Izaskun Buendia

Izaskun Buendia

UNVERIFIED PROFILE

Are you Izaskun Buendia?   Register this Author

Register author
Izaskun Buendia

Izaskun Buendia

Publications by authors named "Izaskun Buendia"

Are you Izaskun Buendia?   Register this Author

30Publications

651Reads

19Profile Views

Immune Responses and Anti-inflammatory Strategies in a Clinically Relevant Model of Thromboembolic Ischemic Stroke with Reperfusion.

Transl Stroke Res 2019 Sep 14. Epub 2019 Sep 14.

Normandie Univ, UNICAEN, INSERM, U1237, PhIND "Physiopathology and Imaging of Neurological Disorders", Institut Blood and Brain @ Caen-Normandie, Cyceron, 14000 Caen, France, Normandie Université, 14000, Caen, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12975-019-00733-8DOI Listing
September 2019

Pharmacological doses of melatonin impede cognitive decline in tau-related Alzheimer models, once tauopathy is initiated, by restoring the autophagic flux.

J Pineal Res 2019 Aug 29;67(1):e12578. Epub 2019 Apr 29.

Department of Pharmacology, School of Medicine, Instituto Teófilo Hernando for Drug Discovery, Universidad Autónoma Madrid, Madrid, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jpi.12578DOI Listing
August 2019

Deficiency in the transcription factor NRF2 worsens inflammatory parameters in a mouse model with combined tauopathy and amyloidopathy.

Redox Biol 2018 09 11;18:173-180. Epub 2018 Jul 11.

Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), ISCIII. Instituto de Investigaciones Biomédicas "Alberto Sols", UAM-CSIC. Instituto de Investigación Sanitaria La Paz (IdiPaz) and Department of Biochemistry, Faculty of Medicine, Autonomous University of MadridMadrid, Spain; Cellular and Molecular Medicine Department, Radiobiology Laboratory, "Victor Babes" National Institute of Pathology, Bucharest, Romania. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S22132317183041
Publisher Site
http://dx.doi.org/10.1016/j.redox.2018.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052199PMC
September 2018

NOX4-dependent neuronal autotoxicity and BBB breakdown explain the superior sensitivity of the brain to ischemic damage.

Proc Natl Acad Sci U S A 2017 11 31;114(46):12315-12320. Epub 2017 Oct 31.

Department of Pharmacology and Personalized Medicine, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 6229 ER Maastricht, The Netherlands;

View Article

Download full-text PDF

Source
http://www.pnas.org/lookup/doi/10.1073/pnas.1705034114
Publisher Site
http://dx.doi.org/10.1073/pnas.1705034114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5699031PMC
November 2017

Mitochondrial complex I deactivation is related to superoxide production in acute hypoxia.

Redox Biol 2017 08 21;12:1040-1051. Epub 2017 Apr 21.

Servicio de Inmunología, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), E-28006 Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.redox.2017.04.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430576PMC
August 2017

Novel Multitarget Hybrid Compounds for the Treatment of Alzheimer's Disease.

Curr Top Med Chem 2017 ;17(9):1027-1043

Instituto Teofilo Hernando, Departamento de Farmacologia y Terapeutica, Facultad de Medicina, UAM; C/ Arzobispo Morcillo, 4, 28029, Madrid,. Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1568026616666160927154116DOI Listing
May 2017

Novel sulfoglycolipid IG20 causes neuroprotection by activating the phase II antioxidant response in rat hippocampal slices.

Neuropharmacology 2017 04 20;116:110-121. Epub 2016 Dec 20.

