Dr. Jack Timothy  Rogers, Ph.D. - Massachusetts General Hospital - Director, Neurochemistry Laboratory

Dr. Jack Timothy Rogers

Ph.D.

Massachusetts General Hospital

Director, Neurochemistry Laboratory

Charlestown, MA | United States

Main Specialties: Biology

Additional Specialties: Iron Mol Biology of Alzheimer's disease

ORCID logohttps://orcid.org/0000-0003-1262-8578


Top Author

Dr. Jack Timothy  Rogers, Ph.D. - Massachusetts General Hospital - Director, Neurochemistry Laboratory

Dr. Jack Timothy Rogers

Ph.D.

Introduction

Jack Rogers, PhD. is a Leading authority on the role that RNA in the maintenance of iron homeostasis related to disease processes in the blood (anemia) and in Alzheimer’s disease, and more recently in the etiology of amyloidosis Down syndrome. Director of the Neurochemistry Laboratory in the Psychiatry Department at Massachusetts General Hospital and an Associate Professor at the Harvard Medical School, Jack has an extensive funded track record in established scientific journals (Cell, J. Biol. Chem. including cover issue, and PNAS). His numerous articles and peer review publications won him a Zenith award from the Alzheimer’s Association on the subjects of iron metabolism, and translational control related disease progression. Currently, he has included a track record and novel iron metabolic approach to Alzheimer’s disease and Parkinson’s disease. This includes a recent focus of energies towards developing a program in drug discovery to find therapies for people with amyloidosis as accelerated by iron imbalances in neurodegenerative diseases, particularly in Alzheimer’s disease/ Down syndrome, undertaken in collaboration with the Metalomics core in Melbourne Australia. An integrative program was instigated to use RNA based therapeutic strategies to ameliorate the progression of Alzheimer’s disease (2002-2018), and for Parkinson’s disease in partnership with the Michael J-Fox Foundation (2009-2013). He is an excellent mentor of postdoctoral fellows, in addition to teaching the molecular biology of disease at the Harvard Medical students. Dr. Rogers contributes a creative approach to gene base therapies and basic science, he serves on several scientific advisory Boards. He and his family live in Arlington, Massachusetts.

Primary Affiliation: Massachusetts General Hospital - Charlestown, MA , United States

Specialties:

Additional Specialties:

Research Interests:


View Dr. Jack Timothy Rogers’s Resume / CV

Education

Dec 1980
University of Pennsylvania

Genetics
May 1973 - Jan 1977
Trinity College Dublin
BA(mod)
Genetics
May 1973 - Jan 1977
Trinity College Dublin
BA(mod)
Genetics

Experience

Jan 2006 - Jan 2018
Mass General Hospital
Assoc. Professor Harvard Medical school
Psychiatry-Neuroscience
Nov 2017
Associate Professor Harvard
Lab Director
Neurochemistry MGH
Nov 2000
Assistant Professor Harvard
Co-Director
Oxidation Biology MGH

Publications

69Publications

829Reads

448Profile Views

Novel upregulation of amyloid-β precursor protein (APP) by microRNA-346 via targeting of APP mRNA 5'-untranslated region: Implications in Alzheimer's disease.

Mol Psychiatry 2019 Mar 23;24(3):345-363. Epub 2018 Nov 23.

Department of Psychiatry, Laboratory of Molecular Neurogenetics, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.

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http://dx.doi.org/10.1038/s41380-018-0266-3DOI Listing
March 2019
9 Reads
14.500 Impact Factor

Manganese causes neurotoxic iron accumulation via translational repression of amyloid precursor protein and H-Ferritin.

J Neurochem 2018 Dec 19;147(6):831-848. Epub 2018 Nov 19.

Neurochemistry Laboratory, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA.

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http://dx.doi.org/10.1111/jnc.14580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310653PMC
December 2018
26 Reads
4.281 Impact Factor

Dysregulation of Neuronal Iron Homeostasis as an Alternative Unifying Effect of Mutations Causing Familial Alzheimer's Disease.

Front Neurosci 2018 13;12:533. Epub 2018 Aug 13.

Centre for Molecular Pathology, School of Biological Sciences, University of Adelaide, Adelaide, SA, Australia.

