Jack D Keene

Jack D Keene

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Jack D Keene

Jack D Keene

Publications by authors named "Jack D Keene"

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RNA Binding Proteins Control Transdifferentiation of Hepatic Stellate Cells into Myofibroblasts.

Cell Physiol Biochem 2018 25;48(3):1215-1229. Epub 2018 Jul 25.

Department of Medicine, Duke University, Durham, North Carolina, USA.

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http://dx.doi.org/10.1159/000491987DOI Listing
September 2018

Ras Post-transcriptionally Enhances a Pre-malignantly Primed EMT to Promote Invasion.

iScience 2018 Jun 18;4:97-108. Epub 2018 May 18.

Department of Molecular Genetics & Microbiology, Duke University Medical Center, Durham, NC 27710, USA. Electronic address:

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http://dx.doi.org/10.1016/j.isci.2018.05.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147080PMC
June 2018

Analysis of post-transcriptional regulation during cancer progression using a donor-derived isogenic model of tumorigenesis.

Methods 2017 08 19;126:193-200. Epub 2017 May 19.

Department of Molecular Genetics & Microbiology, Duke University Medical Center, Durham, NC 27710, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2017.05.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6489129PMC
August 2017

DO-RIP-seq to quantify RNA binding sites transcriptome-wide.

Methods 2017 04 10;118-119:16-23. Epub 2016 Nov 10.

Department of Molecular Genetics & Microbiology, USA; Duke University Medical Center, Durham, NC 27710, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10462023163043
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http://dx.doi.org/10.1016/j.ymeth.2016.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411286PMC
April 2017

Quantifying RNA binding sites transcriptome-wide using DO-RIP-seq.

RNA 2017 01 14;23(1):32-46. Epub 2016 Oct 14.

Department of Molecular Genetics and Microbiology, Center for RNA Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1261/rna.058115.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159647PMC
January 2017

Functional coordination and HuR-mediated regulation of mRNA stability during T cell activation.

Nucleic Acids Res 2016 Jan 20;44(1):426-36. Epub 2015 Oct 20.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA

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http://dx.doi.org/10.1093/nar/gkv1066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705648PMC
January 2016

XRN1 stalling in the 5' UTR of Hepatitis C virus and Bovine Viral Diarrhea virus is associated with dysregulated host mRNA stability.

PLoS Pathog 2015 Mar 6;11(3):e1004708. Epub 2015 Mar 6.

Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1004708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352041PMC
March 2015

Post-transcriptional RNA regulons affecting cell cycle and proliferation.

Semin Cell Dev Biol 2014 Oct 2;34:44-54. Epub 2014 Jun 2.

Department of Molecular Genetics & Microbiology, Duke University Medical Center, Box 3020, Durham, NC 27710, USA. Electronic address:

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http://dx.doi.org/10.1016/j.semcdb.2014.05.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163074PMC
October 2014

Transcriptional and posttranscriptional regulation of cytokine gene expression in HIV-1 antigen-specific CD8+ T cells that mediate virus inhibition.

J Virol 2014 Sep 4;88(17):9514-28. Epub 2014 Jun 4.

Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, USA Department of Surgery, Duke University, Durham, North Carolina, USA Department of Immunology, Duke University, Durham, North Carolina, USA Duke Human Vaccine Institute, Duke University, Durham, North Carolina, USA

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http://jvi.asm.org/cgi/doi/10.1128/JVI.00802-14
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http://dx.doi.org/10.1128/JVI.00802-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136361PMC
September 2014

The globalization of messenger RNA regulation.

Authors:
Jack D Keene

Natl Sci Rev 2014 Jun 14;1(2):184-186. Epub 2014 May 14.

Department of Molecular Genetics & Microbiology, Duke University Medical Center, USA.

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http://dx.doi.org/10.1093/nsr/nwu004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5222540PMC
June 2014

Mechanisms coordinating ELAV/Hu mRNA regulons.

Curr Opin Genet Dev 2013 Feb 9;23(1):35-43. Epub 2013 Jan 9.

Department of Molecular Genetics & Microbiology, Duke University Medical Center, Durham, NC 27710, United States.

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https://linkinghub.elsevier.com/retrieve/pii/S0959437X120015
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http://dx.doi.org/10.1016/j.gde.2012.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617084PMC
February 2013

Neuron-specific ELAV/Hu proteins suppress HuR mRNA during neuronal differentiation by alternative polyadenylation.

Nucleic Acids Res 2012 Mar 1;40(6):2734-46. Epub 2011 Dec 1.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27701, USA.

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http://dx.doi.org/10.1093/nar/gkr1114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315332PMC
March 2012

PARalyzer: definition of RNA binding sites from PAR-CLIP short-read sequence data.

