Publications by authors named "Juan Pedro Martinez-Barbera"

69Publications

Galactose-modified duocarmycin prodrugs as senolytics.

Aging Cell 2020 04 16;19(4):e13133. Epub 2020 Mar 16.

MRC London Institute of Medical Sciences (LMS), London, UK.

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http://dx.doi.org/10.1111/acel.13133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189988PMC
April 2020

Biological Behaviour of Craniopharyngiomas.

Neuroendocrinology 2020 4;110(9-10):797-804. Epub 2020 Mar 4.

Centre for Craniofacial and Regenerative Biology, Faculty of Dental, Oral, and Craniofacial Sciences, King's College London, London, United Kingdom.

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http://dx.doi.org/10.1159/000506904DOI Listing
March 2020

Genetic Deletion of Hesx1 Promotes Exit from the Pluripotent State and Impairs Developmental Diapause.

Stem Cell Reports 2019 12 21;13(6):970-979. Epub 2019 Nov 21.

Developmental Biology and Cancer Programme, Birth Defects Research Centre, Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2019.10.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915801PMC
December 2019

Craniopharyngioma.

Nat Rev Dis Primers 2019 11 7;5(1):75. Epub 2019 Nov 7.

Service de Neurochirurgie, Hôpital Necker-Enfants Malades, Sorbonne Paris Cité, Paris, France.

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http://dx.doi.org/10.1038/s41572-019-0125-9DOI Listing
November 2019

Author Correction: P53 and mTOR signalling determine fitness selection through cell competition during early mouse embryonic development.

Nat Commun 2018 08 2;9(1):3123. Epub 2018 Aug 2.

British Heart Foundation Centre for Research Excellence, National Heart and Lung Institute, Imperial Centre for Translational and Experimental Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK.

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http://dx.doi.org/10.1038/s41467-018-05718-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072750PMC
August 2018

Senescence drives non-cell autonomous tumorigenesis in the pituitary gland.

Mol Cell Oncol 2018 13;5(3):e1435180. Epub 2018 Feb 13.

Developmental Biology and Cancer Research Programme, UCL Great Ormond Street, Institute of Child Health, Guilford Street, London, UK.

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http://dx.doi.org/10.1080/23723556.2018.1435180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964449PMC
February 2018

P53 and mTOR signalling determine fitness selection through cell competition during early mouse embryonic development.

Nat Commun 2018 05 2;9(1):1763. Epub 2018 May 2.

British Heart Foundation Centre for Research Excellence, National Heart and Lung Institute, Imperial Centre for Translational and Experimental Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK.

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http://dx.doi.org/10.1038/s41467-018-04167-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932021PMC
May 2018

Paracrine roles of cellular senescence in promoting tumourigenesis.

Br J Cancer 2018 05 19;118(10):1283-1288. Epub 2018 Apr 19.

Developmental Biology and Cancer Research Programme, UCL Great Ormond Street Institute of Child Health, Guilford Street, London, WC1N 1EH, UK.

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http://dx.doi.org/10.1038/s41416-018-0066-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959857PMC
May 2018

Molecular Analyses Reveal Inflammatory Mediators in the Solid Component and Cyst Fluid of Human Adamantinomatous Craniopharyngioma.

J Neuropathol Exp Neurol 2017 Sep;76(9):779-788

Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado; Developmental Biology and Cancer Programme, Great Ormond Street UCL Institute of Child Health, London, UK; Department of Neurological Surgery, Columbia University Medical Center, New York, New York; Division of Pediatric Neurosurgery, Department of Neurosurgery, Miami Children's Hospital, University of Miami/Miller School of Medicine, Miami, Florida; Department of Neurosurgery, Stanford University Medical Center, Palo Alto, California; Department of Neurological Surgery, Weill Medical College of Cornell University and Memorial Sloan-Kettering Cancer Center, New York, New York; Department of Neurosurgery, Children's Hospital Alabama, Birmingham, Alabama; Department of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, Maryland; Department of Pathology; Department of Neurosurgery; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado; Department of Histopathology, Great Ormond Street Hospital, NHS Trust, London, UK; Morgan Adams Foundation Pediatric Brain Tumor Research Program; Pediatric Neurosurgery, Children's Hospital Colorado; and Adult and Child Center for Health Outcomes Research, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

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http://dx.doi.org/10.1093/jnen/nlx061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005018PMC
September 2017

Stem/progenitor cells in pituitary organ homeostasis and tumourigenesis.

