Publications by authors named "J Andrés Valderrama"

142 Publications

Disparities Influencing Functional Outcomes Between Rural and Urban Patients With Acute Stroke.

Front Neurol 2022 9;13:869772. Epub 2022 May 9.

Faculty of Health Sciences, Universidad Icesi, Cali, Colombia.

Introduction: There is scarce information in Latin America about factors related to stroke patient outcomes in rural areas compared to urban ones.

Objective: To evaluate functional outcomes of stroke code patients from rural and urban areas and their relationship with socioeconomic disparity.

Methods: Prospective cohort study included patients of urban, semi-urban, and rural origin with stroke code from a high complexity hospital in southwestern Colombia between 2018 and 2019. Demographic, clinical data modified Rankin at discharge, and 3-month follow-up were analyzed. The poverty index, barriers to health access and availability of ambulances by the municipality was assessed at an ecological level.

Results: Five hundred and fifty five stroke patients were registered, 21.2% from rural areas, 432 (77.98%) had an ischemic stroke. There were no significant differences in sociodemographic factors and medical background. Urban patients had lower reperfusion therapies rates (23.25%). Favorable mRS at discharge (<3) was higher in urban areas (63.03%) and mortality was superior in rural patients (13.56%). The ambulance rate in semi-urban and rural areas was as low as 0.03 per 100.000 inhabitants, the poverty index was 11.9% in urban areas vs. 23.3% in semi urban and rural areas.

Conclusions: Rural patients treated in our center were more likely to present with severe strokes and unfavorable mRS at hospital discharge and 3-month follow-up compared to urban, despite having similar risk factors. There is an inverse relationship, which is not related to the poverty rate or the percentage of people with barriers to access to health. There is a need for further studies that assess barriers inherent in rural patients and establish a regional stroke network.
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http://dx.doi.org/10.3389/fneur.2022.869772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124848PMC
May 2022

Antifungal Activity and In Silico Studies on 2-Acylated Benzo- and Naphthohydroquinones.

Molecules 2022 May 9;27(9). Epub 2022 May 9.

Química y Farmacia, Facultad de Ciencias de la Salud, Universidad Arturo Prat, Casilla 121, Iquique 1100000, Chile.

The high rates of morbidity and mortality due to fungal infections are associated with a limited antifungal arsenal and the high toxicity of drugs. Therefore, the identification of novel drug targets is challenging due to the several resemblances between fungal and human cells. Here, we report the in vitro antifungal evaluation of two acylphenols series, namely 2-acyl-1,4-benzo- and 2-acyl-1,4-naphthohydroquinones. The antifungal properties were assessed on diverse and filamentous fungi strains through the halo of inhibition (HOI) and minimal inhibitory concentration (MIC). The antifungal activities of 2-acyl-1,4-benzohydroquinone derivatives were higher than those of the 2-acyl-1,4-naphthohydroquinone analogues. The evaluation indicates that 2-octanoylbenzohydroquinone is the most active member of the 2-acylbenzohydroquinone series, with MIC values ranging from 2 to 16 μg/mL. In some fungal strains (i.e., and ), such MIC values of compound (2 and 4 μg/mL) were comparable to that obtained by amphotericin B (1 μg/mL). The compound was evaluated for its antioxidant activity by means of FRAP, ABTS and DPPH assays, showing moderate activity as compared to standard antioxidants. Molecular docking studies of compound and ADMET predictions make this compound a potential candidate for topical pharmacological use. The results obtained using the most active acylbenzohydroquinones are promising because some evaluated strains are known to have decreased sensitivity to standard antifungal treatments.
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http://dx.doi.org/10.3390/molecules27093035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103303PMC
May 2022

Pressure-Surface Tension-Temperature Equation of State for -Alkanes.

Ind Eng Chem Res 2022 Mar 23;61(9):3457-3473. Epub 2022 Feb 23.

Center for Technological Information (CIT), Monseñor Subercaseaux 667, 1710258 La Serena, Chile.

