Publications by authors named "Jack Bowden"

74Publications

Mendelian randomisation analysis of the effect of educational attainment and cognitive ability on smoking behaviour.

Nat Commun 2019 07 3;10(1):2949. Epub 2019 Jul 3.

MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, BS8 2BN, UK.

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http://dx.doi.org/10.1038/s41467-019-10679-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610141PMC
July 2019

Meta-analysis and Mendelian randomization: A review.

Res Synth Methods 2019 Dec 23;10(4):486-496. Epub 2019 Apr 23.

Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1002/jrsm.1346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6973275PMC
December 2019

A comparison of heterogeneity variance estimators in simulated random-effects meta-analyses.

Res Synth Methods 2019 Mar 6;10(1):83-98. Epub 2018 Sep 6.

Centre for Reviews and Dissemination, University of York, York, UK.

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http://dx.doi.org/10.1002/jrsm.1316DOI Listing
March 2019

Adiposity-Mortality Relationships in Type 2 Diabetes, Coronary Heart Disease, and Cancer Subgroups in the UK Biobank, and Their Modification by Smoking.

Diabetes Care 2018 09 3;41(9):1878-1886. Epub 2018 Jul 3.

School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, U.K.

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http://dx.doi.org/10.2337/dc17-2508DOI Listing
September 2018

Investigating causality in associations between education and smoking: a two-sample Mendelian randomization study.

Int J Epidemiol 2018 08;47(4):1131-1140

MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1093/ije/dyy131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124626PMC
August 2018

Evaluating the potential role of pleiotropy in Mendelian randomization studies.

Hum Mol Genet 2018 08;27(R2):R195-R208

MRC Integrative Epidemiology Unit, Population Health Sciences, University of Bristol.

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https://academic.oup.com/hmg/article/27/R2/R195/4996734
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http://dx.doi.org/10.1093/hmg/ddy163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061876PMC
August 2018

Age at menarche and adult body mass index: a Mendelian randomization study.

Int J Obes (Lond) 2018 09 26;42(9):1574-1581. Epub 2018 Feb 26.

Population Health and Occupational Disease, NHLI, Imperial College London, London, UK.

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http://dx.doi.org/10.1038/s41366-018-0048-7DOI Listing
September 2018

Mendelian Randomization Concerns-Reply.

JAMA Psychiatry 2018 04 7;75(4):407-408. Epub 2018 Mar 7.

Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, England.

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http://dx.doi.org/10.1001/jamapsychiatry.2017.4725DOI Listing
April 2018

Response-adaptive designs for binary responses: How to offer patient benefit while being robust to time trends?

Pharm Stat 2018 03 19;17(2):182-197. Epub 2017 Dec 19.

MRC Biostatistics Unit, Cambridge Institute of Public Health, Cambridge, UK.

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http://doi.wiley.com/10.1002/pst.1845
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http://dx.doi.org/10.1002/pst.1845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877788PMC
March 2018

Recent Developments in Mendelian Randomization Studies.

Curr Epidemiol Rep 2017 22;4(4):330-345. Epub 2017 Nov 22.

MRC Integrative Epidemiology Unit, University of Bristol, Oakfield House, Bristol, UK.

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http://dx.doi.org/10.1007/s40471-017-0128-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711966PMC
November 2017

Inflammatory Biomarkers and Risk of Schizophrenia: A 2-Sample Mendelian Randomization Study.

JAMA Psychiatry 2017 12;74(12):1226-1233

Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, England.

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http://dx.doi.org/10.1001/jamapsychiatry.2017.3191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6583386PMC
December 2017

Misconceptions on the use of MR-Egger regression and the evaluation of the InSIDE assumption.

Authors:
Jack Bowden

Int J Epidemiol 2017 12;46(6):2097-2099

MRC Integrative Epidemiology Unit at the University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK.

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http://dx.doi.org/10.1093/ije/dyx192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837449PMC
December 2017

Mendelian randomization incorporating uncertainty about pleiotropy.

Stat Med 2017 Dec 28;36(29):4627-4645. Epub 2017 Aug 28.

Department of Health Sciences, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1002/sim.7442DOI Listing
December 2017

Difficulties in Testing the Instrument Strength Independent of Direct Effect Assumption in Mendelian Randomization.

JAMA Cardiol 2017 08;2(8):929-930

MRC Integrative Epidemiology Unit, University of Bristol, Bristol, England.

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http://dx.doi.org/10.1001/jamacardio.2017.1572DOI Listing
August 2017

Does coffee consumption impact on heaviness of smoking?

Addiction 2017 Oct 12;112(10):1842-1853. Epub 2017 Jul 12.