Genome Biol 2011 Aug 18;12(8):R79. Epub 2011 Aug 18.

Institute for Genome Sciences and Policy, Duke University, Durham, NC 27708, USA.

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http://dx.doi.org/10.1186/gb-2011-12-8-r79DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302668PMC
August 2011

Systematic analysis of posttranscriptional gene expression.

Wiley Interdiscip Rev Syst Biol Med 2010 Mar-Apr;2(2):162-180

University Program in Genetics and Genomics, Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA.

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http://dx.doi.org/10.1002/wsbm.54DOI Listing
February 2011

The global dynamics of RNA stability orchestrates responses to cellular activation.

Authors:
Jack D Keene

BMC Biol 2010 Jul 8;8:95. Epub 2010 Jul 8.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.

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http://bmcbiol.biomedcentral.com/articles/10.1186/1741-7007-
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http://dx.doi.org/10.1186/1741-7007-8-95DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900241PMC
July 2010

Tissue type-specific expression of the dsRNA-binding protein 76 and genome-wide elucidation of its target mRNAs.

PLoS One 2010 Jul 23;5(7):e11710. Epub 2010 Jul 23.

Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0011710PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909144PMC
July 2010

Minireview: global regulation and dynamics of ribonucleic Acid.

Authors:
Jack D Keene

Endocrinology 2010 Apr;151(4):1391-7

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA.

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https://academic.oup.com/endo/article-lookup/doi/10.1210/en.
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http://dx.doi.org/10.1210/en.2009-1250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850242PMC
April 2010

Coordinated posttranscriptional mRNA population dynamics during T-cell activation.

Mol Syst Biol 2009 28;5:288. Epub 2009 Jul 28.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1038/msb.2009.44DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2724974PMC
October 2009

Control of thymic T cell maturation, deletion and egress by the RNA-binding protein HuR.

J Immunol 2009 Jun;182(11):6779-88

Institute of Immunology, Biomedical Sciences Research Centre Alexander Fleming, Vari, Greece.

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http://dx.doi.org/10.4049/jimmunol.0900377DOI Listing
June 2009

Proteomic and immunologic analyses of brain tumor exosomes.

FASEB J 2009 May 24;23(5):1541-57. Epub 2008 Dec 24.

Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA.

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http://www.fasebj.org/doi/10.1096/fj.08-122184
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http://dx.doi.org/10.1096/fj.08-122184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2669426PMC
May 2009

Activity-dependent expression of RNA binding protein HuD and its association with mRNAs in neurons.

RNA Biol 2008 Jul-Sep;5(3):157-68. Epub 2008 Jul 14.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.4161/rna.5.3.6782DOI Listing
March 2009

The ribonome: a dominant force in co-ordinating gene expression.

Biol Cell 2009 Mar;101(3):169-81

Department of Molecular Genetics & Microbiology, Duke University Medical Center, Durham, North Carolina, 27710, USA.

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http://doi.wiley.com/10.1042/BC20080055
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http://dx.doi.org/10.1042/BC20080055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332539PMC
March 2009

Activity-dependent expression of ELAV/Hu RBPs and neuronal mRNAs in seizure and cocaine brain.

J Neurochem 2008 Dec 6;107(6):1529-43. Epub 2008 Nov 6.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.

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http://doi.wiley.com/10.1111/j.1471-4159.2008.05718.x
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http://dx.doi.org/10.1111/j.1471-4159.2008.05718.xDOI Listing
December 2008

Ribonomic analysis of human Pum1 reveals cis-trans conservation across species despite evolution of diverse mRNA target sets.

Mol Cell Biol 2008 Jun 14;28(12):4093-103. Epub 2008 Apr 14.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1128/MCB.00155-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2423135PMC
June 2008

Signal sequence- and translation-independent mRNA localization to the endoplasmic reticulum.

RNA 2008 Mar 11;14(3):445-53. Epub 2008 Jan 11.

Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://www.rnajournal.org/cgi/doi/10.1261/rna.721108
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http://dx.doi.org/10.1261/rna.721108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2248262PMC
March 2008

Caspase-mediated cleavage of HuR in the cytoplasm contributes to pp32/PHAP-I regulation of apoptosis.

J Cell Biol 2008 Jan 7;180(1):113-27. Epub 2008 Jan 7.

Department of Biochemistry, McGill University Health Center, McGill University, Montreal, Quebec H3G 146, Canada.

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http://dx.doi.org/10.1083/jcb.200709030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213623PMC
January 2008

A two-phase innate host response to alphavirus infection identified by mRNP-tagging in vivo.

