Publications by authors named "Iva Gunnarsson"

100Publications

Plasma C4d Correlates With C4d Deposition in Kidneys and With Treatment Response in Lupus Nephritis Patients.

Front Immunol 2020 2;11:582737. Epub 2020 Oct 2.

Department of Medicine, Division of Rheumatology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.3389/fimmu.2020.582737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7561717PMC
October 2020

Treatment of rheumatic immune-related adverse events due to cancer immunotherapy with immune checkpoint inhibitors-is it time for a paradigm shift?

Clin Rheumatol 2020 Sep 28. Epub 2020 Sep 28.

Rheumatology Unit, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s10067-020-05420-wDOI Listing
September 2020

Identifying novel B-cell targets for chronic inflammatory autoimmune disease by screening of chemical probes in a patient-derived cell assay.

Transl Res 2020 Sep 22. Epub 2020 Sep 22.

Division of Rheumatology, Department of Medicine Solna, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.trsl.2020.09.003DOI Listing
September 2020

Proteinase 3 Autoreactivity in Anti-Neutrophil Cytoplasmic Antibody-associated vasculitis-Immunological versus clinical features.

Scand J Immunol 2020 Nov;92(5):e12958

Division of Rheumatology, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1111/sji.12958DOI Listing
November 2020

Contributions of de novo variants to systemic lupus erythematosus.

Eur J Hum Genet 2020 Jul 28. Epub 2020 Jul 28.

Department of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University, 751 23, Uppsala, Sweden.

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http://dx.doi.org/10.1038/s41431-020-0698-5DOI Listing
July 2020

Anti-Inflammatory Properties of Chemical Probes in Human Whole Blood: Focus on Prostaglandin E Production.

Front Pharmacol 2020 6;11:613. Epub 2020 May 6.

Division of Rheumatology, Department of Medicine, Solna, Karolinska Institutet, and Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.3389/fphar.2020.00613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218097PMC
May 2020

The binding of SLE autoantibodies to mitochondria.

Clin Immunol 2020 03 24;212:108349. Epub 2020 Jan 24.

Unit of Rheumatology, Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.clim.2020.108349DOI Listing
March 2020

Comment on: Sudanese and Swedish patients with systemic lupus erythematosus, immunological and clinical comparisons: reply.

Rheumatology (Oxford) 2020 06;59(6):1454-1455

Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala.

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http://dx.doi.org/10.1093/rheumatology/kez477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244775PMC
June 2020

Sjögren Syndrome in Systemic Lupus Erythematosus: A Subset Characterized by a Systemic Inflammatory State.

J Rheumatol 2020 06 15;47(6):865-875. Epub 2019 Sep 15.

From the Department of Medicine Solna, Division of Rheumatology, Karolinska Institutet, Stockholm; Karolinska University Hospital, Stockholm; Karolinska Institutet/AstraZeneca Integrated Cardio Metabolic Centre (KI-AZ ICMC), Stockholm; Department of Medicine Solna, Division of Immunology and Allergy, Karolinska Institutet, Stockholm; Center for Clinical Research, Uppsala University, Sörmland; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala; Cardiovascular, Renal and Metabolism, Innovative Medicines and Early Development (IMED) Biotech Unit, AstraZeneca, Huddinge, Sweden.

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http://dx.doi.org/10.3899/jrheum.190250DOI Listing
June 2020

Microparticles Expressing Myeloperoxidase and Complement C3a and C5a as Markers of Renal Involvement in Antineutrophil Cytoplasmic Antibody-associated Vasculitis.

J Rheumatol 2020 05 1;47(5):714-721. Epub 2019 Aug 1.

From the Division of Rheumatology, Department of Medicine, Department of Molecular Medicine and Surgery, Clinical Chemistry, and Renal Medicine, Karolinska Institutet; Rheumatology, Karolinska University Hospital; CLINTEC Karolinska University Hospital, Renal Medicine, Karolinska Institutet, Stockholm; Department of Medical Sciences, Uppsala University, Uppsala, Sweden; Department of Pediatrics, Medical Faculty, University of Niš, Niš, Serbia.

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http://dx.doi.org/10.3899/jrheum.181347DOI Listing
May 2020

Microparticles in the blood of patients with SLE: Size, content of mitochondria and role in circulating immune complexes.

J Autoimmun 2019 08 16;102:142-149. Epub 2019 May 16.

Unit of Rheumatology, Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, SE-171 76, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.jaut.2019.05.003DOI Listing
August 2019

High levels of circulating interferons type I, type II and type III associate with distinct clinical features of active systemic lupus erythematosus.

Arthritis Res Ther 2019 04 29;21(1):107. Epub 2019 Apr 29.

