Jack Satsangi

Jack Satsangi

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Jack Satsangi

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The Inflammatory Bowel Disease Drug Azathioprine Induces Autophagy via mTORC1 and the Unfolded Protein Response Sensor PERK.

Inflamm Bowel Dis 2019 Aug;25(9):1481-1496

School of Applied Sciences, Edinburgh Napier University, Sighthill Campus, Sighthill Court, Edinburgh, Scotland.

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http://dx.doi.org/10.1093/ibd/izz039DOI Listing
August 2019

The type III intermediate filament vimentin regulates organelle distribution and modulates autophagy.

PLoS One 2019 30;14(1):e0209665. Epub 2019 Jan 30.

School of Applied Sciences, Edinburgh Napier University, Sighthill Campus, Sighthill Court, Edinburgh, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209665PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353089PMC
January 2019

Purine metabolism controls innate lymphoid cell function and protects against intestinal injury.

Immunol Cell Biol 2018 11 10;96(10):1049-1059. Epub 2018 Jul 10.

Medical Research Council (MRC) Centre for Inflammation Research, Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, EH16 4TJ, UK.

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http://dx.doi.org/10.1111/imcb.12167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248310PMC
November 2018

The role of genetics in Crohn's disease: how could it influence future therapies?

Expert Rev Gastroenterol Hepatol 2018 Nov 21;12(11):1075-1077. Epub 2018 Aug 21.

a Translational Gastroenterology Unit, Nuffield Department of Experimental Medicine , University of Oxford , Oxford , UK.

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http://dx.doi.org/10.1080/17474124.2018.1513323DOI Listing
November 2018

Mutational Analysis Identifies Therapeutic Biomarkers in Inflammatory Bowel Disease-Associated Colorectal Cancers.

Clin Cancer Res 2018 Oct 27;24(20):5133-5142. Epub 2018 Jun 27.

Division of Pathology, Centre for Comparative Pathology, Edinburgh Cancer Research Centre, Institute of Genetics & Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, Scotland, United Kingdom.

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-17-3713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193541PMC
October 2018

Mitochondrial DNA Is a Pro-Inflammatory Damage-Associated Molecular Pattern Released During Active IBD.

Inflamm Bowel Dis 2018 09;24(10):2113-2122

MRC Centre for Inflammation Research, Queens Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom.

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https://academic.oup.com/ibdjournal/article/24/10/2113/49872
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http://dx.doi.org/10.1093/ibd/izy095DOI Listing
September 2018

Lymphoma Risk and Overall Safety Profile of Adalimumab in Patients With Crohn's Disease With up to 6 Years of Follow-Up in the Pyramid Registry.

Am J Gastroenterol 2018 06 5;113(6):872-882. Epub 2018 Jun 5.

Academic Medical Center, Amsterdam, Netherlands. Medical university of Vienna, Vienna, Austria. Department of Medicine, university of Calgary, Calgary, Canada. Gastrointestinal Unit, Western General Hospital, Edinburgh, UK. AbbVie Inc., North Chicago, IL, USA. AbbVie Deutschland GmbH & Co. KG, Ludwigshafen, Germany. AbbVie Spain S.L.U., Madrid, Spain. Mayo Clinic, Division of Gastroenterology and Hepatology, Rochester, NY, USA.

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http://dx.doi.org/10.1038/s41395-018-0098-4DOI Listing
June 2018

A plea for TDM-based optimisation for treatment of Crohn's disease - Authors' reply.

Lancet Gastroenterol Hepatol 2017 02 12;2(2):81-82. Epub 2017 Jan 12.

Gastrointestinal Unit, Western General Hospital, Edinburgh, UK.

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http://dx.doi.org/10.1016/S2468-1253(16)30222-9DOI Listing
February 2017

Can Thiopurines Prevent Formation of Antibodies Against Tumor Necrosis Factor Antagonists After Failure of These Therapies?

Clin Gastroenterol Hepatol 2017 01 5;15(1):76-78. Epub 2016 Oct 5.

Gastrointestinal Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1016/j.cgh.2016.09.152DOI Listing
January 2017

Serum Calprotectin: A Novel Diagnostic and Prognostic Marker in Inflammatory Bowel Diseases.

