Publications by authors named "Itzhak Nissim"

50Publications

Association of Obesity With Maternal and Cord Blood Penicillin Levels in Women With Group B Streptococcus Colonization.

Obstet Gynecol 2020 10;136(4):756-764

Maternal and Child Health Research Center, Department of Obstetrics & Gynecology, and the Clinical Microbiology Laboratory, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Perelman School of Medicine, the Division of Genetics and Metabolism, Children's Hospital of Philadelphia, and the Department of Pediatrics, Biochemistry, and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania.

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October 2020

Malic Enzyme Couples Mitochondria with Aerobic Glycolysis in Osteoblasts.

Cell Rep 2020 09;32(10):108108

Translational Research Program in Pediatric Orthopedics, The Children's Hospital of Philadelphia, PA 19104, USA; Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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September 2020

Targeting glutamine metabolism slows soft tissue sarcoma growth.

Nat Commun 2020 01 24;11(1):498. Epub 2020 Jan 24.

Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.

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January 2020

Fructose-1,6-Bisphosphatase 2 Inhibits Sarcoma Progression by Restraining Mitochondrial Biogenesis.

Cell Metab 2020 01 21;31(1):174-188.e7. Epub 2019 Nov 21.

Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Development Biology, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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January 2020

Arginase 2 Suppresses Renal Carcinoma Progression via Biosynthetic Cofactor Pyridoxal Phosphate Depletion and Increased Polyamine Toxicity.

Cell Metab 2018 Jun 10;27(6):1263-1280.e6. Epub 2018 May 10.

Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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June 2018

Functional and Metabolomic Consequences of K Channel Inactivation in Human Islets.

Diabetes 2017 07 25;66(7):1901-1913. Epub 2017 Apr 25.

Division of Endocrinology and Diabetes, Department of Pediatrics, The Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA

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July 2017

Regulation of brain glutamate metabolism by nitric oxide and S-nitrosylation.

Sci Signal 2015 Jul 7;8(384):ra68. Epub 2015 Jul 7.

Neuroscience Graduate Group, University of Pennsylvania, Philadelphia, PA 19104, USA. Division of Neonatology, Department of Pediatrics, Children's Hospital of Philadelphia Research Institute, Philadelphia, PA 19104, USA. Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.

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July 2015

Fructose-1,6-bisphosphatase opposes renal carcinoma progression.

Nature 2014 Sep 20;513(7517):251-5. Epub 2014 Jul 20.

1] Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA [2] Howard Hughes Medical Institute, Philadelphia, Pennsylvania 19104, USA [3] Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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September 2014

mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic state.

Cell 2013 Feb 7;152(4):778-790. Epub 2013 Feb 7.

Department of Biology, University of Pennsylvania, 415 S. University Ave., Philadelphia, Pennsylvania 19104, USA.

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February 2013

Effects of a glucokinase activator on hepatic intermediary metabolism: study with 13C-isotopomer-based metabolomics.

Biochem J 2012 Jun;444(3):537-51

Division of Child Development and Metabolic Disease, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.

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June 2012

Down-regulation of hepatic urea synthesis by oxypurines: xanthine and uric acid inhibit N-acetylglutamate synthase.

J Biol Chem 2011 Jun 3;286(25):22055-68. Epub 2011 May 3.

Division of Child Development, Rehabilitation Medicine, and Metabolic Disease, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.

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June 2011

N-carbamylglutamate augments ureagenesis and reduces ammonia and glutamine in propionic acidemia.

Pediatrics 2010 Jul 21;126(1):e208-14. Epub 2010 Jun 21.

Research Center for Genetic Medicine, Children's National Medical Center, George Washington University, Washington, DC 20010, USA.

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July 2010

Measuring in vivo ureagenesis with stable isotopes.

Mol Genet Metab 2010 26;100 Suppl 1:S37-41. Epub 2010 Feb 26.

Children's Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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July 2010

Dietary branched chain amino acids ameliorate injury-induced cognitive impairment.

Proc Natl Acad Sci U S A 2010 Jan 7;107(1):366-71. Epub 2009 Dec 7.

Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.

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January 2010

Effects of a single dose of N-carbamylglutamate on the rate of ureagenesis.

Mol Genet Metab 2009 Dec 14;98(4):325-30. Epub 2009 Jul 14.

Research Center for Genetic Medicine, Children's National Medical Center, The George Washington University, Washington, DC 20010, USA.

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December 2009

Ketosis and brain handling of glutamate, glutamine, and GABA.

Epilepsia 2008 Nov;49 Suppl 8:73-5

Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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November 2008

Creatine synthesis: hepatic metabolism of guanidinoacetate and creatine in the rat in vitro and in vivo.

Am J Physiol Endocrinol Metab 2009 Feb 18;296(2):E256-61. Epub 2008 Nov 18.

Dept. of Biochemistry, Memorial Univ. of Newfoundland, St. John's, NL, Canada A1B3X9.

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February 2009

3-isobutylmethylxanthine inhibits hepatic urea synthesis: protection by agmatine.

J Biol Chem 2008 May 28;283(22):15063-71. Epub 2008 Mar 28.

Children's Hospital of Philadelphia, Division of Child Development, Department of Pediatrics, University of Pennsylvania School of Medicine, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA.

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May 2008

The ketogenic diet and brain metabolism of amino acids: relationship to the anticonvulsant effect.

