James S Felton

James S Felton

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James S Felton

James S Felton

Publications by authors named "James S Felton"

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Preparation of single cells for imaging/profiling mass spectrometry.

J Am Soc Mass Spectrom 2008 Aug 17;19(8):1230-6. Epub 2008 May 17.

Chemistry, Materials, Earth, and Life Sciences Directorate, Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore, CA 94550, USA.

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http://dx.doi.org/10.1016/j.jasms.2008.05.006DOI Listing
August 2008

Mouse lung CYP1A1 catalyzes the metabolic activation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).

Carcinogenesis 2007 Mar 19;28(3):732-7. Epub 2006 Oct 19.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 37, Room 3106, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1093/carcin/bgl184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1829392PMC
March 2007

Mutagenic potency of food-derived heterocyclic amines.

Mutat Res 2007 Mar 11;616(1-2):90-4. Epub 2006 Dec 11.

Chemistry, Materials and Life Sciences Directorate, Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore, CA 94551, USA.

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http://dx.doi.org/10.1016/j.mrfmmm.2006.11.010DOI Listing
March 2007

A comprehensive investigation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) metabolism in the mouse using a multivariate data analysis approach.

Chem Res Toxicol 2007 Mar 6;20(3):531-42. Epub 2007 Feb 6.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://pubs.acs.org/doi/abs/10.1021/tx600320w
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http://dx.doi.org/10.1021/tx600320wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1850849PMC
March 2007

Identification of 2-amino-1,7-dimethylimidazo[4,5-g]quinoxaline: an abundant mutagenic heterocyclic aromatic amine formed in cooked beef.

Chem Res Toxicol 2007 Mar 23;20(3):520-30. Epub 2007 Feb 23.

Division of Environmental Disease Prevention, Wadsworth Center, New York State Department of Health, Albany, New York 12201, USA.

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http://pubs.acs.org/doi/abs/10.1021/tx600317r
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http://dx.doi.org/10.1021/tx600317rDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533101PMC
March 2007

A meat and potato war: implications for cancer etiology.

Carcinogenesis 2006 Dec 1;27(12):2367-70. Epub 2006 Nov 1.

Biosciences Directorate, Lawrence Livermore National Laboratory Livermore, CA 94551, USA.

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http://dx.doi.org/10.1093/carcin/bgl165DOI Listing
December 2006

What do diet-induced changes in phase I and II enzymes tell us about prevention from exposure to heterocyclic amines?

J Nutr 2006 Oct;136(10):2683S-4S

Lawrence Livermore National Laboratory, Livermore, CA 94551, USA.

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http://dx.doi.org/10.1093/jn/136.10.2683SDOI Listing
October 2006

Insights into the o-acetylation reaction of hydroxylated heterocyclic amines by human arylamine N-acetyltransferases: a computational study.

Chem Res Toxicol 2006 Sep;19(9):1182-90

Biosciences Directorate, Lawrence Livermore National Laboratory, Livermore, California 94550, USA.

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http://pubs.acs.org/doi/abs/10.1021/tx0600999
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http://dx.doi.org/10.1021/tx0600999DOI Listing
September 2006

Chemical and biological differentiation of three human breast cancer cell types using time-of-flight secondary ion mass spectrometry.

Anal Chem 2006 Jun;78(11):3651-8

Biosciences Directorate and Chemistry and Material Sciences Directorate, P.O. Box 808, Lawrence Livermore National Laboratory, Livermore, California 94551, USA.

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http://pubs.acs.org/doi/abs/10.1021/ac060054c
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http://dx.doi.org/10.1021/ac060054cDOI Listing
June 2006

The impact of glucuronidation on the bioactivation and DNA adduction of the cooked-food carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in vivo.

Carcinogenesis 2005 Nov 8;26(11):2019-28. Epub 2005 Jun 8.

Biosciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA 94551, USA.

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http://dx.doi.org/10.1093/carcin/bgi151DOI Listing
November 2005

PhIP carcinogenicity in breast cancer: computational and experimental evidence for competitive interactions with human estrogen receptor.

Chem Res Toxicol 2005 Oct;18(10):1528-36

Biosciences Directorate, Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore, California 94551, USA.

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http://dx.doi.org/10.1021/tx0501031DOI Listing
October 2005

Formation and human risk of carcinogenic heterocyclic amines formed from natural precursors in meat.

Nutr Rev 2005 May;63(5):158-65

Biosciences Directorate, University of California, Lawrence Livermore National Laboratory 7000 East Avenue, Livermore, CA 94550, USA.

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http://dx.doi.org/10.1111/j.1753-4887.2005.tb00133.xDOI Listing
May 2005

Environmental and chemical carcinogenesis.

Semin Cancer Biol 2004 Dec;14(6):473-86

Biological Engineering Division, Massachusetts Institute of Technology, Room 26-009, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.semcancer.2004.06.010DOI Listing
December 2004

Human UDP-glucuronosyltransferase 1A1 is the primary enzyme responsible for the N-glucuronidation of N-hydroxy-PhIP in vitro.

Chem Res Toxicol 2004 Aug;17(8):1137-44

Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, P.O. Box 808, L-452, Livermore, California 94551, USA.

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http://dx.doi.org/10.1021/tx049898mDOI Listing
August 2004

Impact of environmental exposures on the mutagenicity/carcinogenicity of heterocyclic amines.

Toxicology 2004 May;198(1-3):135-45

Biology and Biotechnology Research Program, L-452, Lawrence Livermore National Laboratory, Livermore, CA 94551, USA.

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http://dx.doi.org/10.1016/j.tox.2004.01.024DOI Listing
May 2004

An in vitro model system to predict the bioaccessibility of heterocyclic amines from a cooked meat matrix.

Food Chem Toxicol 2003 Dec;41(12):1701-10

Biology and Biotechnology Research Program, PO Box 808, Lawrence Livermore National Laboratory, Livermore, CA 94551-9900, USA.

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December 2003

Mutagenic activity and heterocyclic amine carcinogens in commercial pet foods.

Mutat Res 2003 Aug;539(1-2):195-201

Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.

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August 2003

Development and characterization of CHO repair-proficient cell lines for comparative mutagenicity and metabolism of heterocyclic amines from cooked food.

Environ Mol Mutagen 2003 ;41(1):7-13

Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, PO Box 808, Livermore, CA 94551, USA.

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http://dx.doi.org/10.1002/em.10125DOI Listing
March 2003

Highlights of the eighth international conference on carcinogenic/mutagenic N-substituted aryl compounds.

Mutat Res 2002 Sep;506-507:1-8

Chemical Carcinogenesis Section, Laboratory of Experimental Carcinogenesis, National Cancer Institute, Bethesda, MD 20892-4258, USA.

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September 2002

Factors affecting human heterocyclic amine intake and the metabolism of PhIP.

Mutat Res 2002 Sep;506-507:153-62

Biology and Biotechnology Research Program, PO Box 808, Lawrence Livermore National Laboratory, Livermore, CA 94551-9900, USA.

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September 2002

Human exposure to heterocyclic amine food mutagens/carcinogens: relevance to breast cancer.

Environ Mol Mutagen 2002 ;39(2-3):112-8

Molecular and Structural Biology Division, Lawrence Livermore National Laboratory, Livermore, California 94551, USA.

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April 2002