Am J Gastroenterol 2016 Dec 6;111(12):1796-1805. Epub 2016 Sep 6.

Gastrointestinal Unit, Centre for Molecular Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK.

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http://dx.doi.org/10.1038/ajg.2016.342DOI Listing
December 2016

Biomarkers in Search of Precision Medicine in IBD.

Am J Gastroenterol 2016 Dec 27;111(12):1682-1690. Epub 2016 Sep 27.

MRC Centre for Inflammation Research, Queens Medical Research Institute, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1038/ajg.2016.441DOI Listing
December 2016

Danish cohort of monozygotic inflammatory bowel disease twins: Clinical characteristics and inflammatory activity.

World J Gastroenterol 2016 Jun;22(21):5050-9

Frederik Trier Moller, Lina Knudsen, Vibeke Andersen, Research Unit for Molecular Diagnostics, Hospital of Southern Jutland, 6200 Aabenraa, Denmark.

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http://dx.doi.org/10.3748/wjg.v22.i21.5050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886380PMC
June 2016

How to Apply for and Secure EU Funding for Collaborative IBD Research Projects.

J Crohns Colitis 2016 Mar 7;10(3):363-70. Epub 2016 Jan 7.

Department of Gastroenterology, University Hospital CHU of Liège, Liège, Belgium

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http://dx.doi.org/10.1093/ecco-jcc/jjv237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957481PMC
March 2016

Systematic Review of Effects of Withdrawal of Immunomodulators or Biologic Agents From Patients With Inflammatory Bowel Disease.

Gastroenterology 2015 Dec 14;149(7):1716-30. Epub 2015 Sep 14.

Gastrointestinal Unit, Centre for Molecular Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland.

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http://dx.doi.org/10.1053/j.gastro.2015.08.055DOI Listing
December 2015

Characterisation of osteoprotegerin autoantibodies in coeliac disease.

Calcif Tissue Int 2015 Aug 20;97(2):125-33. Epub 2015 Jun 20.

Centre for Genomics and Experimental Medicine, Institute of Genetics and Molecular Medicine (IGMM), Edinburgh, EH4 2XU, UK.

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http://dx.doi.org/10.1007/s00223-015-0023-4DOI Listing
August 2015

Killing of Escherichia coli by Crohn's Disease Monocyte-derived Macrophages and Its Enhancement by Hydroxychloroquine and Vitamin D.

Inflamm Bowel Dis 2015 Jul;21(7):1499-510

*Department of Gastroenterology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom; †Department of Biochemistry, Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom; ‡Immunology Unit and Center of Excellence in Immunology and Immune-mediated Disease, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; §Gastrointestinal Unit, Molecular Medicine Centre, University of Edinburgh, Edinburgh, Scotland; and ‖Department of Gastroenterology, Royal Liverpool University Hospital, Liverpool, United Kingdom.

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http://dx.doi.org/10.1097/MIB.0000000000000387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894789PMC
July 2015

Inflammatory bowel disease associates with proinflammatory potential of the immunoglobulin G glycome.

Inflamm Bowel Dis 2015 Jun;21(6):1237-47

*Genos Glycoscience Research Laboratory, Zagreb, Croatia; †Gastrointestinal Unit, Centre for Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom; ‡Centre for Population Health Sciences, University of Edinburgh, Edinburgh, United Kingdom; §Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council Human Genetics Unit, Edinburgh, United Kingdom; ‖Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; ¶Novosibirsk State University, Novosibirsk, Russia; and **Department of Biochemistry and Molecular Biology, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, Croatia.

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http://dx.doi.org/10.1097/MIB.0000000000000372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450892PMC
June 2015

Pathogenesis of Crohn's disease.

F1000Prime Rep 2015 2;7:44. Epub 2015 Apr 2.

Centre for Inflammation Research, Queens Medical Research Institute, University of Edinburgh Edinburgh, EH16 4TJ UK ; Gastrointestinal Unit, Institute of Genetics and Molecular Medicine, Western General Hospital Edinburgh, EH4 2XU UK.