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http://dx.doi.org/10.3389/fnins.2018.00533DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099262PMC
August 2018
6 Reads

A role for. amyloid precursor protein translation to restore iron homeostasis and ameliorate Lead Neurotoxicity

JNC 138, 479-484

Journal of Neurochemistry

Iron supplementation ameliorates the neurotoxicity of the environmental contaminant lead (Pb); however, the mecha- nism remains undefined. Iron is an essential nutrient but high levels are toxic due to the catalytic generation of destructive hydroxyl radicals. Using human neuroblastoma SH-SY5Y cells to model human neurons, we investigated the effect of Pb on proteins of iron homeostasis: the Alzheimer’s amyloid precur- sor protein (APP), which stabilizes the iron exporter ferroportin 1; and, the heavy subunit of the iron-storage protein, ferritin (FTH). Lead (Pb(II) and Pb(IV) inhibited APP translation and raised cytosolic iron(II). Lead also increased iron regulatory protein-1 binding to the cognate 50untranslated region-specific iron-responsive element (IRE) of APP and FTH mRNAs. Concurrent iron treatment rescued cells from Pb toxicity by specifically restoring APP synthesis, i.e. levels of the APP- related protein, APLP-2, were unchanged. Significantly, iron/ IRE-independent over-expression of APP695 protected SH- SY5Y cells from Pb toxicity, demonstrating that APP plays a key role in maintaining safe levels of intracellular iron. Overall, our data support a model of neurotoxicity where Pb enhances iron regulatory protein/IRE-mediated repression of APP and FTH translation. We propose novel treatment options for Pb poisoning to include chelators and the use of small molecules to maintain APP and FTH translation.

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June 2018
4 Reads

HDAC1 Governs Iron Homeostasis Independent of Histone Deacetylation in Iron-Overload Murine Models.

Antioxid Redox Signal 2018 05 13;28(13):1224-1237. Epub 2017 Dec 13.

1 College of Life and Health Sciences, Northeastern University ; The First Affiliated Hospital, Institute of Translational Medicine, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, School of Public Health, School of Medicine, Zhejiang University , Hangzhou, China .

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http://dx.doi.org/10.1089/ars.2017.7161DOI Listing
May 2018
14 Reads
7.410 Impact Factor

S-Adenosyl Methionine and Transmethylation Pathways in Neuropsychiatric Diseases Throughout Life.

Neurotherapeutics 2018 01;15(1):156-175

Neurochemistry Laboratory, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1007/s13311-017-0593-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794704PMC
January 2018
6 Reads

Assessments of plasma ghrelin levels in the early stages of parkinson's disease.

Mov Disord 2017 Oct 6;32(10):1487-1491. Epub 2017 Jul 6.

Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines: Physiology, Medical College of Qingdao University, Qingdao, China.

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http://dx.doi.org/10.1002/mds.27095DOI Listing
October 2017
22 Reads
5.680 Impact Factor

Tat-haFGF Upregulates ADAM10 to Attenuate the Alzheimer Phenotype of APP/PS1 Mice through the PI3K-CREB-IRE1α/XBP1 Pathway.

Mol Ther Nucleic Acids 2017 Jun 10;7:439-452. Epub 2017 May 10.

Guangdong Provincial Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou 510632, China; Cell Biology Department and National Engineering Research Center of Genetic Medicine, Jinan University, Guangzhou 510632, China. Electronic address:

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http://dx.doi.org/10.1016/j.omtn.2017.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5443968PMC
June 2017
32 Reads

Brain Iron Metabolism Dysfunction in Parkinson's Disease.

Mol Neurobiol 2017 05 2;54(4):3078-3101. Epub 2016 Apr 2.

Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines: Physiology, Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders, Medical College of Qingdao University, Qingdao, 266071, China.

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http://dx.doi.org/10.1007/s12035-016-9879-1DOI Listing
May 2017
9 Reads
5.140 Impact Factor

A role for amyloid precursor protein translation to restore iron homeostasis and ameliorate lead (Pb) neurotoxicity.

J Neurochem 2016 08;138(3):479-94

Neurochemistry Laboratory, Department of Psychiatry-Neuroscience, Massachusetts General Hospital (East), Harvard Medical School, Charlestown, Massachusetts, USA.

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http://dx.doi.org/10.1111/jnc.13671DOI Listing
August 2016
29 Reads
4.281 Impact Factor

Differential Expression of the Activator Protein 1 Transcription Factor Regulates Interleukin-1ß Induction of Interleukin 6 in the Developing Enterocyte.

