J-Paul Chapple

J-Paul Chapple

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J-Paul Chapple

J-Paul Chapple

Publications by authors named "J-Paul Chapple"

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Sacsin, mutated in the ataxia ARSACS, regulates intermediate filament assembly and dynamics.

FASEB J 2019 02 17;33(2):2982-2994. Epub 2018 Oct 17.

Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Québec, Canada.

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https://www.fasebj.org/doi/10.1096/fj.201801556R
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http://dx.doi.org/10.1096/fj.201801556RDOI Listing
February 2019

Topography of calcium phosphate ceramics regulates primary cilia length and TGF receptor recruitment associated with osteogenesis.

Acta Biomater 2017 07 27;57:487-497. Epub 2017 Apr 27.

Complex Tissue Regeneration Department, MERLN Institute for Technology Inspired Regenerative Medicine, Maastricht University, Universiteitsingel 40, 6229 ER, The Netherlands; Xpand Biotechnology BV, Bilthoven, The Netherlands; National Engineering Research Center for Biomaterials, Sichuan University, 610064 Chengdu, China. Electronic address:

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http://dx.doi.org/10.1016/j.actbio.2017.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489417PMC
July 2017

Primary cilia: a link between hormone signalling and endocrine-related cancers?

Biochem Soc Trans 2016 10;44(5):1227-1234

Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, U.K.

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http://dx.doi.org/10.1042/BST20160149DOI Listing
October 2016

A reduction in Drp1-mediated fission compromises mitochondrial health in autosomal recessive spastic ataxia of Charlevoix Saguenay.

Hum Mol Genet 2016 08 10;25(15):3232-3244. Epub 2016 Jun 10.

William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London EC1M 6BQ, United Kingdom

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http://dx.doi.org/10.1093/hmg/ddw173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5179924PMC
August 2016

Hedgehog signalling does not stimulate cartilage catabolism and is inhibited by Interleukin-1β.

Arthritis Res Ther 2015 Dec 24;17:373. Epub 2015 Dec 24.

Institute of Bioengineering and School of Engineering and Material Sciences, Queen Mary University of London, Mile End Road, London, E1 4NS, UK.

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http://dx.doi.org/10.1186/s13075-015-0891-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718026PMC
December 2015

Molecular and functional studies of retinal degeneration as a clinical presentation of SACS-related disorder.

Eur J Paediatr Neurol 2015 Jul 3;19(4):472-6. Epub 2015 Mar 3.

Metabolic-Neurogenetic Clinic, Wolfson Medical Center, Holon, Israel; Toldot Genetics Ltd., Tel Aviv, Israel; Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.ejpn.2015.02.005DOI Listing
July 2015

Adipogenic Differentiation of hMSCs is Mediated by Recruitment of IGF-1r Onto the Primary Cilium Associated With Cilia Elongation.

Stem Cells 2015 Jun;33(6):1952-61

Institute of Bioengineering and School of Engineering and Materials Science, Queen Mary University of London, London, United Kingdom.

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http://dx.doi.org/10.1002/stem.1975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737234PMC
June 2015

The role of HSP70 and its co-chaperones in protein misfolding, aggregation and disease.

Subcell Biochem 2015 ;78:243-73

Molecular Endocrinology Centre, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charter House Square, EC1M 6BQ, London, UK,

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http://link.springer.com/content/pdf/10.1007%2F978-3-319-117
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http://link.springer.com/10.1007/978-3-319-11731-7_12
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http://dx.doi.org/10.1007/978-3-319-11731-7_12DOI Listing
April 2015

Interleukin-1β sequesters hypoxia inducible factor 2α to the primary cilium.

Cilia 2013 Dec 13;2(1):17. Epub 2013 Dec 13.

Institute of Bioengineering and School of Engineering and Materials Science, Queen Mary University of London, Mile End, London, E1 4NS, UK.

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http://dx.doi.org/10.1186/2046-2530-2-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886195PMC
December 2013

Familial glucocorticoid deficiency: New genes and mechanisms.

Mol Cell Endocrinol 2013 May 29;371(1-2):195-200. Epub 2012 Dec 29.

Queen Mary University of London, Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, London, UK.

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http://dx.doi.org/10.1016/j.mce.2012.12.010DOI Listing
May 2013

Heat shock induces rapid resorption of primary cilia.

J Cell Sci 2012 Sep 20;125(Pt 18):4297-305. Epub 2012 Jun 20.

Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.

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http://jcs.biologists.org/content/joces/125/18/4297.full.pdf
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http://jcs.biologists.org/cgi/doi/10.1242/jcs.100545
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http://dx.doi.org/10.1242/jcs.100545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516438PMC
September 2012

BiP prevents rod opsin aggregation.

Mol Biol Cell 2012 Sep 1;23(18):3522-31. Epub 2012 Aug 1.

UCL Institute of Ophthalmology, London, United Kingdom.

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http://dx.doi.org/10.1091/mbc.E12-02-0168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442401PMC
September 2012

Somatostatin analogs modulate AIP in somatotroph adenomas: the role of the ZAC1 pathway.