Annu Rev Nutr 2007 ;27:415-30

Children's Hospital of Philadelphia and Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

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November 2007

Troglitazone and pioglitazone interactions via PPAR-gamma-independent and -dependent pathways in regulating physiological responses in renal tubule-derived cell lines.

Am J Physiol Cell Physiol 2007 Mar 25;292(3):C1137-46. Epub 2006 Oct 25.

Dept. of Medicine, Feist-Weiller Cancer Center, Louisiana State University Health Science Center, Shreveport, LA 71130, USA.

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March 2007

Ifosfamide-induced nephrotoxicity: mechanism and prevention.

Cancer Res 2006 Aug;66(15):7824-31

Children's Hospital of Philadelphia, Division of Child Development, Rehabilitation Medicine and Metabolic Disease, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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August 2006

Short-term fasting, seizure control and brain amino acid metabolism.

Neurochem Int 2006 May-Jun;48(6-7):650-6. Epub 2006 Feb 28.

Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, 19104, USA.

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June 2006

Agmatine stimulates hepatic fatty acid oxidation: a possible mechanism for up-regulation of ureagenesis.

J Biol Chem 2006 Mar 1;281(13):8486-96. Epub 2006 Feb 1.

Children's Hospital of Philadelphia, Division of Child Development, Rehabilitation Medicine, and Metabolic Disease, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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March 2006

Brain amino acid requirements and toxicity: the example of leucine.

J Nutr 2005 06;135(6 Suppl):1531S-8S

Children's Hospital of Philadelphia, Division of Child Development, Rehabilitation and Metabolic Disease, Department of Pediatrics, University of Pennsylvania School of Medicine, 19104, USA.

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June 2005

Response of brain amino acid metabolism to ketosis.

Neurochem Int 2005 Jul;47(1-2):119-28

Department of Pediatrics, University of Pennsylvania School of Medicine, Children's Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA.

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July 2005

The role of mitochondrially bound arginase in the regulation of urea synthesis: studies with [U-15N4]arginine, isolated mitochondria, and perfused rat liver.

J Biol Chem 2005 May 7;280(18):17715-24. Epub 2005 Mar 7.

Children's Hospital of Philadelphia, Division of Child Development and Rehabilitation Medicine, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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May 2005

Biosynthesis of agmatine in isolated mitochondria and perfused rat liver: studies with 15N-labelled arginine.

Biochem J 2005 Jun;388(Pt 2):419-25

Children's Hospital of Philadelphia, Division of Child Development and Rehabilitation Medicine, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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June 2005

Restoration of ureagenesis in N-acetylglutamate synthase deficiency by N-carbamylglutamate.

J Pediatr 2004 Oct;145(4):552-4

Children's Research Institute, Children's National Medical Center, The George Washington University, Washington, DC 20010, USA.

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October 2004

Ketogenic diet, brain glutamate metabolism and seizure control.

Prostaglandins Leukot Essent Fatty Acids 2004 Mar;70(3):277-85

Department of Pediatrics, University of Pennsylvania School of Medicine, Children's Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA.

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March 2004

A window into cellular metabolism: hepatic metabolism of (15)N-labelled substrates.

Metab Eng 2004 Jan;6(1):6-11

Department of Biochemistry, Memorial University of Newfoundland, St John's, NF, Canada A1B 3X9.

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January 2004

Preservation of complex I function during hypoxia-reoxygenation-induced mitochondrial injury in proximal tubules.

Am J Physiol Renal Physiol 2004 Apr 9;286(4):F749-59. Epub 2003 Dec 9.

Nephrology Div., Dept. of Internal Medicine, Rm. 1560, MSRB II, Univ. of Michigan Medical Ctr, Ann Arbor, MI 48109-0676, USA.

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April 2004

Troglitazone acts by PPARgamma and PPARgamma-independent pathways on LLC-PK1-F+ acid-base metabolism.

Am J Physiol Renal Physiol 2004 Jan 23;286(1):F100-10. Epub 2003 Sep 23.

Department of Molecular and Cellular Physiology, Louisiana State University Health Science Center, Shreveport, LA 71130, USA.

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January 2004

Role of the glutamate dehydrogenase reaction in furnishing aspartate nitrogen for urea synthesis: studies in perfused rat liver with 15N.

Biochem J 2003 Nov;376(Pt 1):179-88

Division of Child Development and Rehabilitation Medicine, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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November 2003

Metabolism of brain amino acids following pentylenetetrazole treatment.

Epilepsy Res 2003 Feb;53(1-2):151-62

Department of Pediatrics, Division of Child Development, School of Medicine, Children's Hospital of Philadelphia, University of Pennsylvania, 34th Street and Civic Center Blvd, Philadelphia, PA, USA.

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February 2003

Regulation of urea synthesis by agmatine in the perfused liver: studies with 15N.

Am J Physiol Endocrinol Metab 2002 Dec 13;283(6):E1123-34. Epub 2002 Aug 13.

Children's Hospital of Philadelphia and Division of Child Development and Rehabilitation, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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December 2002

Glitazones regulate glutamine metabolism by inducing a cellular acidosis in MDCK cells.

Am J Physiol Endocrinol Metab 2002 Oct;283(4):E729-37

Departments of Molecular and Cellular Physiology, Louisiana State University Health Science Center, Shreveport, Louisiana 71130, USA.

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October 2002

Application of 15N to the study of hepatic nitrogen metabolism.

Adv Enzyme Regul 2002 ;42:305-15

Department of Biochemistry, Memorial University of Newfoundland, St. John's, NF A1B 3X9, Canada.

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December 2002