455 First Avenue, New York, NY 10016, USA.

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http://dx.doi.org/10.1126/science.1250761DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266393PMC
June 2014

Pathobiology of HIV/SIV-associated changes in secondary lymphoid tissues.

Authors:
Jacob D Estes

Immunol Rev 2013 Jul;254(1):65-77

AIDS and Cancer Virus Program, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1111/imr.12070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066369PMC
July 2013

Rate of AIDS progression is associated with gastrointestinal dysfunction in simian immunodeficiency virus-infected pigtail macaques.

J Immunol 2013 Mar 11;190(6):2959-65. Epub 2013 Feb 11.

Laboratory of Molecular Microbiology, Program in Barrier Immunity and Repair, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.4049/jimmunol.1202319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665608PMC
March 2013

Differential infection patterns of CD4+ T cells and lymphoid tissue viral burden distinguish progressive and nonprogressive lentiviral infections.

Blood 2012 Nov 18;120(20):4172-81. Epub 2012 Sep 18.

Program in Barrier Immunity and Repair, National Institute of Allergy and Infectious Diseases, National Institutes ofHealth, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1182/blood-2012-06-437608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501715PMC
November 2012

Enhancing immune responses to limit chronic immune activation during SIV.

Authors:
Jacob D Estes

J Clin Invest 2012 May 23;122(5):1611-4. Epub 2012 Apr 23.

AIDS and Cancer Virus Program, SAIC-Frederick Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, USA.

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http://dx.doi.org/10.1172/JCI63389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337001PMC
May 2012

SIV infection of rhesus macaques results in dysfunctional T- and B-cell responses to neo and recall Leishmania major vaccination.

Blood 2011 Nov 29;118(22):5803-12. Epub 2011 Sep 29.

Program in Barrier Immunity and Repair, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1182/blood-2011-07-365874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3228497PMC
November 2011

Barriers to mucosal transmission of immunodeficiency viruses.

Blood 2011 Jul 9;118(4):839-46. Epub 2011 May 9.

AIDS and Cancer Virus Program, SAIC-Frederick Inc, National Cancer Institute, Frederick, MD, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2010-12-32
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http://dx.doi.org/10.1182/blood-2010-12-325860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148165PMC
July 2011

Mechanisms underlying γδ T-cell subset perturbations in SIV-infected Asian rhesus macaques.

Blood 2010 Nov 26;116(20):4148-57. Epub 2010 Jul 26.

Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1182/blood-2010-05-283549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993620PMC
November 2010

Disruption of intestinal CD4+ T cell homeostasis is a key marker of systemic CD4+ T cell activation in HIV-infected individuals.

J Immunol 2010 Nov 1;185(9):5169-79. Epub 2010 Oct 1.

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.4049/jimmunol.1001801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155848PMC
November 2010

3D visualization of HIV transfer at the virological synapse between dendritic cells and T cells.

Proc Natl Acad Sci U S A 2010 Jul 12;107(30):13336-41. Epub 2010 Jul 12.

Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1073/pnas.1003040107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922156PMC
July 2010