Publications by authors named "Ivan Iossifov"

32Publications

N-terminal variant Asp14Asn of the human p70 S6 Kinase 1 enhances translational signaling causing different effects in developing and mature neuronal cells.

Neurobiol Learn Mem 2020 05 5;171:107203. Epub 2020 Mar 5.

Centre for Brain Development and Repair, Institute for Stem Cell Science and Regenerative Medicine, GKVK Post, Bellary Road, Bangalore, India. Electronic address:

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http://dx.doi.org/10.1016/j.nlm.2020.107203DOI Listing
May 2020

Damaging de novo mutations diminish motor skills in children on the autism spectrum.

Proc Natl Acad Sci U S A 2018 02 6;115(8):E1859-E1866. Epub 2018 Feb 6.

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724.

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http://dx.doi.org/10.1073/pnas.1715427115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828599PMC
February 2018

Measuring shared variants in cohorts of discordant siblings with applications to autism.

Proc Natl Acad Sci U S A 2017 07 19;114(27):7073-7076. Epub 2017 Jun 19.

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724;

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http://dx.doi.org/10.1073/pnas.1700439114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502605PMC
July 2017

Genome-wide variant analysis of simplex autism families with an integrative clinical-bioinformatics pipeline.

Cold Spring Harb Mol Case Stud 2015 Oct;1(1):a000422

Stanley Institute for Cognitive Genomics, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA;; Graduate Genetics Program, Stony Brook University, Stony Brook, New York 11794, USA;; Utah Foundation for Biomedical Research, Salt Lake City, Utah 84107, USA.

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http://dx.doi.org/10.1101/mcs.a000422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850892PMC
October 2015

Low load for disruptive mutations in autism genes and their biased transmission.

Proc Natl Acad Sci U S A 2015 Oct 23;112(41):E5600-7. Epub 2015 Sep 23.

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724; New York Genome Center, New York, NY 10013;

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http://dx.doi.org/10.1073/pnas.1516376112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4611648PMC
October 2015

Reducing INDEL calling errors in whole genome and exome sequencing data.

Genome Med 2014 28;6(10):89. Epub 2014 Oct 28.

Stanley Institute for Cognitive Genomics, Cold Spring Harbor Laboratory, One Bungtown Road, Cold Spring Harbor, NY USA ; Stony Brook University, 100 Nicolls Rd, Stony Brook, NY USA.

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http://schatzlab.cshl.edu/presentations/2014.11.08.Indel%20E
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http://genomemedicine.com/content/6/10/89
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http://dx.doi.org/10.1186/s13073-014-0089-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4240813PMC
November 2014

Accurate de novo and transmitted indel detection in exome-capture data using microassembly.

Nat Methods 2014 Oct 17;11(10):1033-6. Epub 2014 Aug 17.

Simons Center for Quantitative Biology, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.

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http://dx.doi.org/10.1038/nmeth.3069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180789PMC
October 2014

Target-independent prediction of drug synergies using only drug lipophilicity.

J Chem Inf Model 2014 Aug 1;54(8):2286-93. Epub 2014 Aug 1.

Faculty of Engineering and Natural Sciences, Biological Sciences and Bioengineering Program, ⊥Faculty of Engineering and Natural Sciences, Computer Science and Engineering Program, and ▽Nanotechnology Research and Application Center, Sabanci University , Istanbul 34956, Turkey.

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http://dx.doi.org/10.1021/ci500276xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144720PMC
August 2014

Large-scale identification and analysis of suppressive drug interactions.

Chem Biol 2014 Apr 3;21(4):541-551. Epub 2014 Apr 3.

Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada; Center for Cancer Systems Biology, Dana-Farber Cancer Institute, One Jimmy Fund Way, Boston, MA 02215, USA; Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, ON M5G 1X5, Canada; Departments of Molecular Genetics and Computer Science, University of Toronto, Toronto, ON M5S 3E1, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2014.02.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281482PMC
April 2014

The role of de novo mutations in the genetics of autism spectrum disorders.

Nat Rev Genet 2014 Feb 16;15(2):133-41. Epub 2014 Jan 16.

Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA.

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http://dx.doi.org/10.1038/nrg3585DOI Listing
February 2014

A comparative analysis of exome capture.

Genome Biol 2011 Sep 29;12(9):R97. Epub 2011 Sep 29.

Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA.

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http://dx.doi.org/10.1186/gb-2011-12-9-r97DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308060PMC
September 2011

Rare de novo variants associated with autism implicate a large functional network of genes involved in formation and function of synapses.

Neuron 2011 Jun;70(5):898-907

Center for Computational Biology and Bioinformatics and Department of Biomedical Informatics, Columbia University, 1130 St. Nicolas Ave, New York, NY 10032, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S08966273110043
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http://dx.doi.org/10.1016/j.neuron.2011.05.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607702PMC
June 2011

Looking at cerebellar malformations through text-mined interactomes of mice and humans.

PLoS Comput Biol 2009 Nov 6;5(11):e1000559. Epub 2009 Nov 6.

Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America.

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https://dx.plos.org/10.1371/journal.pcbi.1000559
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http://dx.doi.org/10.1371/journal.pcbi.1000559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2767227PMC
November 2009

Figure mining for biomedical research.

Bioinformatics 2009 Aug 13;25(16):2082-4. Epub 2009 May 13.

Systems Biology, Pfizer Inc., Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1093/bioinformatics/btp318DOI Listing
August 2009

Genetic-linkage mapping of complex hereditary disorders to a whole-genome molecular-interaction network.

Genome Res 2008 Jul 16;18(7):1150-62. Epub 2008 Apr 16.

Department of Biomedical Informatics, Center for Computational Biology and Bioinformatics, Columbia University, New York, New York 10032, USA.

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http://dx.doi.org/10.1101/gr.075622.107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2493404PMC
July 2008

Imitating manual curation of text-mined facts in biomedicine.

PLoS Comput Biol 2006 Sep 27;2(9):e118. Epub 2006 Jul 27.

Department of Electrical Engineering, Columbia University, New York, New York, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.0020118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1560402PMC
September 2006

Microparadigms: chains of collective reasoning in publications about molecular interactions.

Proc Natl Acad Sci U S A 2006 Mar 16;103(13):4940-5. Epub 2006 Mar 16.

Department of Biomedical Informatics, Columbia Genome Center, Columbia University, New York, NY 10032, USA.

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http://dx.doi.org/10.1073/pnas.0600591103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1402650PMC
March 2006

Emergent behavior of growing knowledge about molecular interactions.

Nat Biotechnol 2005 Oct;23(10):1243-7

Department of Biological Sciences, Columbia University, New York, New York 10032, USA.

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http://dx.doi.org/10.1038/nbt1005-1243DOI Listing
October 2005

Probabilistic inference of molecular networks from noisy data sources.

Bioinformatics 2004 May 10;20(8):1205-13. Epub 2004 Feb 10.

Department of Medical Informatics, Columbia University, New York, NY 10032, USA.

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http://dx.doi.org/10.1093/bioinformatics/bth061DOI Listing
May 2004

Of truth and pathways: chasing bits of information through myriads of articles.

Bioinformatics 2002 ;18 Suppl 1:S249-57

Department of Medical Informatics, Columbia University, New York, NY 10032, USA.

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http://dx.doi.org/10.1093/bioinformatics/18.suppl_1.s249DOI Listing
October 2004