Publications by authors named "Jack E Dixon"

100Publications

POMK regulates dystroglycan function via LARGE1-mediated elongation of matriglycan.

Elife 2020 09 25;9. Epub 2020 Sep 25.

Howard Hughes Medical Institute, Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Center, Department of Molecular Physiology and Biophysics and Department of Neurology, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, United States.

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http://dx.doi.org/10.7554/eLife.61388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556876PMC
September 2020

Reversible phosphorylation: a birthday tribute to Herb Tabor.

J Biol Chem 2019 02;294(5):1638-1642

From the Departments of Pharmacology.

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http://dx.doi.org/10.1074/jbc.TME118.004161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364790PMC
February 2019

Enzymatic Phosphorylation of Ser in a Type I Collagen Peptide.

Biophys J 2018 12 16;115(12):2327-2335. Epub 2018 Nov 16.

Department of Biomedical Engineering, Tufts University, Medford, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2018.11.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302033PMC
December 2018

Ancient drug curcumin impedes 26S proteasome activity by direct inhibition of dual-specificity tyrosine-regulated kinase 2.

Proc Natl Acad Sci U S A 2018 08 9;115(32):8155-8160. Epub 2018 Jul 9.

The Life Sciences Institute, Zhejiang University, 310058 Hangzhou, China

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http://dx.doi.org/10.1073/pnas.1806797115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094102PMC
August 2018

Structure and evolution of the Fam20 kinases.

Nat Commun 2018 03 23;9(1):1218. Epub 2018 Mar 23.

The State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking-Tsinghua Center for Life Sciences, Peking University, 100871, Beijing, China.

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http://www.nature.com/articles/s41467-018-03615-z
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http://dx.doi.org/10.1038/s41467-018-03615-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865150PMC
March 2018

Structure of Fam20A reveals a pseudokinase featuring a unique disulfide pattern and inverted ATP-binding.

Elife 2017 04 22;6. Epub 2017 Apr 22.

The State Key Laboratory of Protein and Plant Gene Research, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China.

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http://dx.doi.org/10.7554/eLife.23990DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413348PMC
April 2017

Genomics and evolution of protein phosphatases.

Sci Signal 2017 Apr 11;10(474). Epub 2017 Apr 11.

Department of Bioinformatics and Computational Biology, Genentech Inc., South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1126/scisignal.aag1796DOI Listing
April 2017

Structure of protein O-mannose kinase reveals a unique active site architecture.

Elife 2016 11 23;5. Epub 2016 Nov 23.

The State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing, China.

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http://dx.doi.org/10.7554/eLife.22238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142810PMC
November 2016

The 26S proteasome: A cell cycle regulator regulated by cell cycle.

Cell Cycle 2016 3;15(7):875-6. Epub 2016 Mar 3.

b Department of Pharmacology , University of California-San Diego School of Medicine , La Jolla , CA , USA.

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http://dx.doi.org/10.1080/15384101.2016.1151728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889267PMC
April 2017

Site-specific proteasome phosphorylation controls cell proliferation and tumorigenesis.

Nat Cell Biol 2016 Feb 14;18(2):202-12. Epub 2015 Dec 14.

Department of Pharmacology, University of California-San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1038/ncb3289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844191PMC
February 2016

A Single Kinase Generates the Majority of the Secreted Phosphoproteome.

Cell 2015 Jun;161(7):1619-32

Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.05.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963185PMC
June 2015

A new role for sphingosine: Up-regulation of Fam20C, the genuine casein kinase that phosphorylates secreted proteins.

Biochim Biophys Acta 2015 Oct 30;1854(10 Pt B):1718-26. Epub 2015 Apr 30.

Department of Biomedical Sciences and CNR, Institute of Neuroscience, University of Padova, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bbapap.2015.04.023DOI Listing
October 2015

A potent and selective inhibitor for the UBLCP1 proteasome phosphatase.

Bioorg Med Chem 2015 Jun 31;23(12):2798-809. Epub 2015 Mar 31.

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2015.03.066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451428PMC
June 2015

Unpacking the unfolded protein response.

Cell 2014 Sep;158(6):1221-1224

Departments of Pharmacology, Cellular and Molecular Medicine, and Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.08.025DOI Listing
September 2014

PTEN.

Annu Rev Biochem 2014 ;83:641-69

Department of Pharmacology, University of California, San Diego, La Jolla, California 92093-0721; email:

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http://dx.doi.org/10.1146/annurev-biochem-082411-113907DOI Listing
January 2015

Dynamic regulation of FGF23 by Fam20C phosphorylation, GalNAc-T3 glycosylation, and furin proteolysis.

