Publications by authors named "J X Zhang"

111,888 Publications

Stereotactic technology for 3D bioprinting: From the perspective of robot mechanism.

Biofabrication 2021 Jul 27. Epub 2021 Jul 27.

School of Biological Science and Medical Engineering, Beihang University, 37# XueYuan, Haidian District, Beijing, P.R.China, Beijing, 100083, CHINA.

Three-dimensional (3D) bioprinting has been widely applied in the field of biomedical engineering because of its rapidly individualized fabrication and precisely geometric designability. The emerging demand for bioprinted tissues/organs with bio-inspired anisotropic property is stimulating new bioprinting strategies. Stereotactic bioprinting is regarded as a preferable strategy for this purpose, which can perform bioprinting at the target position from any desired orientation in 3D space. In this work, based on the motion characteristics analysis of the stacked bioprinting technologies, mechanism configurations and path planning methods for robotic stereotactic bioprinting were investigated and a prototype system based on the double parallelogram mechanism was introduced in detail. Moreover, the influence of the time dimension on stereotactic bioprinting was discussed. Finally, technical challenges and future trends of stereotactic bioprinting within the field of biomedical engineering were summarized.
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http://dx.doi.org/10.1088/1758-5090/ac1846DOI Listing
July 2021

Victimization and depressive symptoms among Chinese adolescents: A moderated mediation model.

J Affect Disord 2021 Jul 20;294:375-381. Epub 2021 Jul 20.

School of Humanities and Social Sciences, University of Science and Technology of China, No. 96 Jinzhai Road, Baohe District, Hefei 230022, PR China. Electronic address:

Background: Victimization as an inducing factor of depressive symptoms has been confirmed in previous studies. However, little is known about how and when it induces depressive symptoms in adolescents.

Methods: In total, 1174 Chinese adolescents were recruited to complete the Juvenile Victimization Questionnaire, Security Questionnaire, Positive Psychological Capital Questionnaire, and the Chinese version of the Center for Epidemiologic Studies Depression Scale.

Results: After controlling for gender and school type, the sense of security partially mediated the association between victimization and depressive symptoms. Moreover, direct association and the mediating effect of the sense of security were moderated by psychological capital. The moderating effect occurred in the second half of the mediating effect.

Limitations: Causal conclusions cannot be drawn based on cross-sectional research design. All measures were based on participant self-report.

Conclusions: The mediating model constructed in this study emphasized the important influence of stress, emotion, and psychological diathesis on adolescent depressive symptoms.
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http://dx.doi.org/10.1016/j.jad.2021.07.022DOI Listing
July 2021

Tracing dissolved organic matter in inflowing rivers of Nansi Lake as a storage reservoir: Implications for water-quality control.

Chemosphere 2021 Jul 21;286(Pt 1):131624. Epub 2021 Jul 21.

Shandong Key Laboratory of Water Pollution Control and Resource Reuse, School of Environmental Science & Engineering, Shandong University, Qingdao, 266237, PR China. Electronic address:

Quantitative characterization of dissolved organic matter (DOM) in various aquatic ecosystems has become of increasing importance as its transformation plays a key role in inland water carbon, yet few studies have quantified water DOM inputs to storage lakes for water quality control and safety assurance. This study assessed the quantity and quality of DOM in 21 inflow rivers of Nansi Lake as the important storage lake of large-scale water transfer projects by using excitation-emission matrix spectroscopy coupled with parallel factor analysis (EEM-PARAFAC) and ultraviolet-visible (UV-Vis) spectroscopy. The results showed that DOM contents varied significantly with an average value of 5.8 mg L in different inflow rivers, and three fluorescence substances (including UVC humic-like, UVA humic-like and tyrosine-like components) were identified by EEM-PARAFAC. The distribution of the DOM components was distinctively different among sampling sites, and UVA humic-like component mainly dominated in Nansi Lake. Meanwhile, DOM components with higher aromaticity and molecular weight were found in the west side of lake. Fluorescence spectral indexes manifested that the source of DOM was mainly from allochthonous or terrestrial input. Moreover, significant correlations between water quality and DOM characteristics were observed in Nansi Lake. These findings would be beneficial to understand the biogeochemical role and impact of DOM in inflowing rivers in the water-quality monitoring and control of storage lakes.
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http://dx.doi.org/10.1016/j.chemosphere.2021.131624DOI Listing
July 2021

Oral delivery of natural active small molecules by polymeric nanoparticles for the treatment of inflammatory bowel diseases.

Adv Drug Deliv Rev 2021 Jul 24:113887. Epub 2021 Jul 24.

State Key Laboratory of Silkworm Genome Biology, College of Sericulture, Textile, and Biomass Sciences, Southwest University, Beibei, Chongqing 400715, China. Electronic address:

The incidence of inflammatory bowel disease (IBD) is rapidly rising throughout the world. Although tremendous efforts have been made, limited therapeutics are available for IBD management. Natural active small molecules (NASMs), which are a gift of nature to humanity, have been widely used in the prevention and alleviation of IBD; they have numerous advantageous features, including excellent biocompatibility, pharmacological activity, and mass production potential. Oral route is the most common and acceptable approach for drug administration, but the clinical application of NASMs in IBD treatment via oral route has been seriously restricted by their inherent limitations such as their high hydrophobicity, instability, and poor bioavailability. With the development of nanotechnology, polymeric nanoparticles (NPs) have provided a promising platform that can efficiently encapsulate versatile NASMs, overcome multiple drug delivery barriers, and orally deliver the loaded NASMs to targeted tissues or cells while enhancing their stability and bioavailability. Thus, NPs can enhance the preventive and therapeutic effects of NASMs against IBD. Herein, we summarize the recent knowledge about polymeric matrix-based carriers, targeting ligands for drug delivery, and NASMs. We also discuss the current challenges and future developmental directions.
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http://dx.doi.org/10.1016/j.addr.2021.113887DOI Listing
July 2021

Tobacco smoking and older people amid the COVID-19 pandemic: An elephant in the room.

Age Ageing 2021 Jul 26. Epub 2021 Jul 26.

School of Public Health, The University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1093/ageing/afab170DOI Listing
July 2021
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