PLoS One 2016 22;11(1):e0145184. Epub 2016 Jan 22.

Mucosal Immunology and Biology Research Center, Department of Pediatrics, Massachusetts General Hospital for Children, and Harvard Medical School, Charlestown, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0145184PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4723075PMC
July 2016
57 Reads
3.234 Impact Factor

Perturbed iron distribution in Alzheimer's disease serum, cerebrospinal fluid, and selected brain regions: a systematic review and meta-analysis.

J Alzheimers Dis 2014 ;42(2):679-90

Laboratory of Nutrition and Metabolism, Department of Nutrition, Research Center for Nutrition and Health, Institute of Nutrition and Food Safety, School of Public Health, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou, Zhejiang, China.

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http://dx.doi.org/10.3233/JAD-140396DOI Listing
July 2015
24 Reads
4.151 Impact Factor

Parkinson's disease iron deposition caused by nitric oxide-induced loss of β-amyloid precursor protein.

J Neurosci 2015 Feb;35(8):3591-7

Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria 3010, Australia,

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http://dx.doi.org/10.1523/JNEUROSCI.3439-14.2015DOI Listing
February 2015
21 Reads
6.344 Impact Factor

Novel 5' untranslated region directed blockers of iron-regulatory protein-1 dependent amyloid precursor protein translation: implications for down syndrome and Alzheimer's disease.

PLoS One 2013 31;8(7):e65978. Epub 2013 Jul 31.

Neurochemistry Laboratory, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0065978PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3729844PMC
April 2014
25 Reads
3.234 Impact Factor

Alzheimer's disease therapeutics targeted to the control of amyloid precursor protein translation: maintenance of brain iron homeostasis.

Biochem Pharmacol 2014 Apr 7;88(4):486-94. Epub 2014 Feb 7.

Neurochemistry Laboratory, Department of Psychiatry-Neuroscience, Massachusetts General Hospital (East), Charlestown, MA 02129, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2014.01.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064675PMC
April 2014
19 Reads
5.010 Impact Factor

Synthesis of the Alzheimer drug Posiphen into its primary metabolic products (+)-N1-norPosiphen, (+)-N8-norPosiphen and (+)-N1, N8-bisnorPosiphen, their inhibition of amyloid precursor protein, α-Synuclein synthesis, interleukin-1β release, and cholinergic action.

Antiinflamm Antiallergy Agents Med Chem 2013 ;12(2):117-28

Drug Design & Development Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5214460PMC
November 2013
27 Reads

Assessment of gene order computing methods for Alzheimer's disease.

BMC Med Genomics 2013 23;6 Suppl 1:S8. Epub 2013 Jan 23.

College of Management Science, Chengdu University of Technology, Chengdu 610059, China.

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http://dx.doi.org/10.1186/1755-8794-6-S1-S8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552676PMC
August 2013
6 Reads
2.873 Impact Factor

Mechanisms of neuroprotection by hemopexin: modeling the control of heme and iron homeostasis in brain neurons in inflammatory states.

J Neurochem 2013 Apr 25;125(1):89-101. Epub 2013 Feb 25.

School of Biological Sciences, University of Missouri - Kansas City, Kansas City, MO, USA.

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http://dx.doi.org/10.1111/jnc.12165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3752430PMC
April 2013
13 Reads
4.281 Impact Factor

PuF, an antimetastatic and developmental signaling protein, interacts with the Alzheimer's amyloid-β precursor protein via a tissue-specific proximal regulatory element (PRE).

BMC Genomics 2013 Jan 31;14:68. Epub 2013 Jan 31.

Laboratory of Molecular Neurogenetics, Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1186/1471-2164-14-68DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582491PMC
January 2013
6 Reads
3.990 Impact Factor

The role of phosphoinositide 3-kinase signaling in intestinal inflammation.

J Signal Transduct 2012 9;2012:358476. Epub 2012 Apr 9.

Mucosal Immunology Laboratory, Department of Pediatrics, 114 16th Street, Massachusetts General Hospital for Children, Charlestown MA 02129, USA.

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http://dx.doi.org/10.1155/2012/358476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337621PMC
August 2012
16 Reads

The anticholinesterase phenserine and its enantiomer posiphen as 5'untranslated-region-directed translation blockers of the Parkinson's alpha synuclein expression.

Parkinsons Dis 2012 29;2012:142372. Epub 2012 May 29.

