Publications by authors named "J Reyes"

1,439 Publications

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Hakuna mycotic aneurysm, does not always mean "no worries".

Ann Med Surg (Lond) 2021 Sep 4;69:102798. Epub 2021 Sep 4.

Department of Nephrology, Icahn School of Medicine at Mount Sinai Hospital (Elmhurst Hospital Center) NY, USA.

, an easily missed and commonly disregarded Viridians strep species, is usually written off as a culture contaminant, but has been implicated as a rare cause of bacterial endocarditis with serious complications. It is a normal commensal microorganism of the mouth and gut, is usually harmless and even demonstrates anti-inflammatory properties. However, the literature about the complications of a bacteremia remains unclear. This case highlights a patient with mycotic aneurysms due to infective endocarditis in the setting of bacteremia.
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http://dx.doi.org/10.1016/j.amsu.2021.102798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8424443PMC
September 2021

Chasing the dragon and stumbling upon an octopus: A case of heroin-induced leukoencephalopathy and reverse takotsubo cardiomyopathy.

Ann Med Surg (Lond) 2021 Sep 4;69:102797. Epub 2021 Sep 4.

Department of Internal Medicine, Icahn School of Medicine at Mount Sinai - Elmhurst Hospital Center, NY, USA.

The practice of heating heroin and inhaling its vapors, commonly referred to as "chasing the dragon" has been around for decades, but only gained popularity in the United States in the 1990s. Since then, there have been many documented cases of heroin-induced leukoencephalopathy (HIL) and takotsubo cardiomyopathy (TTC). This case highlights a patient with a history of heroin inhalation who presented with multiple neurological features, including bilateral upper and lower extremity weakness, blurry vision and slurred speech. Symptoms progressively worsened over the course of multiple weeks and brain imaging was consistent with toxic leukoencephalopathy secondary to heroin inhalation. Medical course was complicated by a rare associated feature of HIL: reverse Takotsubo cardiomyopathy (rTTC). Transesophageal echocardiogram demonstrated a classic basal hypokinesis and ballooning characteristic of rTTC. The patient's symptoms were treated as currently there is no guideline directed therapy for HIL or rTTC. This case demonstrated a rare and significant complication of heroin inhalation: HIL and rTTC and described potential therapies currently being studied.
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http://dx.doi.org/10.1016/j.amsu.2021.102797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8427217PMC
September 2021

Modeling IKZF1 lesions in B-ALL reveals distinct chemosensitivity patterns and potential therapeutic vulnerabilities.

Blood Adv 2021 Sep 7. Epub 2021 Sep 7.

Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, United States.

IKAROS family zinc finger 1 (IKZF1) alterations represent a diverse group of genetic lesions that are associated with an increased risk of relapse in B-lymphoblastic leukemia (B-ALL). Due to the heterogeneity of concomitant lesions, it remains unclear how IKZF1 abnormalities directly affect cell function and therapy resistance and whether their consideration as a prognostic indicator is valuable in improving outcome. We used CRISPR/Cas9 to engineer multiple panels of isogeneic lymphoid leukemia cell lines with a spectrum of IKZF1 lesions in order to measure changes in chemosensitivity, gene expression, cell cycle, and in vivo engraftment that can be linked to loss of IKAROS protein. IKZF1 knockout and heterozygous null cells displayed relative resistance to a number of common therapies for B-ALL including dexamethasone, asparaginase, and daunorubicin. Transcription profiling revealed a stem/myeloid cell-like phenotype and JAK/STAT upregulation after IKAROS loss. We also used a CRISPR homology-directed repair (HDR) strategy to knock-in the dominant-negative IK6 isoform into the endogenous locus and observed a similar drug resistance profile with the exception of retained dexamethasone sensitivity. Interestingly, IKZF1 knockout and IK6 knock-in cells both have significantly increased sensitivity to cytarabine, likely owing to marked downregulation of SAMHD1 after IKZF1 knockout. Both types of IKZF1 lesions decreased survival time of xenograft mice, with higher numbers of circulating blasts and increased organ infiltration. Given these findings, exact specification of IKZF1 status in patients may be a beneficial addition to risk stratification and could inform therapy.
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http://dx.doi.org/10.1182/bloodadvances.2020002408DOI Listing
September 2021

Paediatric dilated cardiomyopathy with and without endocardial fibroelastosis - a pathological analysis of 89 explants.

Cardiol Young 2021 Sep 6:1-7. Epub 2021 Sep 6.

Department of Paediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Canada.

Heart failure due to dilated cardiomyopathy is a major indication for paediatric cardiac transplantation. Endocardial fibroelastosis is a recognised pathological finding of unknown prognostic significance in paediatric dilated cardiomyopathy. To evaluate the nature of the association between left ventricular endocardial fibroelastosis and paediatric dilated cardiomyopathy, we reviewed surgical pathology reports of dilated cardiomyopathy explants (1986-2016) in order to characterise the pathological findings and to compare and contrast their frequency among four age groups: less than 1 year; 1-5 years; 6-10 years; and greater than 11 years. The 89 explants (47 males and 42 females) were all characterised by increased weight and left ventricular chamber dilatation without increased wall thickness. Ninety-five per cent of the specimens in the two youngest subsets had left ventricular endocardial fibroelastosis. Compared to the oldest age group, recipients aged 1-5 years had a 6-fold increase and those younger than 1 year a 19-fold increase in the odds of observing left ventricular endocardial fibroelastosis. Explants with and without endocardial fibroelastosis were otherwise phenotypically similar. In paediatric dilated cardiomyopathy endocardial fibroelastosis is a very common pathological finding, especially in infants and young children. We propose that the descriptive, clinico-pathological designation "Dilated Cardiomyopathy with Endocardial Fibroelastosis" should be adopted to facilitate future investigation into the potential prognostic/therapeutic significance of left ventricular endocardial fibroelastosis.
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http://dx.doi.org/10.1017/S1047951121003590DOI Listing
September 2021

Serial Assessment of Tricuspid Annular Plane Systolic Excursion is Associated with Death or Lung Transplant in Children with Pulmonary Arterial Hypertension.

J Am Soc Echocardiogr 2021 Aug 27. Epub 2021 Aug 27.

The Labatt Family Heart Centre, Hospital for Sick Children, 555 University Avenue, Toronto M5G 1X8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.echo.2021.08.015DOI Listing
August 2021
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