Israel Vlodavsky

Israel Vlodavsky

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Israel Vlodavsky

Israel Vlodavsky

Publications by authors named "Israel Vlodavsky"

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Novel N-acetyl-Glycol-split heparin biotin-conjugates endowed with anti-heparanase activity.

Eur J Med Chem 2020 Jan 30;186:111831. Epub 2019 Oct 30.

Istituto di Ricerche Chimiche e Biochimiche G. Ronzoni, via G. Colombo, 81, 20133, Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2019.111831DOI Listing
January 2020

Heparanase Loosens E-Cadherin-Mediated Cell-Cell Contact via Activation of Src.

Front Oncol 2020 22;10. Epub 2020 Jan 22.

Rappaport Faculty of Medicine, Technion Integrated Cancer Center (TICC), Technion, Haifa, Israel.

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http://dx.doi.org/10.3389/fonc.2020.00002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6990126PMC
January 2020

Heparanase Accelerates Obesity-Associated Breast Cancer Progression.

Cancer Res 2019 Oct 3;79(20):5342-5354. Epub 2019 Sep 3.

Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-4058DOI Listing
October 2019

Heparanase promotes glioma progression via enhancing CD24 expression.

Int J Cancer 2019 09 14;145(6):1596-1608. Epub 2019 May 14.

Shantou University Medical College, Shantou, China.

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http://dx.doi.org/10.1002/ijc.32375DOI Listing
September 2019

Heparanase protects the heart against chemical or ischemia/reperfusion injury.

J Mol Cell Cardiol 2019 06 17;131:29-40. Epub 2019 Apr 17.

Faculty of Pharmaceutical Sciences, University of British Columbia, 2405 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2019.04.008DOI Listing
June 2019

The heparanase inhibitor PG545 is a potent anti-lymphoma drug: Mode of action.

Matrix Biol 2019 04 7;77:58-72. Epub 2018 Aug 7.

Cancer and Vascular Biology Research Center, Rappaport Faculty of Medicine, Technion, Haifa, Israel. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0945053X183017
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http://dx.doi.org/10.1016/j.matbio.2018.08.005DOI Listing
April 2019

Is host heparanase required for the rapid spread of heparan sulfate binding viruses?

Virology 2019 03 3;529:1-6. Epub 2019 Jan 3.

Cancer & Vascular Biology Group, ACRF Department of Cancer Biology and Therapeutics, The John Curtin School of Medical Research, The Australian National University, Canberra, Australia.

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http://dx.doi.org/10.1016/j.virol.2019.01.001DOI Listing
March 2019

Systemic LPS-induced Aβ-solubilization and clearance in AβPP-transgenic mice is diminished by heparanase overexpression.

Sci Rep 2019 03 14;9(1):4600. Epub 2019 Mar 14.

Department of Pharmacology, University of Oslo and Oslo University Hospital, Postboks 1057, Blindern, NO-0316, OSLO, Norway.

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http://dx.doi.org/10.1038/s41598-019-40999-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418119PMC
March 2019

Proteases and glycosidases on the surface of exosomes: Newly discovered mechanisms for extracellular remodeling.

Matrix Biol 2019 01 26;75-76:160-169. Epub 2017 Oct 26.

Cancer and Vascular Biology Research Center, Rappaport Faculty of Medicine, Technion, Haifa 31096, Israel.

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http://dx.doi.org/10.1016/j.matbio.2017.10.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920797PMC
January 2019

Specific Inhibition of Heparanase by a Glycopolymer with Well-Defined Sulfation Pattern Prevents Breast Cancer Metastasis in Mice.

ACS Appl Mater Interfaces 2019 Jan 31;11(1):244-254. Epub 2018 Dec 31.

Department of Chemistry , Wayne State University , Detroit , Michigan 48202 , United States.

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http://dx.doi.org/10.1021/acsami.8b17625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512314PMC
January 2019

Dendrimer Heparan Sulfate Glycomimetics: Potent Heparanase Inhibitors for Anticancer Therapy.

ACS Chem Biol 2018 12 29;13(12):3236-3242. Epub 2018 Nov 29.

Dept. of Biochemistry, Institute of Integrative Biology , University of Liverpool , Liverpool L69 7ZB , United Kingdom.

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http://dx.doi.org/10.1021/acschembio.8b00909DOI Listing
December 2018

Heparanase inhibitors restrain mesothelioma.

