Ivan Rusyn

Ivan Rusyn

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Ivan Rusyn

Ivan Rusyn

Publications by authors named "Ivan Rusyn"

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Comparative analysis of Rapid Equilibrium Dialysis (RED) and solid phase micro-extraction (SPME) methods for In Vitro-In Vivo extrapolation of environmental chemicals.

Toxicol In Vitro 2019 Oct 10;60:245-251. Epub 2019 Jun 10.

Department of Veterinary Integrative Biosciences, College of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX 77843, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tiv.2019.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717004PMC
October 2019

Population-based toxicity screening in human induced pluripotent stem cell-derived cardiomyocytes.

Toxicol Appl Pharmacol 2019 Oct 16;381:114711. Epub 2019 Aug 16.

Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX 77843-4458, USA. Electronic address:

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http://dx.doi.org/10.1016/j.taap.2019.114711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745256PMC
October 2019

Using Collaborative Cross Mouse Population to Fill Data Gaps in Risk Assessment: A Case Study of Population-Based Analysis of Toxicokinetics and Kidney Toxicodynamics of Tetrachloroethylene.

Environ Health Perspect 2019 Jun 27;127(6):67011. Epub 2019 Jun 27.

1 Department of Veterinary Integrative Biosciences, Texas A&M University , College Station , Texas, USA.

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http://dx.doi.org/10.1289/EHP5105DOI Listing
June 2019

Thorough QT/QTc in a Dish: An In Vitro Human Model That Accurately Predicts Clinical Concentration-QTc Relationships.

Clin Pharmacol Ther 2019 May 2;105(5):1175-1186. Epub 2018 Dec 2.

Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, Texas, USA.

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http://doi.wiley.com/10.1002/cpt.1259
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http://dx.doi.org/10.1002/cpt.1259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465173PMC
May 2019

Long-Term Combinatorial Exposure to Trichloroethylene and Inorganic Arsenic in Genetically Heterogeneous Mice Results in Renal Tubular Damage and Cancer-Associated Molecular Changes.

G3 (Bethesda) 2019 05 7;9(5):1729-1737. Epub 2019 May 7.

Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843

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http://dx.doi.org/10.1534/g3.119.400161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505147PMC
May 2019

Population-Based Analysis of DNA Damage and Epigenetic Effects of 1,3-Butadiene in the Mouse.

Chem Res Toxicol 2019 May 25;32(5):887-898. Epub 2019 Apr 25.

Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences , Texas A&M University , College Station , Texas 77843 , United States.

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http://pubs.acs.org/doi/10.1021/acs.chemrestox.9b00035
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http://dx.doi.org/10.1021/acs.chemrestox.9b00035DOI Listing
May 2019

Sex-specific differences in genotoxic and epigenetic effects of 1,3-butadiene among mouse tissues.

Arch Toxicol 2019 Mar 14;93(3):791-800. Epub 2018 Dec 14.

Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA.

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http://dx.doi.org/10.1007/s00204-018-2374-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451682PMC
March 2019

Multi-dimensional in vitro bioactivity profiling for grouping of glycol ethers.

Regul Toxicol Pharmacol 2019 Feb 22;101:91-102. Epub 2018 Nov 22.

Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, 77843, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S02732300183030
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http://dx.doi.org/10.1016/j.yrtph.2018.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333527PMC
February 2019

Comparative analysis of metabolism of trichloroethylene and tetrachloroethylene among mouse tissues and strains.

Toxicology 2018 11 24;409:33-43. Epub 2018 Jul 24.

Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tox.2018.07.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186498PMC
November 2018

Chemistry-Wide Association Studies (CWAS): A Novel Framework for Identifying and Interpreting Structure-Activity Relationships.

J Chem Inf Model 2018 11 9;58(11):2203-2213. Epub 2018 Nov 9.

Laboratory for Molecular Modeling, UNC Eshelman School of Pharmacy , University of North Carolina , Chapel Hill , North Carolina 27599 , United States.

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http://pubs.acs.org/doi/10.1021/acs.jcim.8b00450
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http://dx.doi.org/10.1021/acs.jcim.8b00450DOI Listing
November 2018

Use of high-throughput in vitro toxicity screening data in cancer hazard evaluations by IARC Monograph Working Groups.

ALTEX 2018 24;35(1):51-64. Epub 2017 Jul 24.

Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, USA.

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http://dx.doi.org/10.14573/altex.1703231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783793PMC
August 2018

Incorporation of the glutathione conjugation pathway in an updated physiologically-based pharmacokinetic model for perchloroethylene in mice.

