Iuliana Ionita-Laza

Iuliana Ionita-Laza

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Iuliana Ionita-Laza

Iuliana Ionita-Laza

Publications by authors named "Iuliana Ionita-Laza"

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A genome-wide scan statistic framework for whole-genome sequence data analysis.

Nat Commun 2019 07 9;10(1):3018. Epub 2019 Jul 9.

Department of Biostatistics, Columbia University, New York, NY, 10032, USA.

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http://dx.doi.org/10.1038/s41467-019-11023-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616627PMC
July 2019

Genomic Mismatch at Locus and Kidney Allograft Rejection.

N Engl J Med 2019 05;380(20):1918-1928

From the Department of Medicine, Division of Nephrology (N.J.S., Y.L., J.A.D., C.F., L.L., K.X., Y.-J.N., Y.D.N., J.Y.Z., R.S., O.B., D.B., N.O., F.O., S.G., K.M., J.W., S.M., J.R., D.J.C., J.B., A.G.G., K.K.), the Department of Surgery (L.E.R.), and the Department of Pathology and Cell Biology (E.-R.M.V., G.V., V.D.), Vagelos College of Physicians and Surgeons, and the Departments of Epidemiology (S.M.) and Biostatistics (I.I.-L.), Mailman School of Public Health, Columbia University, New York; Immunogenetics and Biology of Transplantation, Città della Salute e della Scienza, University Hospital of Turin, and Medical Genetics, Department of Medical Sciences, University of Turin, Turin (Z.D., S.D., A.A.), and the Division of Nephrology, Azienda Ospedaliera Spedali Civili of Brescia, Montichiari Hospital, University of Brescia, Brescia (F.S.) - all in Italy; the Department of Pathology, M.D. Anderson Cancer Center, Houston (F.Z.J.); the Division of Genetics and Genomics, Boston Children's Hospital, and the Department of Medical Oncology, Dana-Farber Cancer Institute, Boston (M.R.); the Department of Pediatrics, Division of Pediatric Nephrology, University of Michigan School of Medicine, Ann Arbor (C.E.G., M.G.S.); the Department of Medicine, Renal, Electrolyte, and Hypertension Division, University of Pennsylvania, Philadelphia (Y.-A.K., K.S.); the Division of Nephrology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey (Y.C.); the Nephrology Research Group, Queen's University of Belfast, Belfast, United Kingdom (A.E.C., A.P.M., A.J.M.); and the Department of Internal Medicine, Division of Nephrology (S.J.L.B., M.H.B.), and the Department of Epidemiology, Unit of Genetic Epidemiology and Bioinformatics (H.S.), University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

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http://dx.doi.org/10.1056/NEJMoa1803731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589355PMC
May 2019

Disease Heritability Inferred from Familial Relationships Reported in Medical Records.

Cell 2018 06 17;173(7):1692-1704.e11. Epub 2018 May 17.

Department of Biomedical Informatics, Columbia University, New York, NY, USA; Institute for Genomic Medicine, Columbia University, New York, NY, USA; Observational Health Data Sciences and Informatics (OHDSI), New York, NY, USA; Department of Medicine, Columbia University, New York, NY, USA; Department of Systems Biology, Columbia University, New York, NY, USA; Data Science Institute, Columbia University, New York, NY, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674183052
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http://dx.doi.org/10.1016/j.cell.2018.04.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015747PMC
June 2018

Rare-variant association tests in longitudinal studies, with an application to the Multi-Ethnic Study of Atherosclerosis (MESA).

Genet Epidemiol 2017 12 27;41(8):801-810. Epub 2017 Oct 27.

Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America.

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http://dx.doi.org/10.1002/gepi.22081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696115PMC
December 2017

Unified Sequence-Based Association Tests Allowing for Multiple Functional Annotations and Meta-analysis of Noncoding Variation in Metabochip Data.

Am J Hum Genet 2017 Sep 24;101(3):340-352. Epub 2017 Aug 24.

Department of Biostatistics, Columbia University, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2017.07.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590864PMC
September 2017

QRank: a novel quantile regression tool for eQTL discovery.

Bioinformatics 2017 Jul;33(14):2123-2130

Department of Biostatistics, Columbia University, New York, NY, USA.

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http://dx.doi.org/10.1093/bioinformatics/btx119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870877PMC
July 2017

Identification of candidate genes for familial early-onset essential tremor.

Eur J Hum Genet 2016 07 28;24(7):1009-15. Epub 2015 Oct 28.

Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.

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http://dx.doi.org/10.1038/ejhg.2015.228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070884PMC
July 2016

Quantile Regression in the Secondary Analysis of Case-Control Data.

J Am Stat Assoc 2016 5;111(513):344-354. Epub 2016 May 5.

Department of Medicine, New York University School of Medicine, New York, NY 10016.

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http://dx.doi.org/10.1080/01621459.2015.1008101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347118PMC
May 2016

A General and Robust Framework for Secondary Traits Analysis.

