Publications by authors named "J Yang"

59,219 Publications

Deep neural network-based approach to improving radiomics analysis reproducibility in liver cancer: effect on image resampling.

Phys Med Biol 2021 Jul 22. Epub 2021 Jul 22.

Nuclear & Radiological Engineering and Medical Physics Programs, Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA, Atlanta, Georgia, UNITED STATES.

Objectives: To test the effect of traditional up-sampling slice thickness (ST) methods on the reproducibility of CT radiomics features of liver tumors and investigate the improvement using a deep neural network (DNN) scheme.

Methods: CT images with ≤ 1 mm ST in the public dataset were converted to low resolution (3 mm, 5 mm) CT images. A DNN model was trained for the conversion from 3 mm-ST and 5 mm-ST to 1 mm-ST and compared with conventional interpolation-based methods (cubic, linear, nearest) using structural similarity (SSIM) and peak-signal-to-noise-ratio (PSNR). Radiomics features were extracted from the tumor and tumor ring regions. The reproducibility of features from images converted using DNN and interpolation schemes were assessed using the concordance correlation coefficients (CCC) with the cutoff of 0.85. The paired t-test and Mann-Whitney U test were used to compare the evaluation metrics, where appropriate.

Results: CT images of 108 patients were used for training (n=63), validation (n=11) and testing (n=34). The DNN method showed significantly higher PSNR and SSIM values (p < 0.05) than interpolation-based methods. The DNN method also showed a significantly higher CCC value than interpolation-based methods. For features in the tumor region, compared with the cubic interpolation approach, the reproducible features increased from 393 (82%) to 422(88%) for the conversion of 3mm-to-1mm, and from 305(64%) to 353(74%) for the conversion of 5mm-to-1mm. For features in the tumor ring region, the improvement was from 395 (82%) to 431 (90%) and from 290 (60%) to 335 (70%), respectively.

Conclusions: The DNN based ST up-sampling approach can improve the reproducibility of CT radiomics features in liver tumors, promoting the standardization of CT radiomics studies in liver cancer.
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http://dx.doi.org/10.1088/1361-6560/ac16e8DOI Listing
July 2021

Prognostic value of lymphovascular invasion in early-stage Merkel cell carcinoma: a retrospective analysis in the National Cancer Database.

J Am Acad Dermatol 2021 Jul 19. Epub 2021 Jul 19.

Veterans Affairs Palo Alto Healthcare System, Palo Alto, California; Department of Dermatology, Stanford University School of Medicine, Palo Alto, California. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2021.07.018DOI Listing
July 2021

Effect of silver diamine fluoride on hyperplastic gingivitis in an adult with intellectual disability-A case report.

Spec Care Dentist 2021 Jul 22. Epub 2021 Jul 22.

National Dental Research Institute Singapore, National Dental Centre Singapore, Singapore, Singapore.

Silver diamine fluoride 38% (SDF) may possess therapeutic effects beyond desensitization, caries prevention and arresting. We report the case of a 41-year-old male with intellectual disability. He had generalized gingivitis on a reduced periodontium and presented with enlarged gingiva with mobile teeth, particularly on the upper anterior and upper left. The inflammation could not be fully resolved despite multiple debridement treatments. Due to prevalent demineralization and hypersensitive teeth on the upper left area, SDF was applied. This not only reduced the perceived hypersensitivity, but significantly improved his periodontal condition and tooth mobility over the applied areas. We discuss the potential of SDF beyond its current use.
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http://dx.doi.org/10.1111/scd.12633DOI Listing
July 2021

USO1 isoforms differentially promote liver cancer progression by dysregulating the ER-Golgi network.

Carcinogenesis 2021 Jul 22. Epub 2021 Jul 22.

Department of Physiology, Ajou University School of Medicine, Suwon, Republic of Korea.

Alternative splicing of RNA transcripts plays an important role in cancer development and progression. Recent advances in RNA-seq technology have made it possible to identify alternately spliced events in various types of cancer; however, research on hepatocellular carcinoma (HCC) is still limited. Here, by performing RNA-Seq profiling of HCC transcripts at isoform level, we identified tumor-specific and molecular subtype-dependent expression of the USO1 isoforms, which we designated as a normal form USO1-N (XM_001290049) and a tumor form USO1-T (NM_003715). The expression of USO1-T, but not USO1-N, was associated with worse prognostic outcomes of HCC patients. We confirmed that the expression of USO1-T promoted an aggressive phenotype of HCC, both in vitro and in vivo. In addition, structural modeling analyses revealed that USO1-T lacks an ARM10 loop encoded by exon 15, which may weaken the dimerization of USO1 and its tethering to GM130. We demonstrated that USO1-T ensured unstacking of the Golgi and accelerated the trafficking from ER to Golgi and plasma membrane in multiple liver cancer cells. ERK and GRASP65 were found to be involved in the USO1-T mediated Golgi dysfunction. Conclusively, we provide new mechanophysical insights into the USO1 isoforms that differentially regulate the ER-Golgi network, promoting the heterogeneous HCC progression.
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http://dx.doi.org/10.1093/carcin/bgab067DOI Listing
July 2021

Facile Production of Phosphorene Nanoribbons towards Application in Lithium Metal Battery.

Adv Mater 2021 Jul 22:e2102083. Epub 2021 Jul 22.

Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore, 117543, Singapore.

Like phosphorene, phosphorene nanoribbon (PNR) promises exotic properties but unzipping phosphorene into edge-defined PNR is non-trivial because of uncontrolled cutting of phosphorene along random directions. Here a facile electrochemical strategy to fabricate zigzag-edged PNRs in high yield (>80%) is reported. The presence of chemically active zigzag edges in PNR allows it to spontaneously react with Li to form a Li ion conducting Li P phase, which can be used as a protective layer on Li metal anode in lithium metal batteries (LMBs). PNR protective layer prevents the parasitic reaction between lithium metal and electrolyte and promotes Li ion diffusion kinetics, enabling homogenous Li ion flux and long-time cycling stability up to 1100 h at a current density of 1 mA cm . LiFePO |PNR-Li full-cell batteries with an areal capacity of 2 mAh cm , a lean electrolyte (20 µl mAh ) and a negative/positive (N/P) electrodes ratio of 3.5 can be stably cycled over 100 cycles.
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http://dx.doi.org/10.1002/adma.202102083DOI Listing
July 2021
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