Toxicol Appl Pharmacol 2018 08 29;352:142-152. Epub 2018 May 29.

Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, USA. Electronic address:

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http://dx.doi.org/10.1016/j.taap.2018.05.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051410PMC
August 2018

High-Content Assay Multiplexing for Muscle Toxicity Screening in Human-Induced Pluripotent Stem Cell-Derived Skeletal Myoblasts.

Assay Drug Dev Technol 2018 Aug/Sep;16(6):333-342. Epub 2018 Aug 2.

Department of Veterinary Integrative Biosciences, Texas A&M University , College Station, Texas.

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http://dx.doi.org/10.1089/adt.2018.860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6114077PMC
August 2018

An empirical Bayes approach for multiple tissue eQTL analysis.

Biostatistics 2018 07;19(3):391-406

Department of Statistics and Operations Research, University of North Carolina at Chapel Hill, 318 E Cameron Ave, Chapel Hill, NC, 27599 USA.

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http://dx.doi.org/10.1093/biostatistics/kxx048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366007PMC
July 2018

gQTL: A Web Application for QTL Analysis Using the Collaborative Cross Mouse Genetic Reference Population.

G3 (Bethesda) 2018 07 31;8(8):2559-2562. Epub 2018 Jul 31.

Texas A&M Institute for Genome Sciences and Society

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http://dx.doi.org/10.1534/g3.118.200230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071593PMC
July 2018

High-Content Assay Multiplexing for Vascular Toxicity Screening in Induced Pluripotent Stem Cell-Derived Endothelial Cells and Human Umbilical Vein Endothelial Cells.

Assay Drug Dev Technol 2017 Aug/Sep;15(6):267-279. Epub 2017 Aug 3.

1 Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, Texas.

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http://dx.doi.org/10.1089/adt.2017.786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576216PMC
May 2018

Conditional Toxicity Value (CTV) Predictor: An Approach for Generating Quantitative Risk Estimates for Chemicals.

Environ Health Perspect 2018 05 29;126(5):057008. Epub 2018 May 29.

Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA

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http://dx.doi.org/10.1289/EHP2998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071978PMC
May 2018

Application of the key characteristics of carcinogens in cancer hazard identification.

Carcinogenesis 2018 04;39(4):614-622

Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA.

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http://dx.doi.org/10.1093/carcin/bgy031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888955PMC
April 2018

ToxPi Graphical User Interface 2.0: Dynamic exploration, visualization, and sharing of integrated data models.

BMC Bioinformatics 2018 03 5;19(1):80. Epub 2018 Mar 5.

Bioinformatics Research Center, Center for Human Health and the Environment, Department of Biological Sciences, North Carolina State University, Box 7566, 1 Lampe Drive, Raleigh, NC, 27695, USA.

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http://dx.doi.org/10.1186/s12859-018-2089-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838926PMC
March 2018

Advancing chemical risk assessment decision-making with population variability data: challenges and opportunities.

Mamm Genome 2018 02 3;29(1-2):182-189. Epub 2018 Jan 3.

Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, 77843, USA.

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http://dx.doi.org/10.1007/s00335-017-9731-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849521PMC
February 2018

Population-based dose-response analysis of liver transcriptional response to trichloroethylene in mouse.

Mamm Genome 2018 Feb 20;29(1-2):168-181. Epub 2018 Jan 20.

Department of Veterinary Integrative Biosciences, Texas A&M University, 4458 TAMU, College Station, Texas, 77843, USA.

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http://dx.doi.org/10.1007/s00335-018-9734-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094947PMC
February 2018

The Impact of Novel Assessment Methodologies in Toxicology on Green Chemistry and Chemical Alternatives.

Toxicol Sci 2018 02;161(2):276-284

Predictive Compound Safety and ADME, AstraZeneca Pharmaceuticals LP, Waltham, Massachusetts 02451.

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https://academic.oup.com/toxsci/article/161/2/276/4161475
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http://dx.doi.org/10.1093/toxsci/kfx196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837797PMC
February 2018

Tissue- and strain-specific effects of a genotoxic carcinogen 1,3-butadiene on chromatin and transcription.

Mamm Genome 2018 02 10;29(1-2):153-167. Epub 2018 Feb 10.

Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA.

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http://dx.doi.org/10.1007/s00335-018-9739-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095468PMC
February 2018

Effects of pirfenidone in acute and sub-chronic liver fibrosis, and an initiation-promotion cancer model in the mouse.