J Clin Endocrinol Metab 2012 Aug 1;97(8):E1411-20. Epub 2012 Jun 1.

Centre for Endocrinology, Barts and the London School of Medicine, Queen Mary University of London, London EC1M 6BQ, United Kingdom.

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http://dx.doi.org/10.1210/jc.2012-1111DOI Listing
August 2012

Mutations in NNT encoding nicotinamide nucleotide transhydrogenase cause familial glucocorticoid deficiency.

Nat Genet 2012 May 27;44(7):740-2. Epub 2012 May 27.

Centre for Endocrinology, Queen Mary University of London, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, London, UK.

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http://dx.doi.org/10.1038/ng.2299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386896PMC
May 2012

The cytosolic chaperone Hsc70 promotes traffic to the cell surface of intracellular retained melanocortin-4 receptor mutants.

Mol Endocrinol 2011 Sep 30;25(9):1650-60. Epub 2011 Jun 30.

Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.

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http://dx.doi.org/10.1210/me.2011-1020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417233PMC
September 2011

The binding of the molecular chaperone Hsc70 to the prion protein PrP is modulated by pH and copper.

Int J Biochem Cell Biol 2010 Jul 29;42(7):1226-32. Epub 2010 Apr 29.

UCL Institute of Ophthalmology, London EC1 V 9EL, UK.

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http://dx.doi.org/10.1016/j.biocel.2010.04.013DOI Listing
July 2010

Clinical, genetic and molecular characterization of patients with familial isolated pituitary adenomas (FIPA).

Trends Endocrinol Metab 2010 Jul 1;21(7):419-27. Epub 2010 Jun 1.

Department of Endocrinology, Barts and the London School of Medicine, Queen Mary University of London, London EC1M 6BQ, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S104327601000045
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http://dx.doi.org/10.1016/j.tem.2010.02.007DOI Listing
July 2010

Can faulty antennae increase adiposity? The link between cilia proteins and obesity.

J Endocrinol 2009 Dec 21;203(3):327-36. Epub 2009 May 21.

Barts and the London School of Medicine and Dentistry, William Harvey Research Institute, Centre for Endocrinology, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.

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https://joe.bioscientifica.com/view/journals/joe/203/3/327.x
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http://dx.doi.org/10.1677/JOE-09-0116DOI Listing
December 2009

Deficiency of ferritin heavy-chain nuclear import in triple a syndrome implies nuclear oxidative damage as the primary disease mechanism.

Mol Endocrinol 2009 Dec 23;23(12):2086-94. Epub 2009 Oct 23.

Centre for Endocrinology, William Harvey Research Institute, Queen Mary University of London, United Kingdom.

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http://dx.doi.org/10.1210/me.2009-0056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419132PMC
December 2009

The ataxia protein sacsin is a functional co-chaperone that protects against polyglutamine-expanded ataxin-1.

Hum Mol Genet 2009 May 10;18(9):1556-65. Epub 2009 Feb 10.

William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, UK.

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http://dx.doi.org/10.1093/hmg/ddp067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667285PMC
May 2009

MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family.

Proc Natl Acad Sci U S A 2009 Apr 27;106(15):6146-51. Epub 2009 Mar 27.

Queen Mary University of London, Centre for Endocrinology, St. Bartholomew's and Royal London School of Medicine and Dentistry, London EC1M 6BQ, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0809918106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661846PMC
April 2009

Distinct melanocortin 2 receptor accessory protein domains are required for melanocortin 2 receptor interaction and promotion of receptor trafficking.

Endocrinology 2009 Feb 25;150(2):720-6. Epub 2008 Sep 25.

Centre for Endocrinology, William Harvey Research Institute, Barts and the London, London, UK.

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http://dx.doi.org/10.1210/en.2008-0941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6602883PMC
February 2009

From hatching to dispatching: the multiple cellular roles of the Hsp70 molecular chaperone machinery.

J Mol Endocrinol 2009 Jan 13;42(1):1-9. Epub 2008 Oct 13.

Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, London EC1M 6BQ, UK.

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http://dx.doi.org/10.1677/JME-08-0116DOI Listing
January 2009

Focal distortion of the nuclear envelope by huntingtin aggregates revealed by lamin immunostaining.

Neurosci Lett 2008 Dec 1;447(2-3):172-4. Epub 2008 Oct 1.

MRC Centre for Neurodegeneration Research, King's College London, Department of Clinical Neuroscience, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, United Kingdom.

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http://linkinghub.elsevier.com/retrieve/pii/S030439400801339
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http://dx.doi.org/10.1016/j.neulet.2008.09.075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2593798PMC
December 2008

The melanocortin 2 receptor accessory protein exists as a homodimer and is essential for the function of the melanocortin 2 receptor in the mouse y1 cell line.

Endocrinology 2008 Apr 27;149(4):1935-41. Epub 2007 Dec 27.