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http://dx.doi.org/10.12703/P7-44DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447044PMC
June 2015

Predicting outcomes in acute severe ulcerative colitis.

Expert Rev Gastroenterol Hepatol 2015 Apr 15;9(4):405-15. Epub 2014 Dec 15.

Centre for Genomics and Molecular medicine, Western General Hospital, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XU, UK.

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http://dx.doi.org/10.1586/17474124.2015.992880DOI Listing
April 2015

Serum C-reactive protein and CRP genotype in pediatric inflammatory bowel disease: influence on phenotype, natural history, and response to therapy.

Inflamm Bowel Dis 2015 Mar;21(3):596-605

*Department of Pediatric Gastroenterology and Nutrition, Royal Hospital for Sick Children, Edinburgh, United Kingdom; †Child Life and Health, University of Edinburgh, Edinburgh, United Kingdom; ‡Gastrointestinal Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom; §IBD Center, Division of Pediatric Gastroenterology and Nutrition, IWK Health Center, Dalhousie University, Halifax, NS, Canada; and ‖Department of Pediatric Gastroenterology, Royal Hospital for Sick Children, Glasgow, United Kingdom.

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http://dx.doi.org/10.1097/MIB.0000000000000296DOI Listing
March 2015

Paneth cell marker CD24 in NOD2 knockout organoids and in inflammatory bowel disease (IBD).

Gut 2015 Feb 23;64(2):353-4. Epub 2013 May 23.

Department of Child Life and Health, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1136/gutjnl-2013-305077DOI Listing
February 2015

Crohn's disease.

BMJ 2014 Nov 19;349:g6670. Epub 2014 Nov 19.

Gastrointestinal Unit, Centre for Molecular Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh EH4 2XU, UK

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http://dx.doi.org/10.1136/bmj.g6670DOI Listing
November 2014

The role of glycosylation in IBD.

Nat Rev Gastroenterol Hepatol 2014 Oct 10;11(10):588-600. Epub 2014 Jun 10.

Department of Biochemistry and Molecular Biology, University of Zagreb Faculty of Pharmacy and Biochemistry, Trg maršala Tita 14, 10000 Zagreb, Croatia.

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http://dx.doi.org/10.1038/nrgastro.2014.78DOI Listing
October 2014

Two-stage genome-wide methylation profiling in childhood-onset Crohn's Disease implicates epigenetic alterations at the VMP1/MIR21 and HLA loci.

Inflamm Bowel Dis 2014 Oct;20(10):1784-93

*Gastrointestinal Unit, Centre for Genetics and Experimental Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom; †Gastrointestinal Research Group, Division of Applied Medicine, University of Aberdeen, Aberdeen, United Kingdom; ‡Department of Paediatric Gastroenterology, Royal Hospital for Sick Children, Glasgow, United Kingdom; and §Paediatric Gastroenterology and Nutrition, Child Life and Health, University of Edinburgh, Royal Hospital for Sick Children, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1097/MIB.0000000000000179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736293PMC
October 2014

Advances in IBD genetics.

Nat Rev Gastroenterol Hepatol 2014 Jun 11;11(6):372-85. Epub 2014 Mar 11.

Gastrointestinal Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XU, UK.

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http://dx.doi.org/10.1038/nrgastro.2014.27DOI Listing
June 2014

Sight-threatening keratopathy complicating anti-TNF therapy in Crohn's disease: a case report.

Inflamm Bowel Dis 2014 Jan;20(1):E2-3

*Gastrointestinal Unit, Western General Hospital, Edinburgh, United Kingdom †Princess Alexandra Eye Pavilion, Edinburgh, United Kingdom ‡Inverclyde Royal Hospital Greenock, Renfrewshire, United Kingdom.

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http://dx.doi.org/10.1097/01.MIB.0000436952.88522.77DOI Listing
January 2014

Beyond gene discovery in inflammatory bowel disease: the emerging role of epigenetics.

Gastroenterology 2013 Aug 8;145(2):293-308. Epub 2013 Jun 8.

Gastrointestinal Unit, Centre for Molecular Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland.

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http://dx.doi.org/10.1053/j.gastro.2013.05.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919211PMC
August 2013

The intermediate filament protein, vimentin, is a regulator of NOD2 activity.

