Ivan Votruba

Ivan Votruba

UNVERIFIED PROFILE

Are you Ivan Votruba?   Register this Author

Register author
Ivan Votruba

Ivan Votruba

Publications by authors named "Ivan Votruba"

Are you Ivan Votruba?   Register this Author

53Publications

559Reads

15Profile Views

9-Norbornyl-6-chloropurine is a novel antileukemic compound interacting with cellular GSH.

Anticancer Res 2013 Aug;33(8):3163-8

Institute of Organic Chemistry and Biochemistry Academy of Sciences of the Czech Republic, Flemingovo nám. 2, 166 10 Prague 6, Czech Republic.

View Article

Download full-text PDF

Source
August 2013

Sugar-modified derivatives of cytostatic 7-(het)aryl-7-deazaadenosines: 2'-C-methylribonucleosides, 2'-deoxy-2'-fluoroarabinonucleosides, arabinonucleosides and 2'-deoxyribonucleosides.

Bioorg Med Chem 2012 Sep 20;20(17):5202-14. Epub 2012 Jul 20.

Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Gilead Sciences & IOCB Research Center, Flemingovo nam. 2, CZ-16610 Prague 6, Czech Republic.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmc.2012.07.003DOI Listing
September 2012

Involvement of MAP kinases in the cytotoxicity of acyclic nucleoside phosphonates.

Anticancer Res 2012 Feb;32(2):497-501

Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nam. 2, 166 10 Prague 6, Czech Republic.

View Article

Download full-text PDF

Source
February 2012

Antiviral activity of tenofovir against Cauliflower mosaic virus and its metabolism in Brassica pekinensis plants.

Antiviral Res 2011 Nov 26;92(2):378-81. Epub 2011 Aug 26.

Biology Centre, v.v.i., Institute of Plant Molecular Biology, Academy of Sciences of the Czech Republic, Branišovská 31, 37005 České Budějovice, Czech Republic.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01663542110041
Publisher Site
http://dx.doi.org/10.1016/j.antiviral.2011.08.014DOI Listing
November 2011

Synthesis and biological activity of desmethoxy analogues of coruscanone A.

Bioorg Med Chem Lett 2011 Oct 19;21(20):6062-6. Epub 2011 Aug 19.

Centre for New Antivirals and Antineoplastics, Department of Inorganic and Organic Chemistry, Charles University, Faculty of Pharmacy, Heyrovského 1203, CZ-500 03 Hradec Králové, Czech Republic.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2011.08.059DOI Listing
October 2011

A novel and efficient one-pot synthesis of symmetrical diamide (bis-amidate) prodrugs of acyclic nucleoside phosphonates and evaluation of their biological activities.

Eur J Med Chem 2011 Sep 23;46(9):3748-54. Epub 2011 May 23.

Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic vvi, Flemingovo nám 2, 16610 Prague 6, Czech Republic.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejmech.2011.05.040DOI Listing
September 2011

Synthesis and significant cytostatic activity of 7-hetaryl-7-deazaadenosines.

J Med Chem 2011 Aug 11;54(15):5498-507. Epub 2011 Jul 11.

Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm2005173DOI Listing
August 2011

Point mutations in human guanylate kinase account for acquired resistance to anticancer nucleotide analogue PMEG.

Biochem Pharmacol 2011 Jul 14;82(2):131-8. Epub 2011 Apr 14.

Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bcp.2011.04.002DOI Listing
July 2011

2´-deoxy-5,6-dihydro-5-azacytidine - a less toxic alternative of 2´-deoxy-5-azacytidine: a comparative study of hypomethylating potential.

Epigenetics 2011 Jun 1;6(6):769-76. Epub 2011 Jun 1.

Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i.; Gilead Sciences and IOCB Research Center, Prague, Czech Republic.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142367PMC
http://dx.doi.org/10.4161/epi.6.6.16215DOI Listing
June 2011

Synthesis and antiviral activity of N9-[3-fluoro-2-(phosphonomethoxy)propyl] analogues derived from N6-substituted adenines and 2,6-diaminopurines.