Rheumatology Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, SE-171 76, Stockholm, Sweden.

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http://dx.doi.org/10.1186/s13075-019-1878-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6489203PMC
April 2019

Cytokine Profiles in Autoantibody Defined Subgroups of Systemic Lupus Erythematosus.

J Proteome Res 2019 03 18;18(3):1208-1217. Epub 2019 Feb 18.

Computational Life Science Cluster (CLiC), Department of Chemistry , Umeå University , 901 87 Umeå , Sweden.

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http://dx.doi.org/10.1021/acs.jproteome.8b00811DOI Listing
March 2019

B cell alterations during BAFF inhibition with belimumab in SLE.

EBioMedicine 2019 Feb 26;40:517-527. Epub 2018 Dec 26.

Department of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, 171 76 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2018.12.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412067PMC
February 2019

Clinical SLEDAI-2K zero may be a pragmatic outcome measure in SLE studies.

Expert Opin Biol Ther 2019 02 27;19(2):157-168. Epub 2018 Dec 27.

a Division of Rheumatology, Department of Medicine , Karolinska Institutet , Stockholm , Sweden.

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http://dx.doi.org/10.1080/14712598.2019.1561856DOI Listing
February 2019

The Impact of Belimumab and Rituximab on Health-Related Quality of Life in Patients With Systemic Lupus Erythematosus.

Arthritis Care Res (Hoboken) 2019 06;71(6):811-821

Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1002/acr.23718DOI Listing
June 2019

Smoking reduces the efficacy of belimumab in mucocutaneous lupus.

Expert Opin Biol Ther 2018 08 9;18(8):911-920. Epub 2018 Jul 9.

a Division of Rheumatology, Department of Medicine , Karolinska Institutet , Stockholm , Sweden.

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http://dx.doi.org/10.1080/14712598.2018.1494719DOI Listing
August 2018

TNF-α and plasma albumin as biomarkers of disease activity in systemic lupus erythematosus.

Lupus Sci Med 2018 4;5(1):e000260. Epub 2018 Jun 4.

Rheumatology Unit, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1136/lupus-2018-000260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018889PMC
June 2018

Kynurenine pathway is altered in patients with SLE and associated with severe fatigue.

Lupus Sci Med 2018 23;5(1):e000254. Epub 2018 May 23.

Rheumatology Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1136/lupus-2017-000254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976103PMC
May 2018

Autoimmune reactivity to malondialdehyde adducts in systemic lupus erythematosus is associated with disease activity and nephritis.

Arthritis Res Ther 2018 02 26;20(1):36. Epub 2018 Feb 26.

Department of Medicine, Rheumatology Unit, Karolinska Institutet and Karolinska University Hospital, Center for Molecular Medicine, Stockholm, Sweden.

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http://dx.doi.org/10.1186/s13075-018-1530-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827973PMC
February 2018

Depressed serum IgM levels in SLE are restricted to defined subgroups.

Clin Immunol 2017 10 15;183:304-315. Epub 2017 Sep 15.

Department of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.clim.2017.09.013DOI Listing
October 2017

Multivariate strategy for the sample selection and integration of multi-batch data in metabolomics.

Metabolomics 2017 24;13(10):114. Epub 2017 Aug 24.

Computational Life Science Cluster (CLiC), Department of Chemistry, Umeå University, 901 81 Umeå, Sweden.

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http://dx.doi.org/10.1007/s11306-017-1248-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570768PMC
August 2017

Transancestral mapping and genetic load in systemic lupus erythematosus.