Neurochemistry Laboratory, Massachusetts General Hospital (East), CNY2, 149, 13th Street, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1155/2012/142372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368596PMC
August 2012
5 Reads

N-methyl D-aspartate (NMDA) receptor antagonists and memantine treatment for Alzheimer's disease, vascular dementia and Parkinson's disease.

Curr Alzheimer Res 2012 Jul;9(6):746-58

Service of Clinical Pharmacology, Hospital Clinico San Carlos, C/Professor Martin Lagos s/n, 28040, Madrid, Spain.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5002349PMC
July 2012
5 Reads
3.890 Impact Factor

Flavanols, mild cognitive impairment, and Alzheimer's dementia.

Int J Clin Exp Med 2008 15;1(2):181-91. Epub 2008 Apr 15.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2596318PMC
July 2011
3 Reads
1.422 Impact Factor

The alpha-synuclein 5'untranslated region targeted translation blockers: anti-alpha synuclein efficacy of cardiac glycosides and Posiphen.

J Neural Transm (Vienna) 2011 Mar 8;118(3):493-507. Epub 2011 Jan 8.

Neurochemistry Laboratory, Psychiatry-Neuroscience, Massachusetts General Hospital, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1007/s00702-010-0513-5DOI Listing
March 2011
15 Reads
2.402 Impact Factor

Novel drug targets based on metallobiology of Alzheimer's disease.

Expert Opin Ther Targets 2010 Nov;14(11):1177-97

Indian Institute of Toxicology Research, Developmental Toxicology, Lucknow, India.

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http://dx.doi.org/10.1517/14728222.2010.525352DOI Listing
November 2010
13 Reads
5.140 Impact Factor

Selective translational control of the Alzheimer amyloid precursor protein transcript by iron regulatory protein-1.

J Biol Chem 2010 Oct 17;285(41):31217-32. Epub 2010 Jun 17.

Neurochemistry Laboratory, Department of Psychiatry-Neuroscience, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://www.jbc.org/content/285/41/31217.full.pdf
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http://www.jbc.org/cgi/doi/10.1074/jbc.M110.149161
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http://dx.doi.org/10.1074/jbc.M110.149161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951196PMC
October 2010
6 Reads
4.573 Impact Factor

A special local clustering algorithm for identifying the genes associated with Alzheimer's disease.

IEEE Trans Nanobioscience 2010 Mar 19;9(1):44-50. Epub 2010 Jan 19.

Biomedical Informatics and Cheminformatics Group, Conjugate and Medicinal Chemistry Laboratory, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1109/TNB.2009.2037745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3008360PMC
March 2010
14 Reads
2.310 Impact Factor

Functional characterization of three single-nucleotide polymorphisms present in the human APOE promoter sequence: Differential effects in neuronal cells and on DNA-protein interactions.

Am J Med Genet B Neuropsychiatr Genet 2010 Jan;153B(1):185-201

Department of Psychiatry, Institute of Psychiatric Research, Laboratory of Molecular Neurogenetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.

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http://dx.doi.org/10.1002/ajmg.b.30973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875733PMC
January 2010
15 Reads
3.420 Impact Factor

L-arginine and Alzheimer's disease.

Int J Clin Exp Pathol 2009 2;2(3):211-38. Epub 2008 Oct 2.

Neurochemistry Laboratory, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2600464PMC
January 2010
11 Reads
1.783 Impact Factor

Amyloid precursor protein and alpha synuclein translation, implications for iron and inflammation in neurodegenerative diseases.

Biochim Biophys Acta 2009 Jul 29;1790(7):615-28. Epub 2008 Dec 29.

Neurochemistry Laboratory, Department of Psychiatry-Neuroscience, Massachusetts General Hospital (East), Harvard Medical School, CNY2, Building 149, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1016/j.bbagen.2008.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3981543PMC
July 2009
9 Reads

The role of T cells in osteoporosis, an update.

Int J Clin Exp Pathol 2009 May 20;2(6):544-52. Epub 2009 May 20.

Department of Orthopedics, Beijing Aerospace General Hospital Beijing, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2713452PMC
May 2009
12 Reads
1.783 Impact Factor

Physiological and pathological role of alpha-synuclein in Parkinson's disease through iron mediated oxidative stress; the role of a putative iron-responsive element.

Int J Mol Sci 2009 Mar 17;10(3):1226-60. Epub 2009 Mar 17.