Oncotarget 2018 Dec 7;9(96):36830-36832. Epub 2018 Dec 7.

Department of Cardiothoracic Surgery, Langone Medical Center, New York University School of Medicine, New York, USA.

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http://dx.doi.org/10.18632/oncotarget.26243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305150PMC
December 2018

Overexpression of heparanase in mice promoted megakaryopoiesis.

Glycobiology 2018 05;28(5):269-275

Department of Medical Biochemistry and Microbiology, SciLifeLab Uppsala, The Biomedical Center, University of Uppsala, Husargatan 3, 75123 Uppsala, Sweden.

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http://dx.doi.org/10.1093/glycob/cwy011DOI Listing
May 2018

Patient derived xenografts (PDX) predict an effective heparanase-based therapy for lung cancer.

Oncotarget 2018 Apr 10;9(27):19294-19306. Epub 2018 Apr 10.

Cancer and Vascular Biology Research Center, Rappaport Faculty of Medicine, Technion, Haifa, Israel.

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http://dx.doi.org/10.18632/oncotarget.25022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922397PMC
April 2018

Supersulfated low-molecular weight heparin synergizes with IGF1R/IR inhibitor to suppress synovial sarcoma growth and metastases.

Cancer Lett 2018 02 7;415:187-197. Epub 2017 Dec 7.

Department of Applied Research and Technological Development, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Amadeo 42, 20133 Milan, Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03043835173077
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http://dx.doi.org/10.1016/j.canlet.2017.12.009DOI Listing
February 2018

Targeting heparanase to the mammary epithelium enhances mammary gland development and promotes tumor growth and metastasis.

Matrix Biol 2018 01 13;65:91-103. Epub 2017 Sep 13.

Cancer and Vascular Biology Research Center, Bruce Rappaport Faculty of Medicine, Technion, Haifa 31096, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.matbio.2017.08.005DOI Listing
January 2018

Dual effects of hyperglycemia on endothelial cells and cardiomyocytes to enhance coronary LPL activity.

Am J Physiol Heart Circ Physiol 2018 01 6;314(1):H82-H94. Epub 2017 Oct 6.

Faculty of Pharmaceutical Sciences, The University of British Columbia , Vancouver, British Columbia , Canada.

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http://dx.doi.org/10.1152/ajpheart.00372.2017DOI Listing
January 2018

Opposing Functions of Heparanase-1 and Heparanase-2 in Cancer Progression.

Trends Biochem Sci 2018 01 20;43(1):18-31. Epub 2017 Nov 20.

University of Alabama at Birmingham, Department of Pathology, Birmingham, AL 35294, USA.

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http://dx.doi.org/10.1016/j.tibs.2017.10.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741533PMC
January 2018

Inhibition of Heparanase in Pediatric Brain Tumor Cells Attenuates their Proliferation, Invasive Capacity, and Tumor Growth.

Mol Cancer Ther 2017 08 17;16(8):1705-1716. Epub 2017 Jul 17.

Department of Immunology, Genetics and Pathology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1158/1535-7163.MCT-16-0900DOI Listing
August 2017

Heparanase Overexpression Reduces Hepcidin Expression, Affects Iron Homeostasis and Alters the Response to Inflammation.

PLoS One 2016 6;11(10):e0164183. Epub 2016 Oct 6.

Molecular Biology laboratory, Department of Molecular and Translational Medicine DMMT, University of Brescia, Viale Europa 11, 25123, Brescia, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0164183PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053418PMC
June 2017

Loss of VEGFB and its signaling in the diabetic heart is associated with increased cell death signaling.

Am J Physiol Heart Circ Physiol 2017 Jun 17;312(6):H1163-H1175. Epub 2017 Mar 17.

Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, British Columbia, Canada; and

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http://dx.doi.org/10.1152/ajpheart.00659.2016DOI Listing
June 2017

Overexpression of heparanase enhances T lymphocyte activities and intensifies the inflammatory response in a model of murine rheumatoid arthritis.

Sci Rep 2017 04 12;7:46229. Epub 2017 Apr 12.

Department of Medical Biochemistry and Microbiology, University of Uppsala, The Biomedical Center, Box 582, SE-751 23 Uppsala, Sweden.

