Jack Griffith

Jack Griffith

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Jack Griffith

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Distinct Binding Modes of Vinculin Isoforms Underlie Their Functional Differences.

Structure 2019 Aug 7. Epub 2019 Aug 7.

Department of Biochemistry and Biophysics and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Departments of Pharmacology and Departments of Biochemistry and Molecular Biology, Penn State College of Medicine, Hershey, PA 17033, USA. Electronic address:

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http://dx.doi.org/10.1016/j.str.2019.07.013DOI Listing
August 2019

Replication fork rescue in mammalian mitochondria.

Sci Rep 2019 Jun 19;9(1):8785. Epub 2019 Jun 19.

Department of Environmental and Biological Sciences, University of Eastern Finland, P.O. Box 111, 80101, Joensuu, Finland.

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http://dx.doi.org/10.1038/s41598-019-45244-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584726PMC
June 2019

Cardiomyopathy Mutations in Metavinculin Disrupt Regulation of Vinculin-Induced F-Actin Assemblies.

J Mol Biol 2019 Apr 5;431(8):1604-1618. Epub 2019 Mar 5.

Department of Biochemistry and Biophysics and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00222836193010
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http://dx.doi.org/10.1016/j.jmb.2019.02.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693633PMC
April 2019

Extracellular vesicles from Kaposi Sarcoma-associated herpesvirus lymphoma induce long-term endothelial cell reprogramming.

PLoS Pathog 2019 02 4;15(2):e1007536. Epub 2019 Feb 4.

Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1371/journal.ppat.1007536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361468PMC
February 2019

Large-scale, cross-flow based isolation of highly pure and endocytosis-competent extracellular vesicles.

J Extracell Vesicles 2018 30;7(1):1541396. Epub 2018 Nov 30.

Lineberger Comprehensive Cancer Center and Department of Microbiology and Immunology, The University of North Carolina, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1080/20013078.2018.1541396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282418PMC
November 2018

Long repeating (TTAGGG) single-stranded DNA self-condenses into compact beaded filaments stabilized by G-quadruplex formation.

J Biol Chem 2018 06 19;293(24):9473-9485. Epub 2018 Apr 19.

From the Lineberger Comprehensive Cancer Center, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina 27599,

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http://dx.doi.org/10.1074/jbc.RA118.002158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005428PMC
June 2018

Replication Fork Reversal during DNA Interstrand Crosslink Repair Requires CMG Unloading.

Cell Rep 2018 Jun;23(12):3419-3428

Howard Hughes Medical Institute and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.05.061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086610PMC
June 2018

Large SOD1 aggregates, unlike trimeric SOD1, do not impact cell viability in a model of amyotrophic lateral sclerosis.

Proc Natl Acad Sci U S A 2018 05 16;115(18):4661-4665. Epub 2018 Apr 16.

Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1800187115
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http://dx.doi.org/10.1073/pnas.1800187115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939103PMC
May 2018

Structural rearrangements in the mitochondrial genome of Drosophila melanogaster induced by elevated levels of the replicative DNA helicase.

Nucleic Acids Res 2018 04;46(6):3034-3046

Department of Biochemistry and Molecular Biology and Center for Mitochondrial Science and Medicine, Michigan State University, East Lansing, MI, USA.

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http://dx.doi.org/10.1093/nar/gky094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887560PMC
April 2018

Nef Secretion into Extracellular Vesicles or Exosomes Is Conserved across Human and Simian Immunodeficiency Viruses.

MBio 2018 02 6;9(1). Epub 2018 Feb 6.

Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

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http://dx.doi.org/10.1128/mBio.02344-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801467PMC
February 2018

DNA polymerase β: A missing link of the base excision repair machinery in mammalian mitochondria.

DNA Repair (Amst) 2017 12 28;60:77-88. Epub 2017 Oct 28.

Genome Integrity and Structural Biology Laboratory, National Institutes of Health, NIEHS, 111 T.W. Alexander Drive, P.O. Box 12233, Research Triangle Park, NC 27709, USA. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2017.10.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919216PMC
December 2017

The UL8 subunit of the helicase-primase complex of herpes simplex virus promotes DNA annealing and has a high affinity for replication forks.