Department of Psychiatry-Neuroscience, Massachusetts General Hospital, Harvard Medical School, Charlestown, 02129, USA.

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http://dx.doi.org/10.3390/ijms10031226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672027PMC
March 2009
14 Reads
2.862 Impact Factor

Independent component analysis of Alzheimer's DNA microarray gene expression data.

Mol Neurodegener 2009 Jan 28;4. Epub 2009 Jan 28.

Biomedical Informatics and Cheminformatics Group, Conjugate and Medicinal Chemistry Laboratory, Division of Nuclear Medicine and Molecular Imaging and Center for Advanced Medical Imaging, Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1186/1750-1326-4-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646728PMC
January 2009
25 Reads
6.563 Impact Factor

A review of independent component analysis application to microarray gene expression data.

Biotechniques 2008 Nov;45(5):501-20

Information Engineering College, Shanghai Maritime University, Shanghai, China.

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http://dx.doi.org/10.2144/000112950DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005719PMC
November 2008
5 Reads
2.950 Impact Factor

Serum ferritin and metal levels as risk factors for amyotrophic lateral sclerosis.

Open Neurol J 2008 Sep 12;2:51-4. Epub 2008 Sep 12.

Neurology Clinical Trials Unit; Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.

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http://dx.doi.org/10.2174/1874205X00802010051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2627516PMC
September 2008
21 Reads

Interleukin (IL) 1beta induction of IL-6 is mediated by a novel phosphatidylinositol 3-kinase-dependent AKT/IkappaB kinase alpha pathway targeting activator protein-1.

J Biol Chem 2008 Sep 30;283(38):25900-12. Epub 2008 May 30.

Neurochemistry Laboratory, Department of Psychiatry-Neuroscience and Genetics and Aging Research Unit, Massachusetts General Hospital (East), Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1074/jbc.M707692200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533786PMC
September 2008
3 Reads
4.573 Impact Factor

MicroRNAs can regulate human APP levels.

Mol Neurodegener 2008 Aug 6;3:10. Epub 2008 Aug 6.

Department of Bioscience & Biotechnology, Drexel University, Philadelphia, PA, USA.

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http://dx.doi.org/10.1186/1750-1326-3-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2529281PMC
August 2008
32 Reads
6.563 Impact Factor

Taking down the unindicted co-conspirators of amyloid beta-peptide-mediated neuronal death: shared gene regulation of BACE1 and APP genes interacting with CREB, Fe65 and YY1 transcription factors.

Curr Alzheimer Res 2006 Dec;3(5):475-83

Indiana University School of Medicine, Department of Psychiatry, Institute of Psychiatric Research, Indianapolis, IN 46202, USA.

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December 2006
7 Reads
3.890 Impact Factor

A high-throughput drug screen targeted to the 5'untranslated region of Alzheimer amyloid precursor protein mRNA.

J Biomol Screen 2006 Aug 28;11(5):469-80. Epub 2006 Apr 28.

Neurochemistry Laboratory, Genetics and Aging Research Unit, Psychiatry Department, Massachusetts General Hospital, Boston, MA, USA, and School of Biological and Environmental Science, University College Dublin, Belfield, Ireland.

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http://dx.doi.org/10.1177/1087057106287271DOI Listing
August 2006
20 Reads
2.423 Impact Factor

Interleukin-1alpha stimulates non-amyloidogenic pathway by alpha-secretase (ADAM-10 and ADAM-17) cleavage of APP in human astrocytic cells involving p38 MAP kinase.

J Neurosci Res 2006 Jul;84(1):106-18

Neurochemistry Laboratory, Department of Psychiatry and Genetics and Aging Research Unit, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1002/jnr.20864DOI Listing
July 2006
14 Reads
2.594 Impact Factor

Metal exposure and Alzheimer's pathogenesis.

J Struct Biol 2006 Jul 9;155(1):45-51. Epub 2006 Feb 9.

Environmental Science Division, School of Earth and Space Sciences, University of Science and Technology of China, Hefei, China.

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http://dx.doi.org/10.1016/j.jsb.2005.12.011DOI Listing
July 2006
11 Reads
3.231 Impact Factor

RNA therapeutics directed to the non coding regions of APP mRNA, in vivo anti-amyloid efficacy of paroxetine, erythromycin, and N-acetyl cysteine.

