Publications by authors named "J P Prytherch"

9 Publications

Shipborne eddy covariance observations of methane fluxes constrain Arctic sea emissions.

Sci Adv 2020 Jan 29;6(5):eaay7934. Epub 2020 Jan 29.

Department of Geological Sciences, Stockholm University, 106 91 Stockholm, Sweden.

We demonstrate direct eddy covariance (EC) observations of methane (CH) fluxes between the sea and atmosphere from an icebreaker in the eastern Arctic Ocean. EC-derived CH emissions averaged 4.58, 1.74, and 0.14 mg m day in the Laptev, East Siberian, and Chukchi seas, respectively, corresponding to annual sea-wide fluxes of 0.83, 0.62, and 0.03 Tg year. These EC results answer concerns that previous diffusive emission estimates, which excluded bubbling, may underestimate total emissions. We assert that bubbling dominates sea-air CH fluxes in only small constrained areas: A ~100-m area of the East Siberian Sea showed sea-air CH fluxes exceeding 600 mg m day; in a similarly sized area of the Laptev Sea, peak CH fluxes were ~170 mg m day. Calculating additional emissions below the noise level of our EC system suggests total ESAS CH emissions of 3.02 Tg year, closely matching an earlier diffusive emission estimate of 2.9 Tg year.
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http://dx.doi.org/10.1126/sciadv.aay7934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989137PMC
January 2020

General reproduction, perinatal-postnatal, and teratology studies of nitrofurantoin macrocrystals in rats and rabbits.

J Toxicol Environ Health 1984 ;13(4-6):811-23

Urinary tract infections in pregnant women are common and require prompt, effective treatment. Currently, no antibacterial agents have received regulatory approbation for use without restriction during pregnancy. The choice of a drug for use in pregnant women requires careful examination of its possible maternal and fetal toxicity as well as its teratogenic potential. We conducted studies to determine the effects of nitrofurantoin macrocrystals (Macrodantin, Norwich Eaton Pharmaceuticals, Inc.), a synthetic antibacterial, on reproductive capability, fetal development, and neonatal survival in the rat and the rabbit. Doses of 10.0, 20.0, and 30.0 mg/kg.d, approximately 2, 4, and 6 times the daily human therapeutic dose, were administered orally in a methylcellulose suspension to rats and rabbits in general reproduction, perinatal-postnatal, and teratology studies. Safety was assessed by evaluating reproductive capability, fertility, gestation period, fetal and neonatal death, litter size and viability, birth weight and postnatal growth, and malformations. Under the conditions of these studies, treatment with nitrofurantoin macrocrystals in rats and rabbits before or during pregnancy or during lactation caused no adverse effects in the mother, fetus, or neonate. These findings support the premise that nitrofurantoin macrocrystals constitute a safe treatment for urinary tract infection during pregnancy.
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http://dx.doi.org/10.1080/15287398409530542DOI Listing
November 1984

THE INHIBITION OF NICOTINE-INDUCED CONVULSIONS IN THE RAT.

Arch Int Pharmacodyn Ther 1963 Nov;146:238-44

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November 1963
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