J Biol Chem 2017 09 25;292(38):15611-15621. Epub 2017 Jul 25.

From the Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7295 and.

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http://dx.doi.org/10.1074/jbc.M117.799064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612096PMC
September 2017

Defective postsecretory maturation of MUC5B mucin in cystic fibrosis airways.

JCI Insight 2017 03 23;2(6):e89752. Epub 2017 Mar 23.

Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center, University of North Carolina at Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1172/jci.insight.89752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358479PMC
March 2017

Telomere Recognition and Assembly Mechanism of Mammalian Shelterin.

Cell Rep 2017 01;18(1):41-53

Laboratory for Cell Biology and Genetics, Rockefeller University, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225662PMC
January 2017

Transcription of telomeric DNA leads to high levels of homologous recombination and t-loops.

Nucleic Acids Res 2016 Nov 7;44(19):9369-9380. Epub 2016 Sep 7.

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599-7295, USA

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gkw779DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100571PMC
November 2016

Yeast mitochondrial HMG proteins: DNA-binding properties of the most evolutionarily divergent component of mitochondrial nucleoids.

Biosci Rep 2015 Dec 8;36(1):e00288. Epub 2015 Dec 8.

Departments of Genetics and Biochemistry, Comenius University in Bratislava, Faculty of Natural Sciences, Mlynska dolina, Ilkovicova 6, 842 15 Bratislava, Slovak Republic

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http://dx.doi.org/10.1042/BSR20150275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725248PMC
December 2015

Mitochondrial Single-stranded DNA-binding Proteins Stimulate the Activity of DNA Polymerase γ by Organization of the Template DNA.

J Biol Chem 2015 Nov 7;290(48):28697-707. Epub 2015 Oct 7.

From the Institute of Biosciences and Medical Technology, University of Tampere, 33520 Tampere, Finland, the Department of Biochemistry and Molecular Biology and Center for Mitochondrial Science and Medicine, Michigan State University, East Lansing, Michigan 48823, and

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http://dx.doi.org/10.1074/jbc.M115.673707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661385PMC
November 2015

Production of Extrachromosomal MicroDNAs Is Linked to Mismatch Repair Pathways and Transcriptional Activity.

Cell Rep 2015 Jun 4;11(11):1749-59. Epub 2015 Jun 4.

Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.05.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481157PMC
June 2015

A rolling circle replication mechanism produces multimeric lariats of mitochondrial DNA in Caenorhabditis elegans.

PLoS Genet 2015 Feb 18;11(2):e1004985. Epub 2015 Feb 18.

Department of Biology and Interdepartmental Graduate Program in Genetics, Genomics and Bioinformatics, University of California Riverside, Riverside, California, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1004985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334201PMC
February 2015

DNA replication catalyzed by herpes simplex virus type 1 proteins reveals trombone loops at the fork.

J Biol Chem 2015 Jan 3;290(5):2539-45. Epub 2014 Dec 3.

From the Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7295

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http://dx.doi.org/10.1074/jbc.M114.623009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317027PMC
January 2015

Top3α is required during the convergent migration step of double Holliday junction dissolution.

PLoS One 2014 2;9(1):e83582. Epub 2014 Jan 2.

Department of Biochemistry, Duke University Medical Center, Durham, North Carolina, United States of America ; Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0083582PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879244PMC
November 2014

TRF1 and TRF2 differentially modulate Rad51-mediated telomeric and nontelomeric displacement loop formation in vitro.

Biochemistry 2014 Sep 21;53(34):5485-95. Epub 2014 Aug 21.

Curriculum in Genetics and Molecular Biology, University of North Carolina , Chapel Hill, North Carolina 27599, United States.

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http://pubs.acs.org/doi/10.1021/bi5006249
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http://dx.doi.org/10.1021/bi5006249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151696PMC
September 2014

Interaction of Kaposi's sarcoma-associated herpesvirus ORF6 protein with single-stranded DNA.

J Virol 2014 Aug 21;88(15):8687-95. Epub 2014 May 21.

Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, USA Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA

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http://dx.doi.org/10.1128/JVI.03652-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135933PMC
August 2014

Systemically circulating viral and tumor-derived microRNAs in KSHV-associated malignancies.

