Jaclyn Hechtman

Jaclyn Hechtman

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Jaclyn Hechtman

Publications by authors named "Jaclyn Hechtman"

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Detection of Fusions: Merits and Limitations of Current Diagnostic Platforms.

Cancer Res 2019 Jul 13;79(13):3163-3168. Epub 2019 Jun 13.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1158/0008-5472.CAN-19-0372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606326PMC
July 2019

Somatic HNF1A mutations in the malignant transformation of hepatocellular adenomas: a retrospective analysis of data from MSK-IMPACT and TCGA.

Hum Pathol 2019 Jan 17;83:1-6. Epub 2018 Aug 17.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Pathology, Weill Cornell Medical College, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.humpath.2018.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365190PMC
January 2019

Efficacy of Larotrectinib in TRK Fusion-Positive Cancers in Adults and Children.

N Engl J Med 2018 02;378(8):731-739

From Memorial Sloan Kettering Cancer Center (A. Drilon, J.F.H., R.B., M.L., D.M.H.) and Weill Cornell Medical College (A. Drilon, D.M.H.), New York; University of Texas Southwestern Medical Center-Children's Health, Dallas (T.W.L.); Stanford Cancer Center, Stanford University, Palo Alto (S.K.), Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California (L.M.), and UCLA David Geffen School of Medicine (N.F.), Los Angeles, and Loxo Oncology, South San Francisco (B.B.T., K.E., S.C., N.C.K., M.C.C.) - all in California; Dana-Farber-Boston Children's Cancer and Blood Disorders Center (S.G.D.), Dana-Farber Cancer Institute (G.D.D., M.N.), Ludwig Center at Harvard (G.D.D.), and Massachusetts General Hospital (A.F.F.) - all in Boston; the Finsen Center, Rigshospitalet, Copenhagen (U.N.L.); University of Colorado, Aurora (R.C.D.); St. Jude Children's Research Hospital, Memphis (A.S.P.), and Vanderbilt University, Nashville (J.B.) - both in Tennessee; Cincinnati Children's Hospital Medical Center, Cincinnati (B.T.); University Hospitals of Cleveland Medical Center (A. Dowlati) and Taussig Cancer Institute, Cleveland Clinic (D.P.S.S.), Cleveland; University of Pennsylvania Perelman School of Medicine, Department of Otorhinolaryngology and Head and Neck Surgery, and the Abramson Cancer Center (M.S.B.), and Fox Chase Cancer Center (W.S.E.-D.), Philadelphia; University of Washington-Seattle Cancer Care Alliance (C.B.), Seattle Children's Hospital (E.R.R.), and Seattle Children's Hospital, University of Washington, Fred Hutchinson Cancer Research Center (D.S. Hawkins), Seattle; University of Texas M.D. Anderson Cancer Center, Houston (F.M.-B., D.S. Hong); Inova Schar Cancer Institute, Falls Church, VA (J.D.); START Madrid, Centro Integral Oncológico Clara Campal, Madrid (V.B.); Nemours Children's Hospital, Orlando (R.N.), and Memorial Cancer Institute-Florida International University, Miami (L.E.R.) - both in Florida; Oregon Health and Science University, Portland (M.T.); and WVU Cancer Institute, West Virginia University, Morgantown (P.C.M.).

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http://dx.doi.org/10.1056/NEJMoa1714448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857389PMC
February 2018

Clinical Sequencing Defines the Genomic Landscape of Metastatic Colorectal Cancer.

Cancer Cell 2018 01;33(1):125-136.e3

Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Departments of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765991PMC
January 2018

Clinical Features and Outcomes of Patients with Colorectal Cancers Harboring NRAS Mutations.

Clin Cancer Res 2017 Aug 26;23(16):4753-4760. Epub 2017 Apr 26.

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-0400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788017PMC
August 2017

Erratum: Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.