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http://dx.doi.org/10.1038/srep46229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388921PMC
April 2017

The Heparanase Inhibitor PG545 Attenuates Colon Cancer Initiation and Growth, Associating with Increased p21 Expression.

Neoplasia 2017 03 29;19(3):175-184. Epub 2017 Jan 29.

Department of Gastroenterology, Rambam Health Care Campus and Bruce Rappaport School of Medicine, Technion, Haifa 3109601, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2016.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5279702PMC
March 2017

Overexpression of heparanase attenuated TGF-β-stimulated signaling in tumor cells.

FEBS Open Bio 2017 Mar 11;7(3):405-413. Epub 2017 Feb 11.

Department of Medical Biochemistry and Microbiology and SciLifeLab University of Uppsala Sweden.

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http://dx.doi.org/10.1002/2211-5463.12190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5337900PMC
March 2017

Heparanase regulation of cancer, autophagy and inflammation: new mechanisms and targets for therapy.

FEBS J 2017 01 16;284(1):42-55. Epub 2016 Nov 16.

Cancer and Vascular Biology Research Center, Rappaport Faculty of Medicine, Technion, Haifa, Israel.

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http://dx.doi.org/10.1111/febs.13932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226874PMC
January 2017

Heparanase Promotes Glioma Progression and Is Inversely Correlated with Patient Survival.

Mol Cancer Res 2016 12 26;14(12):1243-1253. Epub 2016 Aug 26.

Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1158/1541-7786.MCR-16-0223DOI Listing
December 2016

High glucose facilitated endothelial heparanase transfer to the cardiomyocyte modifies its cell death signature.

Cardiovasc Res 2016 12;112(3):656-668

Faculty of Pharmaceutical Sciences, The University of British Columbia, 2405 Wesbrook Mall, Vancouver, BC, Canada V6T 1Z3

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http://dx.doi.org/10.1093/cvr/cvw211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5157136PMC
December 2016

Heparanase is required for activation and function of macrophages.

Proc Natl Acad Sci U S A 2016 11 14;113(48):E7808-E7817. Epub 2016 Nov 14.

Cancer and Vascular Biology Research Center, Bruce Rappaport Faculty of Medicine, Technion, Haifa 31096, Israel;

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http://dx.doi.org/10.1073/pnas.1611380113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137702PMC
November 2016

Heparanase: From basic research to therapeutic applications in cancer and inflammation.

Drug Resist Updat 2016 11 6;29:54-75. Epub 2016 Oct 6.

Cancer and Vascular Biology Research Center, Rappaport Faculty of Medicine, Technion, Haifa 31096, Israel.

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https://linkinghub.elsevier.com/retrieve/pii/S13687646163004
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http://dx.doi.org/10.1016/j.drup.2016.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447241PMC
November 2016

Heparanase and cancer progression: New directions, new promises.

Hum Vaccin Immunother 2016 09 7;12(9):2253-6. Epub 2016 Apr 7.

a Cancer and Vascular Biology Research Center, Rappaport Faculty of Medicine, Technion , Haifa , Israel.

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http://dx.doi.org/10.1080/21645515.2016.1171442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027699PMC
September 2016

Chemotherapy induces expression and release of heparanase leading to changes associated with an aggressive tumor phenotype.

Matrix Biol 2016 09 22;55:22-34. Epub 2016 Mar 22.

Department of Pathology, University of Alabama at Birmingham, AL, USA; Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.matbio.2016.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033659PMC
September 2016

Heparanase expression upregulates platelet adhesion activity and thrombogenicity.

Oncotarget 2016 Jun;7(26):39486-39496

Department of Medical Biochemistry and Microbiology, SciLifeLab Uppsala, The Biomedical Center, University of Uppsala, Husargatan, Uppsala, Sweden.

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http://dx.doi.org/10.18632/oncotarget.8960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129947PMC
June 2016

Function from within: Autophagy induction by HPSE/heparanase--new possibilities for intervention.

Autophagy 2015 ;11(12):2387-9

a Cancer and Vascular Biology Research Center; the Bruce Rappaport Faculty of Medicine ; Technion ; Haifa , Israel.

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http://dx.doi.org/10.1080/15548627.2015.1115174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835213PMC
May 2016

Heparanase 2 Attenuates Head and Neck Tumor Vascularity and Growth.

Cancer Res 2016 05 24;76(9):2791-801. Epub 2016 Mar 24.