MRC Integrative Epidemiology Unit, (IEU) at the University of Bristol, UK.

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http://dx.doi.org/10.1111/add.13888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600104PMC
October 2017

Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study.

Authors:
Philip C Haycock Stephen Burgess Aayah Nounu Jie Zheng George N Okoli Jack Bowden Kaitlin Hazel Wade Nicholas J Timpson David M Evans Peter Willeit Abraham Aviv Tom R Gaunt Gibran Hemani Massimo Mangino Hayley Patricia Ellis Kathreena M Kurian Karen A Pooley Rosalind A Eeles Jeffrey E Lee Shenying Fang Wei V Chen Matthew H Law Lisa M Bowdler Mark M Iles Qiong Yang Bradford B Worrall Hugh Stephen Markus Rayjean J Hung Chris I Amos Amanda B Spurdle Deborah J Thompson Tracy A O'Mara Brian Wolpin Laufey Amundadottir Rachael Stolzenberg-Solomon Antonia Trichopoulou N Charlotte Onland-Moret Eiliv Lund Eric J Duell Federico Canzian Gianluca Severi Kim Overvad Marc J Gunter Rosario Tumino Ulrika Svenson Andre van Rij Annette F Baas Matthew J Bown Nilesh J Samani Femke N G van t'Hof Gerard Tromp Gregory T Jones Helena Kuivaniemi James R Elmore Mattias Johansson James Mckay Ghislaine Scelo Robert Carreras-Torres Valerie Gaborieau Paul Brennan Paige M Bracci Rachel E Neale Sara H Olson Steven Gallinger Donghui Li Gloria M Petersen Harvey A Risch Alison P Klein Jiali Han Christian C Abnet Neal D Freedman Philip R Taylor John M Maris Katja K Aben Lambertus A Kiemeney Sita H Vermeulen John K Wiencke Kyle M Walsh Margaret Wrensch Terri Rice Clare Turnbull Kevin Litchfield Lavinia Paternoster Marie Standl Gonçalo R Abecasis John Paul SanGiovanni Yong Li Vladan Mijatovic Yadav Sapkota Siew-Kee Low Krina T Zondervan Grant W Montgomery Dale R Nyholt David A van Heel Karen Hunt Dan E Arking Foram N Ashar Nona Sotoodehnia Daniel Woo Jonathan Rosand Mary E Comeau W Mark Brown Edwin K Silverman John E Hokanson Michael H Cho Jennie Hui Manuel A Ferreira Philip J Thompson Alanna C Morrison Janine F Felix Nicholas L Smith Angela M Christiano Lynn Petukhova Regina C Betz Xing Fan Xuejun Zhang Caihong Zhu Carl D Langefeld Susan D Thompson Feijie Wang Xu Lin David A Schwartz Tasha Fingerlin Jerome I Rotter Mary Frances Cotch Richard A Jensen Matthias Munz Henrik Dommisch Arne S Schaefer Fang Han Hanna M Ollila Ryan P Hillary Omar Albagha Stuart H Ralston Chenjie Zeng Wei Zheng Xiao-Ou Shu Andre Reis Steffen Uebe Ulrike Hüffmeier Yoshiya Kawamura Takeshi Otowa Tsukasa Sasaki Martin Lloyd Hibberd Sonia Davila Gang Xie Katherine Siminovitch Jin-Xin Bei Yi-Xin Zeng Asta Försti Bowang Chen Stefano Landi Andre Franke Annegret Fischer David Ellinghaus Carlos Flores Imre Noth Shwu-Fan Ma Jia Nee Foo Jianjun Liu Jong-Won Kim David G Cox Olivier Delattre Olivier Mirabeau Christine F Skibola Clara S Tang Merce Garcia-Barcelo Kai-Ping Chang Wen-Hui Su Yu-Sun Chang Nicholas G Martin Scott Gordon Tracey D Wade Chaeyoung Lee Michiaki Kubo Pei-Chieng Cha Yusuke Nakamura Daniel Levy Masayuki Kimura Shih-Jen Hwang Steven Hunt Tim Spector Nicole Soranzo Ani W Manichaikul R Graham Barr Bratati Kahali Elizabeth Speliotes Laura M Yerges-Armstrong Ching-Yu Cheng Jost B Jonas Tien Yin Wong Isabella Fogh Kuang Lin John F Powell Kenneth Rice Caroline L Relton Richard M Martin George Davey Smith

JAMA Oncol 2017 May;3(5):636-651

MRC Integrative Epidemiology Unit, University of Bristol, Bristol, England2School of Social and Community Medicine, University of Bristol, Bristol, England.