Bioorg Med Chem 2011 Apr 4;19(7):2114-24. Epub 2011 Mar 4.

Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i. Flemingovo nám. 2, 16610 Prague 6, Czech Republic.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmc.2011.02.050DOI Listing
April 2011

Inhibition of SAH-hydrolase activity during seed germination leads to deregulation of flowering genes and altered flower morphology in tobacco.

Mol Genet Genomics 2011 Mar 28;285(3):225-36. Epub 2011 Jan 28.

Institute of Biophysics, Academy of Sciences of the Czech Republic, vvi, Kralovopolska 135, 612 65 Brno, Czech Republic.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00438-011-0601-8DOI Listing
March 2011

Phosphoramidate pronucleotides of cytostatic 6-aryl-7-deazapurine ribonucleosides.

Bioorg Med Chem 2011 Jan 4;19(1):229-42. Epub 2010 Dec 4.

Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Gilead Sciences & IOCB Research Center, Flemingovo nám. 2, CZ-16610 Prague 6, Czech Republic.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmc.2010.11.029DOI Listing
January 2011

8-Aza-7,9-dideazaxanthine acyclic nucleoside phosphonate inhibitors of thymidine phosphorylase.

Bioorg Med Chem Lett 2011 Jan 10;21(2):652-4. Epub 2010 Dec 10.

Institute of Organic Chemistry and Biochemistry, v.v.i., Gilead Sciences & IOCB Research Center, Academy of Sciences of the Czech Republic, Flemingovo nám. 2, 166 10 Prague 6, Czech Republic.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2010.12.027DOI Listing
January 2011

3,5-disubstituted pyranone analogues of highly antifungally active furanones: conversion of biological effect from antifungal to cytostatic.

Bioorg Med Chem Lett 2010 Dec 21;20(24):7358-60. Epub 2010 Oct 21.

Centre for New Antivirals and Antineoplastics, Department of Inorganic and Organic Chemistry, Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Hradec Králové, Czech Republic.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2010.10.052DOI Listing
December 2010

Pyrimidine acyclic nucleoside phosphonates and phosphorylated analogs. Part 2. Syntheses and investigation of their inhibitory effects towards human thymidine phosphorylase.

Nucleic Acids Symp Ser (Oxf) 2008 (52):657-8

Gilead Sciences & IOCB Research Centre, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Centre for New Antivirals and Antineoplastics (IOCB), Flemingovo nám. 2,166 10, Prague, Czech Republic.

View Article

Download full-text PDF

Source
https://academic.oup.com/nass/article-lookup/doi/10.1093/nas
Publisher Site
http://dx.doi.org/10.1093/nass/nrn332DOI Listing
November 2010

Distinct modulation of telomere length in two T-lymphoblastic leukemia cell lines by cytotoxic nucleoside phosphonates PMEG and PMEDAP.

Eur J Pharmacol 2010 Sep 22;643(1):6-12. Epub 2010 Jun 22.

Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejphar.2010.06.006DOI Listing
September 2010

CycloSal-phosphate pronucleotides of cytostatic 6-(Het)aryl-7-deazapurine ribonucleosides: Synthesis, cytostatic activity, and inhibition of adenosine kinases.

ChemMedChem 2010 Aug;5(8):1386-96

Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Gilead Sciences & IOCB Research Center, Prague, Czech Republic.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cmdc.201000192DOI Listing
August 2010

Role of caspases and CD95/Fas in the apoptotic effects of a nucleotide analog PMEG in CCRF-CEM cells.

Anticancer Res 2010 Jul;30(7):2791-8

Institute of Organic Chemistry and Biochemistry AS CR, Flemingovo nám. 2, 166 10 Prague 6, Czech Republic.