Proc Natl Acad Sci U S A 2014 Apr 26;111(15):5520-5. Epub 2014 Mar 26.

Departments of Pharmacology, Pediatrics, Cellular and Molecular Medicine, and Chemistry and Biochemistry and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093.

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http://dx.doi.org/10.1073/pnas.1402218111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992636PMC
April 2014

Spatial control of phospholipid flux restricts endoplasmic reticulum sheet formation to allow nuclear envelope breakdown.

Genes Dev 2014 Jan;28(2):121-6

Ludwig Institute for Cancer Research, Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California 92093, USA;

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http://dx.doi.org/10.1101/gad.230599.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909786PMC
January 2014

The EBAX-type Cullin-RING E3 ligase and Hsp90 guard the protein quality of the SAX-3/Robo receptor in developing neurons.

Neuron 2013 Sep;79(5):903-16

Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1016/j.neuron.2013.06.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779136PMC
September 2013

Response to Wang et al.: Secreted protein kinases?

Trends Biochem Sci 2013 Sep;38(9):425

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http://dx.doi.org/10.1016/j.tibs.2013.06.007DOI Listing
September 2013

Phosphorylation of substrates destined for secretion by the Fam20 kinases.

Biochem Soc Trans 2013 Aug;41(4):1061-5

Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1042/BST20130059DOI Listing
August 2013

Crystal structure of the Golgi casein kinase.

Proc Natl Acad Sci U S A 2013 Jun 10;110(26):10574-9. Epub 2013 Jun 10.

Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1073/pnas.1309211110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696822PMC
June 2013

Secreted protein kinases.

Trends Biochem Sci 2013 Mar 29;38(3):121-30. Epub 2012 Dec 29.

Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA.

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http://dx.doi.org/10.1016/j.tibs.2012.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582740PMC
March 2013

Widespread dynamic DNA methylation in response to biotic stress.

Proc Natl Acad Sci U S A 2012 Aug 25;109(32):E2183-91. Epub 2012 Jun 25.

Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.1209329109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420206PMC
August 2012

Secreted kinase phosphorylates extracellular proteins that regulate biomineralization.

Science 2012 Jun 10;336(6085):1150-3. Epub 2012 May 10.

Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093-0721, USA.

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http://dx.doi.org/10.1126/science.1217817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754843PMC
June 2012

UBLCP1 is a 26S proteasome phosphatase that regulates nuclear proteasome activity.

Proc Natl Acad Sci U S A 2011 Nov 26;108(46):18649-54. Epub 2011 Sep 26.

Department of Pharmacology, University of California-San Diego, La Jolla, CA 92093-0721, USA.

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http://dx.doi.org/10.1073/pnas.1113170108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219150PMC
November 2011

Comparative analysis of Histophilus somni immunoglobulin-binding protein A (IbpA) with other fic domain-containing enzymes reveals differences in substrate and nucleotide specificities.

J Biol Chem 2011 Sep 27;286(37):32834-42. Epub 2011 Jul 27.

Department of Pharmacology, Howard Hughes Medical Institute, University of California, San Diego, La Jolla, California 92093-0721, USA.

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http://dx.doi.org/10.1074/jbc.M111.227603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173180PMC
September 2011

Structural and functional analysis of PTPMT1, a phosphatase required for cardiolipin synthesis.

Proc Natl Acad Sci U S A 2011 Jul 5;108(29):11860-5. Epub 2011 Jul 5.

Department of Pharmacology, University of California, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1073/pnas.1109290108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142007PMC
July 2011

Expansion of type II CAAX proteases reveals evolutionary origin of γ-secretase subunit APH-1.

J Mol Biol 2011 Jul 5;410(1):18-26. Epub 2011 May 5.

Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390-9050, USA.

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http://dx.doi.org/10.1016/j.jmb.2011.04.066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155266PMC
July 2011

Voltage-sensing phosphatase: its molecular relationship with PTEN.

Physiology (Bethesda) 2011 Feb;26(1):6-13

Department of Physiology, Graduate School of Medicine, Osaka University, Osaka, Japan.

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http://dx.doi.org/10.1152/physiol.00035.2010DOI Listing
February 2011

Glycogen synthase: an old enzyme with a new trick.

Cell Metab 2011 Mar;13(3):233-4

Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1016/j.cmet.2011.02.006DOI Listing
March 2011

Structural basis of Fic-mediated adenylylation.

Nat Struct Mol Biol 2010 Aug 11;17(8):1004-10. Epub 2010 Jul 11.