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http://dx.doi.org/10.1001/jamaoncol.2016.5945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638008PMC
May 2017

A framework for the investigation of pleiotropy in two-sample summary data Mendelian randomization.

Stat Med 2017 05 23;36(11):1783-1802. Epub 2017 Jan 23.

Department of Health Sciences, University of Leicester, Leicester, U.K.

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http://dx.doi.org/10.1002/sim.7221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434863PMC
May 2017

Weighing Evidence "Steampunk" Style via the Meta-Analyser.

Am Stat 2016 Oct 21;70(4):385-394. Epub 2016 Nov 21.

MRC Biostatistics Unit, University of Cambridge , Cambridge , UK.

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http://dx.doi.org/10.1080/00031305.2016.1165735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125286PMC
October 2016

Sensitivity Analyses for Robust Causal Inference from Mendelian Randomization Analyses with Multiple Genetic Variants.

Epidemiology 2017 01;28(1):30-42

From the aCardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; bMedical Research Council Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom; and cDepartment of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1097/EDE.0000000000000559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133381PMC
January 2017

Response to Hartwig and Davies.

Int J Epidemiol 2016 10 20;45(5):1679-1680. Epub 2016 Sep 20.

MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1093/ije/dyw252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100626PMC
October 2016

Body mass index and psychiatric disorders: a Mendelian randomization study.

Sci Rep 2016 09 7;6:32730. Epub 2016 Sep 7.

Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.

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http://dx.doi.org/10.1038/srep32730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013405PMC
September 2016

Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator.

Genet Epidemiol 2016 May 7;40(4):304-14. Epub 2016 Apr 7.

Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1002/gepi.21965DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849733PMC
May 2016

Accounting for selection and correlation in the analysis of two-stage genome-wide association studies.

Biostatistics 2016 10 18;17(4):634-49. Epub 2016 Mar 18.

MRC Integrative Epidemiology Unit, University of Bristol, Oakfield House, Bristol BS8 2BN, UK and MRC Biostatistics Unit, IPH Forvie Site, Robinson Way, Cambridge CB2 0SR, UK.

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http://dx.doi.org/10.1093/biostatistics/kxw012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031943PMC
October 2016

An optimal stratified Simon two-stage design.

Pharm Stat 2016 07 2;15(4):333-40. Epub 2016 Mar 2.

MRC Biostatistics Unit Hub for Trials Methodology Research, Coventry, UK.

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http://dx.doi.org/10.1002/pst.1742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405342PMC
July 2016

Methods to estimate the between-study variance and its uncertainty in meta-analysis.

Res Synth Methods 2016 Mar 2;7(1):55-79. Epub 2015 Sep 2.

Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece.

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http://dx.doi.org/10.1002/jrsm.1164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4950030PMC
March 2016

Approximate confidence intervals for moment-based estimators of the between-study variance in random effects meta-analysis.

Res Synth Methods 2015 Dec 19;6(4):372-82. Epub 2015 Aug 19.

School of Business, University of Salford, Salford, UK.

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http://dx.doi.org/10.1002/jrsm.1162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839498PMC
December 2015

Unbiased estimation for response adaptive clinical trials.

Stat Methods Med Res 2017 Oct 11;26(5):2376-2388. Epub 2015 Aug 11.

3 Dana-Farber Cancer Institute, Boston, USA.

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http://dx.doi.org/10.1177/0962280215597716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395089PMC
October 2017

Response-adaptive randomization for multi-arm clinical trials using the forward looking Gittins index rule.

Biometrics 2015 Dec 22;71(4):969-78. Epub 2015 Jun 22.

MRC Biostatistics Unit, Institute of Public Health, University Forvie Site, Robinson Way, Cambridge CB2 0SR, U.K.

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http://dx.doi.org/10.1111/biom.12337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856210PMC
December 2015

Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression.

Int J Epidemiol 2015 Apr 6;44(2):512-25. Epub 2015 Jun 6.

MRC Biostatistics Unit, Cambridge Institute of Public Health, Cambridge, UK, MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK and Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK MRC Biostatistics Unit, Cambridge Institute of Public Health, Cambridge, UK, MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK and Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1093/ije/dyv080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4469799PMC
April 2015

Correcting for bias in the selection and validation of informative diagnostic tests.

Stat Med 2015 Apr 1;34(8):1417-37. Epub 2015 Feb 1.

MRC Biostatistics Unit, Institute of Public Health, Cambridge, UK.

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http://doi.wiley.com/10.1002/sim.6413
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http://dx.doi.org/10.1002/sim.6413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415464PMC
April 2015

Multi-armed Bandit Models for the Optimal Design of Clinical Trials: Benefits and Challenges.