View Article

Download full-text PDF

Source
July 2010

The acyclic 2,4-diaminopyrimidine nucleoside phosphonate acts as a purine mimetic in HIV-1 reverse transcriptase DNA polymerization.

J Biol Chem 2010 Apr 17;285(16):12101-8. Epub 2010 Feb 17.

Department of Medicine, Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M109.096529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852949PMC
April 2010

Antifungal 3,5-disubstituted furanones: From 5-acyloxymethyl to 5-alkylidene derivatives.

Bioorg Med Chem 2010 Mar 25;18(5):1988-2000. Epub 2010 Jan 25.

Centre for New Antivirals and Antineoplastics, Department of Inorganic and Organic Chemistry, Charles University, Faculty of Pharmacy, Heyrovského 1203, CZ-500 03 Hradec Králové, Czech Republic.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmc.2010.01.030DOI Listing
March 2010

6-(Het)aryl-7-deazapurine ribonucleosides as novel potent cytostatic agents.

J Med Chem 2010 Jan;53(1):460-70

Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Gilead Sciences & IOCB Research Center, Flemingovo nam. 2, CZ-16610 Prague 6, Czech Republic.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm901428kDOI Listing
January 2010

Lasioglossins: three novel antimicrobial peptides from the venom of the eusocial bee Lasioglossum laticeps (Hymenoptera: Halictidae).

Chembiochem 2009 Aug;10(12):2089-99

Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 166 10 Prague 6 (Czech Republic).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbic.200900133DOI Listing
August 2009

In vivo modulation of angiogenic gene expression by acyclic nucleoside phosphonates PMEDAP and PMEG.

Anticancer Res 2009 Apr;29(4):1295-302

Institute of Biology and Medical Genetics, Charles University, Prague, Czech Republic.

View Article

Download full-text PDF

Source
April 2009

Intracellular metabolism of the new antiviral compound 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine.

Biochem Pharmacol 2008 Oct 19;76(8):997-1005. Epub 2008 Aug 19.

Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bcp.2008.08.009DOI Listing
October 2008

Synthesis and photophysical properties of 7-deaza-2'-deoxyadenosines bearing bipyridine ligands and their Ru(II)-complexes in position 7.

Org Biomol Chem 2008 Aug 16;6(16):2852-60. Epub 2008 Jun 16.

Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Gilead & IOCB Research Center, Flemingovo nam. 2, CZ-16610, Prague 6, Czech Republic.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/b805632cDOI Listing
August 2008

Synthesis of substituted 6-cyclopropylpurine bases and nucleosides by cross-coupling reactions or cyclopropanations.

Org Biomol Chem 2008 Jul 2;6(13):2377-87. Epub 2008 May 2.

Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Gilead & IOCB Research Center, Flemingovo nam. 2, CZ-16610 Prague 6, Czech Republic.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/b802833hDOI Listing
July 2008

Syntheses of pyrimidine acyclic nucleoside phosphonates as potent inhibitors of thymidine phosphorylase (PD-ECGF) from SD-lymphoma.

Nucleosides Nucleotides Nucleic Acids 2007 ;26(8-9):1025-8

Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15257770701508679DOI Listing
March 2008

Synthesis, cytostatic and anti-HCV activity of 6-(N-substituted aminomethyl)-, 6-(O-substituted hydroxymethyl)- and 6-(S-substituted sulfanylmethyl)purine nucleosides.

Bioorg Med Chem 2008 Mar 29;16(5):2329-66. Epub 2007 Nov 29.

Institute of Organic Chemistry and Biochemistry, v.v.i., Academy of Sciences of the Czech Republic, Gilead Sciences & IOCB Research Center, Flemingovo nam. 2, CZ-16610 Prague 6, Czech Republic.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmc.2007.11.067DOI Listing
March 2008

Synthesis, cytostatic, and antiviral activity of novel 6-[2-(dialkylamino)ethyl]-, 6-(2-alkoxyethyl)-, 6-[2-(alkylsulfanyl)ethyl]-, and 6-[2-(dialkylamino)vinyl]purine nucleosides.