PLoS Pathog 2013 18;9(7):e1003484. Epub 2013 Jul 18.

Lineberger Comprehensive Cancer Center, Program in Global Oncology, Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1003484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3715412PMC
February 2014

Reconstitution of long and short patch mismatch repair reactions using Saccharomyces cerevisiae proteins.

Proc Natl Acad Sci U S A 2013 Nov 1;110(46):18472-7. Epub 2013 Nov 1.

Ludwig Institute for Cancer Research, Departments of Medicine and Cellular and Molecular Medicine, Moores-University of California, San Diego Cancer Center, and Institute of Genomic Medicine, University of California San Diego School of Medicine, La Jolla, CA 92093.

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http://dx.doi.org/10.1073/pnas.1318971110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831976PMC
November 2013

Many ways to loop DNA.

Authors:
Jack D Griffith

J Biol Chem 2013 Oct 4;288(41):29724-35. Epub 2013 Sep 4.

From the Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7295.

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http://dx.doi.org/10.1074/jbc.X113.515981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795270PMC
October 2013

Elastosis perforans serpiginosa in association with scabies mite.

J Clin Aesthet Dermatol 2013 Oct;6(10):36-40

Western University of Health Sciences / Pacific Hospital of Long Beach Department of Dermatology, Long Beach, California;

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805305PMC
October 2013

Synthesis and dissolution of hemicatenanes by type IA DNA topoisomerases.

Proc Natl Acad Sci U S A 2013 Sep 3;110(38):E3587-94. Epub 2013 Sep 3.

Institute of Cellular and Organismic Biology and Molecular Cell Biology, Taiwan International Graduate Program, Academia Sinica, Taipei, Taiwan 115.

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http://dx.doi.org/10.1073/pnas.1304103110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3780852PMC
September 2013

Modulation of B-cell exosome proteins by gamma herpesvirus infection.

Proc Natl Acad Sci U S A 2013 Jul 1;110(31):E2925-33. Epub 2013 Jul 1.

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1073/pnas.1303906110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732930PMC
July 2013

Details of ssDNA annealing revealed by an HSV-1 ICP8-ssDNA binary complex.

Nucleic Acids Res 2013 Jun 19;41(11):5927-37. Epub 2013 Apr 19.

Lineberger Comprehensive Cancer Center, and Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1093/nar/gkt266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675482PMC
June 2013

Improved methods for creating migratable Holliday junction substrates.

Nucleic Acids Res 2013 Mar 28;41(5):e60. Epub 2012 Dec 28.

Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA.

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https://academic.oup.com/nar/article/41/5/e60/2414508
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http://dx.doi.org/10.1093/nar/gks1343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597647PMC
March 2013

The NAD(+)-dependent protein deacetylase activity of SIRT1 is regulated by its oligomeric status.

Sci Rep 2012 7;2:640. Epub 2012 Sep 7.

Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, ResearchTriangle Park, NC 27709, USA.

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http://dx.doi.org/10.1038/srep00640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435561PMC
February 2013

Human Rap1 interacts directly with telomeric DNA and regulates TRF2 localization at the telomere.

J Biol Chem 2012 Dec 20;287(50):41583-94. Epub 2012 Oct 20.

Department of Biochemistry, Lineberger ComprehensiveCancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1074/jbc.M112.415984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516710PMC
December 2012

Synergism of the two Myb domains of Tay1 protein results in high affinity binding to telomeres.

J Biol Chem 2012 Sep 18;287(38):32206-15. Epub 2012 Jul 18.

Department of Genetics and Biochemistry, Comenius University, Faculty of Natural Sciences, Mlynska dolina, 842 15 Bratislava, Slovakia.

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http://dx.doi.org/10.1074/jbc.M112.385591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442551PMC
September 2012

Penile nodules in the penal system.

Cutis 2012 May;89(5):237-9

Department of Dermatology, Western University of Health Sciences, Pacific Hospital of Long Beach, Skypark Bldg 1, 23550 Hawthorne Blvd, Ste 200, Torrance, CA 90505, USA.

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May 2012

Extrachromosomal microDNAs and chromosomal microdeletions in normal tissues.