Genetics 2016 Apr 19;202(4):1329-43. Epub 2016 Feb 19.

Department of Biostatistics, Columbia University, New York, New York 10032.

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http://dx.doi.org/10.1534/genetics.115.181073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827729PMC
April 2016

De Novo Synonymous Mutations in Regulatory Elements Contribute to the Genetic Etiology of Autism and Schizophrenia.

Neuron 2016 Mar;89(5):940-7

Department of Psychiatry, Columbia University Medical Center, New York, NY 10032, USA; New York State Psychiatric Institute, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2016.02.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4793939PMC
March 2016

A spectral approach integrating functional genomic annotations for coding and noncoding variants.

Nat Genet 2016 Feb 4;48(2):214-20. Epub 2016 Jan 4.

Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

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http://dx.doi.org/10.1038/ng.3477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731313PMC
February 2016

Empirical Bayes scan statistics for detecting clusters of disease risk variants in genetic studies.

Biometrics 2015 Dec 1;71(4):1111-20. Epub 2015 Jun 1.

Department of Biostatistics, Columbia University, New York, New York 10032, U.S.A.

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http://dx.doi.org/10.1111/biom.12331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666841PMC
December 2015

Genetic variants within the serotonin transporter associated with familial risk for major depression.

Psychiatry Res 2015 Jul 18;228(1):170-3. Epub 2015 Apr 18.

Department of Psychiatry, Columbia University Medical Center, New York, NY, USA; Division of Epidemiology, New York State Psychiatric Institute, New York, NY, USA; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, USA; Sackler Institute for Developmental Psychobiology, Columbia University, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.psychres.2015.04.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451257PMC
July 2015

Identifying rare disease variants in the Genetic Analysis Workshop 17 simulated data: a comparison of several statistical approaches.

BMC Proc 2011 29;5 Suppl 9:S17. Epub 2011 Nov 29.

Department of Biostatistics, Mailman School of Public Health, Columbia University, 722 West 168th Street, New York, NY 10032, USA.

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http://dx.doi.org/10.1186/1753-6561-5-S9-S17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287851PMC
April 2015

Identification of rare causal variants in sequence-based studies: methods and applications to VPS13B, a gene involved in Cohen syndrome and autism.

PLoS Genet 2014 Dec 11;10(12):e1004729. Epub 2014 Dec 11.

Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America; Departments of Psychiatry, Mount Sinai School of Medicine, New York, New York, United States of America; Departments of Genetics and Genomic Sciences, and Neuroscience, and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America; Mindich Child Health and Development Institute, Mount Sinai School of Medicine, New York, New York, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1004729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263785PMC
December 2014

Comparing the power of family-based association tests for sequence data with applications in the GAW18 simulated data.

BMC Proc 2014 17;8(Suppl 1):S27. Epub 2014 Jun 17.

Department of Biostatistics, Columbia University, Mailman School of Public Health, New York City, NY 10032, USA.

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http://dx.doi.org/10.1186/1753-6561-8-S1-S27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143708PMC
December 2014

Small sample properties of rare variant analysis methods.

BMC Proc 2014 17;8(Suppl 1 Genetic Analysis Workshop 18Vanessa Olmo):S13. Epub 2014 Jun 17.

Department of Biostatistics, Columbia University, Mailman School of Public Health, New York, NY 10032, USA.

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http://dx.doi.org/10.1186/1753-6561-8-S1-S13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143716PMC
December 2014

Loss-of-function variants in schizophrenia risk and SETD1A as a candidate susceptibility gene.

Neuron 2014 May;82(4):773-80

Department of Psychiatry, Columbia University Medical Center, New York, NY 10032, USA; New York State Psychiatric Institute, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2014.04.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387883PMC
May 2014

Scan statistic-based analysis of exome sequencing data identifies FAN1 at 15q13.3 as a susceptibility gene for schizophrenia and autism.

Proc Natl Acad Sci U S A 2014 Jan 16;111(1):343-8. Epub 2013 Dec 16.

Departments of Biostatistics, Psychiatry, Neuroscience, Physiology, and Cellular Biophysics, Columbia University, New York, NY 10032.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1309475110
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http://dx.doi.org/10.1073/pnas.1309475110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890869PMC
January 2014

Essential Tremor in a Charcot-Marie-Tooth Type 2C Kindred Does Not Segregate with the TRPV4 R269H Mutation.

Case Rep Neurol 2014 Jan 22;6(1):1-6. Epub 2014 Jan 22.

Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, N.Y., USA ; Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, N.Y., USA.

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https://www.karger.com/Article/FullText/357665
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http://dx.doi.org/10.1159/000357665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934698PMC
January 2014

Family-based association tests for sequence data, and comparisons with population-based association tests.

Eur J Hum Genet 2013 Oct 6;21(10):1158-62. Epub 2013 Feb 6.

Department of Biostatistics, Columbia University, New York, NY, USA.

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http://dx.doi.org/10.1038/ejhg.2012.308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778346PMC
October 2013

Rare variant analysis for family-based design.