Instituto Teófilo Hernando, Facultad de Medicina, Universidad Autónoma de Madrid, C/ Arzobispo Morcillo, 4, 28029 Madrid, Spain; Departamento de Farmacología y Terapéutica, Facultad de Medicina, Universidad Autónoma de Madrid, C/ Arzobispo Morcillo, 4, 28029 Madrid, Spain; Servicio de Farmacología Clínica, Instituto de Investigación Sanitaria, Hospital Universitario de la Princesa, Universidad Autónoma de Madrid, c/ Diego de León, 62, 28006 Madrid, Spain. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuropharm.2016.12.016DOI Listing
April 2017

Inclusion complex of ITH12674 with 2-hydroxypropyl-β-cyclodextrin: Preparation, physical characterization and pharmacological effect.

Carbohydr Polym 2017 Feb 24;157:94-104. Epub 2016 Sep 24.

Instituto-Fundación Teófilo Hernando y Departamento de Farmacología y Terapéutica, Facultad de Medicina, Universidad Autónoma de Madrid, 28029 Madrid, Spain; Instituto de Investigación Sanitaria, Servicio de Farmacología Clínica, Hospital Universitario de la Princesa, 28006 Madrid, Spain. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.carbpol.2016.09.072DOI Listing
February 2017

ITH14001, a CGP37157-Nimodipine Hybrid Designed to Regulate Calcium Homeostasis and Oxidative Stress, Exerts Neuroprotection in Cerebral Ischemia.

ACS Chem Neurosci 2017 01 22;8(1):67-81. Epub 2016 Nov 22.

Instituto Teófilo Hernando y Departamento de Farmacología y Terapéutica, Facultad de Medicina, Universidad Autónoma de Madrid , 28029 Madrid, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acschemneuro.6b00181DOI Listing
January 2017

Sensory Input-Dependent Changes in Glutamatergic Neurotransmission- Related Genes and Proteins in the Adult Rat Trigeminal Ganglion.

Front Mol Neurosci 2016 28;9:132. Epub 2016 Nov 28.

Departamento de Anatomía, Histología y Neurociencia, Universidad Autónoma de Madrid Madrid, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fnmol.2016.00132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5124698PMC
November 2016

New melatonin-cinnamate hybrids as multi-target drugs for neurodegenerative diseases: Nrf2-induction, antioxidant effect and neuroprotection.

Future Med Chem 2015 23;7(15):1961-9. Epub 2015 Oct 23.

Departamento de Farmacología y Terapéutica, Facultad de Medicina, Instituto Teófilo Hernando, Universidad Autónoma de Madrid, 28029 Madrid, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4155/fmc.15.99DOI Listing
August 2016

Agmatine, by Improving Neuroplasticity Markers and Inducing Nrf2, Prevents Corticosterone-Induced Depressive-Like Behavior in Mice.

Mol Neurobiol 2016 07 13;53(5):3030-3045. Epub 2015 May 13.

Departamento de Farmacología y Terapéutica and Instituto Teófilo Hernando. Facultad de Medicina, Universidad Autónoma de Madrid, 28029, Madrid, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12035-015-9182-6DOI Listing
July 2016

Agmatine induces Nrf2 and protects against corticosterone effects in hippocampal neuronal cell line.

Mol Neurobiol 2015 2;51(3):1504-19. Epub 2014 Aug 2.

Instituto Teofilo Hernando, Departamento de Farmacología y Terapéutica, Facultad de Medicina, Universidad Autónoma de Madrid, 4-28029, Madrid, Spain,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12035-014-8827-1DOI Listing
March 2016

Nrf2-ARE pathway: An emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases.

Pharmacol Ther 2016 Jan 23;157:84-104. Epub 2015 Nov 23.

Instituto de Investigación Sanitaria, Hospital Universitario de la Princesa, 28006 Madrid, Spain; Instituto Teófilo Hernando, Departamento de Farmacología y Terapéutica, Facultad de Medicina, UAM, 28029 Madrid, Spain. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pharmthera.2015.11.003DOI Listing
January 2016

Neuroprotective mechanism of the novel melatonin derivative Neu-P11 in brain ischemia related models.

Neuropharmacology 2015 Dec 15;99:187-95. Epub 2015 Jul 15.

