Publications by authors named "Jack J Bleesing"

60Publications

Experience with a Reduced Toxicity Allogeneic Transplant Regimen for Non-CGD Primary Immune Deficiencies Requiring Myeloablation.

J Clin Immunol 2020 Oct 16. Epub 2020 Oct 16.

Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, MLC 7015, Cincinnati, OH, 45229, USA.

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http://dx.doi.org/10.1007/s10875-020-00888-2DOI Listing
October 2020

Defective FAS-Mediated Apoptosis and Immune Dysregulation in Gaucher Disease.

J Allergy Clin Immunol Pract 2020 Jul 21. Epub 2020 Jul 21.

Unit of Rare Diseases, Department of Pediatrics, Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Giannina Gaslini, Genoa, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.jaip.2020.06.065DOI Listing
July 2020

Current Flow Cytometric Assays for the Screening and Diagnosis of Primary HLH.

Front Immunol 2019 23;10:1740. Epub 2019 Jul 23.

Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.

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http://dx.doi.org/10.3389/fimmu.2019.01740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664088PMC
July 2019

Outcomes and Treatment Strategies for Autoimmunity and Hyperinflammation in Patients with RAG Deficiency.

J Allergy Clin Immunol Pract 2019 Jul - Aug;7(6):1970-1985.e4. Epub 2019 Mar 12.

University of South Florida and Johns Hopkins All Children's Hospital, Saint Petersburg, Fla; Division of Allergy and Immunology, Massachusetts General Hospital for Children, Boston, Mass. Electronic address:

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http://dx.doi.org/10.1016/j.jaip.2019.02.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612449PMC
September 2020

SCID genotype and 6-month posttransplant CD4 count predict survival and immune recovery.

Blood 2018 10 28;132(17):1737-1749. Epub 2018 Aug 28.

Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1182/blood-2018-03-840702DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202916PMC
October 2018

Suspected thrombotic microangiopathy in a child with Epstein-Barr virus-induced hemophagocytic lymphohistiocytosis.

Pediatr Blood Cancer 2018 06 7;65(6):e27002. Epub 2018 Feb 7.

Division of Pediatric Infectious Diseases, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota.

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http://dx.doi.org/10.1002/pbc.27002DOI Listing
June 2018

Long-term follow-up of IPEX syndrome patients after different therapeutic strategies: An international multicenter retrospective study.

J Allergy Clin Immunol 2018 03 11;141(3):1036-1049.e5. Epub 2017 Dec 11.

Division of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, Calif. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2017.10.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050203PMC
March 2018

Persistent Enteropathy in a Toddler with a Novel FOXP3 Mutation and Normal FOXP3 Protein Expression.

J Pediatr 2017 07 27;186:183-185. Epub 2017 Apr 27.

Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, OH. Electronic address:

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http://dx.doi.org/10.1016/j.jpeds.2017.03.051DOI Listing
July 2017

CTLA-4 haploinsufficiency in a patient with an autoimmune lymphoproliferative disorder.

J Allergy Clin Immunol 2017 09 30;140(3):862-864.e4. Epub 2017 Mar 30.

Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

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https://linkinghub.elsevier.com/retrieve/pii/S00916749173050
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http://dx.doi.org/10.1016/j.jaci.2017.02.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591763PMC
September 2017

Incidence and Outcomes of Central Nervous System Hemophagocytic Lymphohistiocytosis Relapse after Reduced-Intensity Conditioning Hematopoietic Stem Cell Transplantation.

Biol Blood Marrow Transplant 2017 May 17;23(5):857-860. Epub 2017 Feb 17.

Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

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https://linkinghub.elsevier.com/retrieve/pii/S10838791173028
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http://dx.doi.org/10.1016/j.bbmt.2017.02.011DOI Listing
May 2017

A challenging undertaking: Stem cell transplantation for immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome.

J Allergy Clin Immunol 2016 Mar 11;137(3):953-5.e4. Epub 2015 Nov 11.

Division of Bone Marrow Transplantation and Immune deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

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http://dx.doi.org/10.1016/j.jaci.2015.09.030DOI Listing
March 2016

Sirolimus is effective in relapsed/refractory autoimmune cytopenias: results of a prospective multi-institutional trial.

