Publications by authors named "Jørgen Sparup"

2 Publications

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Fourteen-year-old girl with endobronchial carcinoid tumour presenting with asthma and lobar emphysema.

Clin Respir J 2010 Apr;4(2):120-4

Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, Copenhagen University Hospital, København Ø, Denmark.

Introduction: Bronchial carcinoid tumours seldom occur in children, and represent a rare cause of pulmonary obstruction. Because of low clinical suspicion and the variable ways of presentation, diagnosis may be delayed.

Objectives: We report on a patient with this tumour. It is hoped that increased awareness of the tumour can lead to earlier diagnosis.

Methods: Report of a case.

Results: This case describes a 14-year-old previously healthy girl, presenting with asthma-like symptoms throughout 2 years, decreased lung function and emphysema in left lower lobe on chest x-ray. Computerized tomography (CT) showed an intraluminal process in the left main bronchus and emphysema in both the upper and lower left lobe and showed no signs of metastasis or spread to lung tissue. Bronchoscopy showed an inflammatory polyp. Surgical resection demonstrated a typical carcinoid tumour. Later control biopsy revealed no persisting malignant tissue. The asthma symptoms returned and a new bronchoscopy showed scarring and narrowing of the left bronchus. Treatment comprised of dilatation by bronchoscopy plus daily combination corticosteroids and beta-2-agonist inhalation and the symptoms improved. No signs of relapse 16 months postdiagnosis.

Conclusions: The case clearly shows the delay, which is common in the diagnosis of children with bronchial carcinoid tumours. Symptoms of the obstructive nature of the tumour are variable and might present as emphysema seen on x-ray and CT. Carcinoid tumour should be considered in children with longstanding pulmonary symptoms with no response to conventional treatment. Prognosis is good but long-term follow up is needed.
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http://dx.doi.org/10.1111/j.1752-699X.2009.00149.xDOI Listing
April 2010

[Self-expanding nitinol stents in the treatment of tracheobronchial stenoses].

Ugeskr Laeger 2002 Aug;164(33):3858-61

Hjertecentret, thoraxkirurgisk afdeling-2152, H:S Rigshospitalet, DK-2100 København ø.

Introduction: Several types of metal stents are available for the treatment of tracheobronchial stenosis. They can be self-expanding, balloon expandable, covered with a silicone membrane or uncovered. We have used a new self-expanding tracheobronchial nitinol wire stent since 1998, and our results are presented below.

Material And Methods: Over a period of two years, 25 patients had a stent in the trachea or bronchus. The stents were inserted while the patients were under general anaesthesia, and flexible bronchoscopy was used. Respiratory function, histopathology, stent data, complications, and mortality were prospectively recorded.

Results: Eighteen patients had a malignant stenosis. Bronchial stenosis following a single lung transplantation (3) was the most frequent reason for a benign stenosis (7). Most of the patients had the stent placed in the trachea (14). All the stent insertions were performed without complications, and respiratory function was immediately improved in all patients except for two. The postoperative complications were inflammatory granuloma (5), stent dislocation (3), delayed expansion (2), stent rupture (1), and stent occlusion caused by retained secretions (1).

Discussion: The tracheobronchial ultraflex nitinol stent was easy to handle and was troublesome for only a few patients. Nitinol stents are considered to have a good biocompatibility, but 12% of the patients developed inflammatory granulations requiring electroresection.
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August 2002
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