Publications by authors named "J E Madewell"

153 Publications

Advanced Imaging in Musculoskeletal Oncology: Moving Away From RECIST and Embracing Advanced Bone and Soft Tissue Tumor Imaging (ABASTI)-Part II-Novel Functional Imaging Techniques.

Semin Ultrasound CT MR 2021 Apr 29;42(2):215-227. Epub 2020 Aug 29.

The University of Texas MD Anderson Cancer Center, Department of Musculoskeletal Imaging, Houston, TX.

Functional imaging can add valuable information to conventional imaging in the settings of tumor characterization and treatment response assessment. Traditional response criteria rely primarily on physical measurements, while functional imaging can potentially give a more comprehensive evaluation of oncological status. The second part of this review article discusses advanced imaging techniques such as susceptibility-weighted imaging, tumor-associated macrophage imaging, diffusion-weighted imaging, perfusion-weighted imaging, Dixon imaging, whole-body magnetic resonance imaging, whole-body low-dose dual energy computed tomography with virtual noncalcium technique, and ultrasound elastography.
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http://dx.doi.org/10.1053/j.sult.2020.08.013DOI Listing
April 2021

Advanced Imaging in Musculoskeletal Oncology: Moving Away From RECIST and Embracing Advanced Bone and Soft Tissue Tumor Imaging (ABASTI) - Part I - Tumor Response Criteria and Established Functional Imaging Techniques.

Semin Ultrasound CT MR 2021 Apr 29;42(2):201-214. Epub 2020 Aug 29.

The University of Texas MD Anderson Cancer Center, Department of Musculoskeletal Imaging, Houston, Texas.

According to the Revised Response Evaluation Criteria in Solid Tumors (RECIST) 1.1, the majority of bone metastases are considered to be nonmeasurable disease. Traditional response criteria rely on physical measurements. New criteria would be valuable if they incorporated newly developed imaging features in order to provide a more comprehensive assessment of oncological status. Advanced magnetic resonance imaging (MRI) sequences such as diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) with dynamic contrast-enhanced (DCE) perfusion imaging are reviewed in the context of the initial and post-therapeutic assessment of musculoskeletal tumors. Particular attention is directed to the pseudoprogression phenomenon in which a successfully treated tumor enlarges from the pretherapeutic baseline, followed by regression without a change in therapy.
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http://dx.doi.org/10.1053/j.sult.2020.08.012DOI Listing
April 2021

Multiple Myeloma: Role of Imaging in Diagnosis, Staging, and Treatment Response Assessment.

Semin Ultrasound CT MR 2021 Apr 30;42(2):184-193. Epub 2020 Aug 30.

Department of Musculoskeletal Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address:

Multiple myeloma is a common hematologic malignancy of plasma cells. Differentiating multiple myeloma from the precursor stages of monoclonal gammopathy of undetermined significance and smoldering multiple myeloma is very important because the treatment approach is different for each. The diagnosis is mainly clinical, while the role of imaging is confined to the staging process, assessing response to therapy, and monitoring for disease progression. In this article, we examine the role of different imaging modalities in patients with multiple myeloma.
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http://dx.doi.org/10.1053/j.sult.2020.08.019DOI Listing
April 2021

Bone Metastases: Mechanisms of the Metastatic Process, Imaging and Therapy.

Semin Ultrasound CT MR 2021 Apr 29;42(2):164-183. Epub 2020 Aug 29.

Department of Musculoskeletal Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX.

The mechanisms by which tumors metastasize to bone are complex. Upon the successful establishment of metastatic deposits in the skeleton, detection of the disease becomes essential for therapeutic planning. The roles of CT, skeletal scintigraphy, SPECT/CT, MRI, PET/CT and PET/MRI will be reviewed. Therapeutic response criteria specifically designed to evaluate bone metastases (MD Anderson/MDA criteria) can guide image interpretation. Knowledge of therapeutic strategies such as systemic therapy with bisphosphonates or radiopharmaceuticals, radiation therapy, surgery, and percutaneous interventions such as vertebroplasty and radiofrequency ablation can help the radiologist produce reports that will provide maximum benefit to clinicians and patients.
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http://dx.doi.org/10.1053/j.sult.2020.08.016DOI Listing
April 2021

An Approach to Undiagnosed Bone Tumors.

Semin Ultrasound CT MR 2021 Apr 1;42(2):114-122. Epub 2020 Sep 1.

The University of Texas MD Anderson Cancer Center, Department of Musculoskeletal Imaging, Houston, TX.

The radiographic appearance of primary bone tumors is important for initial diagnosis and often augments histopathological analysis. The original grading system relied on the radiographic analysis of the margin of the lesions to determine tumor aggression, which often corresponds with malignant potential. The recently developed, modified Lodwick-Madewell grading system also incorporates the appearance of lesion margins on radiographs but also considers the change in margins on serial radiographs and includes a category for clinically suspected, radiographically occult, aggressive lesions. This article reviews the prior and modified grading systems, and the concepts necessary for proper interpretation of the initial appearance of bone tumors which often determines the radiologist's recommendation for biopsy or follow-up imaging.
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http://dx.doi.org/10.1053/j.sult.2020.08.014DOI Listing
April 2021
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