Publications by authors named "J Julian Blanc"

953 Publications

Single-Breath-Hold MRI-SPACE Cholangiopancreatography with Compressed Sensing versus Conventional Respiratory-Triggered MRI-SPACE Cholangiopancreatography at 3Tesla: Comparison of Image Quality and Diagnostic Confidence.

Diagnostics (Basel) 2021 Oct 13;11(10). Epub 2021 Oct 13.

Department of Vascular and Interventional Radiology, Image-Guided Therapy Center, François-Mitterrand University Hospital, 14 Rue Paul Gaffarel, BP 77908, 21079 Dijon, France.

To compare two magnetic resonance cholangiopancreatography (MRCP) sequences at 3 Tesla (3T): the conventional 3D Respiratory-Triggered SPACE sequence (RT-MRCP) and a prototype 3D Compressed-Sensing Breath-Hold SPACE sequence (CS-BH-MRCP), in terms of qualitative and quantitative image quality and radiologist's diagnostic confidence for detecting common bile duct (CBD) lithiasis, biliary anastomosis stenosis in liver-transplant recipients, and communication of pancreatic cyst with the main pancreatic duct (MPD). Sixty-eight patients with suspicion of choledocholithiasis or biliary anastomosis stenosis after liver transplant, or branch-duct intraductal papillary mucinous neoplasm of the pancreas (BD-IPMN), were included. The relative CBD to peri-biliary tissues (PBT) contrast ratio (CR) was assessed. Overall image quality, presence of artefacts, background noise suppression and the visualization of 12 separated segments of the pancreatic and bile ducts were evaluated by two observers working independently on a five-point scale. Diagnostic confidence was scored on a 1-3 scale. The CS-BH-MRCP presented significantly better CRs ( < 0.0001), image quality ( = 0.004), background noise suppression ( = 0.011), fewer artefacts ( = 0.004) and better visualization of pancreatic and bile ducts segments with the exception of the proximal CBD ( = 0.054), cystic duct confluence ( = 0.459), the four secondary intrahepatic bile ducts, and central part of the MPD ( = 0.885) for which no significant differences were found. Overall, diagnostic confidence was significantly better with the CS-BH-MRCP sequence for both readers ( = 0.038 and = 0.038, respectively). This study shows that the CS-BH-MRCP sequence presents overall better image quality and bile and pancreatic ducts visualization compared to the conventional RT-MRCP sequence at 3T.
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http://dx.doi.org/10.3390/diagnostics11101886DOI Listing
October 2021

ASO Author Reflections: Despite Medicaid Expansion, Large Disparities in Breast Reconstruction Persist.

Ann Surg Oncol 2021 Oct 21. Epub 2021 Oct 21.

Department of Surgery, Yale New Haven Breast Center, New Haven, USA.

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http://dx.doi.org/10.1245/s10434-021-10954-7DOI Listing
October 2021

Discovery and Optimization of Orally Bioavailable Phthalazone and Cinnolone Carboxylic Acid Derivatives as S1P2 Antagonists against Fibrotic Diseases.

J Med Chem 2021 Oct 28;64(19):14557-14586. Epub 2021 Sep 28.

Galapagos NV, Generaal De Wittelaan L11 A3, 2800 Mechelen, Belgium.

Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease. Current treatments only slow down disease progression, making new therapeutic strategies compelling. Increasing evidence suggests that S1P2 antagonists could be effective agents against fibrotic diseases. Our compound collection was mined for molecules possessing substructure features associated with S1P2 activity. The weakly potent indole hit evolved into a potent phthalazone series, bearing a carboxylic acid, with the aid of a homology model. Suboptimal pharmacokinetics of a benzimidazole subseries were improved by modifications targeting potential interactions with transporters, based on concepts deriving from the extended clearance classification system (ECCS). Scaffold hopping, as a part of a chemical enablement strategy, permitted the rapid exploration of the position adjacent to the carboxylic acid. Compound , with good pharmacokinetics and potency, was efficacious at 10 mg/kg BID in three different mouse models of fibrotic diseases in a therapeutic setting.
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http://dx.doi.org/10.1021/acs.jmedchem.1c01066DOI Listing
October 2021

Brain-Derived Neurotrophic Factor Mitigates the Association Between Platelet Dysfunction and Cognitive Impairment.