Gut 2013 May 8;62(5):695-707. Epub 2012 Jun 8.

Centre for Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK.

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http://dx.doi.org/10.1136/gutjnl-2011-301775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225453PMC
May 2013

Barrett's esophagus: evolutionary insights from genomics.

Gastroenterology 2013 Apr 21;144(4):667-9. Epub 2013 Feb 21.

Queen Mary University of London, England, United Kingdom.

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http://dx.doi.org/10.1053/j.gastro.2013.02.014DOI Listing
April 2013

A role for vimentin in Crohn disease.

Autophagy 2012 Nov 28;8(11):1695-6. Epub 2012 Aug 28.

Department of Child Life and Health, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.4161/auto.21690DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494605PMC
November 2012

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.

Authors:
Luke Jostins Stephan Ripke Rinse K Weersma Richard H Duerr Dermot P McGovern Ken Y Hui James C Lee L Philip Schumm Yashoda Sharma Carl A Anderson Jonah Essers Mitja Mitrovic Kaida Ning Isabelle Cleynen Emilie Theatre Sarah L Spain Soumya Raychaudhuri Philippe Goyette Zhi Wei Clara Abraham Jean-Paul Achkar Tariq Ahmad Leila Amininejad Ashwin N Ananthakrishnan Vibeke Andersen Jane M Andrews Leonard Baidoo Tobias Balschun Peter A Bampton Alain Bitton Gabrielle Boucher Stephan Brand Carsten Büning Ariella Cohain Sven Cichon Mauro D'Amato Dirk De Jong Kathy L Devaney Marla Dubinsky Cathryn Edwards David Ellinghaus Lynnette R Ferguson Denis Franchimont Karin Fransen Richard Gearry Michel Georges Christian Gieger Jürgen Glas Talin Haritunians Ailsa Hart Chris Hawkey Matija Hedl Xinli Hu Tom H Karlsen Limas Kupcinskas Subra Kugathasan Anna Latiano Debby Laukens Ian C Lawrance Charlie W Lees Edouard Louis Gillian Mahy John Mansfield Angharad R Morgan Craig Mowat William Newman Orazio Palmieri Cyriel Y Ponsioen Uros Potocnik Natalie J Prescott Miguel Regueiro Jerome I Rotter Richard K Russell Jeremy D Sanderson Miquel Sans Jack Satsangi Stefan Schreiber Lisa A Simms Jurgita Sventoraityte Stephan R Targan Kent D Taylor Mark Tremelling Hein W Verspaget Martine De Vos Cisca Wijmenga David C Wilson Juliane Winkelmann Ramnik J Xavier Sebastian Zeissig Bin Zhang Clarence K Zhang Hongyu Zhao Mark S Silverberg Vito Annese Hakon Hakonarson Steven R Brant Graham Radford-Smith Christopher G Mathew John D Rioux Eric E Schadt Mark J Daly Andre Franke Miles Parkes Severine Vermeire Jeffrey C Barrett Judy H Cho

Nature 2012 Nov;491(7422):119-24

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK.

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http://dx.doi.org/10.1038/nature11582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491803PMC
November 2012

Rising incidence of pediatric inflammatory bowel disease in Scotland.

Inflamm Bowel Dis 2012 Jun 17;18(6):999-1005. Epub 2011 Jun 17.

Department of Child Life and Health, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1002/ibd.21797DOI Listing
June 2012

Genome-wide methylation profiling in Crohn's disease identifies altered epigenetic regulation of key host defense mechanisms including the Th17 pathway.

Inflamm Bowel Dis 2012 May 21;18(5):889-99. Epub 2011 Oct 21.

Gastrointestinal Unit, Centre for Molecular Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK.

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http://dx.doi.org/10.1002/ibd.21912DOI Listing
May 2012

Cigarette smoke extract (CSE) delays NOD2 expression and affects NOD2/RIPK2 interactions in intestinal epithelial cells.

PLoS One 2011 12;6(9):e24715. Epub 2011 Sep 12.