Curr Alzheimer Res 2006 Jul;3(3):221-7

Neurochemistry Laboratory, Division of Psychiatric Neurosciences and Genetics and Aging Research Unit, Massachusetts General Hospital, Boston, MA 02114, USA.

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July 2006
11 Reads
3.890 Impact Factor

The acute box cis-element in human heavy ferritin mRNA 5'-untranslated region is a unique translation enhancer that binds poly(C)-binding proteins.

J Biol Chem 2005 Aug 20;280(34):30032-45. Epub 2005 Jun 20.

Laboratory for Cancer Medicine, School of Medicine and Pharmacology, UWA Centre for Medical Research, Western Australian Institute for Medical Research and University of Western Australia, Royal Perth Hospital.

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http://dx.doi.org/10.1074/jbc.M502951200DOI Listing
August 2005
5 Reads
4.573 Impact Factor

Pilot study of the reducing effect on amyloidosis in vivo by three FDA pre-approved drugs via the Alzheimer's APP 5' untranslated region.

Curr Alzheimer Res 2005 Apr;2(2):249-54

Genetics and Aging Research Unit, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02125, USA.

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April 2005
5 Reads
3.890 Impact Factor

Preliminary studies of a novel bifunctional metal chelator targeting Alzheimer's amyloidogenesis.

Exp Gerontol 2004 Nov-Dec;39(11-12):1641-9

Geriatric Research Education and Clinical Center, Bedford Veterans' Administration Medical Center, Bedford, MA 01730, USA.

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http://dx.doi.org/10.1016/j.exger.2004.08.016DOI Listing
April 2005
12 Reads
3.485 Impact Factor

The integrated role of desferrioxamine and phenserine targeted to an iron-responsive element in the APP-mRNA 5'-untranslated region.

Ann N Y Acad Sci 2004 Dec;1035:34-48

Genetics and Aging Research Unit, Department of Psychiatry, Massachusetts General Hospital East, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1196/annals.1332.003DOI Listing
December 2004
3 Reads
4.313 Impact Factor

FDA-preapproved drugs targeted to the translational regulation and processing of the amyloid precursor protein.

J Mol Neurosci 2004 ;24(1):129-36

Laboratory for Functional Genomics, Brigham and Women's Hospital, Harvard Medical School, USA.

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http://dx.doi.org/10.1385/JMN:24:1:129DOI Listing
December 2004
10 Reads
2.343 Impact Factor

Melatonin, metals, and gene expression: implications in aging and neurodegenerative disorders.

Ann N Y Acad Sci 2004 Dec;1035:216-30

Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, 46202,

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http://dx.doi.org/10.1196/annals.1332.014DOI Listing
December 2004
4 Reads
4.313 Impact Factor

New therapeutic strategies and drug candidates for neurodegenerative diseases: p53 and TNF-alpha inhibitors, and GLP-1 receptor agonists.

Ann N Y Acad Sci 2004 Dec;1035:290-315

Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1196/annals.1332.018DOI Listing
December 2004
5 Reads
4.313 Impact Factor

Redox-active metals, oxidative stress, and Alzheimer's disease pathology.

Ann N Y Acad Sci 2004 Mar;1012:153-63

Laboratory for Oxidation Biology, Genetics and Aging Research Unit, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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March 2004
12 Reads
4.313 Impact Factor

Drug discovery targeted to the Alzheimer's APP mRNA 5'-untranslated region: the action of paroxetine and dimercaptopropanol.

J Mol Neurosci 2003 ;20(3):267-75

Genetics and Aging Research Unit, Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1385/JMN:20:3:267DOI Listing
December 2003
3 Reads
2.343 Impact Factor

Alzheimer's disease drug discovery targeted to the APP mRNA 5'untranslated region.

J Mol Neurosci 2002 Aug-Oct;19(1-2):77-82

Genetics and Aging Unit, Massachusetts General Hospital Harvard Medical School, Charlestown 02129-4404, USA.

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http://dx.doi.org/10.1007/s12031-002-0014-6DOI Listing
January 2003
5 Reads
2.343 Impact Factor

An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript.

J Biol Chem 2002 Nov 26;277(47):45518-28. Epub 2002 Aug 26.

Genetics and Aging Research Unit, Department of Psychiatry, Massachusetts General Hospital, Charlestown, Massachusetts 02129-4404, USA.