PLoS One 2013 15;8(1):e48495. Epub 2013 Jan 15.

Department of Biostatistics, Harvard University, Boston, MA, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0048495PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546113PMC
July 2013

Sequence kernel association tests for the combined effect of rare and common variants.

Am J Hum Genet 2013 Jun 16;92(6):841-53. Epub 2013 May 16.

Department of Biostatistics, Columbia University, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2013.04.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675243PMC
June 2013

Copy number variation genotyping using family information.

BMC Bioinformatics 2013 May 9;14:157. Epub 2013 May 9.

Channing Division of Network Medicine, Brigham and Women's Hospital, ,MA, USA.

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http://dx.doi.org/10.1186/1471-2105-14-157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668900PMC
May 2013

Does rate of progression run in essential tremor families? Slower vs. faster progressors.

Parkinsonism Relat Disord 2013 Mar 31;19(3):363-6. Epub 2012 Oct 31.

GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S13538020120038
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http://dx.doi.org/10.1016/j.parkreldis.2012.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578031PMC
March 2013

Domain-dependent clustering and genotype-phenotype analysis of LGI1 mutations in ADPEAF.

Neurology 2012 Feb 8;78(8):563-8. Epub 2012 Feb 8.

Department of Psychiatry, Columbia University, New York, NY, USA.

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http://dx.doi.org/10.1212/WNL.0b013e318247ccbfDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280014PMC
February 2012

Finding disease variants in Mendelian disorders by using sequence data: methods and applications.

Am J Hum Genet 2011 Dec 1;89(6):701-12. Epub 2011 Dec 1.

Department of Biostatistics, Columbia University, New York, NY 10032, USA.

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http://dx.doi.org/10.1016/j.ajhg.2011.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234377PMC
December 2011

Study designs for identification of rare disease variants in complex diseases: the utility of family-based designs.

Genetics 2011 Nov 11;189(3):1061-8. Epub 2011 Aug 11.

Department of Biostatistics, Columbia University, New York, New York 10032, USA.

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http://dx.doi.org/10.1534/genetics.111.131813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3213373PMC
November 2011

A new testing strategy to identify rare variants with either risk or protective effect on disease.

PLoS Genet 2011 Feb 3;7(2):e1001289. Epub 2011 Feb 3.

Department of Biostatistics, Columbia University, New York, New York, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1001289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033379PMC
February 2011

On the optimal design of genetic variant discovery studies.

Stat Appl Genet Mol Biol 2010 27;9:Article33. Epub 2010 Aug 27.

Columbia University, USA.

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http://dx.doi.org/10.2202/1544-6115.1581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2942028PMC
December 2010

Joint study of genetic regulators for expression traits related to breast cancer.

BMC Proc 2007 18;1 Suppl 1:S10. Epub 2007 Dec 18.

Department of Statistics, Columbia University, New York, New York 10027, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367474PMC
http://dx.doi.org/10.1186/1753-6561-1-s1-s10DOI Listing
December 2009

Constructing gene association networks for rheumatoid arthritis using the backward genotype-trait association (BGTA) algorithm.

BMC Proc 2007 18;1 Suppl 1:S13. Epub 2007 Dec 18.

Department of Statistics, Columbia University, New York, New York 10027, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367461PMC
http://dx.doi.org/10.1186/1753-6561-1-s1-s13DOI Listing
December 2009

On quality control measures in genome-wide association studies: a test to assess the genotyping quality of individual probands in family-based association studies and an application to the HapMap data.

PLoS Genet 2009 Jul 24;5(7):e1000572. Epub 2009 Jul 24.

Department of Biostatistics, University of Kentucky College of Public Health, Lexington, Kentucky, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1000572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2706974PMC
July 2009

Estimating the number of unseen variants in the human genome.

Proc Natl Acad Sci U S A 2009 Mar 10;106(13):5008-13. Epub 2009 Mar 10.

Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.0807815106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664058PMC
March 2009

Genetic association analysis of copy-number variation (CNV) in human disease pathogenesis.

Genomics 2009 Jan 19;93(1):22-6. Epub 2008 Oct 19.

Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.ygeno.2008.08.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2631358PMC
January 2009

On the frequency of copy number variants.

Bioinformatics 2008 Oct 8;24(20):2350-5. Epub 2008 Aug 8.

Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA.

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http://dx.doi.org/10.1093/bioinformatics/btn421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562008PMC
October 2008

On the analysis of copy-number variations in genome-wide association studies: a translation of the family-based association test.

Genet Epidemiol 2008 Apr;32(3):273-84

Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Boston, Massachusetts, USA.

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http://doi.wiley.com/10.1002/gepi.20302
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http://dx.doi.org/10.1002/gepi.20302DOI Listing
April 2008

Genomewide weighted hypothesis testing in family-based association studies, with an application to a 100K scan.

Am J Hum Genet 2007 Sep 17;81(3):607-14. Epub 2007 Jul 17.

Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S000292970761357
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http://dx.doi.org/10.1086/519748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950836PMC
September 2007