Science 2012 Apr 8;336(6077):82-6. Epub 2012 Mar 8.

Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA, USA.

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http://dx.doi.org/10.1126/science.1213307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703515PMC
April 2012

RAD51 protein ATP cap regulates nucleoprotein filament stability.

J Biol Chem 2012 Mar 24;287(12):8724-36. Epub 2012 Jan 24.

Biophysics Graduate Program, Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University, Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.1074/jbc.M111.239426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308741PMC
March 2012

E. coli DNA replication in the absence of free β clamps.

EMBO J 2011 May 25;30(9):1830-40. Epub 2011 Mar 25.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/emboj.2011.84DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101994PMC
May 2011

The Kaposi's sarcoma-associated herpesvirus ORF6 DNA binding protein forms long DNA-free helical protein filaments.

J Struct Biol 2011 Apr 31;174(1):37-43. Epub 2010 Oct 31.

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599-7295, USA.

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http://dx.doi.org/10.1016/j.jsb.2010.10.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3056921PMC
April 2011

Tay1 protein, a novel telomere binding factor from Yarrowia lipolytica.

J Biol Chem 2010 Dec 5;285(49):38078-92. Epub 2010 Oct 5.

Department of Genetics, Comenius University, Faculty of Natural Sciences, Mlynska dolina, 842 15 Bratislava, Slovakia.

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http://dx.doi.org/10.1074/jbc.M110.127605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992242PMC
December 2010

The killing of African trypanosomes by ethidium bromide.

PLoS Pathog 2010 Dec 16;6(12):e1001226. Epub 2010 Dec 16.

Department of Biological Chemistry, Johns Hopkins Medical School, Baltimore, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1001226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002999PMC
December 2010

The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA.

Nat Struct Mol Biol 2010 Oct 22;17(10):1263-5. Epub 2010 Aug 22.

London Research Institute, Cancer Research UK, Clare Hall Laboratories, South Mimms, Hertfordshire, UK.

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http://www.nature.com/articles/nsmb.1905
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http://dx.doi.org/10.1038/nsmb.1905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041013PMC
October 2010

Mechanism of Holliday junction resolution by the human GEN1 protein.

Genes Dev 2010 Jul;24(14):1559-69

London Research Institute, Cancer Research UK, Clare Hall Laboratories, South Mimms, Herts, United Kingdom.

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http://dx.doi.org/10.1101/gad.585310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904945PMC
July 2010

Ring-shaped Rad51 paralog protein complexes bind Holliday junctions and replication forks as visualized by electron microscopy.

J Biol Chem 2010 Apr 5;285(18):13349-56. Epub 2010 Mar 5.

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M109.074286
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http://dx.doi.org/10.1074/jbc.M109.074286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2859493PMC
April 2010

TbPIF1, a Trypanosoma brucei mitochondrial DNA helicase, is essential for kinetoplast minicircle replication.

J Biol Chem 2010 Mar 30;285(10):7056-66. Epub 2009 Dec 30.

Department of Biological Chemistry, Johns Hopkins Medical School, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1074/jbc.M109.084038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844155PMC
March 2010

Unpacking a gel-forming mucin: a view of MUC5B organization after granular release.

Am J Physiol Lung Cell Mol Physiol 2010 Jan 25;298(1):L15-22. Epub 2009 Sep 25.

1Department of Biochemistry and Biophysics and Cystic Fibrosis/Pulmonary Research and Treatment Center, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1152/ajplung.00194.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806194PMC
January 2010

Telomeric circles are abundant in the stn1-M1 mutant that maintains its telomeres through recombination.

Nucleic Acids Res 2010 Jan 25;38(1):182-9. Epub 2009 Oct 25.

Department of Genetics, University of Georgia, Athens, GA 30602, USA.

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http://dx.doi.org/10.1093/nar/gkp814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2800209PMC
January 2010

Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing.

Cell 2009 Nov 5;139(4):719-30. Epub 2009 Nov 5.

Clare Hall Laboratories, Cancer Research UK London Research Institute, South Mimms EN6 3LD, UK.

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http://dx.doi.org/10.1016/j.cell.2009.10.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2804858PMC
November 2009

Telomeric circles: universal players in telomere maintenance?