Gastrointestinal Unit, Molecular Medicine Centre, Western General Hospital, University of Edinburgh, Edinburgh, Scotland, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0024715PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171477PMC
February 2012

TLE1 modifies the effects of NOD2 in the pathogenesis of Crohn's disease.

Gastroenterology 2011 Sep 27;141(3):972-981.e1-2. Epub 2011 May 27.

Gastrointestinal Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Molecular Medicine Centre, Western General Hospital, Edinburgh, UK.

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http://dx.doi.org/10.1053/j.gastro.2011.05.043DOI Listing
September 2011

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.

Authors:
Carl A Anderson Gabrielle Boucher Charlie W Lees Andre Franke Mauro D'Amato Kent D Taylor James C Lee Philippe Goyette Marcin Imielinski Anna Latiano Caroline Lagacé Regan Scott Leila Amininejad Suzannah Bumpstead Leonard Baidoo Robert N Baldassano Murray Barclay Theodore M Bayless Stephan Brand Carsten Büning Jean-Frédéric Colombel Lee A Denson Martine De Vos Marla Dubinsky Cathryn Edwards David Ellinghaus Rudolf S N Fehrmann James A B Floyd Timothy Florin Denis Franchimont Lude Franke Michel Georges Jürgen Glas Nicole L Glazer Stephen L Guthery Talin Haritunians Nicholas K Hayward Jean-Pierre Hugot Gilles Jobin Debby Laukens Ian Lawrance Marc Lémann Arie Levine Cecile Libioulle Edouard Louis Dermot P McGovern Monica Milla Grant W Montgomery Katherine I Morley Craig Mowat Aylwin Ng William Newman Roel A Ophoff Laura Papi Orazio Palmieri Laurent Peyrin-Biroulet Julián Panés Anne Phillips Natalie J Prescott Deborah D Proctor Rebecca Roberts Richard Russell Paul Rutgeerts Jeremy Sanderson Miquel Sans Philip Schumm Frank Seibold Yashoda Sharma Lisa A Simms Mark Seielstad A Hillary Steinhart Stephan R Targan Leonard H van den Berg Morten Vatn Hein Verspaget Thomas Walters Cisca Wijmenga David C Wilson Harm-Jan Westra Ramnik J Xavier Zhen Z Zhao Cyriel Y Ponsioen Vibeke Andersen Leif Torkvist Maria Gazouli Nicholas P Anagnou Tom H Karlsen Limas Kupcinskas Jurgita Sventoraityte John C Mansfield Subra Kugathasan Mark S Silverberg Jonas Halfvarson Jerome I Rotter Christopher G Mathew Anne M Griffiths Richard Gearry Tariq Ahmad Steven R Brant Mathias Chamaillard Jack Satsangi Judy H Cho Stefan Schreiber Mark J Daly Jeffrey C Barrett Miles Parkes Vito Annese Hakon Hakonarson Graham Radford-Smith Richard H Duerr Séverine Vermeire Rinse K Weersma John D Rioux

Nat Genet 2011 Mar 6;43(3):246-52. Epub 2011 Feb 6.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.

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http://dx.doi.org/10.1038/ng.764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084597PMC
March 2011

Genetics of childhood-onset inflammatory bowel disease.

Inflamm Bowel Dis 2011 Jan;17(1):346-61

Department of Paediatric Gastroenterology, Hepatology and Nutrition, Royal Hospital for Sick Children, Edinburgh, UK.

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http://dx.doi.org/10.1002/ibd.21283DOI Listing
January 2011

Measurement methods and accuracy in copy number variation: failure to replicate associations of beta-defensin copy number with Crohn's disease.

Hum Mol Genet 2010 Dec 21;19(24):4930-8. Epub 2010 Sep 21.

Gastrointestinal Unit, School of Clinical and Molecular Medicine, Western General Hospital, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland, UK.

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http://dx.doi.org/10.1093/hmg/ddq411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989891PMC
December 2010

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.

Nat Genet 2010 Dec;42(12):1118-25

Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel, Kiel, Germany.

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http://dx.doi.org/10.1038/ng.717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299551PMC
December 2010

Characterization of intestinal gene expression profiles in Crohn's disease by genome-wide microarray analysis.