Cancer and Vascular Biology Research Center, The Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-1975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873389PMC
May 2016

Heparanase Is Essential for the Development of Acute Experimental Glomerulonephritis.

Am J Pathol 2016 Apr 9;186(4):805-15. Epub 2016 Feb 9.

Department of Nephrology, Radboud University Medical Center, Nijmegen, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2015.12.008DOI Listing
April 2016

Heparanase 2 expression inversely correlates with bladder carcinoma grade and stage.

Oncotarget 2016 Apr;7(16):22556-65

Cancer and Vascular Biology Research Center, Rappaport Faculty of Medicine, Technion, Haifa, Israel.

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http://dx.doi.org/10.18632/oncotarget.8003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008381PMC
April 2016

Nephroprotective effect of heparanase in experimental nephrotic syndrome.

PLoS One 2015 18;10(3):e0119610. Epub 2015 Mar 18.

Research Unit, Rambam Health Care Campus, Haifa, Israel; Department of Physiology, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0119610PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364762PMC
February 2016

Cardiomyocyte VEGF Regulates Endothelial Cell GPIHBP1 to Relocate Lipoprotein Lipase to the Coronary Lumen During Diabetes Mellitus.

Arterioscler Thromb Vasc Biol 2016 Jan 19;36(1):145-55. Epub 2015 Nov 19.

From the Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, British Columbia, Canada (A.P.-L.C., A.W., N.L., D.Z., F.W., B.H., B.R.); and Cancer and Vascular Biology Research Center, Rappaport Faculty of Medicine, Technion, Haifa, Israel (I.V.).

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http://dx.doi.org/10.1161/ATVBAHA.115.306774DOI Listing
January 2016

Heparanase-neutralizing antibodies attenuate lymphoma tumor growth and metastasis.

Proc Natl Acad Sci U S A 2016 Jan 4;113(3):704-9. Epub 2016 Jan 4.

Cancer and Vascular Biology Research Center, Rappaport Faculty of Medicine, Technion, Haifa 31096, Israel;

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http://dx.doi.org/10.1073/pnas.1519453113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725485PMC
January 2016

Heparanase Enhances Tumor Growth and Chemoresistance by Promoting Autophagy.

Cancer Res 2015 Sep 6;75(18):3946-57. Epub 2015 Aug 6.

Cancer and Vascular Biology Research Center, the Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-0037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573896PMC
September 2015

Mammary Branching Morphogenesis Requires Reciprocal Signaling by Heparanase and MMP-14.

J Cell Biochem 2015 Aug;116(8):1668-79

Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, 94720.

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http://dx.doi.org/10.1002/jcb.25127DOI Listing
August 2015

Heparanase of murine effector lymphocytes and neutrophils is not required for their diapedesis into sites of inflammation.

FASEB J 2015 May 29;29(5):2010-21. Epub 2015 Jan 29.

*Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel; and Cancer and Vascular Biology Research Center, The Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel

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http://dx.doi.org/10.1096/fj.14-265447DOI Listing
May 2015

Antitumor properties of a new non-anticoagulant heparin analog from the mollusk Nodipecten nodosus: Effect on P-selectin, heparanase, metastasis and cellular recruitment.

Glycobiology 2015 Apr 3;25(4):386-93. Epub 2014 Nov 3.

Laboratório de Bioquímica e Biologia Celular de Glicoconjugados, Programa de Glicobiologia, Instituto de Bioquímica Médica Leopoldo de Meis and Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941 913, Brazil

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http://dx.doi.org/10.1093/glycob/cwu119DOI Listing
April 2015

A mouse model of urofacial syndrome with dysfunctional urination.

Hum Mol Genet 2015 Apr 15;24(7):1991-9. Epub 2014 Dec 15.

Departments of Urology and Pathology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA, Department of Surgery, Harvard Medical School, Boston, MA, USA,

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http://dx.doi.org/10.1093/hmg/ddu613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355027PMC
April 2015

Overexpression of heparanase lowers the amyloid burden in amyloid-β precursor protein transgenic mice.

J Biol Chem 2015 Feb 29;290(8):5053-64. Epub 2014 Dec 29.

the Department of Medical Biochemistry and Microbiology, SciLifeLab Uppsala, The Biomedical Center, University of Uppsala, Box 582, Husargatan 3, 75123 Uppsala, Sweden,

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http://dx.doi.org/10.1074/jbc.M114.600569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335241PMC
February 2015

Involvement of Heparanase in Empyema: Implication for Novel Therapeutic Approaches.

