Jack E Baldwin

Jack E Baldwin

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Jack E Baldwin

Jack E Baldwin

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The crystal structure of an isopenicillin N synthase complex with an ethereal substrate analogue reveals water in the oxygen binding site.

FEBS Lett 2013 Aug 13;587(16):2705-9. Epub 2013 Jul 13.

Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.

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http://doi.wiley.com/10.1016/j.febslet.2013.07.016
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http://dx.doi.org/10.1016/j.febslet.2013.07.016DOI Listing
August 2013

The crystal structure of isopenicillin N synthase with a dipeptide substrate analogue.

Arch Biochem Biophys 2013 Feb 19;530(1):48-53. Epub 2012 Dec 19.

Chemistry Research Laboratory, University of Oxford, Mansfield Rd, Oxford OX1 3TA, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S00039861120042
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http://dx.doi.org/10.1016/j.abb.2012.12.012DOI Listing
February 2013

Synthesis of new bulky bis(pyrazolyl)methane carboxylate (heteroscorpionate) ligands and their complexes with iron, manganese and nickel.

Dalton Trans 2012 Dec 12;41(46):14068-86. Epub 2012 Oct 12.

Chemistry Research Laboratory, The University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK.

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http://xlink.rsc.org/?DOI=c2dt31859h
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http://dx.doi.org/10.1039/c2dt31859hDOI Listing
December 2012

Isopenicillin N synthase binds δ-(L-α-aminoadipoyl)-L-cysteinyl-D-thia-allo-isoleucine through both sulfur atoms.

Chembiochem 2011 Aug 15;12(12):1881-5. Epub 2011 Jun 15.

Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, UK.

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http://doi.wiley.com/10.1002/cbic.201100149
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http://dx.doi.org/10.1002/cbic.201100149DOI Listing
August 2011

Biomimetic synthesis of polycyclic polyprenylated acylphloroglucinol natural products isolated from Hypericum papuanum.

Org Lett 2010 Aug;12(15):3532-5

School of Chemistry & Physics, University of Adelaide, North Terrace, Adelaide SA 5005, Australia.

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http://pubs.acs.org/doi/abs/10.1021/ol101380a
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http://dx.doi.org/10.1021/ol101380aDOI Listing
August 2010

Crystallographic studies on the binding of selectively deuterated LLD- and LLL-substrate epimers by isopenicillin N synthase.

Biochem Biophys Res Commun 2010 Aug 13;398(4):659-64. Epub 2010 Jul 13.

Chemistry Research Laboratory, University of Oxford, Mansfield Rd., Oxford OX1 3TA, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S0006291X1001286
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http://dx.doi.org/10.1016/j.bbrc.2010.06.129DOI Listing
August 2010

Enantiospecific, biosynthetically inspired formal total synthesis of (+)-liphagal.

Org Lett 2010 May;12(10):2394-7

Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.

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http://dx.doi.org/10.1021/ol100756zDOI Listing
May 2010

A short biomimetic synthesis of the meroterpenoids guajadial and psidial A.

Org Lett 2010 Apr;12(8):1676-9

Department of Chemistry, Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, United Kingdom.

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http://dx.doi.org/10.1021/ol100138kDOI Listing
April 2010

The crystal structure of an LLL-configured depsipeptide substrate analogue bound to isopenicillin N synthase.

Org Biomol Chem 2010 Jan 29;8(1):122-7. Epub 2009 Oct 29.

Chemistry Research Laboratory, University of Oxford, UK.

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http://xlink.rsc.org/?DOI=B910170E
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http://dx.doi.org/10.1039/b910170eDOI Listing
January 2010

Cryophotolysis of a caged oxygen compound for use in low temperature biological studies.

Photochem Photobiol Sci 2009 Aug 1;8(8):1150-6. Epub 2009 Jun 1.

Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, UK OX1 3TA.

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http://dx.doi.org/10.1039/b821516bDOI Listing
August 2009

Isopenicillin N synthase mediates thiolate oxidation to sulfenate in a depsipeptide substrate analogue: implications for oxygen binding and a link to nitrile hydratase?