Inflamm Bowel Dis 2010 Oct;16(10):1717-28

Gastrointestinal Unit, University of Edinburgh, Western General Hospital, Edinburgh, UK.

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http://dx.doi.org/10.1002/ibd.21263DOI Listing
October 2010

Meta-analysis and imputation refines the association of 15q25 with smoking quantity.

Authors:
Jason Z Liu Federica Tozzi Dawn M Waterworth Sreekumar G Pillai Pierandrea Muglia Lefkos Middleton Wade Berrettini Christopher W Knouff Xin Yuan Gérard Waeber Peter Vollenweider Martin Preisig Nicholas J Wareham Jing Hua Zhao Ruth J F Loos Inês Barroso Kay-Tee Khaw Scott Grundy Philip Barter Robert Mahley Antero Kesaniemi Ruth McPherson John B Vincent John Strauss James L Kennedy Anne Farmer Peter McGuffin Richard Day Keith Matthews Per Bakke Amund Gulsvik Susanne Lucae Marcus Ising Tanja Brueckl Sonja Horstmann H-Erich Wichmann Rajesh Rawal Norbert Dahmen Claudia Lamina Ozren Polasek Lina Zgaga Jennifer Huffman Susan Campbell Jaspal Kooner John C Chambers Mary Susan Burnett Joseph M Devaney Augusto D Pichard Kenneth M Kent Lowell Satler Joseph M Lindsay Ron Waksman Stephen Epstein James F Wilson Sarah H Wild Harry Campbell Veronique Vitart Muredach P Reilly Mingyao Li Liming Qu Robert Wilensky William Matthai Hakon H Hakonarson Daniel J Rader Andre Franke Michael Wittig Arne Schäfer Manuela Uda Antonio Terracciano Xiangjun Xiao Fabio Busonero Paul Scheet David Schlessinger David St Clair Dan Rujescu Gonçalo R Abecasis Hans Jörgen Grabe Alexander Teumer Henry Völzke Astrid Petersmann Ulrich John Igor Rudan Caroline Hayward Alan F Wright Ivana Kolcic Benjamin J Wright John R Thompson Anthony J Balmforth Alistair S Hall Nilesh J Samani Carl A Anderson Tariq Ahmad Christopher G Mathew Miles Parkes Jack Satsangi Mark Caulfield Patricia B Munroe Martin Farrall Anna Dominiczak Jane Worthington Wendy Thomson Steve Eyre Anne Barton Vincent Mooser Clyde Francks Jonathan Marchini

Nat Genet 2010 May 25;42(5):436-40. Epub 2010 Apr 25.

Department of Statistics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/ng.572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612983PMC
May 2010

Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls.

