Publications by authors named "J Ritchie Sharon Solomon"

1,140 Publications

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Going above and beyond: using nursing theories to explore volunteerism during the COVID-19 pandemic.

Authors:
Jennifer Solomon

Br J Nurs 2021 Nov;30(21):1238-1240

Chair and Director, Nursing and Allied Health Sciences, St George's University, Grenada.

Historically, nurses have volunteered to serve in wars and natural catastrophes. However, instead of a distant disaster, many nurses in the UK volunteered, working above and beyond, to assist their colleagues, local communities and health systems in the NHS during the peaks of the COVID-19 pandemic. Although the motivations and benefits to the community or self of volunteerism have been discussed in the literature, there is a paucity of literature and theoretical understanding from the field of nursing. Using a reflective and personal account of volunteering, this article aims to provide a better understanding of the concept of volunteerism in nursing. By exploring associated nursing theories from Jean Watson and Kristen Swanson, this article aims to illuminate and expand the knowledge base about nursing volunteerism. These nursing theories can frame the act of volunteerism and nursing and illustrate the interrelations of nursing theory and the practice of nursing volunteerism.
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http://dx.doi.org/10.12968/bjon.2021.30.21.1238DOI Listing
November 2021

Pediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2.

Indian J Pediatr 2021 Nov 24. Epub 2021 Nov 24.

Department of Pediatric Cardiology, Institute of Child Health and Hospital for Children, Chennai, Tamil Nadu, India.

Objectives: To know the clinical presentation and outcome of children with pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV- 2 (PIMS-TS) at a pediatric tertiary care center in Chennai.

Methods: Clinical and biochemical parameters of 65 children with PIMS-TS treated between July and October 2020 were studied. All children had their COVID RT-PCR and IgG COVID antibodies tests done.

Results: Mean age of the study group was 5.65 ± 3.68 y. Fever with red eyes, rash, vomiting, abdominal pain, and shock were common presenting features. Sixty percent of the study group had Kawasaki/incomplete Kawasaki features. Sixty-seven percent of the study group had coronary dilatation, 41% presented with shock, and 25% had left ventricular dysfunction. Coronary aneurysms were documented in 58% of the study group (z score more than 2.5). Respiratory presentation with pneumonia was seen in 10%. Four children presented with acute abdomen. Acute kidney injury, acute liver failure, hemolysis, pancytopenia, macrophage activation syndrome, encephalopathy, and multiorgan dysfunction syndrome (MODS) were other features. Forty-three percent required noninvasive oxygen support and 15.4% required mechanical ventilation. Intravenous immunoglobulin (73.8%) and methylprednisolone (49.8%) were used for therapy. Mortality in the study was 6%, which was due to MODS.

Conclusions: Acute febrile illness with mucocutaneous and gastrointestinal manifestations should have PIMS-TS as a possible differential diagnosis and needs evaluation with inflammatory markers and SARS-CoV-2 antibodies.
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http://dx.doi.org/10.1007/s12098-021-03954-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8611247PMC
November 2021

Volumetric Parameterization of the Placenta to a Flattened Template.

IEEE Trans Med Imaging 2021 Nov 16;PP. Epub 2021 Nov 16.

We present a volumetric mesh-based algorithm for parameterizing the placenta to a flattened template to enable effective visualization of local anatomy and function. MRI shows potential as a research tool as it provides signals directly related to placental function. However, due to the curved and highly variable in vivo shape of the placenta, interpreting and visualizing these images is difficult. We address interpretation challenges by mapping the placenta so that it resembles the familiar ex vivo shape. We formulate the parameterization as an optimization problem for mapping the placental shape represented by a volumetric mesh to a flattened template. We employ the symmetric Dirichlet energy to control local distortion throughout the volume. Local injectivity in the mapping is enforced by a constrained line search during the gradient descent optimization. We validate our method using a research study of 111 placental shapes extracted from BOLD MRI images. Our mapping achieves sub-voxel accuracy in matching the template while maintaining low distortion throughout the volume. We demonstrate how the resulting flattening of the placenta improves visualization of anatomy and function. Our code is freely available at https://github.com/ mabulnaga/placenta-flattening.
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http://dx.doi.org/10.1109/TMI.2021.3128743DOI Listing
November 2021

Adaptive sports for promoting physical activity in community-dwelling adults with stroke: A feasibility study.

J Bodyw Mov Ther 2021 Oct 14;28:341-347. Epub 2021 Jul 14.

Department of Physiotherapy, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, Karnataka, India; Centre for Comprehensive Stroke Rehabilitation and Research (CCSRR), Manipal Academy of Higher Education, Manipal, Karnataka, India. Electronic address:

Background: Despite proven health benefits of regular participation in physical activities (PA), adults with stroke fail to achieve recommended levels of PA. Sports being an enjoyable activity is more likely to encourage participation. Therefore, the objectives of the present study are i) to develop and test the feasibility of adaptive sports for promoting PA and Quality of Life (QoL) in community-dwelling adults with stroke, and ii) to explore the participants perception and experiences of playing adaptive sports.

Methods: Two focus groups were conducted among the eight experts and a person with stroke to develop adaptive sports. To test the feasibility of these adaptive sports, in a multi methods study eighteen community dwelling adults with stroke were recruited. Participants played adaptive sports twice a week for two months in a community center. Participants pre and post intervention PA levels and QoL were measured. Participants were also interviewed at the end of the program to explore their experiences of participation in adaptive sports.

Results: At the end of the program retention rate of the participants was 83.33% and there was a significant improvement in PA levels, while the improvement in QoL was not statistically significant. Participants expressed positive experience with the program. There were no adverse events during or after the participation. Health benefits, fitness, and fun were reported as facilitators, while lack of access to the sporting facility and lack of caregiver support were reported as barriers to participation.

Conclusion: Adaptive sports appear to be safe, feasible, and well accepted by the adults with stroke.
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http://dx.doi.org/10.1016/j.jbmt.2021.07.004DOI Listing
October 2021

Comparison of RNA-Based Next-Generation Sequencing Assays for the Detection of NTRK Gene Fusions.

J Mol Diagn 2021 11;23(11):1443-1451

Department of Laboratory Medicine and Pathology, Weill Cornell Medicine, New York, New York. Electronic address:

Recently, the US Food and Drug Administration approved several targeted therapies directed against oncogenic fusions. One of the most effective such targeted therapies is Vitrakvi (larotrectinib), highly specific oral tropomyosin receptor kinase inhibitor indicated for the treatment of patients with any solid tumor harboring a fusion involving one of the neurotrophic receptor tyrosine kinase (NTRK) genes. Although several diagnostic approaches can be used to detect these NTRK fusions, RNA-based next-generation sequencing remains one of the most sensitive methods, as it can directly detect the transcribed end product of gene fusion at the mRNA level. In this study, performance characteristics of three RNA-based next-generation sequencing assays with distinct mechanisms and chemistries were investigated: anchored multiplex PCR, amplicon-based multiplex PCR, and hybrid capture-based enrichment method. Analytical sensitivity analysis shows that the amplicon-based multiplex PCR method has the lowest limit of detection. However, both hybrid-capture and anchored multiplex PCR methods can detect NTRK fusions with uncommon or novel fusion partners, which is challenging for the amplicon-based multiplex method. As for clinical sensitivity, all three methods were highly concordant in detecting NTRK fusions in patient samples. Additionally, they all presented equivalent high-level performance in specificity, suggesting that all three platforms can detect NTRK fusions in clinical samples with similar performance characteristics.
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http://dx.doi.org/10.1016/j.jmoldx.2021.07.027DOI Listing
November 2021
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