Publications by authors named "Jack D Sadowsky"

24Publications

Effect of Modulating FcRn Binding on Direct and Pretargeted Tumor Uptake of Full-length Antibodies.

Mol Cancer Ther 2020 04 5;19(4):1052-1058. Epub 2020 Feb 5.

Preclinical and Translational Pharmacokinetics, Genentech Research and Early Development, South San Francisco, California.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1535-7163.MCT-19-1015DOI Listing
April 2020

Exposure-Efficacy Analysis of Antibody-Drug Conjugates Delivering an Excessive Level of Payload to Tissues.

Drug Metab Dispos 2019 10 29;47(10):1146-1155. Epub 2019 Jul 29.

Drug Metabolism & Pharmacokinetics (D.Z., Y.M., D.S., W.W., S.C.K., C.E.C.A.H.), Discovery Chemistry (P.S.D., T.H.P.), Translational Oncology (S.-F.Y., A.P.), and Protein Chemistry (J.D.S.), Genentech, South San Francisco, California

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/dmd.119.087023DOI Listing
October 2019

Catalytic Cleavage of Disulfide Bonds in Small Molecules and Linkers of Antibody-Drug Conjugates.

Drug Metab Dispos 2019 10 13;47(10):1156-1163. Epub 2019 May 13.

Drug Metabolism & Pharmacokinetics (D.Z., R.T.C., L.L., Y.D., C.E.C.A.H., S.C.K.), Biochemical and Cellular Pharmacology (A.F.-O., K.R.K., Y.L.), Discovery Chemistry (P.S.D., T.H.P.), and Protein Chemistry (J.D.S.), Genentech, Inc., South San Francisco, California

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/dmd.118.086132DOI Listing
October 2019

Immolation of p-Aminobenzyl Ether Linker and Payload Potency and Stability Determine the Cell-Killing Activity of Antibody-Drug Conjugates with Phenol-Containing Payloads.

Bioconjug Chem 2018 02 7;29(2):267-274. Epub 2018 Feb 7.

Drug Metabolism & Pharmacokinetics, ‡Biochemical and Cellular Pharmacology, §Molecular Oncology, ⊥Discovery Chemistry, and ∥Protein Chemistry, Genentech , South San Francisco, California 94080, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.bioconjchem.7b00576DOI Listing
February 2018

Intratumoral Payload Concentration Correlates with the Activity of Antibody-Drug Conjugates.

Mol Cancer Ther 2018 03 18;17(3):677-685. Epub 2018 Jan 18.

Drug Metabolism & Pharmacokinetics, Genentech Inc., South San Francisco, California.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1535-7163.MCT-17-0697DOI Listing
March 2018

Linker Immolation Determines Cell Killing Activity of Disulfide-Linked Pyrrolobenzodiazepine Antibody-Drug Conjugates.

ACS Med Chem Lett 2016 Nov 26;7(11):988-993. Epub 2016 Aug 26.

Drug Metabolism & Pharmacokinetics, Discovery Chemistry, Biochemical and Cellular Pharmacology, Protein Chemistry, and Molecular Oncology, Genentech , South San Francisco, California 94080, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsmedchemlett.6b00233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108036PMC
November 2016

Chemical Structure and Concentration of Intratumor Catabolites Determine Efficacy of Antibody Drug Conjugates.

Drug Metab Dispos 2016 09 14;44(9):1517-23. Epub 2016 Jul 14.

Drug Metabolism and Pharmacokinetics (D.Z., Y.M., C.E.C.A.H, S.C.K.), Translational Oncology (S.Y., G.D.R.), BioAnalytical Sciences (K.X., L.L., J.H.), Discovery Chemistry (P.S.D., T.H.P., Z.P.), Protein Chemistry (J.D.S., H.K.E.), Genentech, South San Francisco, California.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/dmd.116.070631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998580PMC
September 2016

A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1.

Proc Natl Acad Sci U S A 2014 Dec 17;111(52):18590-5. Epub 2014 Dec 17.

Department of Pharmaceutical Chemistry, Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1415365112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284534PMC
December 2014

Ordering a dynamic protein via a small-molecule stabilizer.

J Am Chem Soc 2013 Mar 22;135(9):3363-6. Epub 2013 Feb 22.

Program in Chemical Biology, University of Michigan, Ann Arbor, Michigan 48109, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ja3122334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607081PMC
March 2013

Turning a protein kinase on or off from a single allosteric site via disulfide trapping.

Proc Natl Acad Sci U S A 2011 Apr 23;108(15):6056-61. Epub 2011 Mar 23.

Departments of Pharmaceutical Chemistry and Cellular and Molecular Pharmacology, University of California, 1700 Fourth Street, San Francisco, CA 94158, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1102376108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076885PMC
April 2011

High-resolution structural characterization of a helical alpha/beta-peptide foldamer bound to the anti-apoptotic protein Bcl-xL.

Angew Chem Int Ed Engl 2009 ;48(24):4318-22

Structural Biology Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/anie.200805761DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2843084PMC
September 2009

Exploration of structure--activity relationships among foldamer ligands for a specific protein binding site via parallel and split-and-mix library synthesis.

J Comb Chem 2008 Mar-Apr;10(2):204-15. Epub 2008 Feb 15.

Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/cc700153zDOI Listing
August 2008

H/D exchange- and mass spectrometry-based strategy for the thermodynamic analysis of protein-ligand binding.

Anal Chem 2007 Aug 21;79(15):5869-77. Epub 2007 Jun 21.

Department of Chemistry, Duke University, Durham, North Carolina 27708, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ac0700777DOI Listing
August 2007

Efficient synthesis of a beta-peptide combinatorial library with microwave irradiation.

J Am Chem Soc 2005 Sep;127(38):13271-80

Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ja052733vDOI Listing
September 2005

NMR studies on the solution structure of a deletion mutant of the transcarboxylase biotin carrier subunit.

Int J Biol Macromol 2002 Oct;30(5):233-42

Institut für Analytische Chemie, Universität Leipzig, Linnestrasse 3, D-04103, Leipzig, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0141-8130(02)00033-8DOI Listing
October 2002