Authors:
Carl D Langefeld Hannah C Ainsworth Deborah S Cunninghame Graham Jennifer A Kelly Mary E Comeau Miranda C Marion Timothy D Howard Paula S Ramos Jennifer A Croker David L Morris Johanna K Sandling Jonas Carlsson Almlöf Eduardo M Acevedo-Vásquez Graciela S Alarcón Alejandra M Babini Vicente Baca Anders A Bengtsson Guillermo A Berbotto Marc Bijl Elizabeth E Brown Hermine I Brunner Mario H Cardiel Luis Catoggio Ricard Cervera Jorge M Cucho-Venegas Solbritt Rantapää Dahlqvist Sandra D'Alfonso Berta Martins Da Silva Iñigo de la Rúa Figueroa Andrea Doria Jeffrey C Edberg Emőke Endreffy Jorge A Esquivel-Valerio Paul R Fortin Barry I Freedman Johan Frostegård Mercedes A García Ignacio García de la Torre Gary S Gilkeson Dafna D Gladman Iva Gunnarsson Joel M Guthridge Jennifer L Huggins Judith A James Cees G M Kallenberg Diane L Kamen David R Karp Kenneth M Kaufman Leah C Kottyan László Kovács Helle Laustrup Bernard R Lauwerys Quan-Zhen Li Marco A Maradiaga-Ceceña Javier Martín Joseph M McCune David R McWilliams Joan T Merrill Pedro Miranda José F Moctezuma Swapan K Nath Timothy B Niewold Lorena Orozco Norberto Ortego-Centeno Michelle Petri Christian A Pineau Bernardo A Pons-Estel Janet Pope Prithvi Raj Rosalind Ramsey-Goldman John D Reveille Laurie P Russell José M Sabio Carlos A Aguilar-Salinas Hugo R Scherbarth Raffaella Scorza Michael F Seldin Christopher Sjöwall Elisabet Svenungsson Susan D Thompson Sergio M A Toloza Lennart Truedsson Teresa Tusié-Luna Carlos Vasconcelos Luis M Vilá Daniel J Wallace Michael H Weisman Joan E Wither Tushar Bhangale Jorge R Oksenberg John D Rioux Peter K Gregersen Ann-Christine Syvänen Lars Rönnblom Lindsey A Criswell Chaim O Jacob Kathy L Sivils Betty P Tsao Laura E Schanberg Timothy W Behrens Earl D Silverman Marta E Alarcón-Riquelme Robert P Kimberly John B Harley Edward K Wakeland Robert R Graham Patrick M Gaffney Timothy J Vyse

Nat Commun 2017 07 17;8:16021. Epub 2017 Jul 17.

Divisions of Genetics and Molecular Medicine and Immunology, Infection and Inflammatory Diseases, King's College London, Guy's Hospital, London SE1 9RT, UK.

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http://dx.doi.org/10.1038/ncomms16021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520018PMC
July 2017

IFN-λ1 with Th17 axis cytokines and IFN-α define different subsets in systemic lupus erythematosus (SLE).

Arthritis Res Ther 2017 06 15;19(1):139. Epub 2017 Jun 15.

Rheumatology Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, SE-171 76, Stockholm, Sweden.

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http://dx.doi.org/10.1186/s13075-017-1344-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471711PMC
June 2017

A single nucleotide polymorphism in the gene leading to reduced oxidative burst is associated with systemic lupus erythematosus.

Ann Rheum Dis 2017 Sep 12;76(9):1607-1613. Epub 2017 Jun 12.

Division of Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1136/annrheumdis-2017-211287DOI Listing
September 2017

Smoking and pre-existing organ damage reduce the efficacy of belimumab in systemic lupus erythematosus.

Autoimmun Rev 2017 Apr 13;16(4):343-351. Epub 2017 Feb 13.

Department of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.autrev.2017.02.005DOI Listing
April 2017

Cross-cultural validation of Lupus Impact Tracker in five European clinical practice settings.

Rheumatology (Oxford) 2017 05;56(5):818-828

Department of Internal Medicine and Systemic Diseases, University Hospital of Dijon, 5bis INSERM U866 5ter INSERM CIC-EC 1432, Dijon, France.

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http://dx.doi.org/10.1093/rheumatology/kew492DOI Listing
May 2017

Effect of Corticosteroids and Cyclophosphamide on Sex Hormone Profiles in Male Patients With Systemic Lupus Erythematosus or Systemic Sclerosis.

Arthritis Rheumatol 2017 06 4;69(6):1272-1279. Epub 2017 May 4.

Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1002/art.40057DOI Listing
June 2017

Interferon (IFN)-λ is a potential mediator in lupus nephritis.

Lupus Sci Med 2016 22;3(1):e000170. Epub 2016 Nov 22.

Department of Medicine, Unit of Rheumatology , Karolinska University Hospital, Karolinska Institute , Stockholm , Sweden.

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http://dx.doi.org/10.1136/lupus-2016-000170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133405PMC
November 2016

Microparticles in the blood of patients with systemic lupus erythematosus (SLE): phenotypic characterization and clinical associations.

Sci Rep 2016 10 25;6:36025. Epub 2016 Oct 25.

Unit of Rheumatology, Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, SE-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1038/srep36025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078765PMC
October 2016

Ofatumumab treatment in lupus nephritis patients.

Clin Kidney J 2016 Aug 5;9(4):552-5. Epub 2016 Jun 5.

Department of Medicine, Rheumatology Unit , Karolinska Institute , Stockholm , Sweden.

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http://dx.doi.org/10.1093/ckj/sfw022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957712PMC
August 2016

Antiphospholipid Antibodies in Lupus Nephritis.

PLoS One 2016 23;11(6):e0158076. Epub 2016 Jun 23.