Toxicol Appl Pharmacol 2018 01 6;339:1-9. Epub 2017 Dec 6.

Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA. Electronic address:

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http://dx.doi.org/10.1016/j.taap.2017.11.024DOI Listing
January 2018

Characterization of inter-tissue and inter-strain variability of TCE glutathione conjugation metabolites DCVG, DCVC, and NAcDCVC in the mouse.

J Toxicol Environ Health A 2018 30;81(1-3):37-52. Epub 2017 Nov 30.

a Department of Veterinary Integrative Biosciences , Texas A&M University , College Station , TX , USA.

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http://dx.doi.org/10.1080/15287394.2017.1408512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6088749PMC
December 2017

A Pipeline for High-Throughput Concentration Response Modeling of Gene Expression for Toxicogenomics.

Front Genet 2017 1;8:168. Epub 2017 Nov 1.

Bioinformatics Research Center, North Carolina State University, Raleigh, NC, United States.

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http://dx.doi.org/10.3389/fgene.2017.00168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5672545PMC
November 2017

A tiered, Bayesian approach to estimating of population variability for regulatory decision-making.

ALTEX 2017 13;34(3):377-388. Epub 2016 Dec 13.

Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, USA.

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http://dx.doi.org/10.14573/altex.1608251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468494PMC
October 2017

MicroRNA deregulation in nonalcoholic steatohepatitis-associated liver carcinogenesis.

Oncotarget 2017 Oct 1;8(51):88517-88528. Epub 2017 Aug 1.

Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas, USA.

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http://dx.doi.org/10.18632/oncotarget.19774DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687623PMC
October 2017

Genetic and epigenetic determinants of inter-individual variability in responses to toxicants.

Curr Opin Toxicol 2017 Oct 12;6:50-59. Epub 2017 Sep 12.

Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, Texas.

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http://dx.doi.org/10.1016/j.cotox.2017.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739339PMC
October 2017

Editorial overview of the special issue on genomic toxicology epigenetics.

Curr Opin Toxicol 2017 Oct 30;6:i-iii. Epub 2017 Nov 30.

Division of Biochemical Toxicology, U.S. FDA-National Center for Toxicological Research, Jefferson, AR, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S24682020173015
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http://dx.doi.org/10.1016/j.cotox.2017.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875441PMC
October 2017

Epigenetic alterations induced by genotoxic occupational and environmental human chemical carcinogens: A systematic literature review.

Mutat Res Rev Mutat Res 2016 Apr-Jun;768:27-45. Epub 2016 Mar 31.

Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, USA. Electronic address:

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http://dx.doi.org/10.1016/j.mrrev.2016.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884606PMC
July 2017

miR-1247 blocks SOX9-mediated regeneration in alcohol- and fibrosis-associated acute kidney injury in mice.

Toxicology 2017 06 8;384:40-49. Epub 2017 Mar 8.

Division of Biochemical Toxicology, National Center for Toxicological Research 3900 NCTR Rd, Jefferson, AR 72079, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tox.2017.03.004DOI Listing
June 2017

Grouping of Petroleum Substances as Example UVCBs by Ion Mobility-Mass Spectrometry to Enable Chemical Composition-Based Read-Across.

Environ Sci Technol 2017 Jun 26;51(12):7197-7207. Epub 2017 May 26.

Department of Veterinary Integrative Biosciences, Texas A&M University , College Station, Texas 77843-4461, United States.

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http://dx.doi.org/10.1021/acs.est.6b06413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627358PMC
June 2017

Impact of Nonalcoholic Fatty Liver Disease on Toxicokinetics of Tetrachloroethylene in Mice.

J Pharmacol Exp Ther 2017 04 1;361(1):17-28. Epub 2017 Feb 1.

Department of Veterinary Integrative Biosciences (J.A.C; S.F; Y.S.L; Y.I; W.C; I.R), Texas A&M Institute for Genome Sciences and Society (K.K; D.W.T; I.R), Department of Environmental and Occupational Health (T.J.M), and Department of Molecular and Cellular Medicine (D.W.T), Texas A&M University, College Station, Texas; and National Center for Toxicological Research, US FDA, Jefferson, Arkansas (I.P)

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http://dx.doi.org/10.1124/jpet.116.238790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363767PMC
April 2017

Assessment of biological responses of EpiAirway 3-D cell constructs versus A549 cells for determining toxicity of ambient air pollution.