Herein, the geometric similitude concept is applied to propose a cubic equation that relates surface tension, saturation pressure, and temperature for -alkanes. The input properties for each fluid are the molecular mass, pressure, temperature, and compressibility factor at the critical point. The model is applied to temperatures below 0.93· (critical point temperature). A total of 2429 surface tension values have been selected for 32 -alkanes. The parameters of the model have been obtained with a fit of the surface tension values for 19 pure -alkanes that are randomly chosen. Then, it is tested for the other 13 pure -alkanes and used to predict the surface tension for 11 binary and 4 ternary mixtures. These predictions are compared with the reported experimental data. For pure -alkanes, the overall absolute average deviation is 2.4%, including the correlation and testing sets. No additional adjustable coefficients are used for mixtures, yielding an overall absolute average deviation of 2.98% for the binary systems and 7.97% for the ternary ones. The results show that the model is accurate enough for predictions and that the highest deviations are due to the lack of agreement in the values of surface tension of pure fluids obtained from different sources.
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http://dx.doi.org/10.1021/acs.iecr.1c04979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919510PMC
March 2022

Auditory brainstem responses obtained with randomised stimulation level.

Int J Audiol 2022 Mar 17:1-8. Epub 2022 Mar 17.

ENT Service, San Cecilio University Hospital, Granada, Spain.

Objective: To present randomised stimulation level (RSL) - a stimulation paradigm in which the level of the stimuli is randomised, rather than presented sequentially as in the conventional paradigm.

Design: The value of RSL was evaluated by (i) comparing the morphology of auditory brainstem responses (ABRs) elicited by the conventional and RSL paradigms, and by (ii) an online survey investigating the hearing comfort of the stimulus sequence.

Study Sample: ABRs were obtained from 11 normal-hearing adults (8 females, 25-29 years). The online survey was administered to 238 adults from the general community.

Results: Results showed that (i) both stimulation paradigms elicit ABR signals of similar morphology, (ii) RSL provides a faster comprehensive representation of the ABR session, and that (iii) the general population found RSL stimuli to be more comfortable.

Conclusions: The simultaneous evaluation of all ABR traces of the session provided by RSL has potential to improve the identification of ABR components by enabling clinicians to make use of the strategy from the start of the test, which is critical in situations where ABRs present an abnormal morphology. New research opportunities and the clinical potential of RSL are discussed.
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http://dx.doi.org/10.1080/14992027.2022.2047233DOI Listing
March 2022

Life expectancy after aortic valve replacement in young patients.

Rev Esp Cardiol (Engl Ed) 2022 Apr 5;75(4):294-299. Epub 2021 Jun 5.

Servicio de Cirugía Cardiaca, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain.

Introduction And Objectives: In young patients with severe aortic stenosis, it is unknown whether their life expectancy restored after aortic valve replacement (AVR) is unknown.

Methods: We analyzed all patients aged between 50 and 65 years who underwent isolated AVR in 27 Spanish centers during an 18-year period. We compared observed and expected survival at 15 years of follow-up. We repeated all analyses for patients without complications in the postoperative period.

Results: A total of 5084 patients were analyzed. For the overall sample, observed survival at 10 and 15 years was 85.3% (95%CI, 84.1%-86.4%) and 73.7% (95%CI, 71.6%-75.6%), respectively. Expected survival was 90.1% and 82.1%. Cumulative relative survival for 1, 5, 10 and 15 years of follow-up was 97.4% (95%CI, 96.9%-97.9%), 96.5% (95%CI, 95.7%-97.3%), 94.7% (95%CI, 93.3%-95.9%), and 89.8% (95%CI, 87.3%-92.1%). For patients without complications, cumulative relative survival for 1, 5, 10 and 15 years was 100.3% (95%CI, 99.8%-100.5%), 98.9% (95%CI 97.6% -99.9%), 97.3% (95%CI, 94.9%-99.4%), and 91.9% (95%CI, 86.5%-96.8%).

Conclusions: Life expectancy in young patients who have severe aortic stenosis and undergo AVR is lower than that of the general population. Life expectancy of individuals without complications during the postoperative period is also reduced. Therefore, baseline characteristics are likely the main factors that explain the reduction in life expectancy.
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http://dx.doi.org/10.1016/j.rec.2021.04.010DOI Listing
April 2022
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