Blood 2016 Jan 26;127(1):17-28. Epub 2015 Oct 26.

Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, PA; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA;

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http://dx.doi.org/10.1182/blood-2015-07-657981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705607PMC
January 2016

Accuracy of flow cytometric perforin screening for detecting patients with FHL due to PRF1 mutations.

Blood 2015 Oct;126(15):1858-60

Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

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http://dx.doi.org/10.1182/blood-2015-06-648659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4828082PMC
October 2015

AUTOIMMUNE DISEASE. Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy.

Science 2015 Jul;349(6246):436-40

Division of Bone Marrow Transplantation and Immune Deficiency, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA. Division of Immunobiology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center/ University of Cincinnati, Cincinnati, OH, USA.

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http://dx.doi.org/10.1126/science.aaa1663DOI Listing
July 2015

Outcomes of donor lymphocyte infusion for treatment of mixed donor chimerism after a reduced-intensity preparative regimen for pediatric patients with nonmalignant diseases.

Biol Blood Marrow Transplant 2015 Feb 18;21(2):288-92. Epub 2014 Oct 18.

Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio. Electronic address:

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http://dx.doi.org/10.1016/j.bbmt.2014.10.010DOI Listing
February 2015

IL-10/Janus kinase/signal transducer and activator of transcription 3 signaling dysregulates Bim expression in autoimmune lymphoproliferative syndrome.

J Allergy Clin Immunol 2015 Mar 28;135(3):762-70. Epub 2014 Aug 28.

Division of Cellular and Molecular Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2014.07.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344440PMC
March 2015

Reduced-intensity conditioning hematopoietic cell transplantation is an effective treatment for patients with SLAM-associated protein deficiency/X-linked lymphoproliferative disease type 1.

Biol Blood Marrow Transplant 2014 Oct 9;20(10):1641-5. Epub 2014 Jun 9.

Division of Bone Marrow Transplantation and Immune Deficiency, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital, Cincinnati, Ohio.

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http://dx.doi.org/10.1016/j.bbmt.2014.06.003DOI Listing
October 2014

Clinical flow cytometric screening of SAP and XIAP expression accurately identifies patients with SH2D1A and XIAP/BIRC4 mutations.

Cytometry B Clin Cytom 2014 Jul 19;86(4):263-71. Epub 2014 Feb 19.

Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

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http://dx.doi.org/10.1002/cyto.b.21166DOI Listing
July 2014

Elevated Granzyme B in Cytotoxic Lymphocytes is a Signature of Immune Activation in Hemophagocytic Lymphohistiocytosis.

Front Immunol 2013 22;4:72. Epub 2013 Mar 22.

Immunodeficiency and Histiocytosis Program, Division of Bone Marrow Transplantation, Cincinnati Children's Hospital Medical Center Cincinnati, OH, USA.

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http://dx.doi.org/10.3389/fimmu.2013.00072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605512PMC
March 2013

Flow cytometric measurement of SLAM-associated protein and X-linked inhibitor of apoptosis.

Methods Mol Biol 2013 ;979:189-97

Division of Bone Marrow Transplantation and Immune Deficiency, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

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http://dx.doi.org/10.1007/978-1-62703-290-2_15DOI Listing
August 2013

Salvage therapy of refractory hemophagocytic lymphohistiocytosis with alemtuzumab.

Pediatr Blood Cancer 2013 Jan 22;60(1):101-9. Epub 2012 Apr 22.

Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1002/pbc.24188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410971PMC
January 2013

Impaired immune function in children with Fanconi anaemia.

Br J Haematol 2011 Jul 4;154(2):234-40. Epub 2011 May 4.

Divisions of Bone Marrow Transplant and Immune Deficiency, Department of Pediatrics, Cincinnati Children's Hospital and Medical Center, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1111/j.1365-2141.2011.08721.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922775PMC
July 2011

Blood, and not urine, BK viral load predicts renal outcome in children with hemorrhagic cystitis following hematopoietic stem cell transplantation.

Biol Blood Marrow Transplant 2011 Oct 6;17(10):1512-9. Epub 2011 Mar 6.

Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1016/j.bbmt.2011.02.012DOI Listing
October 2011

Contemporary diagnostic methods for hemophagocytic lymphohistiocytic disorders.