J Am Chem Soc 2008 Aug 12;130(31):10096-102. Epub 2008 Jul 12.

Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK.

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http://pubs.acs.org/doi/abs/10.1021/ja8005397
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http://dx.doi.org/10.1021/ja8005397DOI Listing
August 2008

Biomimetic synthesis of pyrone-derived natural products: exploring chemical pathways from a unique polyketide precursor.

J Org Chem 2008 Jul 3;73(13):4830-9. Epub 2008 Jun 3.

The Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.

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http://dx.doi.org/10.1021/jo800220wDOI Listing
July 2008

A cyclobutanone analogue mimics penicillin in binding to isopenicillin N synthase.

Chembiochem 2007 Nov;8(16):2003-7

Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK.

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http://doi.wiley.com/10.1002/cbic.200700176
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http://dx.doi.org/10.1002/cbic.200700176DOI Listing
November 2007

Interactions of isopenicillin N synthase with cyclopropyl-containing substrate analogues reveal new mechanistic insight.

Biochemistry 2007 Apr 31;46(16):4755-62. Epub 2007 Mar 31.

Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.

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http://pubs.acs.org/doi/abs/10.1021/bi062314q
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http://dx.doi.org/10.1021/bi062314qDOI Listing
April 2007

Stereochemical reassignment of Mehta and Kundu's spiculoic acid a analogue.

Org Lett 2006 Nov;8(24):5537-40

Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK.

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http://dx.doi.org/10.1021/ol062361aDOI Listing
November 2006

Development of enzyme-linked immunosorbent assays for the detection of deacetoxycephalosporin C and isopenicillin N synthase activity.

Anal Chim Acta 2006 Sep 27;577(2):153-62. Epub 2006 Jun 27.

Chemistry Research Laboratory, 12 Mansfield Road, Oxford OX1 3TA, United Kingdom.

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http://dx.doi.org/10.1016/j.aca.2006.06.040DOI Listing
September 2006

Biomimetic synthesis of marine sponge metabolite spiculoic acid A and establishment of the absolute configuration of the natural product.

Chem Commun (Camb) 2006 Jul(27):2863-5

Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, UK OX1 3TA.

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http://dx.doi.org/10.1039/b607035cDOI Listing
July 2006

Unexpected oxidation of a depsipeptide substrate analogue in crystalline isopenicillin N synthase.

Chembiochem 2006 Feb;7(2):351-8

Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK.

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http://dx.doi.org/10.1002/cbic.200500282DOI Listing
February 2006

Unique binding of a non-natural L,L,L-substrate by isopenicillin N synthase.

Biochem Biophys Res Commun 2005 Oct;336(2):702-8

Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.

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http://dx.doi.org/10.1016/j.bbrc.2005.08.155DOI Listing
October 2005

A new and efficient method for o-quinone methide intermediate generation: application to the biomimetic synthesis of the benzopyran derived natural products (+/-)-lucidene and (+/-)-alboatrin.

Org Biomol Chem 2005 Oct 7;3(19):3488-95. Epub 2005 Sep 7.

The Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, UKOX1 3TA.

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http://dx.doi.org/10.1039/b508972gDOI Listing
October 2005

A novel oxidative rearrangement of 6-methoxypyran-2-ones.

Org Lett 2005 Aug;7(17):3705-7

Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, U.K.

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http://dx.doi.org/10.1021/ol0513490DOI Listing
August 2005

The total synthesis of spectinabilin and its biomimetic conversion to SNF4435C and SNF4435D.

Org Lett 2005 Jun;7(12):2473-6

Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, United Kingdom.

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http://dx.doi.org/10.1021/ol0507874DOI Listing
June 2005

Significant enhancement of the Stille reaction with a new combination of reagents-copper(I) iodide with cesium fluoride.

Chemistry 2005 May;11(11):3294-308

Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.

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http://doi.wiley.com/10.1002/chem.200401162
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http://dx.doi.org/10.1002/chem.200401162DOI Listing
May 2005

Biomimetic synthesis of (+/-)-9,10-deoxytridachione.