Authors:
Nick Craddock Matthew E Hurles Niall Cardin Richard D Pearson Vincent Plagnol Samuel Robson Damjan Vukcevic Chris Barnes Donald F Conrad Eleni Giannoulatou Chris Holmes Jonathan L Marchini Kathy Stirrups Martin D Tobin Louise V Wain Chris Yau Jan Aerts Tariq Ahmad T Daniel Andrews Hazel Arbury Anthony Attwood Adam Auton Stephen G Ball Anthony J Balmforth Jeffrey C Barrett Inês Barroso Anne Barton Amanda J Bennett Sanjeev Bhaskar Katarzyna Blaszczyk John Bowes Oliver J Brand Peter S Braund Francesca Bredin Gerome Breen Morris J Brown Ian N Bruce Jaswinder Bull Oliver S Burren John Burton Jake Byrnes Sian Caesar Chris M Clee Alison J Coffey John M C Connell Jason D Cooper Anna F Dominiczak Kate Downes Hazel E Drummond Darshna Dudakia Andrew Dunham Bernadette Ebbs Diana Eccles Sarah Edkins Cathryn Edwards Anna Elliot Paul Emery David M Evans Gareth Evans Steve Eyre Anne Farmer I Nicol Ferrier Lars Feuk Tomas Fitzgerald Edward Flynn Alistair Forbes Liz Forty Jayne A Franklyn Rachel M Freathy Polly Gibbs Paul Gilbert Omer Gokumen Katherine Gordon-Smith Emma Gray Elaine Green Chris J Groves Detelina Grozeva Rhian Gwilliam Anita Hall Naomi Hammond Matt Hardy Pile Harrison Neelam Hassanali Husam Hebaishi Sarah Hines Anne Hinks Graham A Hitman Lynne Hocking Eleanor Howard Philip Howard Joanna M M Howson Debbie Hughes Sarah Hunt John D Isaacs Mahim Jain Derek P Jewell Toby Johnson Jennifer D Jolley Ian R Jones Lisa A Jones George Kirov Cordelia F Langford Hana Lango-Allen G Mark Lathrop James Lee Kate L Lee Charlie Lees Kevin Lewis Cecilia M Lindgren Meeta Maisuria-Armer Julian Maller John Mansfield Paul Martin Dunecan C O Massey Wendy L McArdle Peter McGuffin Kirsten E McLay Alex Mentzer Michael L Mimmack Ann E Morgan Andrew P Morris Craig Mowat Simon Myers William Newman Elaine R Nimmo Michael C O'Donovan Abiodun Onipinla Ifejinelo Onyiah Nigel R Ovington Michael J Owen Kimmo Palin Kirstie Parnell David Pernet John R B Perry Anne Phillips Dalila Pinto Natalie J Prescott Inga Prokopenko Michael A Quail Suzanne Rafelt Nigel W Rayner Richard Redon David M Reid Renwick Susan M Ring Neil Robertson Ellie Russell David St Clair Jennifer G Sambrook Jeremy D Sanderson Helen Schuilenburg Carol E Scott Richard Scott Sheila Seal Sue Shaw-Hawkins Beverley M Shields Matthew J Simmonds Debbie J Smyth Elilan Somaskantharajah Katarina Spanova Sophia Steer Jonathan Stephens Helen E Stevens Millicent A Stone Zhan Su Deborah P M Symmons John R Thompson Wendy Thomson Mary E Travers Clare Turnbull Armand Valsesia Mark Walker Neil M Walker Chris Wallace Margaret Warren-Perry Nicholas A Watkins John Webster Michael N Weedon Anthony G Wilson Matthew Woodburn B Paul Wordsworth Allan H Young Eleftheria Zeggini Nigel P Carter Timothy M Frayling Charles Lee Gil McVean Patricia B Munroe Aarno Palotie Stephen J Sawcer Stephen W Scherer David P Strachan Chris Tyler-Smith Matthew A Brown Paul R Burton Mark J Caulfield Alastair Compston Martin Farrall Stephen C L Gough Alistair S Hall Andrew T Hattersley Adrian V S Hill Christopher G Mathew Marcus Pembrey Jack Satsangi Michael R Stratton Jane Worthington Panos Deloukas Audrey Duncanson Dominic P Kwiatkowski Mark I McCarthy Willem Ouwehand Miles Parkes Nazneen Rahman John A Todd Nilesh J Samani Peter Donnelly

Nature 2010 Apr;464(7289):713-20

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http://dx.doi.org/10.1038/nature08979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892339PMC
April 2010

Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.

Nat Genet 2009 Dec 15;41(12):1330-4. Epub 2009 Nov 15.

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http://dx.doi.org/10.1038/ng.483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812019PMC
December 2009

Common variants at five new loci associated with early-onset inflammatory bowel disease.