Department of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0158076PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919007PMC
July 2017

IL-17 and IL-23 in lupus nephritis - association to histopathology and response to treatment.

BMC Immunol 2015 Feb 12;16. Epub 2015 Feb 12.

Department of Medicine, Unit of Rheumatology, Karolinska University Hospital, Karolinska Institute, SE-171 76, Stockholm, Sweden.

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http://dx.doi.org/10.1186/s12865-015-0070-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326189PMC
February 2015

Cigarette smoking, antiphospholipid antibodies and vascular events in Systemic Lupus Erythematosus.

Ann Rheum Dis 2015 Aug 1;74(8):1537-43. Epub 2014 Apr 1.

Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1136/annrheumdis-2013-205159DOI Listing
August 2015

Genetic evidence for involvement of adaptive immunity in the development of IgA nephropathy: MHC class II alleles are protective in a Caucasian population.

Hum Immunol 2013 Aug 27;74(8):957-60. Epub 2013 Apr 27.

Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.humimm.2013.04.016DOI Listing
August 2013

Macrophage migration inhibitory factor (MIF) and thyroid hormone alterations in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).

Mol Med 2013 May 20;19:109-14. Epub 2013 May 20.

Department of Renal Medicine, Karolinska University Hospital, Department of Clinical Sciences, Intervention and Technology, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.2119/molmed.2012.00352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667215PMC
May 2013

Risk factors for cardiovascular mortality in patients with systemic lupus erythematosus, a prospective cohort study.

Arthritis Res Ther 2012 ;14(2):R46

Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Solna, Karolinska Institutet, SE-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1186/ar3759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060356PMC
May 2013

Renal expression and serum levels of high mobility group box 1 protein in lupus nephritis.

Arthritis Res Ther 2012 Feb 20;14(1):R36. Epub 2012 Feb 20.

Department of Medicine, Unit of Rheumatology, D2:00 Solna, Karolinska University Hospital, Karolinska Institute, S-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1186/ar3747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392835PMC
February 2012

Soluble interleukin-2 receptor alfa predicts renal outcome in IgA nephropathy.

Nephrol Dial Transplant 2012 May 22;27(5):1916-23. Epub 2011 Sep 22.

Nephrology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1093/ndt/gfr554DOI Listing
May 2012

Biologicals for the treatment of systemic lupus erythematosus?

Ann Med 2012 May 15;44(3):225-32. Epub 2011 Apr 15.

Department of Medicine, Rheumatology Unit, Karolinska University Hospital, the Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.3109/07853890.2011.561362DOI Listing
May 2012

Association of soluble CD89 levels with disease progression but not susceptibility in IgA nephropathy.

Kidney Int 2010 Dec 1;78(12):1281-7. Epub 2010 Sep 1.

Rheumatology Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital at Solna, Stockholm, Sweden.

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http://linkinghub.elsevier.com/retrieve/pii/S008525381554487
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http://dx.doi.org/10.1038/ki.2010.314DOI Listing
December 2010

Women's experience of SLE-related fatigue: a focus group interview study.

Rheumatology (Oxford) 2010 Oct 23;49(10):1935-42. Epub 2010 Jun 23.

Department of Neurobiology, Care Sciences and Society (NVS), Division of Nursing, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1093/rheumatology/keq174DOI Listing
October 2010

Copy number, linkage disequilibrium and disease association in the FCGR locus.

Hum Mol Genet 2010 Aug 27;19(16):3282-94. Epub 2010 May 27.

Department of Medicine, Cambridge Institute for Medical Research, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0XY, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2908468PMC
http://dx.doi.org/10.1093/hmg/ddq216DOI Listing
August 2010

Clinical improvements in proliferative vs membranous lupus nephritis following B-cell depletion: pooled data from two cohorts.

Rheumatology (Oxford) 2010 Aug 27;49(8):1502-4. Epub 2010 Apr 27.

Department of Medicine, Unit of Rheumatology, Karolinska University Hospital, Karolinska Institutet, S-171 76 Stockholm, Sweden.

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https://academic.oup.com/rheumatology/article-lookup/doi/10.
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http://dx.doi.org/10.1093/rheumatology/keq055DOI Listing
August 2010

Serum levels of autoantibodies against C-reactive protein correlate with renal disease activity and response to therapy in lupus nephritis.

Arthritis Res Ther 2009 11;11(6):R188. Epub 2009 Dec 11.

Rheumatology/AIR, Clinical and Experimental Medicine, Linköping University, SE-581 85 Linköping, Sweden.

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http://dx.doi.org/10.1186/ar2880DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003497PMC
May 2010