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http://dx.doi.org/10.1074/jbc.M207435200DOI Listing
November 2002
6 Reads
4.573 Impact Factor

Thyrotropin-releasing hormone and epidermal growth factor regulate iron-regulatory protein binding in pituitary cells via protein kinase C-dependent and -independent signaling pathways.

J Biol Chem 2000 Oct;275(41):31609-15

Laboratory for Cancer Medicine and University Department of Medicine, University of Western Australia, Western Australian Institute for Medical Research, Royal Perth Hospital, Perth, Western Australia 6000, Australia.

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http://dx.doi.org/10.1074/jbc.M002354200DOI Listing
October 2000
3 Reads
4.573 Impact Factor

Optimized RNA gel-shift and UV cross-linking assays for characterization of cytoplasmic RNA-protein interactions.

Biotechniques 1999 Nov;27(5):1032-9, 1042

Royal Perth Hospital, Australia.

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http://dx.doi.org/10.2144/99275rr03DOI Listing
November 1999
4 Reads
2.950 Impact Factor

Iron-regulatory proteins, iron-responsive elements and ferritin mRNA translation.

Int J Biochem Cell Biol 1999 Oct;31(10):1139-52

Laboratory for Cancer Medicine, Royal Perth Hospital, WA, Australia.

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October 1999
1 Read
4.050 Impact Factor

Translation of the alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5'-untranslated region sequences.

J Biol Chem 1999 Mar;274(10):6421-31

Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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March 1999
3 Reads
4.573 Impact Factor

Hypoxia alters iron-regulatory protein-1 binding capacity and modulates cellular iron homeostasis in human hepatoma and erythroleukemia cells.

J Biol Chem 1999 Feb;274(7):4467-73

Joint Center for Sickle Cell and Thalassemic Disorders, Hematology Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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February 1999
4 Reads
4.573 Impact Factor

The essential role of inflammation and induced gene expression in the pathogenic pathway of Alzheimer's disease.

Front Biosci 1998 Apr 16;3:d436-46. Epub 1998 Apr 16.

Department of Neurobiology, Harvard Medical School and Division of Hematology, Boston, MA 02115, USA.

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April 1998
4 Reads

Thyroid hormone modulates the interaction between iron regulatory proteins and the ferritin mRNA iron-responsive element.

J Biol Chem 1996 May;271(20):12017-23

Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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May 1996
3 Reads
4.573 Impact Factor

Ferritin translation by interleukin-1and interleukin-6: the role of sequences upstream of the start codons of the heavy and light subunit genes.

Authors:
J T Rogers

Blood 1996 Mar;87(6):2525-37

Division of Hematology/Oncology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115 USA.

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March 1996
2 Reads
10.452 Impact Factor

The role of cytokines in the regulation of ferritin expression.

Adv Exp Med Biol 1994 ;356:127-32

Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115.

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April 1995
2 Reads

Ascorbic acid enhances iron-induced ferritin translation in human leukemia and hepatoma cells.

J Biol Chem 1995 Feb;270(6):2846-52

Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts 02115.

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February 1995
4 Reads
4.573 Impact Factor

Translational enhancement of H-ferritin mRNA by interleukin-1 beta acts through 5' leader sequences distinct from the iron responsive element.

Nucleic Acids Res 1994 Jul;22(13):2678-86

Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC308227PMC
July 1994
3 Reads
9.112 Impact Factor

Translational control during the acute phase response. Ferritin synthesis in response to interleukin-1.

J Biol Chem 1990 Aug;265(24):14572-8

Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115.

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August 1990
4 Reads
4.573 Impact Factor

Top co-authors

Xudong Huang
Xudong Huang

Massachusetts General Hospital

24
Debomoy K Lahiri
Debomoy K Lahiri

Institute of Psychiatric Research

17
Catherine M Cahill
Catherine M Cahill

Queen's University

17
Ashley I Bush
Ashley I Bush

The Florey Institute of Neuroscience and Mental Health

11
Nigel H Greig
Nigel H Greig

National Institute on Aging

10
Sanghamitra Bandyopadhyay
Sanghamitra Bandyopadhyay

Indian Statistical Institute

7
Rudolph E Tanzi
Rudolph E Tanzi

MassGeneral Institute for Neurodegenerative Disease

6
Charles R Vanderburg
Charles R Vanderburg

Harvard Medical School

6
Bryan Maloney
Bryan Maloney

Indiana University School of Medicine

4
Robert D Moir
Robert D Moir

MassGeneral Institute for Neurodegenerative Disease

4