Chem Commun (Camb) 2005 Apr 7(13):1687-9. Epub 2005 Feb 7.

Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, UK OX1 3TA.

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http://dx.doi.org/10.1039/b418988dDOI Listing
April 2005

Application of bis-acetylenic ketones in synthesis: one-pot preparation of the 1,2,4-triazepine and oxatriazaindenone cores.

J Org Chem 2005 Apr;70(8):3307-8

Centre for Synthesis and Chemical Biology (CSCB), Department of Pharmaceutical and Medicinal Chemistry, The Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Dublin, Ireland.

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http://dx.doi.org/10.1021/jo047991+DOI Listing
April 2005

Biomimetic total synthesis of (+)-himbacine.

Org Lett 2005 Feb;7(4):585-8

Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, United Kingdom.

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http://dx.doi.org/10.1021/ol047676+DOI Listing
February 2005

A short total synthesis of aureothin and N-acetylaureothamine.

Org Lett 2005 Feb;7(4):641-4

Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, United Kingdom.

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http://dx.doi.org/10.1021/ol047594lDOI Listing
February 2005

Dimerization of butenolide structures. A biomimetic approach to the dimeric sesquiterpene lactones (+/-)-biatractylolide and (+/-)-biepiasterolide.

J Org Chem 2004 Dec;69(26):9100-8

Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.

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http://dx.doi.org/10.1021/jo0488053DOI Listing
December 2004

Biomimetic synthesis of the pyrrolobenzoxazine core of paeciloxazine.

Chem Commun (Camb) 2004 Nov 25(22):2552-3. Epub 2004 Oct 25.

Department of Chemistry, University of Oxford, Chemical Research Laboratory, UK.

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http://dx.doi.org/10.1039/b412300jDOI Listing
November 2004

A new and efficient method for o-quinone methide intermediate generation: application to the biomimetic synthesis of (+/-)-Alboatrin.

Org Lett 2004 Sep;6(20):3617-9

Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, United Kingdom.

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http://dx.doi.org/10.1021/ol048479dDOI Listing
September 2004

Controlling the substrate selectivity of deacetoxycephalosporin/deacetylcephalosporin C synthase.

J Biol Chem 2004 Apr 20;279(15):15420-6. Epub 2004 Jan 20.

Department of Pharmacy & Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M313928200DOI Listing
April 2004

Stille coupling made easier-the synergic effect of copper(I) salts and the fluoride ion.

Angew Chem Int Ed Engl 2004 Feb;43(9):1132-6

The Dyson Perrins Laboratory, University of Oxford, South Parks Road, Oxford OX1 3QY, UK.

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http://dx.doi.org/10.1002/anie.200352979DOI Listing
February 2004

Biomimetic studies on polyenes.

Org Biomol Chem 2003 Nov;1(21):3670-84

The Dyson Perrins Laboratory, University of Oxford, Oxford, UK OX1 3QY.

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http://dx.doi.org/10.1039/b306933hDOI Listing
November 2003

Total synthesis of panepophenanthrin.

Org Lett 2003 Aug;5(17):2987-8

Dyson Perrins Laboratory, Oxford University, South Parks Road, Oxford OX1 3QY, UK.

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http://dx.doi.org/10.1021/ol0349817DOI Listing
August 2003

Biomimetic synthesis of biatractylolide and biepiasterolide.

Org Lett 2003 Aug;5(17):3049-52

Dyson Perrins Laboratory, Oxford University, South Parks Road, Oxford OX1 3QY, UK.

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http://pubs.acs.org/doi/abs/10.1021/ol035022f
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http://dx.doi.org/10.1021/ol035022fDOI Listing
August 2003

An unusual oxidative cyclization: studies towards the biomimetic synthesis of pyridomacrolidin.

Org Lett 2003 Jun;5(13):2351-4

Dyson Perrins Laboratory, Department of Chemistry, Oxford University, South Parks Road, Oxford OX1 3QY, United Kingdom.

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http://dx.doi.org/10.1021/ol034736nDOI Listing
June 2003

Crystallographic studies on the reaction of isopenicillin N synthase with an unsaturated substrate analogue.