Stat Sci 2015;30(2):199-215

Senior Investigator Statistician at MRC BSU, Cambridge, MRC Biostatistics Unit, Cambridge Institute of Public Health, Forvie Site, Robinson Way, Cambridge Biomedical Campus, Cambridge CB2 0SR, United Kingdom.

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http://dx.doi.org/10.1214/14-STS504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856206PMC
January 2015

A multi-stage drop-the-losers design for multi-arm clinical trials.

Stat Methods Med Res 2017 Feb 30;26(1):508-524. Epub 2016 Sep 30.

3 Department of Mathematical Sciences, University of Bath, Bath, UK.

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http://dx.doi.org/10.1177/0962280214550759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302074PMC
February 2017

Accelerated longitudinal designs: An overview of modelling, power, costs and handling missing data.

Stat Methods Med Res 2017 Feb 11;26(1):374-398. Epub 2016 Jul 11.

2 MRC Biostatistics Unit, Cambridge, UK.

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http://dx.doi.org/10.1177/0962280214547150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302089PMC
February 2017

Palliative treatment for symptomatic malignant pericardial effusion†.

Interact Cardiovasc Thorac Surg 2014 Dec 20;19(6):1019-26. Epub 2014 Aug 20.

Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research (CIMR), Wellcome Trust/MRC Building, Cambridge, UK Papworth Hospital NHS Foundation Trust, Cambridge, UK Division of Respiratory Medicine, Department of Medicine, Addenbrooke's Hospital, Cambridge, UK.

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http://dx.doi.org/10.1093/icvts/ivu267DOI Listing
December 2014

Conditionally unbiased and near unbiased estimation of the selected treatment mean for multistage drop-the-losers trials.

Biom J 2014 Mar 18;56(2):332-49. Epub 2013 Dec 18.

MRC Biostatistics Unit, Cambridge, CB2 OSR, UK.

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http://dx.doi.org/10.1002/bimj.201200245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034592PMC
March 2014

Empirical Bayes estimation of the selected treatment mean for two-stage drop-the-loser trials: a meta-analytic approach.

Stat Med 2014 Feb 22;33(3):388-400. Epub 2013 Jul 22.

MRC Biostatistics Unit Hub for Trials Methodology Research, Cambridge, U.K.

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http://dx.doi.org/10.1002/sim.5920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282323PMC
February 2014

Impact of lack-of-benefit stopping rules on treatment effect estimates of two-arm multi-stage (TAMS) trials with time to event outcome.

Trials 2013 Jan 23;14:23. Epub 2013 Jan 23.

London Hub for Trials Methodology Research, MRC Clinical Trials Unit, Aviation House, 125 Kingsway, WC2B 6NH, London.

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http://dx.doi.org/10.1186/1745-6215-14-23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599134PMC
January 2013

Identifying combined design and analysis procedures in two-stage trials with a binary end point.

Stat Med 2012 Dec 11;31(29):3874-84. Epub 2012 Jul 11.

MRC Biostatistics Unit, Cambridge, UK.

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http://dx.doi.org/10.1002/sim.5468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546375PMC
December 2012

Meta-analysis of time-to-event data: a comparison of two-stage methods.

Res Synth Methods 2011 Sep 14;2(3):139-49. Epub 2011 Dec 14.

MRC Biostatistics Unit, Cambridge, UK.

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http://dx.doi.org/10.1002/jrsm.44DOI Listing
September 2011

Mendelian randomization analysis of case-control data using structural mean models.

Stat Med 2011 Mar 16;30(6):678-94. Epub 2010 Dec 16.

MRC Biostatistics Unit, Cambridge, U.K..

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http://dx.doi.org/10.1002/sim.4138DOI Listing
March 2011

Modelling multiple sources of dissemination bias in meta-analysis.

Stat Med 2010 Mar;29(7-8):945-55

MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 0SR, U.K.

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http://dx.doi.org/10.1002/sim.3813DOI Listing
March 2010

A re-evaluation of the 'quantile approximation method' for random effects meta-analysis.

Stat Med 2009 Jan;28(2):338-48

MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 2SR, U.K.

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http://dx.doi.org/10.1002/sim.3487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991773PMC
January 2009

Unbiased estimation of selected treatment means in two-stage trials.

Biom J 2008 Aug;50(4):515-27

MRC Biostatistics Unit, Cambridge, CB2 0SR, UK.

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http://dx.doi.org/10.1002/bimj.200810442DOI Listing
August 2008

Using pseudo-data to correct for publication bias in meta-analysis.

Stat Med 2006 Nov;25(22):3798-813

Department of Health Sciences, Centre for Biostatistics and Genetic Epidemiology, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1002/sim.2487DOI Listing
November 2006