Department of Pharmacology, Howard Hughes Medical Institute, University of California, San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1038/nsmb.1867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920259PMC
August 2010

Pharmacological targeting of the mitochondrial phosphatase PTPMT1.

J Pharmacol Exp Ther 2010 May 18;333(2):584-92. Epub 2010 Feb 18.

Department of Pharmacology and Cancer Biology, Duke University, Durham, North Carolina 27710-3813, USA.

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http://dx.doi.org/10.1124/jpet.109.163329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872949PMC
May 2010

Lafora disease: insights into neurodegeneration from plant metabolism.

Trends Biochem Sci 2009 Dec 7;34(12):628-39. Epub 2009 Oct 7.

Department of Molecular and Cellular Biochemistry and Center for Structural Biology, University of Kentucky, Lexington, KY 40536-0509, USA.

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http://dx.doi.org/10.1016/j.tibs.2009.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805077PMC
December 2009

Distinguishing mitochondrial inner membrane orientation of dual specific phosphatase 18 and 21.

Methods Enzymol 2009 ;457:275-87

Department of Pharmacology, Cellular and Molecular Medicine, and Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1016/S0076-6879(09)05015-0DOI Listing
July 2009

Chapter 13 Localization and function of the 2Fe-2S outer mitochondrial membrane protein mitoNEET.

Methods Enzymol 2009 ;456:233-46

Department of Pharmacology, University of California, San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1016/S0076-6879(08)04413-3DOI Listing
June 2009

A family of bacterial cysteine protease type III effectors utilizes acylation-dependent and -independent strategies to localize to plasma membranes.

J Biol Chem 2009 Jun 3;284(23):15867-79. Epub 2009 Apr 3.

Departments of Pharmacology, Cellular and Molecular Medicine, and Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093-0721, USA.

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http://dx.doi.org/10.1074/jbc.M900519200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2708883PMC
June 2009

Monitoring phosphorylation of the pyruvate dehydrogenase complex.

Anal Biochem 2009 Jun 31;389(2):157-64. Epub 2009 Mar 31.

Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1016/j.ab.2009.03.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2713743PMC
June 2009

Structural and functional dissection of the heterocyclic peptide cytotoxin streptolysin S.

J Biol Chem 2009 May 13;284(19):13004-12. Epub 2009 Mar 13.

Department of Pharmacology, University of California San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1074/jbc.M900802200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676033PMC
May 2009

A voltage-sensing phosphatase, Ci-VSP, which shares sequence identity with PTEN, dephosphorylates phosphatidylinositol 4,5-bisphosphate.

Proc Natl Acad Sci U S A 2008 Jun 4;105(23):7970-5. Epub 2008 Jun 4.

Section for Developmental Neurophysiology, Okazaki Center for Integrative Biosciences, National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji-cho, Okazaki, Aichi 4448787, Japan.

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http://dx.doi.org/10.1073/pnas.0803936105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430346PMC
June 2008

Dual specificity phosphatases 18 and 21 target to opposing sides of the mitochondrial inner membrane.

J Biol Chem 2008 May 2;283(22):15440-50. Epub 2008 Apr 2.

Departments of Pharmacology, Cellular and Molecular Medicine, and Chemistry and Biochemistry, Biomedical Sciences Graduate Program, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0721, USA.

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http://dx.doi.org/10.1074/jbc.M709547200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2397459PMC
May 2008

Discovery of a widely distributed toxin biosynthetic gene cluster.

Proc Natl Acad Sci U S A 2008 Apr 28;105(15):5879-84. Epub 2008 Mar 28.

Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1073/pnas.0801338105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2311365PMC
April 2008

Analysis of Rho-GTPase mimicry by a family of bacterial type III effector proteins.

Methods Enzymol 2008 ;439:131-43

Department of Microbiology, University of Texas Southwestern, Dallas, Texas, USA.

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http://dx.doi.org/10.1016/S0076-6879(07)00410-7DOI Listing
June 2008

Loss of the inactive myotubularin-related phosphatase Mtmr13 leads to a Charcot-Marie-Tooth 4B2-like peripheral neuropathy in mice.

Proc Natl Acad Sci U S A 2008 Mar 18;105(12):4916-21. Epub 2008 Mar 18.

Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1073/pnas.0800742105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2290800PMC
March 2008

RNA interference in cultured Drosophila cells.

Curr Protoc Mol Biol 2004 Feb;Chapter 26:Unit 26.5

University of California at San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1002/0471142727.mb2605s65DOI Listing
February 2004

Subversion of myosin function by E. coli.