Inhal Toxicol 2016 ;28(6):251-9

a Department of Environmental Sciences & Engineering , University of North Carolina at Chapel Hill , Chapel Hill , NC, USA .

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http://dx.doi.org/10.3109/08958378.2016.1157227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913276PMC
January 2017

The role of microRNAs in the development and progression of chemical-associated cancers.

Toxicol Appl Pharmacol 2016 Dec 24;312:3-10. Epub 2015 Nov 24.

Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX 77843, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S0041008X153014
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http://dx.doi.org/10.1016/j.taap.2015.11.013DOI Listing
December 2016

Development of an Ion Mobility Spectrometry-Orbitrap Mass Spectrometer Platform.

Anal Chem 2016 12 1;88(24):12152-12160. Epub 2016 Dec 1.

Biological Sciences Division, Pacific Northwest National Laboratory , P.O. Box 999, Richland, Washington 99352, United States.

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http://dx.doi.org/10.1021/acs.analchem.6b03027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211177PMC
December 2016

A mouse model of alcoholic liver fibrosis-associated acute kidney injury identifies key molecular pathways.

Toxicol Appl Pharmacol 2016 Nov 15;310:129-139. Epub 2016 Sep 15.

Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, USA. Electronic address:

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http://dx.doi.org/10.1016/j.taap.2016.09.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323078PMC
November 2016

Target Organ Metabolism, Toxicity, and Mechanisms of Trichloroethylene and Perchloroethylene: Key Similarities, Differences, and Data Gaps.

J Pharmacol Exp Ther 2016 Oct 10;359(1):110-23. Epub 2016 Aug 10.

Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas (J.A.C., W.A.C., I.R.); International Agency for Research on Cancer, Lyon, France (K.Z.G., N.G.); Department of Pharmacology, Wayne State University School of Medicine, Detroit, Michigan (L.H.L.)

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034707PMC
http://dx.doi.org/10.1124/jpet.116.232629DOI Listing
October 2016

Cheminformatics-aided pharmacovigilance: application to Stevens-Johnson Syndrome.

J Am Med Inform Assoc 2016 09 24;23(5):968-78. Epub 2015 Oct 24.

Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, USA

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http://dx.doi.org/10.1093/jamia/ocv127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997030PMC
September 2016

Differences in the carcinogenic evaluation of glyphosate between the International Agency for Research on Cancer (IARC) and the European Food Safety Authority (EFSA).

Authors:
Christopher J Portier Bruce K Armstrong Bruce C Baguley Xaver Baur Igor Belyaev Robert Bellé Fiorella Belpoggi Annibale Biggeri Maarten C Bosland Paolo Bruzzi Lygia Therese Budnik Merete D Bugge Kathleen Burns Gloria M Calaf David O Carpenter Hillary M Carpenter Lizbeth López-Carrillo Richard Clapp Pierluigi Cocco Dario Consonni Pietro Comba Elena Craft Mohamed Aqiel Dalvie Devra Davis Paul A Demers Anneclaire J De Roos Jamie DeWitt Francesco Forastiere Jonathan H Freedman Lin Fritschi Caroline Gaus Julia M Gohlke Marcel Goldberg Eberhard Greiser Johnni Hansen Lennart Hardell Michael Hauptmann Wei Huang James Huff Margaret O James C W Jameson Andreas Kortenkamp Annette Kopp-Schneider Hans Kromhout Marcelo L Larramendy Philip J Landrigan Lawrence H Lash Dariusz Leszczynski Charles F Lynch Corrado Magnani Daniele Mandrioli Francis L Martin Enzo Merler Paola Michelozzi Lucia Miligi Anthony B Miller Dario Mirabelli Franklin E Mirer Saloshni Naidoo Melissa J Perry Maria Grazia Petronio Roberta Pirastu Ralph J Portier Kenneth S Ramos Larry W Robertson Theresa Rodriguez Martin Röösli Matt K Ross Deodutta Roy Ivan Rusyn Paulo Saldiva Jennifer Sass Kai Savolainen Paul T J Scheepers Consolato Sergi Ellen K Silbergeld Martyn T Smith Bernard W Stewart Patrice Sutton Fabio Tateo Benedetto Terracini Heinz W Thielmann David B Thomas Harri Vainio John E Vena Paolo Vineis Elisabete Weiderpass Dennis D Weisenburger Tracey J Woodruff Takashi Yorifuji Il Je Yu Paola Zambon Hajo Zeeb Shu-Feng Zhou

J Epidemiol Community Health 2016 08 3;70(8):741-5. Epub 2016 Mar 3.