Centre for Endocrinology, William Harvey Research Institute, Barts and the London, Queen Mary University of London, West Smithfield, London, United Kingdom.

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http://dx.doi.org/10.1210/en.2007-1463DOI Listing
April 2008

Expression, localization and tau exon 10 splicing activity of the brain RNA-binding protein TNRC4.

Hum Mol Genet 2007 Nov 28;16(22):2760-9. Epub 2007 Aug 28.

MRC Centre for Neurodegeneration Research, Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF, UK.

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http://hmg.oxfordjournals.org/content/16/22/2760.full.pdf
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http://www.hmg.oxfordjournals.org/cgi/doi/10.1093/hmg/ddm233
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http://dx.doi.org/10.1093/hmg/ddm233DOI Listing
November 2007

The Notch-1 intracellular domain is found in sub-nuclear bodies in SH-SY5Y neuroblastomas and in primary cortical neurons.

Neurosci Lett 2007 Mar 27;415(2):135-9. Epub 2007 Jan 27.

King's College London, MRC Centre for Neurodegenerative Research, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK.

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http://dx.doi.org/10.1016/j.neulet.2007.01.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1885995PMC
March 2007

TAp73 isoforms antagonize Notch signalling in SH-SY5Y neuroblastomas and in primary neurones.

J Neurochem 2006 Nov;99(3):989-99

King's College London, MRC Centre for Neurodegenerative Research, Institute of Psychiatry, London, UK.

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http://doi.wiley.com/10.1111/j.1471-4159.2006.04142.x
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http://dx.doi.org/10.1111/j.1471-4159.2006.04142.xDOI Listing
November 2006

Assay and functional analysis of the ARL3 effector RP2 involved in X-linked retinitis pigmentosa.

Methods Enzymol 2005 ;404:468-80

Institute of Ophthalmology, University College London, United Kingdom.

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http://dx.doi.org/10.1016/S0076-6879(05)04041-3DOI Listing
March 2006

Isolation and characterization of murine Cds (CDP-diacylglycerol synthase) 1 and 2.

Gene 2005 Aug;356:19-31

Institute of Ophthalmology, University College London, 11-43 Bath Street, London, EC1V 9EL, UK.

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http://dx.doi.org/10.1016/j.gene.2005.04.037DOI Listing
August 2005

HSJ1 is a neuronal shuttling factor for the sorting of chaperone clients to the proteasome.

Curr Biol 2005 Jun;15(11):1058-64

Institute for Cell Biology, Rheinische Friedrich-Wilhelms University Bonn, Ulrich-Haberland-Strasse 61a, D-53121 Bonn, Germany.

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http://dx.doi.org/10.1016/j.cub.2005.04.058DOI Listing
June 2005

Mechanisms of cell death in rhodopsin retinitis pigmentosa: implications for therapy.

Trends Mol Med 2005 Apr;11(4):177-85

Division of Pathology, Institute of Ophthalmology, University College London, 11-43 Bath Street, London, EC1V 9EL, UK.

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http://dx.doi.org/10.1016/j.molmed.2005.02.007DOI Listing
April 2005

Mutations in MRAP, encoding a new interacting partner of the ACTH receptor, cause familial glucocorticoid deficiency type 2.

Nat Genet 2005 Feb 16;37(2):166-70. Epub 2005 Jan 16.

Department of Endocrinology, William Harvey Research Institute, Barts & the London, Queen Mary, University of London, West Smithfield, London EC1A 7BE, UK.

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http://dx.doi.org/10.1038/ng1501DOI Listing
February 2005

Nuclear translocation of the Hsp70/Hsp90 organizing protein mSTI1 is regulated by cell cycle kinases.

J Cell Sci 2004 Feb;117(Pt 5):701-10

Department of Biochemistry, Microbiology and Biotechnology, Rhodes University, Grahamstown 6140, South Africa.

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http://jcs.biologists.org/cgi/doi/10.1242/jcs.00905
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http://dx.doi.org/10.1242/jcs.00905DOI Listing
February 2004

The chaperone environment at the cytoplasmic face of the endoplasmic reticulum can modulate rhodopsin processing and inclusion formation.

J Biol Chem 2003 May;278(21):19087-94

Division of Pathology, Institute of Ophthalmology, University College of London, London EC1V 9EL, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M212349200DOI Listing
May 2003

Delineation of the plasma membrane targeting domain of the X-linked retinitis pigmentosa protein RP2.

Invest Ophthalmol Vis Sci 2002 Jun;43(6):2015-20

Department of Pathology, Institute of Ophthalmology, University College London, London, United Kingdom.

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June 2002

The Leber congenital amaurosis gene product AIPL1 is localized exclusively in rod photoreceptors of the adult human retina.

Hum Mol Genet 2002 Apr;11(7):823-31

Department of Pathology, Institute of Ophthalmology, University College London, Bath Street, London EC1V 9EL, UK.

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http://dx.doi.org/10.1093/hmg/11.7.823DOI Listing
April 2002