Dev Cell 2008 Jan;14(1):8-10

The Howard Hughes Medical Institute, University of California at San Diego, La Jolla, CA 92093-0721, USA.

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http://dx.doi.org/10.1016/j.devcel.2007.12.016DOI Listing
January 2008

Malin decreases glycogen accumulation by promoting the degradation of protein targeting to glycogen (PTG).

J Biol Chem 2008 Feb 10;283(7):4069-76. Epub 2007 Dec 10.

Department of Pharmacology, University of California at San Diego, La Jolla, California 92093-0721, USA.

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http://dx.doi.org/10.1074/jbc.M708712200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2251628PMC
February 2008

A role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori's disease.

Genes Dev 2007 Oct;21(19):2399-409

Department of Internal Medicine, Life Sciences Institute, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1101/gad.1553207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1993871PMC
October 2007

Interactions of bacterial effector proteins with host proteins.

Curr Opin Immunol 2007 Aug 26;19(4):392-401. Epub 2007 Jul 26.

The Howard Hughes Medical Institute, Leichtag Biomedical Research Building, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0721, USA.

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http://dx.doi.org/10.1016/j.coi.2007.06.005DOI Listing
August 2007

The phosphatase laforin crosses evolutionary boundaries and links carbohydrate metabolism to neuronal disease.

J Cell Biol 2007 Jul 23;178(3):477-88. Epub 2007 Jul 23.

Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1083/jcb.200704094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064834PMC
July 2007

The outer mitochondrial membrane protein mitoNEET contains a novel redox-active 2Fe-2S cluster.

J Biol Chem 2007 Aug 21;282(33):23745-9. Epub 2007 Jun 21.

Department of Pharmacology, University of California, San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1074/jbc.C700107200DOI Listing
August 2007

Identification of a molecular target for the Yersinia protein kinase A.

Mol Cell 2007 May;26(4):465-77

Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1016/j.molcel.2007.04.025DOI Listing
May 2007

A conserved phosphatase cascade that regulates nuclear membrane biogenesis.

Proc Natl Acad Sci U S A 2007 Apr 9;104(16):6596-601. Epub 2007 Apr 9.

Departments of Pharmacology and Cellular and Molecular Medicine, School of Medicine, University of California at San Diego, La Jolla, CA 92093, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1871831PMC
http://dx.doi.org/10.1073/pnas.0702099104DOI Listing
April 2007

MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity.

Proc Natl Acad Sci U S A 2007 Mar 21;104(13):5318-23. Epub 2007 Mar 21.

Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0701078104
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http://dx.doi.org/10.1073/pnas.0701078104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1838440PMC
March 2007

Determinants for dephosphorylation of the RNA polymerase II C-terminal domain by Scp1.

Mol Cell 2006 Dec;24(5):759-770

Howard Hughes Medical Institute, Jack H. Skirball Center for Chemical Biology and Proteomics, The Salk Institute for Biological Studies, La Jolla, California 92037. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2006.10.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2859291PMC
December 2006

Laforin, a dual specificity phosphatase that dephosphorylates complex carbohydrates.

J Biol Chem 2006 Oct 10;281(41):30412-8. Epub 2006 Aug 10.

Department of Pharmacology, University of California at San Diego, La Jolla, California 92093-0721, USA.

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http://dx.doi.org/10.1074/jbc.M606117200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774450PMC
October 2006

Myotubularin phosphatases: policing 3-phosphoinositides.

Trends Cell Biol 2006 Aug 7;16(8):403-12. Epub 2006 Jul 7.

Department of Pharmacology, School of Medicine, University of California San Diego, Leichtag Biomedical Research Building, Rm. 284, 9500 Gilman Drive, La Jolla, CA 92093-0721, USA.

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http://dx.doi.org/10.1016/j.tcb.2006.06.001DOI Listing
August 2006

The p53-targeting human phosphatase hCdc14A interacts with the Cdk1/cyclin B complex and is differentially expressed in human cancers.

Mol Cancer 2006 Jun 19;5:25. Epub 2006 Jun 19.

Department of Radiation Oncology, Division of Radiation & Cancer Biology, University of Michigan Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA.

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http://molecular-cancer.biomedcentral.com/articles/10.1186/1
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http://dx.doi.org/10.1186/1476-4598-5-25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1524803PMC
June 2006

Microbiology. Bacteria seize control by acetylating host proteins.

Science 2006 May;312(5777):1150-1

Department of Pharmacology, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1126/science.1128785DOI Listing
May 2006

Identification of a bacterial type III effector family with G protein mimicry functions.