College of Pharmacy, University of South Florida, Tampa, Florida, USA.

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http://dx.doi.org/10.1136/jech-2015-207005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975799PMC
August 2016

Differentially expressed MicroRNAs provide mechanistic insight into fibrosis-associated liver carcinogenesis in mice.

Mol Carcinog 2016 May 11;55(5):808-17. Epub 2015 Apr 11.

Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas.

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http://dx.doi.org/10.1002/mc.22323DOI Listing
May 2016

Characterization of copy number alterations in a mouse model of fibrosis-associated hepatocellular carcinoma reveals concordance with human disease.

Cancer Med 2016 Mar 18;5(3):574-85. Epub 2016 Jan 18.

Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, Texas, 77843.

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http://dx.doi.org/10.1002/cam4.606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4799957PMC
March 2016

In vitro screening for population variability in toxicity of pesticide-containing mixtures.

Environ Int 2015 Dec 19;85:147-55. Epub 2015 Sep 19.

Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, NC, USA; Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, USA. Electronic address:

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http://dx.doi.org/10.1016/j.envint.2015.09.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773193PMC
December 2015

High-Content Assay Multiplexing for Toxicity Screening in Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Hepatocytes.

Assay Drug Dev Technol 2015 Nov 5;13(9):529-46. Epub 2015 Nov 5.

1 Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University , College Station, Texas.

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http://dx.doi.org/10.1089/adt.2015.659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652224PMC
November 2015

IARC monographs: 40 years of evaluating carcinogenic hazards to humans.

Authors:
Neil Pearce Aaron Blair Paolo Vineis Wolfgang Ahrens Aage Andersen Josep M Anto Bruce K Armstrong Andrea A Baccarelli Frederick A Beland Amy Berrington Pier Alberto Bertazzi Linda S Birnbaum Ross C Brownson John R Bucher Kenneth P Cantor Elisabeth Cardis John W Cherrie David C Christiani Pierluigi Cocco David Coggon Pietro Comba Paul A Demers John M Dement Jeroen Douwes Ellen A Eisen Lawrence S Engel Richard A Fenske Lora E Fleming Tony Fletcher Elizabeth Fontham Francesco Forastiere Rainer Frentzel-Beyme Lin Fritschi Michel Gerin Marcel Goldberg Philippe Grandjean Tom K Grimsrud Per Gustavsson Andy Haines Patricia Hartge Johnni Hansen Michael Hauptmann Dick Heederik Kari Hemminki Denis Hemon Irva Hertz-Picciotto Jane A Hoppin James Huff Bengt Jarvholm Daehee Kang Margaret R Karagas Kristina Kjaerheim Helge Kjuus Manolis Kogevinas David Kriebel Petter Kristensen Hans Kromhout Francine Laden Pierre Lebailly Grace LeMasters Jay H Lubin Charles F Lynch Elsebeth Lynge Andrea 't Mannetje Anthony J McMichael John R McLaughlin Loraine Marrett Marco Martuzzi James A Merchant Enzo Merler Franco Merletti Anthony Miller Franklin E Mirer Richard Monson Karl-Cristian Nordby Andrew F Olshan Marie-Elise Parent Frederica P Perera Melissa J Perry Angela Cecilia Pesatori Roberta Pirastu Miquel Porta Eero Pukkala Carol Rice David B Richardson Leonard Ritter Beate Ritz Cecile M Ronckers Lesley Rushton Jennifer A Rusiecki Ivan Rusyn Jonathan M Samet Dale P Sandler Silvia de Sanjose Eva Schernhammer Adele Seniori Costantini Noah Seixas Carl Shy Jack Siemiatycki Debra T Silverman Lorenzo Simonato Allan H Smith Martyn T Smith John J Spinelli Margaret R Spitz Lorann Stallones Leslie T Stayner Kyle Steenland Mark Stenzel Bernard W Stewart Patricia A Stewart Elaine Symanski Benedetto Terracini Paige E Tolbert Harri Vainio John Vena Roel Vermeulen Cesar G Victora Elizabeth M Ward Clarice R Weinberg Dennis Weisenburger Catharina Wesseling Elisabete Weiderpass Shelia Hoar Zahm

Environ Health Perspect 2015 Jun 24;123(6):507-14. Epub 2015 Feb 24.

Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, United Kingdom.

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http://dx.doi.org/10.1289/ehp.1409149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455595PMC
June 2015

Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: liver effects.

