Jack F Youngren

Jack F Youngren

UNVERIFIED PROFILE

Are you Jack F Youngren?   Register this Author

Register author
Jack F Youngren

Jack F Youngren

Publications by authors named "Jack F Youngren"

Are you Jack F Youngren?   Register this Author

30Publications

540Reads

17Profile Views

Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer.

Cell 2018 07 19;174(3):758-769.e9. Epub 2018 Jul 19.

Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, CA, USA; Division of Hematology and Oncology, Department of Medicine, UCSF, San Francisco, CA, USA; Department of Radiation Oncology, UCSF, San Francisco, CA, USA; Department of Urology, UCSF, San Francisco, CA, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2018.06.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425931PMC
July 2018

Insulin resistance induced by hyperinsulinemia coincides with a persistent alteration at the insulin receptor tyrosine kinase domain.

PLoS One 2014 26;9(9):e108693. Epub 2014 Sep 26.

Department of Obstetrics and Gynecology and the Diabetes Center, University of California San Francisco, San Francisco, California, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0108693PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178179PMC
January 2016

Chromium supplementation in non-obese non-diabetic subjects is associated with a decline in insulin sensitivity.

BMC Endocr Disord 2012 Nov 30;12:31. Epub 2012 Nov 30.

Department of Medicine, Diabetes Center, University of California San Francisco, 400 Parnassus Avenue, San Francisco, CA, 94143-1222, USA.

View Article

Download full-text PDF

Source
http://bmcendocrdisord.biomedcentral.com/articles/10.1186/14
Publisher Site
http://dx.doi.org/10.1186/1472-6823-12-31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3537689PMC
November 2012

The effects of type 1 IGF receptor inhibition in a mouse model of diabetic kidney disease.

Growth Horm IGF Res 2011 Oct 23;21(5):285-91. Epub 2011 Aug 23.

Shraga Segal Department of Microbiology and Immunology, Ben Gurion University of the Negev, Beer Sheva, Israel.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ghir.2011.07.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238882PMC
October 2011

Effects of controlled-release alpha lipoic acid in lean, nondiabetic patients with polycystic ovary syndrome.

J Diabetes Sci Technol 2010 Mar 1;4(2):359-64. Epub 2010 Mar 1.

Department of Medicine, University of California, San Francisco, Diabetes Center, San Francisco, California 94143 , USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864173PMC
http://dx.doi.org/10.1177/193229681000400218DOI Listing
March 2010

Influence of gender on the relationship between insulin sensitivity, adiposity, and plasma lipids in lean nondiabetic subjects.

Metabolism 2009 Nov 15;58(11):1602-8. Epub 2009 Jul 15.

Division of Endocrinology and Metabolism, Department of Medicine, University of California San Francisco, San Francisco, CA 94115, USA.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S002604950900210
Publisher Site
http://dx.doi.org/10.1016/j.metabol.2009.05.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763945PMC
November 2009

Nordihydroguaiaretic acid inhibits transforming growth factor beta type 1 receptor activity and downstream signaling.

Eur J Pharmacol 2009 Aug 17;616(1-3):31-7. Epub 2009 Jun 17.

Department of Medicine, University of California, San Francisco, California 94143, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejphar.2009.06.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742219PMC
August 2009

Technical evaluation of in vivo abdominal fat and IMCL quantification using MRI and MRSI at 3 T.

Magn Reson Imaging 2008 Feb 2;26(2):188-97. Epub 2007 Aug 2.

Musculoskeletal Quantitative Imaging Research, Department of Radiology, University of California, San Francisco, CA 94107, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mri.2007.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2713003PMC
February 2008

A pilot dose-escalation study of the effects of nordihydroguareacetic acid on hormone and prostate specific antigen levels in patients with relapsed prostate cancer.

BJU Int 2008 Feb;101(4):436-9

Department of Medicine and the [corrected] UCSF Comprehensive Cancer Center, University of California San Francisco, CA 94143, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1464-410X.2007.07330.xDOI Listing
February 2008

Inhibition of IGF-1R and lipoxygenase by nordihydroguaiaretic acid (NDGA) analogs.

Bioorg Med Chem Lett 2007 Jul 29;17(14):4026-9. Epub 2007 Apr 29.

Department of Chemistry & Biochemistry, San Francisco State University, San Francisco, CA 94132-4163, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2007.04.092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2253493PMC
July 2007

Parallel synthesis of diarylureas and their evaluation as inhibitors of insulin-like growth factor receptor.