Nat Struct Mol Biol 2009 Oct 6;16(10):1010-5. Epub 2009 Oct 6.

Department of Genetics, Comenius University in Bratislava, Faculty of Natural Sciences, Bratislava, Slovakia.

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http://dx.doi.org/10.1038/nsmb.1660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041010PMC
October 2009

Structure of long telomeric RNA transcripts: the G-rich RNA forms a compact repeating structure containing G-quartets.

J Biol Chem 2009 May 26;284(21):13980-6. Epub 2009 Mar 26.

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1074/jbc.M900631200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682846PMC
May 2009

The bipolar filaments formed by herpes simplex virus type 1 SSB/recombination protein (ICP8) suggest a mechanism for DNA annealing.

J Mol Biol 2009 Feb 31;386(2):273-9. Epub 2008 Dec 31.

Lineberger Comprehensive Cancer Center, Department Microbiology and Immunology, University of North Carolina at Chapel Hill, 27517, USA.

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http://dx.doi.org/10.1016/j.jmb.2008.12.059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757162PMC
February 2009

The Werner syndrome protein binds replication fork and holliday junction DNAs as an oligomer.

J Biol Chem 2008 Sep 2;283(36):24478-83. Epub 2008 Jul 2.

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1074/jbc.M803370200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2528990PMC
September 2008

Mechanism of replication-coupled DNA interstrand crosslink repair.

Cell 2008 Sep;134(6):969-80

Harvard Medical School, Department of Biological Chemistry and Molecular Pharmacology, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.cell.2008.08.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748255PMC
September 2008

Discovery of abundant cellulose microfibers encased in 250 Ma Permian halite: a macromolecular target in the search for life on other planets.

Astrobiology 2008 Apr;8(2):215-28

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1089/ast.2007.0196DOI Listing
April 2008

Tethering telomeric double- and single-stranded DNA-binding proteins inhibits telomere elongation.

J Biol Chem 2008 Mar 3;283(11):6935-41. Epub 2008 Jan 3.

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.

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March 2008

C. elegans telomeres contain G-strand and C-strand overhangs that are bound by distinct proteins.

Cell 2008 Mar;132(5):745-57

The Salk Institute for Biological Studies, 10010 North Torrey Pines Road., La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.cell.2007.12.039DOI Listing
March 2008

Telomere loops and homologous recombination-dependent telomeric circles in a Kluyveromyces lactis telomere mutant strain.

Mol Cell Biol 2008 Jan 29;28(1):20-9. Epub 2007 Oct 29.

Corresonding author. Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1128/MCB.01122-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2223312PMC
January 2008

Remodeling of the human papillomavirus type 11 replication origin into discrete nucleoprotein particles and looped structures by the E2 protein.

J Mol Biol 2008 Jan 12;375(4):1165-77. Epub 2007 Nov 12.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7295, USA.

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http://dx.doi.org/10.1016/j.jmb.2007.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757166PMC
January 2008

Muscleblind-like 1 interacts with RNA hairpins in splicing target and pathogenic RNAs.

Nucleic Acids Res 2007 15;35(16):5474-86. Epub 2007 Aug 15.

Department of Molecular Genetics and Microbiology and the Genetics Institute, University of Florida, College of Medicine, Gainesville, FL, USA.

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http://dx.doi.org/10.1093/nar/gkm601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2018611PMC
September 2007

5-Azacytidine induced methyltransferase-DNA adducts block DNA replication in vivo.

Cancer Res 2007 Sep;67(17):8248-54

Department of Biochemistry, Duke University, Durham, NC 27710, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-1038DOI Listing
September 2007

Separation of topological forms of plasmid DNA by anion-exchange HPLC: shifts in elution order of linear DNA.

J Chromatogr B Analyt Technol Biomed Life Sci 2007 Jul 13;854(1-2):121-7. Epub 2007 Apr 13.

BioPharmaceutical Product Development-US, GlaxoSmithKline, 5 Moore Drive, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1016/j.jchromb.2007.04.005DOI Listing
July 2007

Xrcc3 and Nbs1 are required for the production of extrachromosomal telomeric circles in human alternative lengthening of telomere cells.