J Endocrinol 2018 Jan 30;236(1):R1-R13. Epub 2017 Aug 30.

Developmental Biology and Cancer Research ProgrammeBirth Defects Research Centre, UCL Great Ormond Street Institute of Child Health, London, UK

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http://dx.doi.org/10.1530/JOE-17-0258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5744558PMC
January 2018

Hypothalamic sonic hedgehog is required for cell specification and proliferation of LHX3/LHX4 pituitary embryonic precursors.

Development 2017 09 14;144(18):3289-3302. Epub 2017 Aug 14.

Developmental Biology and Cancer Programme, Birth Defects Research Centre, Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK

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http://dx.doi.org/10.1242/dev.153387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612255PMC
September 2017

Genetically engineered mouse models of craniopharyngioma: an opportunity for therapy development and understanding of tumor biology.

Brain Pathol 2017 May;27(3):364-369

Developmental Biology and Cancer, UCL Great Ormond Street Institute of Child Health, University College London, Guilford Street, London, WC1N 1EH, UK.

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http://dx.doi.org/10.1111/bpa.12501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705945PMC
May 2017

New outlook on the diagnosis, treatment and follow-up of childhood-onset craniopharyngioma.

Nat Rev Endocrinol 2017 05 3;13(5):299-312. Epub 2017 Feb 3.

Developmental Biology and Cancer Programme, Birth Defects Research Centre, University College London (UCL) Great Ormond Street Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK.

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http://dx.doi.org/10.1038/nrendo.2016.217DOI Listing
May 2017

Molecular pathology of adamantinomatous craniopharyngioma: review and opportunities for practice.

Neurosurg Focus 2016 Dec;41(6):E4

Developmental Biology and Cancer Programme, Birth Defects Research Centre, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.

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http://dx.doi.org/10.3171/2016.8.FOCUS16307DOI Listing
December 2016

Stem cells and their role in pituitary tumorigenesis.

Mol Cell Endocrinol 2017 04 6;445:27-34. Epub 2016 Oct 6.

Developmental Biology and Cancer Program, Birth Defects Research Centre, Institute of Child Health, University College London, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2016.10.005DOI Listing
April 2017

Concise Review: Paracrine Role of Stem Cells in Pituitary Tumors: A Focus on Adamantinomatous Craniopharyngioma.

Stem Cells 2016 Feb 13;34(2):268-76. Epub 2016 Jan 13.

Craniofacial Development and Stem Cell Biology, King's College London, Guy's Campus, London, United Kingdom.

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http://dx.doi.org/10.1002/stem.2267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864894PMC
February 2016

60 YEARS OF NEUROENDOCRINOLOGY: Biology of human craniopharyngioma: lessons from mouse models.

J Endocrinol 2015 Aug 29;226(2):T161-72. Epub 2015 Apr 29.

Developmental Biology and Cancer ProgrammeInstitute of Child Health, Birth Defects Research Centre, University College London, 30 Guilford Street, WC1N 1EH London, UK

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http://dx.doi.org/10.1530/JOE-15-0145DOI Listing
August 2015

Molecular and cellular pathogenesis of adamantinomatous craniopharyngioma.

Neuropathol Appl Neurobiol 2015 Oct 23;41(6):721-32. Epub 2015 Apr 23.

Birth Defects Research Centre, Developmental Biology and Cancer Programme, Institute of Child Health, University College London, London, UK.