Authors:
Ahmet Zehir Ryma Benayed Ronak H Shah Aijazuddin Syed Sumit Middha Hyunjae R Kim Preethi Srinivasan Jianjiong Gao Debyani Chakravarty Sean M Devlin Matthew D Hellmann David A Barron Alison M Schram Meera Hameed Snjezana Dogan Dara S Ross Jaclyn F Hechtman Deborah F DeLair JinJuan Yao Diana L Mandelker Donavan T Cheng Raghu Chandramohan Abhinita S Mohanty Ryan N Ptashkin Gowtham Jayakumaran Meera Prasad Mustafa H Syed Anoop Balakrishnan Rema Zhen Y Liu Khedoudja Nafa Laetitia Borsu Justyna Sadowska Jacklyn Casanova Ruben Bacares Iwona J Kiecka Anna Razumova Julie B Son Lisa Stewart Tessara Baldi Kerry A Mullaney Hikmat Al-Ahmadie Efsevia Vakiani Adam A Abeshouse Alexander V Penson Philip Jonsson Niedzica Camacho Matthew T Chang Helen H Won Benjamin E Gross Ritika Kundra Zachary J Heins Hsiao-Wei Chen Sarah Phillips Hongxin Zhang Jiaojiao Wang Angelica Ochoa Jonathan Wills Michael Eubank Stacy B Thomas Stuart M Gardos Dalicia N Reales Jesse Galle Robert Durany Roy Cambria Wassim Abida Andrea Cercek Darren R Feldman Mrinal M Gounder A Ari Hakimi James J Harding Gopa Iyer Yelena Y Janjigian Emmet J Jordan Ciara M Kelly Maeve A Lowery Luc G T Morris Antonio M Omuro Nitya Raj Pedram Razavi Alexander N Shoushtari Neerav Shukla Tara E Soumerai Anna M Varghese Rona Yaeger Jonathan Coleman Bernard Bochner Gregory J Riely Leonard B Saltz Howard I Scher Paul J Sabbatini Mark E Robson David S Klimstra Barry S Taylor Jose Baselga Nikolaus Schultz David M Hyman Maria E Arcila David B Solit Marc Ladanyi Michael F Berger

Nat Med 2017 08;23(8):1004

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http://dx.doi.org/10.1038/nm0817-1004cDOI Listing
August 2017

Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.

Authors:
Ahmet Zehir Ryma Benayed Ronak H Shah Aijazuddin Syed Sumit Middha Hyunjae R Kim Preethi Srinivasan Jianjiong Gao Debyani Chakravarty Sean M Devlin Matthew D Hellmann David A Barron Alison M Schram Meera Hameed Snjezana Dogan Dara S Ross Jaclyn F Hechtman Deborah F DeLair JinJuan Yao Diana L Mandelker Donavan T Cheng Raghu Chandramohan Abhinita S Mohanty Ryan N Ptashkin Gowtham Jayakumaran Meera Prasad Mustafa H Syed Anoop Balakrishnan Rema Zhen Y Liu Khedoudja Nafa Laetitia Borsu Justyna Sadowska Jacklyn Casanova Ruben Bacares Iwona J Kiecka Anna Razumova Julie B Son Lisa Stewart Tessara Baldi Kerry A Mullaney Hikmat Al-Ahmadie Efsevia Vakiani Adam A Abeshouse Alexander V Penson Philip Jonsson Niedzica Camacho Matthew T Chang Helen H Won Benjamin E Gross Ritika Kundra Zachary J Heins Hsiao-Wei Chen Sarah Phillips Hongxin Zhang Jiaojiao Wang Angelica Ochoa Jonathan Wills Michael Eubank Stacy B Thomas Stuart M Gardos Dalicia N Reales Jesse Galle Robert Durany Roy Cambria Wassim Abida Andrea Cercek Darren R Feldman Mrinal M Gounder A Ari Hakimi James J Harding Gopa Iyer Yelena Y Janjigian Emmet J Jordan Ciara M Kelly Maeve A Lowery Luc G T Morris Antonio M Omuro Nitya Raj Pedram Razavi Alexander N Shoushtari Neerav Shukla Tara E Soumerai Anna M Varghese Rona Yaeger Jonathan Coleman Bernard Bochner Gregory J Riely Leonard B Saltz Howard I Scher Paul J Sabbatini Mark E Robson David S Klimstra Barry S Taylor Jose Baselga Nikolaus Schultz David M Hyman Maria E Arcila David B Solit Marc Ladanyi Michael F Berger