Cancer Res 2007 Feb;67(4):1513-9

Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Mason Farm Road, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-3672DOI Listing
February 2007

Architecture of the bacteriophage T4 replication complex revealed with nanoscale biopointers.

J Biol Chem 2007 Jan 13;282(2):1098-108. Epub 2006 Nov 13.

Laboratory of Molecular and Cellular Biology, NIDDK, National Institutes of Health, Bethesda, Maryland 20892-0830, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M606772200
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January 2007

The basic domain of TRF2 directs binding to DNA junctions irrespective of the presence of TTAGGG repeats.

J Biol Chem 2006 Dec 18;281(49):37486-95. Epub 2006 Oct 18.

Lineberger Comprehensive Cancer Center and Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M608778200
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December 2006

Replication fork regression in repetitive DNAs.

Nucleic Acids Res 2006 28;34(20):6044-50. Epub 2006 Oct 28.

Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, The University of North Carolina, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1093/nar/gkl757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1635326PMC
December 2006

Electron microscopic visualization of telomerase from Euplotes aediculatus bound to a model telomere DNA.

Biochemistry 2006 Aug;45(31):9624-31

Lineberger Comprehensive Cancer Center and Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

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http://pubs.acs.org/doi/abs/10.1021/bi060313s
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August 2006

Role of p38 in replication of Trypanosoma brucei kinetoplast DNA.

Mol Cell Biol 2006 Jul;26(14):5382-93

Department of Biological Chemistry, Johns Hopkins Medical School, 725 N. Wolfe St., Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1128/MCB.00369-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1592711PMC
July 2006

Visualization of the annealing of complementary single-stranded DNA catalyzed by the herpes simplex virus type 1 ICP8 SSB/recombinase.

J Mol Biol 2006 Feb 28;355(5):911-22. Epub 2005 Nov 28.

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599-7295, USA.

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http://dx.doi.org/10.1016/j.jmb.2005.11.022DOI Listing
February 2006

Characterization of a topologically aberrant plasmid population from pilot-scale production of clinical-grade DNA.

J Biotechnol 2006 Jan 15;121(1):1-12. Epub 2005 Sep 15.

BioPharmaceutical Product Development-US, GlaxoSmithKline, 5 Moore Drive, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1016/j.jbiotec.2005.06.019DOI Listing
January 2006

Regulation of the interaction of inosine monophosphate dehydrogenase with mycophenolic Acid by GTP.

J Biol Chem 2006 Jan 21;281(1):206-12. Epub 2005 Oct 21.

Department of Pharmacology and The Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599-7295, USA.

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http://dx.doi.org/10.1074/jbc.M507056200DOI Listing
January 2006

p53 Monitors replication fork regression by binding to "chickenfoot" intermediates.

J Biol Chem 2005 Dec 4;280(52):42568-72. Epub 2005 Oct 4.

Lineberger Comprehensive Cancer Center and Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1074/jbc.M506348200DOI Listing
December 2005

Termination factor-mediated DNA loop between termination and initiation sites drives mitochondrial rRNA synthesis.

Cell 2005 Dec;123(7):1227-40

Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.

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http://dx.doi.org/10.1016/j.cell.2005.09.040DOI Listing
December 2005

Recombination at long mutant telomeres produces tiny single- and double-stranded telomeric circles.

Mol Cell Biol 2005 Jun;25(11):4406-12

University of Georgia at Athens, Department of Genetics, Room C318, Life Sciences Building, Athens, GA 30602, USA.

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http://dx.doi.org/10.1128/MCB.25.11.4406-4412.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1140610PMC
June 2005

Differential single-stranded DNA binding properties of the paralogous SsbA and SsbB proteins from Streptococcus pneumoniae.

J Biol Chem 2005 Mar 12;280(12):11067-73. Epub 2005 Jan 12.

Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA.

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March 2005

Amplification of telomeric arrays via rolling-circle mechanism.

J Biol Chem 2005 Mar 18;280(11):10840-5. Epub 2005 Jan 18.

Department of Biochemistry, Mlynska dolina CH-1, Comenius University, 842 15 Bratislava, Slovakia.

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March 2005

Modulation of p53 binding to Holliday junctions and 3-cytosine bulges by phosphorylation events.