Org Biomol Chem 2003 May;1(9):1455-60

Dyson Perrins Laboratory, Oxford Centre for Molecular Sciences, University of Oxford, South Parks Road, Oxford, UK OX1 3QY.

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http://dx.doi.org/10.1039/b212270gDOI Listing
May 2003

Biomimetic synthesis of the crispatene core.

Org Lett 2003 Mar;5(5):661-3

Dyson Perrins Laboratory, Department of Chemistry, Oxford University, South Parks Road, Oxford OX1 3QY, UK.

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http://dx.doi.org/10.1021/ol020242zDOI Listing
March 2003

Studies on the biomimetic synthesis of SNF4435 C and D.

Org Lett 2002 Oct;4(21):3731-4

Chemical Crystallography, Oxford University, South Parks Road, Oxford OX1 3QR, U.K.

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http://dx.doi.org/10.1021/ol020157rDOI Listing
October 2002

A device for the high-pressure oxygenation of protein crystals.

Anal Biochem 2002 Sep;308(2):265-8

The Dyson Perrins Laboratory and the Oxford Centre for Molecular Sciences, University of Oxford, UK.

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http://dx.doi.org/10.1016/s0003-2697(02)00246-4DOI Listing
September 2002

Biomimetic cycloaddition approach to tropolone natural products via a tropolone ortho-quinone methide.

Org Lett 2002 Aug;4(17):3009-11

Dyson Perrins Laboratory, University of Oxford, South Parks Road, Oxford OX1 3QY, UK.

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http://dx.doi.org/10.1021/ol026467rDOI Listing
August 2002

The role of arginine residues in substrate binding and catalysis by deacetoxycephalosporin C synthase.

Eur J Biochem 2002 Jun;269(11):2735-9

Oxford Centre for Molecular Sciences and the Dyson Perrins Laboratory, Oxford, UK.

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http://dx.doi.org/10.1046/j.1432-1033.2002.02945.xDOI Listing
June 2002

Total synthesis of pyridovericin: studies toward the biomimetic synthesis of pyridomacrolidin.

Org Lett 2002 Jun;4(13):2125-7

Dyson Perrins Laboratory, Oxford University, South Parks Road, Oxford OX1 3QY, UK.

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http://dx.doi.org/10.1021/ol0200504DOI Listing
June 2002

X-ray crystal structure of Escherichia coli taurine/alpha-ketoglutarate dioxygenase complexed to ferrous iron and substrates.

Biochemistry 2002 Apr;41(16):5185-92

Dyson Perrins Laboratory, Oxford University, South Parks Road, Oxford, England, OX1 3QY, and Departments of Microbiology & Molecular Genetics and Biochemistry & Molecular Biology, Michigan State University, East Lansing, Michigan 48824-1011.

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http://dx.doi.org/10.1021/bi016014eDOI Listing
April 2002

The iron-sulfur center of biotin synthase: site-directed mutants.

J Biol Inorg Chem 2002 Jan 11;7(1-2):83-93. Epub 2001 Jul 11.

Oxford Center for Molecular Sciences, Dyson Perrins Laboratory, South Parks Road, Oxford OX1 3QY, UK.

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http://dx.doi.org/10.1007/s007750100268DOI Listing
January 2002

Investigations into the Manzamine Alkaloid Biosynthetic Hypothesis.

Angew Chem Int Ed Engl 1998 Oct;37(19):2661-2663

Glaxo Wellcome Research and Development, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY (UK).

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http://dx.doi.org/10.1002/(SICI)1521-3773(19981016)37:19<2661::AID-ANIE2661>3.0.CO;2-DDOI Listing
October 1998

The Mechanism of ACV Synthetase.

Chem Rev 1997 Nov;97(7):2631-2650

The Oxford Centre for Molecular Sciences and Dyson Perrins Laboratory, South Parks Road, Oxford OX1 3QY U.K.

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http://dx.doi.org/10.1021/cr960018lDOI Listing
November 1997