Bioorg Med Chem 2008 Feb 23;16(3):1400-24. Epub 2007 Oct 23.

Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Gilead Sciences & IOCB Research Center, Flemingovo nam. 2, CZ-16610 Prague 6, Czech Republic.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmc.2007.10.063DOI Listing
February 2008

Alpha anomer of 5-aza-2'-deoxycytidine down-regulates hTERT mRNA expression in human leukemia HL-60 cells.

Biochem Pharmacol 2008 Feb 22;75(4):965-72. Epub 2007 Oct 22.

Gilead Sciences Research Center, Institute of Organic Chemistry and Biochemistry v.v.i., AS CR, 166 10 Prague 6, Czech Republic.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bcp.2007.10.018DOI Listing
February 2008

Syntheses of N3-substituted thymine acyclic nucleoside phosphonates and a comparison of their inhibitory effect towards thymidine phosphorylase.

Bioorg Med Chem Lett 2008 Feb 8;18(4):1364-7. Epub 2008 Jan 8.

Gilead Sciences & IOCB Research Centre, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i, Centre for New Antivirals and Antineoplastics (IOCB), Prague, Czech Republic.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2008.01.006DOI Listing
February 2008

Discovery of 5-substituted-6-chlorouracils as efficient inhibitors of human thymidine phosphorylase.

J Med Chem 2007 Nov 27;50(24):6016-23. Epub 2007 Oct 27.

Gilead Sciences & IOCB Research Centre, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Centre for New Antivirals and Antineoplastics, Flemingovo nám. 2, Prague 6, Czech Republic.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm070644iDOI Listing
November 2007

Synthesis of 2'-deoxyadenosine nucleosides bearing bipyridine-type ligands and their Ru-complexes in position 8 through cross-coupling reactions.

Org Biomol Chem 2007 Sep 31;5(17):2849-57. Epub 2007 Jul 31.

Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Gilead & IOCB Research Center, Flemingovo nam. 2, CZ-16610 Prague 6, Czech Republic.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/b709245hDOI Listing
September 2007

Efficacy of DNA hypomethylating capacities of 5-aza-2'-deoxycytidine and its alpha anomer.

Pharmacol Res 2007 Jan 29;55(1):16-22. Epub 2006 Sep 29.

Institute of Biophysics, Academy of Sciences of the Czech Republic, Kralovopolska 135, 612 65 Brno, Czech Republic.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.phrs.2006.09.008DOI Listing
January 2007

N6-methyl-AMP aminohydrolase activates N6-substituted purine acyclic nucleoside phosphonates.

Biochem Pharmacol 2006 Apr 28;71(9):1370-6. Epub 2006 Feb 28.

Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 166 10 Prague 6, Czech Republic.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bcp.2006.01.013DOI Listing
April 2006

Design and synthesis of novel 5,6-disubstituted uracil derivatives as potent inhibitors of thymidine phosphorylase.

Bioorg Med Chem Lett 2006 Mar 5;16(5):1335-7. Epub 2005 Dec 5.

Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 166 10 Prague 6, Czech Republic.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2005.11.050DOI Listing
March 2006

Inhibition of human telomerase by diphosphates of acyclic nucleoside phosphonates.

Biochem Pharmacol 2005 Sep;70(6):894-900

Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 166 10 Prague 6, Czech Republic.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bcp.2005.06.007DOI Listing
September 2005

Cytostatic 6-arylpurine nucleosides. 6. SAR in anti-HCV and cytostatic activity of extended series of 6-hetarylpurine ribonucleosides.

J Med Chem 2005 Sep;48(18):5869-73

Centre for New Antivirals and Antineoplastics, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nám. 2, CZ-16610 Prague 6, Czech Republic.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm050335xDOI Listing
September 2005

The first synthesis and cytostatic activity of novel 6-(fluoromethyl)purine bases and nucleosides.