Instituto Teófilo Hernando (ITH), Universidad Autónoma de Madrid, Madrid, Spain; Departamento de Farmacología y Terapéutica, Facultad de Medicina, Universidad Autónoma de Madrid, Madrid, Spain. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuropharm.2015.07.014DOI Listing
December 2015

Alpha7 nicotinic receptor activation protects against oxidative stress via heme-oxygenase I induction.

Biochem Pharmacol 2015 Oct 23;97(4):473-481. Epub 2015 Jul 23.

Instituto Teófilo Hernando, Universidad Autónoma de Madrid, Madrid, Spain; Departamento de Farmacología y Terapéutica, Facultad de Medicina, Universidad Autónoma de Madrid, Spain; Instituto de Investigación Sanitaria, Hospital Universitario de la Princesa, Universidad Autónoma de Madrid, Madrid, Spain. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bcp.2015.07.022DOI Listing
October 2015

Anti-inflammatory role of microglial alpha7 nAChRs and its role in neuroprotection.

Biochem Pharmacol 2015 Oct 29;97(4):463-472. Epub 2015 Jul 29.

Instituto de Investigación Sanitaria, Servicio de Farmacología Clínica, Hospital Universitario de la Princesa, 28006 Madrid, Spain; Instituto de I+D del Medicamento Teófilo Hernando (ITH), Facultad de Medicina, Universidad Autónoma de Madrid, Spain; Departamento de Farmacología y Terapéutica, Facultad de Medicina, Universidad Autónoma de Madrid, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bcp.2015.07.032DOI Listing
October 2015

Microglial HO-1 induction by curcumin provides antioxidant, antineuroinflammatory, and glioprotective effects.

Mol Nutr Food Res 2015 Sep 30;59(9):1690-700. Epub 2015 Jun 30.

Instituto Teófilo Hernando, Facultad de Medicina, Universidad Autónoma de Madrid, Madrid, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/mnfr.201500279DOI Listing
September 2015

Melatonin-sulforaphane hybrid ITH12674 induces neuroprotection in oxidative stress conditions by a 'drug-prodrug' mechanism of action.

Br J Pharmacol 2015 Apr 10;172(7):1807-21. Epub 2015 Feb 10.

Departamento de Farmacología y Terapéutica, Instituto Teófilo Hernando de I + D del medicamento Facultad de Medicina, Universidad Autónoma de Madrid, Madrid, Spain; Instituto de Investigación Sanitaria, Servicio de Farmacología Clínica, Hospital Universitario de la Princesa, Madrid, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bph.13025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376458PMC
April 2015

The melatonin-N,N-dibenzyl(N-methyl)amine hybrid ITH91/IQM157 affords neuroprotection in an in vitro Alzheimer's model via hemo-oxygenase-1 induction.

ACS Chem Neurosci 2015 Feb 25;6(2):288-96. Epub 2014 Nov 25.

Instituto Teófilo Hernando (ITH), Universidad Autónoma de Madrid , Madrid 28029, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/cn5002073DOI Listing
February 2015

Neuroprotective effect of melatonin against ischemia is partially mediated by alpha-7 nicotinic receptor modulation and HO-1 overexpression.

J Pineal Res 2014 Mar 16;56(2):204-12. Epub 2014 Jan 16.

Departamento de Farmacología y Terapéutica, Facultad de Medicina, Instituto Teófilo Hernando, Universidad Autónoma de Madrid, Madrid, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jpi.12113DOI Listing
March 2014

The microglial α7-acetylcholine nicotinic receptor is a key element in promoting neuroprotection by inducing heme oxygenase-1 via nuclear factor erythroid-2-related factor 2.

Antioxid Redox Signal 2013 Oct 25;19(11):1135-48. Epub 2013 Feb 25.

1 Instituto Teófilo Hernando and Department of Pharmacology, School of Medicine, Universidad Autónoma de Madrid , Madrid, Spain .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/ars.2012.4671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785807PMC
October 2013