J Comb Chem 2006 Sep-Oct;8(5):784-90

Department of Pharmaceutical Chemistry, University of California, Box 2280, San Francisco, California 94143-2280, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/cc050136zDOI Listing
November 2006

Expression of genes regulating malonyl-CoA in human skeletal muscle.

J Cell Biochem 2006 Oct;99(3):860-7

Department of Medicine, Diabetes and Endocrine Research, Mount Zion Medical Center, University of California, San Francisco, California 94143-1616, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcb.20944DOI Listing
October 2006

Overexpression of the insulin receptor inhibitor PC-1/ENPP1 induces insulin resistance and hyperglycemia.

Am J Physiol Endocrinol Metab 2006 Apr 8;290(4):E746-9. Epub 2005 Nov 8.

Department of Medicine and Diabetes Center, University of California, San Francisco 94143-1616, USA.

View Article

Download full-text PDF

Source
http://www.physiology.org/doi/10.1152/ajpendo.00298.2005
Publisher Site
http://dx.doi.org/10.1152/ajpendo.00298.2005DOI Listing
April 2006

Diarylureas are small-molecule inhibitors of insulin-like growth factor I receptor signaling and breast cancer cell growth.

Mol Cancer Ther 2006 Apr;5(4):1079-86

Diabetes and Endocrine Research University of California, San Francisco/Mt. Zion Medical Center, Box 1616, San Francisco, CA 94143-1616, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1535-7163.MCT-05-0397DOI Listing
April 2006

Nordihydroguaiaretic acid (NDGA) inhibits the IGF-1 and c-erbB2/HER2/neu receptors and suppresses growth in breast cancer cells.

Breast Cancer Res Treat 2005 Nov;94(1):37-46

Division of Diabetes and Endocrine Research, San Francisco/Mt. Zion Medical Center, University of California, San Francisco, CA 94143-1616, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10549-005-6939-zDOI Listing
November 2005

Insulin resistance in the skeletal muscle of women with PCOS involves intrinsic and acquired defects in insulin signaling.

Am J Physiol Endocrinol Metab 2005 May 21;288(5):E1047-54. Epub 2004 Dec 21.

Division of Women's Health, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpendo.00361.2004DOI Listing
May 2005

Analysis of insulin-stimulated insulin receptor activation and glucose transport in cultured skeletal muscle cells from obese subjects.

Metabolism 2005 May;54(5):598-603

Division of Diabetes and Endocrine Research, Department of Medicine, Mount Zion Medical Center, University of California-San Francisco, Box 1616, San Francisco, CA 94143, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.metabol.2004.11.018DOI Listing
May 2005

Increased hepatic levels of the insulin receptor inhibitor, PC-1/NPP1, induce insulin resistance and glucose intolerance.

Diabetes 2005 Feb;54(2):367-72

Department of Gene Therapy and Molecular Medicine, Mount Sinai School of Medicine, New York, New York, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/diabetes.54.2.367DOI Listing
February 2005

Effective treatments for insulin resistance: trim the fat and douse the fire.

Trends Endocrinol Metab 2004 Nov;15(9):425-31

Medical Research Institute, San Francisco, CA 94107, USA.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S104327600400215
Publisher Site
http://dx.doi.org/10.1016/j.tem.2004.09.005DOI Listing
November 2004

Regulation of insulin receptor function by a small molecule insulin receptor activator.

J Biol Chem 2002 Nov 3;277(46):43565-71. Epub 2002 Sep 3.

Mount Zion Medical Center, University of California, San Francisco 94143-1616, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M202426200DOI Listing
November 2002

Decreased insulin receptor (IR) autophosphorylation in fibroblasts from patients with PCOS: effects of serine kinase inhibitors and IR activators.

J Clin Endocrinol Metab 2002 Sep;87(9):4088-93

University of California at San Francisco, Mount Zion Medical Center, San Francisco, California 94143, USA.

View Article

Download full-text PDF

Source
https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.
Publisher Site
http://dx.doi.org/10.1210/jc.2002-020363DOI Listing
September 2002

Elevated plasma cell membrane glycoprotein levels and diminished insulin receptor autophosphorylation in obese, insulin-resistant rhesus monkeys.

Metabolism 2002 Apr;51(4):465-70

Diabetes and Obesity Research Center, School of Medicine, Department of Physiology, University of Maryland at Baltimore, Baltimore, MD, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/meta.2002.31327DOI Listing
April 2002