Nat Med 2017 Jun 8;23(6):703-713. Epub 2017 May 8.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

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http://www.nature.com/doifinder/10.1038/nm.4333
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http://dx.doi.org/10.1038/nm.4333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461196PMC
June 2017

ARID1A expression in early stage colorectal adenocarcinoma: an exploration of its prognostic significance.

Hum Pathol 2016 07 2;53:97-104. Epub 2016 Mar 2.

Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY, 10065. Electronic address:

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http://dx.doi.org/10.1016/j.humpath.2016.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994515PMC
July 2016

Reliable Detection of Mismatch Repair Deficiency in Colorectal Cancers Using Mutational Load in Next-Generation Sequencing Panels.

J Clin Oncol 2016 06 28;34(18):2141-7. Epub 2016 Mar 28.

Zsofia K. Stadler, Francesca Battaglin, Sumit Middha, Jaclyn F. Hechtman, Christina Tran, Andrea Cercek, Rona Yaeger, Neil H. Segal, Anna M. Varghese, Diane L. Reidy-Lagunes, Nancy E. Kemeny, Erin E. Salo-Mullen, Asad Ashraf, Martin R. Weiser, Julio Garcia-Aguilar, Mark E. Robson, Kenneth Offit, Maria E. Arcila, Michael F. Berger, Jinru Shia, David B. Solit, and Leonard B. Saltz, Memorial Sloan Kettering Cancer Center, New York, NY; and Francesca Battaglin, Veneto Institute of Oncology, Padua, Italy.

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http://dx.doi.org/10.1200/JCO.2015.65.1067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962706PMC
June 2016

Identification of Targetable Kinase Alterations in Patients with Colorectal Carcinoma That are Preferentially Associated with Wild-Type RAS/RAF.

Mol Cancer Res 2016 Mar 11;14(3):296-301. Epub 2015 Dec 11.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York. Human Oncology & Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1158/1541-7786.MCR-15-0392-TDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972456PMC
March 2016

EBV-associated lymphoepithelioma-like carcinoma of the pancreas: Case report with targeted sequencing analysis.

Pancreatology 2015 May-Jun;15(3):302-4. Epub 2015 Apr 9.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.pan.2015.03.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029421PMC
February 2016

Outcomes following resection of intrahepatic cholangiocarcinoma.

HPB (Oxford) 2015 Apr 14;17(4):344-51. Epub 2014 Nov 14.

Department of Surgery, Division of Surgical Oncology, Mount Sinai Medical Center, New York, NY, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S1365182X153128
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http://dx.doi.org/10.1111/hpb.12359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368399PMC
April 2015

Neurogenic polyps of the gastrointestinal tract: a clinicopathologic review with emphasis on differential diagnosis and syndromic associations.

Arch Pathol Lab Med 2015 Jan;139(1):133-9

From the Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York (Dr Hechtman); and the Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, New York (Dr Harpaz).

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http://dx.doi.org/10.5858/arpa.2013-0431-RSDOI Listing
January 2015

Loss of central inhibition: implications for behavioral hypersensitivity after contusive spinal cord injury in rats.

Pain Res Treat 2014 10;2014:178278. Epub 2014 Aug 10.

The Miami Project to Cure Paralysis, The University of Miami Miller School of Medicine, Miami, FL 33136, USA ; The Department of Neurological Surgery, The Neuroscience Program, The Interdisciplinary Stem Cell Institute, The University of Miami Miller School of Medicine, Miami, FL 33136, USA.

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http://dx.doi.org/10.1155/2014/178278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142659PMC
September 2014

Mycobacterial pseudotumor of the plantar fascia: how common is it?

Clin Imaging 2013 Jul-Aug;37(4):802-5. Epub 2013 Apr 4.