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http://dx.doi.org/10.1111/nan.12226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949713PMC
October 2015

Adamantinomatous craniopharyngioma: pathology, molecular genetics and mouse models.

J Pediatr Endocrinol Metab 2015 Jan;28(1-2):7-17

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http://dx.doi.org/10.1515/jpem-2014-0442DOI Listing
January 2015

HOIP deficiency causes embryonic lethality by aberrant TNFR1-mediated endothelial cell death.

Cell Rep 2014 Oct 2;9(1):153-165. Epub 2014 Oct 2.

Centre for Cell Death, Cancer, and Inflammation (CCCI), UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6DD, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.08.066DOI Listing
October 2014

Dynamic haematopoietic cell contribution to the developing and adult epicardium.

Nat Commun 2014 Jun 6;5:4054. Epub 2014 Jun 6.

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, UK.

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http://dx.doi.org/10.1038/ncomms5054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059938PMC
June 2014

Developmental mechanisms directing early anterior forebrain specification in vertebrates.

Cell Mol Life Sci 2013 Oct 9;70(20):3739-52. Epub 2013 Feb 9.

Birth Defects Research Centre, UCL Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK.

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http://dx.doi.org/10.1007/s00018-013-1269-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781296PMC
October 2013

Variations in PROKR2, but not PROK2, are associated with hypopituitarism and septo-optic dysplasia.

J Clin Endocrinol Metab 2013 Mar 5;98(3):E547-57. Epub 2013 Feb 5.

Developmental Endocrinology Research Group, Clinical and Molecular Genetics Unit, University College London (UCL)-Institute of Child Health, London WC1N 1EH, United Kingdom.

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http://dx.doi.org/10.1210/jc.2012-3067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612801PMC
March 2013

PROKR2 variants in multiple hypopituitarism with pituitary stalk interruption.

J Clin Endocrinol Metab 2012 Jun 30;97(6):E1068-73. Epub 2012 Mar 30.

Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille (CRN2M), Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7286, Aix-Marseille University, France.

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http://dx.doi.org/10.1210/jc.2011-3056DOI Listing
June 2012

The future of genomic endocrinology.

Front Endocrinol (Lausanne) 2011 25;2:11. Epub 2011 May 25.

Institute of Child Health, University College London London, UK.

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http://dx.doi.org/10.3389/fendo.2011.00011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355890PMC
August 2012

Absence of SIX3 mutations in patients with congenital hypopituitarism.

Am J Med Genet A 2009 Dec;149A(12):2874-6

Neural Development Unit, Institute of Child Health, University College London, 30 Guilford Street, WC1N 1EH London, UK.

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http://dx.doi.org/10.1002/ajmg.a.33103DOI Listing
December 2009

NOA36/ZNF330 is a conserved cystein-rich protein with proapoptotic activity in human cells.

Biochim Biophys Acta 2009 Dec 4;1793(12):1876-85. Epub 2009 Nov 4.

Departamento de Biomedicina, Biotecnología y Salud Pública, Universidad de Cádiz, 1150 Puerto Real, Spain.

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http://dx.doi.org/10.1016/j.bbamcr.2009.10.011DOI Listing
December 2009

Genetic ablation of retinal pigment epithelial cells reveals the adaptive response of the epithelium and impact on photoreceptors.

Proc Natl Acad Sci U S A 2009 Nov 22;106(44):18728-33. Epub 2009 Oct 22.

MacTel Laboratory Research Group, Department of Cell Biology, University College London Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0902593106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765920PMC
November 2009

The cell and molecular basis of mechanical, cold, and inflammatory pain.

Science 2008 Aug;321(5889):702-5

Molecular Nociception Group, University College London (UCL), Gower Street, London, WC1E 6BT, UK.

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http://dx.doi.org/10.1126/science.1156916DOI Listing
August 2008

DNMT1 interacts with the developmental transcriptional repressor HESX1.