Authors:
Marcin Imielinski Robert N Baldassano Anne Griffiths Richard K Russell Vito Annese Marla Dubinsky Subra Kugathasan Jonathan P Bradfield Thomas D Walters Patrick Sleiman Cecilia E Kim Aleixo Muise Kai Wang Joseph T Glessner Shehzad Saeed Haitao Zhang Edward C Frackelton Cuiping Hou James H Flory George Otieno Rosetta M Chiavacci Robert Grundmeier Massimo Castro Anna Latiano Bruno Dallapiccola Joanne Stempak Debra J Abrams Kent Taylor Dermot McGovern Gary Silber Iwona Wrobel Antonio Quiros Jeffrey C Barrett Sarah Hansoul Dan L Nicolae Judy H Cho Richard H Duerr John D Rioux Steven R Brant Mark S Silverberg Kent D Taylor M Michael Barmuda Alain Bitton Themistocles Dassopoulos Lisa Wu Datta Todd Green Anne M Griffiths Emily O Kistner Michael T Murtha Miguel D Regueiro Jerome I Rotter L Philip Schumm A Hillary Steinhart Stephen R Targan Ramnik J Xavier Cécile Libioulle Cynthia Sandor Mark Lathrop Jacques Belaiche Olivier Dewit Ivo Gut Simon Heath Debby Laukens Myriam Mni Paul Rutgeerts André Van Gossum Diana Zelenika Denis Franchimont J P Hugot Martine de Vos Severine Vermeire Edouard Louis Lon R Cardon Carl A Anderson Hazel Drummond Elaine Nimmo Tariq Ahmad Natalie J Prescott Clive M Onnie Sheila A Fisher Jonathan Marchini Jilur Ghori Suzannah Bumpstead Rhian Gwillam Mark Tremelling Panos Delukas John Mansfield Derek Jewell Jack Satsangi Christopher G Mathew Miles Parkes Michel Georges Mark J Daly Melvin B Heyman George D Ferry Barbara Kirschner Jessica Lee Jonah Essers Richard Grand Michael Stephens Arie Levine David Piccoli John Van Limbergen Salvatore Cucchiara Dimitri S Monos Stephen L Guthery Lee Denson David C Wilson Straun F A Grant Mark Daly Mark S Silverberg Jack Satsangi Hakon Hakonarson

Nat Genet 2009 Dec 15;41(12):1335-40. Epub 2009 Nov 15.

Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1038/ng.489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267927PMC
December 2009

The genetics of Crohn's disease.

Annu Rev Genomics Hum Genet 2009 ;10:89-116

Department of Pediatric Gastroenterology and Nutrition, Royal Hospital for Sick Children, Edinburgh EH9 1LF, United Kingdom.

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http://dx.doi.org/10.1146/annurev-genom-082908-150013DOI Listing
October 2009

Genetics of inflammatory bowel disease: implications for disease pathogenesis and natural history.

Expert Rev Gastroenterol Hepatol 2009 Oct;3(5):513-34

Gastrointestinal Unit, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK.

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http://dx.doi.org/10.1586/egh.09.45DOI Listing
October 2009

Systematic review: the role of breastfeeding in the development of pediatric inflammatory bowel disease.

J Pediatr 2009 Sep 22;155(3):421-6. Epub 2009 May 22.

Department of Child Health, University of Glasgow, Glasgow, UK.

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http://dx.doi.org/10.1016/j.jpeds.2009.03.017DOI Listing
September 2009

Dysregulation of human beta-defensin-2 protein in inflammatory bowel disease.

PLoS One 2009 Jul 20;4(7):e6285. Epub 2009 Jul 20.

Gastrointestinal Unit, School of Clinical and Molecular Medicine, University of Edinburgh, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland, UK.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0006285PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2708916PMC
July 2009

Does nicotine influence cytokine profile and subsequent cell cycling/apoptotic responses in inflammatory bowel disease?

Inflamm Bowel Dis 2008 Nov;14(11):1469-82

Gastrointestinal Unit, School of Clinical and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, UK.

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http://dx.doi.org/10.1002/ibd.20523DOI Listing
November 2008

What do the terms "genetic predisposition" and "genetic heterogeneity" mean in relation to inflammatory bowel disease?

Authors:
Jack Satsangi

Inflamm Bowel Dis 2008 Oct;14 Suppl 2:S31-2

University of Edinburg, Western General Hospital, Edinburg, UK.

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http://dx.doi.org/10.1002/ibd.20563DOI Listing
October 2008

Early combined immunosuppression in Crohn's disease.

Lancet 2008 Jun;371(9629):1995; author reply 1996-7

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http://dx.doi.org/10.1016/S0140-6736(08)60859-4DOI Listing
June 2008

Therapeutic options in acute severe ulcerative colitis.

Expert Rev Gastroenterol Hepatol 2008 Jun;2(3):357-70

Gastrointestinal Unit, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK.

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http://dx.doi.org/10.1586/17474124.2.3.357DOI Listing
June 2008