Mount Sinai School of Medicine, New York, NY, USA.

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http://dx.doi.org/10.1016/j.clinimag.2013.02.012DOI Listing
June 2014

Multiple endocrine neoplasia type 1 associated with a new mutation in the menin gene and a midgut neuroendocrine tumor.

Pancreas 2014 Jan;43(1):145-6

Center for Carcinoid and Neuroendocrine Tumors in the Department of Gastroenterology Mount Sinai School of Medicine New York, NY Mount Sinai Liver Cancer Program Mount Sinai School of Medicine New York, NY Department of Pathology Mount Sinai School of Medicine New York, NY Center for Carcinoid and Neuroendocrine Tumors in the Department of Gastroenterology Mount Sinai School of Medicine New York, NY

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http://dx.doi.org/10.1097/MPA.0b013e31829f9d3dDOI Listing
January 2014

Corpora amylacea in gastrointestinal leiomyomas: a clinical, light microscopic, ultrastructural and immunohistochemical study with comparison to hyaline globules.

J Clin Pathol 2013 Nov 6;66(11):951-5. Epub 2013 Jul 6.

Department of Pathology, Icahn School of Medicine at Mount Sinai, , New York, New York, USA.

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http://dx.doi.org/10.1136/jclinpath-2013-201701DOI Listing
November 2013

Promyelocytic leukemia zinc finger and histone H1.5 differentially stain low- and high-grade pulmonary neuroendocrine tumors: a pilot immunohistochemical study.

Hum Pathol 2013 Jul 14;44(7):1400-5. Epub 2013 Feb 14.

Department of Pathology, Mount Sinai School of Medicine and Medical Center, New York, NY 10029, USA.

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http://dx.doi.org/10.1016/j.humpath.2012.11.014DOI Listing
July 2013

Intramuscular corpora amylacea adjacent to ileal low-grade neuroendocrine tumours (typical carcinoids): a light microscopic, immunohistochemical and ultrastructural study.

J Clin Pathol 2013 Jul 26;66(7):569-72. Epub 2013 Feb 26.

Department of Pathology, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1136/jclinpath-2012-201415DOI Listing
July 2013

Intraductal polypoid lipid-rich neuroendocrine tumor of the pancreas with entrapped ductules: case report and review of the literature.

Endocr Pathol 2013 Mar;24(1):30-5

Department of Pathology, Mount Sinai School of Medicine, One Gustave L Levy Place, 1194, New York, NY 10029, USA.

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http://dx.doi.org/10.1007/s12022-012-9231-xDOI Listing
March 2013

Thymomas diagnosed during pregnancy: two cases in young women without paraneoplastic or autoimmune disease.

Ann Diagn Pathol 2012 Oct 8;16(5):392-6. Epub 2011 Jun 8.

Department of Pathology, Mount Sinai School of Medicine, New York, NY, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S10929134110005
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http://dx.doi.org/10.1016/j.anndiagpath.2011.03.003DOI Listing
October 2012

HER2/neu gene amplification and protein overexpression in gastric and gastroesophageal junction adenocarcinoma: a review of histopathology, diagnostic testing, and clinical implications.

Arch Pathol Lab Med 2012 Jun;136(6):691-7

Department of Pathology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA.

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http://dx.doi.org/10.5858/arpa.2011-0168-RSDOI Listing
June 2012

Hepatic mass in a 73-year-old man.

Gastroenterology 2012 Mar 26;142(3):434, 679. Epub 2012 Jan 26.

Department of Pathology, Mount Sinai School of Medicine, New York, New York, USA.

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http://dx.doi.org/10.1053/j.gastro.2011.09.006DOI Listing
March 2012

Ischemic bowel due to embolization from an isolated mobile thrombus of the ascending aorta: a case report and review of the literature.

J Thromb Thrombolysis 2011 Aug;32(2):238-41

Department of Pathology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA.

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http://dx.doi.org/10.1007/s11239-011-0581-xDOI Listing
August 2011