Front Cardiovasc Med 2021 7;8:739045. Epub 2021 Sep 7.

Research Center, Montreal Heart Institute, Montreal, QC, Canada.

Platelet hyperactivity is deleterious in coronary artery disease (CAD), requiring lifelong antiplatelet therapy, and is associated with worse cognitive outcomes. Upon activation, platelets release Brain-Derived Neurotrophic Factor (BDNF), a neurotrophin protective against cognitive decline. Given these apparently opposing effects of platelet activation on cognitive health, we investigated whether BDNF levels intercede in the relationship between platelet activation and cognitive function; and whether this relationship is moderated by the presence of CAD. In this cross-sectional study, 1,280 participants with ( = 673) and without CAD ( = 607) completed the Montreal Cognitive Assessment (MoCA). Plasma BDNF and soluble P-selectin (a marker of platelet activity) levels were assessed using multiplex flow cytometry. In a mediation model, platelet activity was correlated with higher plasma BDNF concentrations (b = 0.53, < 0.0001). The relationship between sP-selectin and BDNF concentrations was stronger for individuals without CAD (b = 0.71, < 0.0001) than for CAD participants (b = 0.43, < 0.0001; <0.0001). Higher BDNF concentrations were associated with higher MoCA scores (b = 0.26, = 0.03). The overall effect of platelet activity on cognitive performance was non-significant (total effect: b = -0.12, = 0.13), and became significant when accounting for BDNF as a mediating factor (direct effect: b = -0.26, = 0.01). This resulted in a positive indirect effect of platelet activity (via BDNF) on MoCA scores (b = 0.14, CI 95% 0.02-0.30), that was smaller in CAD participants than in non-CAD participants [Δ -0.07 (95% CI -0.14 to -0.01)]. BDNF released from activated platelets could be a mitigating factor in a negative association between platelet activity and cognitive function.
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http://dx.doi.org/10.3389/fcvm.2021.739045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452906PMC
September 2021

Congenital infection of SARS-CoV-2 with intrauterine foetal death: a clinicopathological study with molecular analysis.

Clin Infect Dis 2021 Sep 23. Epub 2021 Sep 23.

Department of Pathology and Neuropathology, La Timone Hospital, Aix Marseille, University, Marseille, France.

Observations of vertical transmission of SARS-CoV-2 infection from mother to foetus have recently been described in the literature. However, the consequences of such transmission, whether foetal or neonatal, are poorly understood. From a case of in utero foetal death at 24 +2 weeks of gestation that occurred seven days after the diagnosis of symptomatic SARS-CoV-2 infection in the mother, we isolated the incriminating virus by immunochemistry and molecular techniques in several foetal tissues, with a variant analysis of the SARS-CoV-2 genome. Moreover, the foetal demise could be explained by the presence of placental histological lesions, such as histiocytic intervillositis and trophoblastic necrosis, in addition to foetal tissue damage. We observed mild foetal growth retardation and visceral damage to the liver, causing hepatocellular damage and haemosiderosis. To the best of our knowledge, this is the first report in the literature of foetal demise secondary to maternal-foetal transmission of SARS-CoV-2 with a congenital infection and a pathological description of placental and foetal tissue damage. SARS-CoV-2 was identified in both specimens by three independent techniques (immunochemistry, RT-qPCR and RT-dPCR). Furthermore, the incriminating variant has been identified.
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http://dx.doi.org/10.1093/cid/ciab840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500004PMC
September 2021
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