Biochemistry 2005 Feb;44(7):2536-44

Lineberger Comprehensive Cancer Center and Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7295, USA.

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http://dx.doi.org/10.1021/bi048700uDOI Listing
February 2005

Taz1 binding to a fission yeast model telomere: formation of telomeric loops and higher order structures.

J Biol Chem 2004 Dec 21;279(49):50764-72. Epub 2004 Sep 21.

Department of Genetics, Comenius University, Faculty of Natural Sciences, Mlynska dolina, 842 15 Bratislava, Slovakia.

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December 2004

Telomeric DNA in ALT cells is characterized by free telomeric circles and heterogeneous t-loops.

Mol Cell Biol 2004 Nov;24(22):9948-57

Lineberger Comprehensive Cancer Center, Rm. 11-119, CB 7295, Mason Farm Rd., University of North Carolina, Chapel Hill, NC 27599-7295, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC525488PMC
November 2004

Human claspin is a ring-shaped DNA-binding protein with high affinity to branched DNA structures.

J Biol Chem 2004 Sep 28;279(38):39289-95. Epub 2004 Jun 28.

Department of Biochemistry and Biophysics and Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA.

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September 2004

The Epstein-Barr virus polymerase accessory factor BMRF1 adopts a ring-shaped structure as visualized by electron microscopy.

J Biol Chem 2004 Sep 30;279(39):40358-61. Epub 2004 Jul 30.

Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599-7295, USA.

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September 2004

Two-dimensional crystallization of herpes simplex virus type 1 single-stranded DNA-binding protein, ICP8, on a lipid monolayer.

Biochim Biophys Acta 2004 Sep;1701(1-2):101-8

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Campus Box 7295, Chapel Hill, NC 27599-7295, USA.

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http://dx.doi.org/10.1016/j.bbapap.2004.06.006DOI Listing
September 2004

Mapping subunit location on the Saccharomyces cerevisiae origin recognition complex free and bound to DNA using a novel nanoscale biopointer.

J Biol Chem 2004 Aug 16;279(35):36354-62. Epub 2004 Jun 16.

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599-7295, USA.

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August 2004

Establishing a dental practice in a rural, low-income county health department.

Authors:
Jack Griffith

J Public Health Manag Pract 2003 Nov-Dec;9(6):538-41

Pender County Health Department, 803 S. Walker Street, Burgaw, NC 28425, USA.

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January 2004

Telomere looping in P. sativum (common garden pea).

Plant J 2003 Oct;36(2):271-9

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7295, USA.

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October 2003

A single-stranded DNA-binding protein of bacteriophage T7 defective in DNA annealing.

J Biol Chem 2003 Aug 14;278(31):29098-105. Epub 2003 May 14.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1074/jbc.M303374200DOI Listing
August 2003

The carboxyl-terminal domain of bacteriophage T7 single-stranded DNA-binding protein modulates DNA binding and interaction with T7 DNA polymerase.

J Biol Chem 2003 Aug 24;278(32):29538-45. Epub 2003 May 24.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1074/jbc.M304318200DOI Listing
August 2003

Architecture of the replication complex and DNA loops at the fork generated by the bacteriophage t4 proteins.

J Biol Chem 2003 Jun 20;278(23):21276-85. Epub 2003 Mar 20.

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

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June 2003

Origin-specific unwinding of herpes simplex virus 1 DNA by the viral UL9 and ICP8 proteins: visualization of a specific preunwinding complex.

Proc Natl Acad Sci U S A 2003 Feb 24;100(3):898-903. Epub 2003 Jan 24.

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599-7295, USA.

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http://dx.doi.org/10.1073/pnas.0237171100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC298698PMC
February 2003

Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro.

Proc Natl Acad Sci U S A 2003 Feb 10;100(4):1633-8. Epub 2003 Feb 10.

Program in Molecular Biology, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

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http://dx.doi.org/10.1073/pnas.0437927100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC149884PMC
February 2003

t-Loops in yeast mitochondria.

Mitochondrion 2002 May;1(5):455-9

Department of Genetics, Comenius University, Faculty of Natural Sciences, Mlynska dolina B-1, 842 15 Bratislava, Slovakia.

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May 2002