PLoS Pathog 2007 Dec;3(12):e199

Department of Microbiology and Immunology University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.0030199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151086PMC
December 2007

RNA regulons: coordination of post-transcriptional events.

Authors:
Jack D Keene

Nat Rev Genet 2007 Jul;8(7):533-43

Department of Molecular Genetics & Microbiology, Duke University Medical Center, Box 3020, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1038/nrg2111DOI Listing
July 2007

RIP-Chip: the isolation and identification of mRNAs, microRNAs and protein components of ribonucleoprotein complexes from cell extracts.

Nat Protoc 2006 ;1(1):302-7

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1038/nprot.2006.47DOI Listing
June 2007

Stable ribosome binding to the endoplasmic reticulum enables compartment-specific regulation of mRNA translation.

Mol Biol Cell 2005 Dec 12;16(12):5819-31. Epub 2005 Oct 12.

Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1091/mbc.e05-07-0685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1289424PMC
December 2005

Post-transcriptional operons and regulons co-ordinating gene expression.

Chromosome Res 2005 ;13(3):327-37

Center for RNA Biology, Department of Molecular Genetics & Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1007/s10577-005-0848-1DOI Listing
August 2005

Biotinylated tags for recovery and characterization of ribonucleoprotein complexes.

Biotechniques 2004 Oct;37(4):604, 606, 608-10

Duke University Medical Center, Durham, NC 27710, USA.

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https://www.future-science.com/doi/10.2144/04374ST05
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http://dx.doi.org/10.2144/04374ST05DOI Listing
October 2004

RNA-binding proteins to assess gene expression states of co-cultivated cells in response to tumor cells.

Mol Cancer 2004 Sep 7;3:24. Epub 2004 Sep 7.

Department of Molecular Genetics and Microbiology, Center for RNA biology, 414 Jones Building, Research Drive, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1186/1476-4598-3-24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC521085PMC
September 2004

Gene expression analysis of messenger RNP complexes.

Methods Mol Biol 2004 ;257:125-34

The Center For RNA Biology, Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA.

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http://dx.doi.org/10.1385/1-59259-750-5:125DOI Listing
April 2004

La gets its wings.

Nat Struct Mol Biol 2004 Apr;11(4):303-5

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http://www.nature.com/articles/nsmb0404-303
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http://dx.doi.org/10.1038/nsmb0404-303DOI Listing
April 2004

Posttranscriptional generation of macromolecular complexes.

Authors:
Jack D Keene

Mol Cell 2003 Dec;12(6):1347-9

Center for RNA Biology, Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1016/s1097-2765(03)00496-9DOI Listing
December 2003

Differential phosphorylation and subcellular localization of La RNPs associated with precursor tRNAs and translation-related mRNAs.

Mol Cell 2003 Nov;12(5):1301-7

Laboratory of Molecular Growth Regulation, National Institute of Child Health and Development, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/s1097-2765(03)00429-5DOI Listing
November 2003

Genome-wide regulatory analysis using en masse nuclear run-ons and ribonomic profiling with autoimmune sera.

Gene 2003 Oct;317(1-2):79-87

Center for RNA Biology, Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1016/s0378-1119(03)00661-9DOI Listing
October 2003

Partitioning and translation of mRNAs encoding soluble proteins on membrane-bound ribosomes.

RNA 2003 Sep;9(9):1123-37

Departments of Cell Biology and Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1370476PMC
http://dx.doi.org/10.1261/rna.5610403DOI Listing
September 2003

RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation.

Proc Natl Acad Sci U S A 2003 Jul 23;100(14):8354-9. Epub 2003 Jun 23.

Laboratory of Cellular and Molecular Biology, National Institute on Aging-Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1073/pnas.1432104100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC166233PMC
July 2003

Organizing mRNA export.

Authors:
Jack D Keene

Nat Genet 2003 Feb;33(2):111-2

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http://dx.doi.org/10.1038/ng0203-111DOI Listing
February 2003

Eukaryotic mRNPs may represent posttranscriptional operons.

Mol Cell 2002 Jun;9(6):1161-7

Center for RNA Biology, Department of Microbiology, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1016/s1097-2765(02)00559-2DOI Listing
June 2002

Autoimmune epitopes in messenger RNA.

RNA 2002 Jun;8(6):762-71

Department of Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1370295PMC
http://dx.doi.org/10.1017/s1355838202021507DOI Listing
June 2002

Ribonomics: identifying mRNA subsets in mRNP complexes using antibodies to RNA-binding proteins and genomic arrays.

Methods 2002 Feb;26(2):191-8

Department of Microbiology, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1016/S1046-2023(02)00022-1DOI Listing
February 2002