J Toxicol Environ Health A 2015 ;78(1):15-31

a Department of Environmental Sciences and Engineering , University of North Carolina at Chapel Hill , Chapel Hill , North Carolina , USA.

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http://dx.doi.org/10.1080/15287394.2015.958417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281929PMC
January 2015

Epigenetic events determine tissue-specific toxicity of inhalational exposure to the genotoxic chemical 1,3-butadiene in male C57BL/6J mice.

Toxicol Sci 2014 Dec 18;142(2):375-84. Epub 2014 Sep 18.

*Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, North Carolina 27599, Division of Biochemical Toxicology, National Center for Toxicological Research, FDA, Jefferson, Arkansas 72079 and Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455

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http://toxsci.oxfordjournals.org/cgi/doi/10.1093/toxsci/kfu1
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http://dx.doi.org/10.1093/toxsci/kfu191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250847PMC
December 2014

High-content assays for hepatotoxicity using induced pluripotent stem cell-derived cells.

Assay Drug Dev Technol 2014 Jan-Feb;12(1):43-54. Epub 2013 Nov 14.

1 Molecular Devices, LLC , Sunnyvale, California.

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http://dx.doi.org/10.1089/adt.2013.520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934660PMC
October 2014

Prediction of binding affinity and efficacy of thyroid hormone receptor ligands using QSAR and structure-based modeling methods.

Toxicol Appl Pharmacol 2014 Oct 21;280(1):177-89. Epub 2014 Jul 21.

Laboratory for Molecular Modeling, Division of Chemical Biology and Medicinal Chemistry, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address:

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http://dx.doi.org/10.1016/j.taap.2014.07.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814443PMC
October 2014

The DEN and CCl4 -Induced Mouse Model of Fibrosis and Inflammation-Associated Hepatocellular Carcinoma.

Curr Protoc Pharmacol 2014 Sep 2;66:14.30.1-10. Epub 2014 Sep 2.

Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, North Carolina; Strategic Development Department, Shionogi & Co, Osaka, Japan.

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http://dx.doi.org/10.1002/0471141755.ph1430s66DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214366PMC
September 2014

Genetic and epigenetic changes in fibrosis-associated hepatocarcinogenesis in mice.

Int J Cancer 2014 Jun 14;134(12):2778-88. Epub 2013 Dec 14.

Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, NC.

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http://dx.doi.org/10.1002/ijc.28610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209252PMC
June 2014

Co-regulation of primary mouse hepatocyte viability and function by oxygen and matrix.

Biotechnol Bioeng 2014 May 31;111(5):1018-27. Epub 2014 Jan 31.

Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Room 16-429, Cambridge, Massachusetts, 02139.

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http://dx.doi.org/10.1002/bit.25152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110975PMC
May 2014

Physiologically based pharmacokinetic (PBPK) modeling of interstrain variability in trichloroethylene metabolism in the mouse.

Environ Health Perspect 2014 May 11;122(5):456-63. Epub 2014 Feb 11.

National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Washington, DC, USA.

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http://dx.doi.org/10.1289/ehp.1307623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014769PMC
May 2014

Mechanisms of HCV-induced liver cancer: what did we learn from in vitro and animal studies?

Cancer Lett 2014 Apr 18;345(2):210-5. Epub 2013 Jul 18.

Division of Infectious Diseases, Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1016/j.canlet.2013.06.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844040PMC
April 2014

A systematic approach for identifying and presenting mechanistic evidence in human health assessments.

Regul Toxicol Pharmacol 2013 Nov 16;67(2):266-77. Epub 2013 Aug 16.

Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.

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http://dx.doi.org/10.1016/j.yrtph.2013.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818152PMC
November 2013

Integrative chemical-biological read-across approach for chemical hazard classification.

Chem Res Toxicol 2013 Aug 5;26(8):1199-208. Epub 2013 Aug 5.

Laboratory for Molecular Modeling, Division of Chemical Biology and Medicinal Chemistry, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818153PMC
August 2013

Strain-dependent dysregulation of one-carbon metabolism in male mice is associated with choline- and folate-deficient diet-induced liver injury.

FASEB J 2013 Jun 25;27(6):2233-43. Epub 2013 Feb 25.

Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA.

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http://dx.doi.org/10.1096/fj.12-227116DOI Listing
June 2013

models for liver toxicity testing.

Toxicol Res (Camb) 2013 Jan 23;2(1):23-39. Epub 2012 Nov 23.

Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, NC 27599, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3593300PMC
January 2013