J Immunol Methods 2011 Feb 24;364(1-2):1-13. Epub 2010 Nov 24.

Immunotherapy Center, Medical College of Georgia, 1120 Fifteenth Street, Augusta, GA, USA.

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http://dx.doi.org/10.1016/j.jim.2010.11.006DOI Listing
February 2011

Successful early intervention for hyperacute transplant-associated thrombotic microangiopathy following pediatric hematopoietic stem cell transplantation.

Pediatr Transplant 2012 Mar 5;16(2):E39-42. Epub 2010 Nov 5.

Division of Bone Marrow Transplant and Immune Deficiency, Cincinnati Children's Hospital Medical Center Hoxworth Blood Center, University of Cincinnati, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1111/j.1399-3046.2010.01408.xDOI Listing
March 2012

Reduced-intensity conditioning significantly improves survival of patients with hemophagocytic lymphohistiocytosis undergoing allogeneic hematopoietic cell transplantation.

Blood 2010 Dec 20;116(26):5824-31. Epub 2010 Sep 20.

Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1182/blood-2010-04-282392DOI Listing
December 2010

Using flow cytometry to screen patients for X-linked lymphoproliferative disease due to SAP deficiency and XIAP deficiency.

J Immunol Methods 2010 Oct 9;362(1-2):1-9. Epub 2010 Sep 9.

Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1016/j.jim.2010.08.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964414PMC
October 2010

XIAP deficiency: a unique primary immunodeficiency best classified as X-linked familial hemophagocytic lymphohistiocytosis and not as X-linked lymphoproliferative disease.

Blood 2010 Aug 20;116(7):1079-82. Epub 2010 May 20.

Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1182/blood-2010-01-256099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938130PMC
August 2010

STX11 mutations and clinical phenotypes of familial hemophagocytic lymphohistiocytosis in North America.

Pediatr Blood Cancer 2010 Jul;55(1):134-40

Division of Bone Marrow Transplant and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA.

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http://dx.doi.org/10.1002/pbc.22499DOI Listing
July 2010

Assays for B cell and germinal center development.

Curr Protoc Immunol 2004 Nov;Chapter 7:Unit 7.35

Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

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http://dx.doi.org/10.1002/0471142735.im0735s63DOI Listing
November 2004

Autoimmune lymphoproliferative syndrome (ALPS): a case with congenital onset.

Pediatr Dev Pathol 2007 Jul-Aug;10(4):315-9

Department of Laboratory Medicine, Columbus Children's Hospital, Columbus, OH 43205, USA.

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http://dx.doi.org/10.2350/06-06-0105.1DOI Listing
September 2007

Sorting out the causes of ALPS.

J Pediatr 2005 Nov;147(5):571-4

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http://dx.doi.org/10.1016/j.jpeds.2005.09.025DOI Listing
November 2005

Autoimmune lymphoproliferative syndrome (ALPS).

Curr Pharm Des 2003 ;9(3):265-78

Arkansas Children's Hospital Research Institute, Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA.

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http://dx.doi.org/10.2174/1381612033392107DOI Listing
June 2003

Human B cells express a CD45 isoform that is similar to murine B220 and is downregulated with acquisition of the memory B-cell marker CD27.

Cytometry B Clin Cytom 2003 Jan;51(1):1-8

Department of Laboratory Medicine, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1002/cyto.b.10007DOI Listing
January 2003

Common expression of an unusual CD45 isoform on T cells from patients with large granular lymphocyte leukaemia and autoimmune lymphoproliferative syndrome.

Br J Haematol 2003 Jan;120(1):93-6

The Immunology Service, Department of Laboratory Medicine, Clinical Center and Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1046/j.1365-2141.2003.04034.xDOI Listing
January 2003

Immune thrombocytopenic purpura.

N Engl J Med 2002 Aug;347(6):449-50; author reply 449-50

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August 2002

A composite picture of TcR alpha/beta(+) CD4(-)CD8(-) T Cells (alpha/beta-DNTCs) in humans with autoimmune lymphoproliferative syndrome.

Clin Immunol 2002 Jul;104(1):21-30

Department of Laboratory Medicine, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1006/clim.2002.5225DOI Listing
July 2002