Org Biomol Chem 2005 Aug 4;3(16):3001-7. Epub 2005 Jul 4.

Centre for New Antivirals and Antineoplastics, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nam. 2, CZ-16610, Prague 6, Czech Republic.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/b508122jDOI Listing
August 2005

Inhibition of thymidine phosphorylase (PD-ECGF) from SD-lymphoma by phosphonomethoxyalkyl thymines.

Biochem Pharmacol 2005 May;69(10):1517-21

Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 166 10 Prague, Czech Republic.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bcp.2005.03.003DOI Listing
May 2005

Cocyclotrimerization of 6-alkynylpurines with alpha,omega-diynes as a novel approach to biologically active 6-arylpurines.

J Org Chem 2004 Dec;69(26):9224-33

Department of Organic and Nuclear Chemistry, Faculty of Science, Charles University, Hlavova 8, 128 43 Prague 2, Czech Republic.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jo0486342DOI Listing
December 2004

Facile and efficient synthesis of 6-(hydroxymethyl)purines.

Org Lett 2004 Sep;6(19):3225-8

Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nam. 2, CZ-16610 Prague 6, Czech Republic.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ol049059rDOI Listing
September 2004

Synthesis and antiproliferative activity of 2,6-diamino-9-benzyl-9-deazapurine and related compounds.

Bioorg Med Chem 2004 Jun;12(12):3187-95

Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nám. 2, 166 10 Prague 6, Czech Republic.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmc.2004.04.003DOI Listing
June 2004

PMEDAP and its N6-substituted derivatives: genotoxic effect and apoptosis in in vitro conditions.

Anticancer Res 2003 Nov-Dec;23(6C):4933-9

Institute of Biology and Medical Genetics, 1st Medical Faculty, Charles University, 128 00 Prague 2, Czech Republic.

View Article

Download full-text PDF

Source
April 2004

Ferrocene-modified purines as potential electrochemical markers: synthesis, crystal structures, electrochemistry and cytostatic activity of (ferrocenylethynyl)- and (ferrocenylethyl)purines.

Chemistry 2004 Apr;10(8):2058-66

Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nám. 2, 16610 Prague 6, Czech Republic.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/chem.200305621DOI Listing
April 2004

In vitro activities of 3-(halogenated phenyl)-5-acyloxymethyl- 2,5-dihydrofuran-2-ones against common and emerging yeasts and molds.

Antimicrob Agents Chemother 2004 Mar;48(3):873-8

Department of Biological and Medical Sciences, Faculty of Pharmacy, Charles University in Prague, CZ-500 05 Hradec Kralove, Czech Republic.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC353114PMC
http://dx.doi.org/10.1128/aac.48.3.873-878.2004DOI Listing
March 2004

The substrate activity of (S)-9-[3-hydroxy-(2-phosphonomethoxy)propyl]adenine diphosphate toward DNA polymerases alpha, delta and epsilon.

Antivir Chem Chemother 2004 Jan;15(1):23-33

Institute of Organic Chemistry & Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/095632020401500103DOI Listing
January 2004

Tenofovir diphosphate is a poor substrate and a weak inhibitor of rat DNA polymerases alpha, delta, and epsilon*.

Antimicrob Agents Chemother 2002 May;46(5):1610-3

Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC127178PMC
http://dx.doi.org/10.1128/aac.46.5.1610-1613.2002DOI Listing
May 2002

Covalent analogues of DNA base-pairs and triplets. Part 2: synthesis and cytostatic activity of bis(purin-6-yl)acetylenes,-diacetylenes and related compounds.

Bioorg Med Chem Lett 2002 Apr;12(7):1055-8

Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nám. 2, CZ-16610 6 Prague, Czech Republic.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0960-894x(02)00077-xDOI Listing
April 2002

6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity.

J Med Chem 2002 Apr;45(9):1918-29

Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nám. 2, CZ-166 10 Praha 6, Czech Republic.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm011095yDOI Listing
April 2002