Cell 2006 Jan;124(1):133-45

Department of Pharmacology, Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S009286740501229
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http://dx.doi.org/10.1016/j.cell.2005.10.031DOI Listing
January 2006

Molecular basis for substrate recognition by MTMR2, a myotubularin family phosphoinositide phosphatase.

Proc Natl Acad Sci U S A 2006 Jan 12;103(4):927-32. Epub 2006 Jan 12.

Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1073/pnas.0510006103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1347996PMC
January 2006

Identification of otubain 1 as a novel substrate for the Yersinia protein kinase using chemical genetics and mass spectrometry.

FEBS Lett 2006 Jan 9;580(1):179-83. Epub 2005 Dec 9.

Department of Chemistry and Biochemistry, University of Windsor, 401 Sunset Avenue, Windsor, Ont., Canada N9B3P4.

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http://dx.doi.org/10.1016/j.febslet.2005.11.071DOI Listing
January 2006

Mitochondrial modulation: reversible phosphorylation takes center stage?

Trends Biochem Sci 2006 Jan 5;31(1):26-34. Epub 2005 Dec 5.

Department of Pharmacology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0721, USA.

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http://dx.doi.org/10.1016/j.tibs.2005.11.005DOI Listing
January 2006

The structure and regulation of myotubularin phosphatases.

Curr Opin Struct Biol 2005 Dec 9;15(6):614-20. Epub 2005 Nov 9.

Department of Pharmacology, University of California, San Diego, La Jolla, CA 2093-0721, USA.

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http://dx.doi.org/10.1016/j.sbi.2005.10.016DOI Listing
December 2005

Phosphoinositide phosphatases: emerging roles as voltage sensors?

Mol Interv 2005 Oct;5(5):274-7

Department of Pharmacology, University of California-San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1124/mi.5.5.5DOI Listing
October 2005

The phosphoinositide-3-phosphatase MTMR2 associates with MTMR13, a membrane-associated pseudophosphatase also mutated in type 4B Charcot-Marie-Tooth disease.

J Biol Chem 2005 Sep 5;280(36):31699-707. Epub 2005 Jul 5.

Department of Pharmacology, The University of California San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1074/jbc.M505159200DOI Listing
September 2005

Insights into Lafora disease: malin is an E3 ubiquitin ligase that ubiquitinates and promotes the degradation of laforin.

Proc Natl Acad Sci U S A 2005 Jun 1;102(24):8501-6. Epub 2005 Jun 1.

Department of Pharmacology, School of Medicine, University of California at San Diego, La Jolla, CA 92093-0721, USA.

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http://dx.doi.org/10.1073/pnas.0503285102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1150849PMC
June 2005

Functions of the Yersinia effector proteins in inhibiting host immune responses.

Curr Opin Microbiol 2005 Feb;8(1):21-7

Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093-0721, USA.

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http://dx.doi.org/10.1016/j.mib.2004.12.014DOI Listing
February 2005

A PTEN-like phosphatase with a novel substrate specificity.

J Biol Chem 2004 Sep 9;279(37):38590-6. Epub 2004 Jul 9.

Department of Pharmacology, University of California, San Diego, La Jolla, California 92093-0721, USA.

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September 2004

Assaying phosphoinositide phosphatases.

Methods Mol Biol 2004 ;284:217-27

Department of Pharmacology, University of California San Diego, La Jolla, USA.

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September 2004

Suppression of a phosphatidylinositol 3-kinase signal by a specific spliced variant of Drosophila PTEN.

FEBS Lett 2004 May;565(1-3):43-7

Department of Pharmacology, Tokyo Metropolitan Institute of Medical Science, 3-18-22 Honkomagome, Tokyo 113-8613, Japan.

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May 2004

The crystal structure of Pseudomonas avirulence protein AvrPphB: a papain-like fold with a distinct substrate-binding site.

Proc Natl Acad Sci U S A 2004 Jan 23;101(1):302-7. Epub 2003 Dec 23.

Department of Biological Chemistry, Medical School and Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.2036536100
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC314180PMC
January 2004

PTEN and myotubularins: families of phosphoinositide phosphatases.

Methods Enzymol 2003 ;366:43-56

Departments of Pharmacology, Cellular and Molecular Medicine, Chemistry and Biochemistry, University of California, Basic Science Building 3092A-M/C 0636, 9500 Gilman Drive, La Jolla, California 92093-0636, USA.

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January 2004

Cleavage of Arabidopsis PBS1 by a bacterial type III effector.

Science 2003 Aug;301(5637):1230-3

Department of Biological Chemistry, Medical School and Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.

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August 2003