Biochim Biophys Acta 2008 Jan 7;1783(1):131-43. Epub 2007 Sep 7.

Neural Development Unit, Institute of Child Health, University College London, 30 Guilford Street, WC1N 1EH, London, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S016748890700215
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http://dx.doi.org/10.1016/j.bbamcr.2007.08.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2233781PMC
January 2008

Adrenal development is initiated by Cited2 and Wt1 through modulation of Sf-1 dosage.

Development 2007 Jun;134(12):2349-58

Section of Gene Function and Regulation, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK.

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http://dx.doi.org/10.1242/dev.004390DOI Listing
June 2007

Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development.

Dev Biol 2006 Feb 20;290(1):44-56. Epub 2005 Dec 20.

Cell and Developmental Biology Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA.

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http://dx.doi.org/10.1016/j.ydbio.2005.11.006DOI Listing
February 2006

In vivo genetic ablation by Cre-mediated expression of diphtheria toxin fragment A.

Genesis 2005 Nov;43(3):129-35

Neural Development Unit, Institute of Child Health, University College London, United Kingdom.

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http://dx.doi.org/10.1002/gene.20162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2233880PMC
November 2005

Over- and underdosage of SOX3 is associated with infundibular hypoplasia and hypopituitarism.

Am J Hum Genet 2005 May 30;76(5):833-49. Epub 2005 Mar 30.

London Centre for Paediatric Endocrinology, Biochemistry, Endocrinology, and Metabolism Unit, Institute of Child Health, University College London, London, United Kingdom.

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http://dx.doi.org/10.1086/430134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1199372PMC
May 2005

Cited2 is required both for heart morphogenesis and establishment of the left-right axis in mouse development.

Development 2005 Mar;132(6):1337-48

Integrative Morphology Group, Department of Anatomy, University of Vienna, Waehringerstrasse 13, A-1090 Vienna, Austria.

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http://dev.biologists.org/cgi/doi/10.1242/dev.01696
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http://dx.doi.org/10.1242/dev.01696DOI Listing
March 2005

Targeted deletion of the novel cytoplasmic dynein mD2LIC disrupts the embryonic organiser, formation of the body axes and specification of ventral cell fates.

Development 2004 Oct 15;131(20):4999-5007. Epub 2004 Sep 15.

Division of Mammalian Development, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.

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http://dx.doi.org/10.1242/dev.01389DOI Listing
October 2004

Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas.

Development 2004 Feb 21;131(4):797-806. Epub 2004 Jan 21.

Cell and Developmental Biology Program, Fox Chase Cancer Center, 7701 Burholme Aveue, Philadelphia, PA 19111, USA.

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http://dev.biologists.org/content/develop/131/4/797.full.pdf
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http://dev.biologists.org/cgi/doi/10.1242/dev.00965
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http://dx.doi.org/10.1242/dev.00965DOI Listing
February 2004

The homeoprotein Hex is required for hemangioblast differentiation.

Blood 2003 Oct 5;102(7):2428-35. Epub 2003 Jun 5.

Department of Medicine, Indiana University Cancer Center, Indianapolis, IN, USA.

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http://dx.doi.org/10.1182/blood-2003-02-0634DOI Listing
October 2003

The paired-type homeobox gene Dmbx1 marks the midbrain and pretectum.

Mech Dev 2002 Jun;114(1-2):213-7

MRC Centre for Developmental Neurobiology, 4th Floor, New Hunt's House, Guy's Campus, King's College London, London SE1 1UL, UK.

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http://dx.doi.org/10.1016/s0925-4773(02)00067-9DOI Listing
June 2002

Folic acid prevents exencephaly in Cited2 deficient mice.

Hum Mol Genet 2002 Feb;11(3):283-93

MRC Centre for Developmental Neurobiology, 4th floor New Hunt's House, King's College London, Guy's Campus, London Bridge, London SE1 1UL, UK.

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http://dx.doi.org/10.1093/hmg/11.3.283DOI Listing
February 2002