J Clin Cell Immunol 2015 Feb;6(1)

Cancer and Vascular Biology Research Center, Rappaport Faculty of Medicine, Technion, Haifa, Israel.

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http://dx.doi.org/10.4172/2155-9899.1000290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441338PMC
February 2015

Processing of heparanase is mediated by syndecan-1 cytoplasmic domain and involves syntenin and α-actinin.

Cell Mol Life Sci 2014 Nov 1;71(22):4457-70. Epub 2014 May 1.

Cancer and Vascular Biology Research Center, the Bruce Rappaport Faculty of Medicine, Technion, 9649, 31096, Haifa, Israel.

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http://dx.doi.org/10.1007/s00018-014-1629-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209210PMC
November 2014

Heparanase interacts with resistin and augments its activity.

PLoS One 2014 21;9(1):e85944. Epub 2014 Jan 21.

Cancer and Vascular Biology Research Center, The Rappaport Faculty of Medicine, Technion, Haifa, Israel.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0085944PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897609PMC
October 2014

Heparanase expression in Langerhans cell histiocytosis.

Pediatr Blood Cancer 2014 Oct 15;61(10):1883-5. Epub 2014 Apr 15.

Department of Pediatric Hemato-Oncology, Tel-Aviv Sourasky Medical Center affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

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http://dx.doi.org/10.1002/pbc.25046DOI Listing
October 2014

Endothelial cell heparanase taken up by cardiomyocytes regulates lipoprotein lipase transfer to the coronary lumen after diabetes.

Diabetes 2014 Aug 7;63(8):2643-55. Epub 2014 Mar 7.

Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, BC, Canada

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http://dx.doi.org/10.2337/db13-1842DOI Listing
August 2014

Heparanase cooperates with Ras to drive breast and skin tumorigenesis.

Cancer Res 2014 Aug 26;74(16):4504-14. Epub 2014 Jun 26.

Cancer and Vascular Biology Research Center, The Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-2962DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134691PMC
August 2014

Endothelial cells respond to hyperglycemia by increasing the LPL transporter GPIHBP1.

Am J Physiol Endocrinol Metab 2014 Jun 15;306(11):E1274-83. Epub 2014 Apr 15.

Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada; and

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http://ajpendo.physiology.org/content/ajpendo/306/11/E1274.f
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http://ajpendo.physiology.org/content/ajpendo/early/2014/04/
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http://ajpendo.physiology.org/cgi/doi/10.1152/ajpendo.00007.
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http://dx.doi.org/10.1152/ajpendo.00007.2014DOI Listing
June 2014

The potential of heparanase as a therapeutic target in cancer.

Biochem Pharmacol 2014 May 22;89(1):12-9. Epub 2014 Feb 22.

Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2014.02.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709407PMC
May 2014

Expression of heparanase in soft tissue sarcomas of adults.

J Exp Clin Cancer Res 2014 May 10;33:39. Epub 2014 May 10.

Division of Oncology, Rambam Health Care Campus, 8 Ha'Aliyah Street, Haifa 35254, Israel.

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http://dx.doi.org/10.1186/1756-9966-33-39DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026817PMC
May 2014

Hyperglycemia-induced secretion of endothelial heparanase stimulates a vascular endothelial growth factor autocrine network in cardiomyocytes that promotes recruitment of lipoprotein lipase.

Arterioscler Thromb Vasc Biol 2013 Dec 10;33(12):2830-8. Epub 2013 Oct 10.

From the Faculty of Pharmaceutical Sciences (D.Z., A.W., A.P.-L.C., Y.W., F.W., K.N., N.L., B.R.), and Department of Cellular and Physiological Sciences (M.J.B., J.D.J.), University of British Columbia, Canada; and Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Israel (I.V.).

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http://dx.doi.org/10.1161/ATVBAHA.113.302222DOI Listing
December 2013

Heparanase: multiple functions in inflammation, diabetes and atherosclerosis.

Matrix Biol 2013 Jun 7;32(5):220-2. Epub 2013 Mar 7.

Cancer and Vascular Biology Research Center, The Rappaport Faculty of Medicine and, Research Institute, Technion, Haifa, Israel.

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http://dx.doi.org/10.1016/j.matbio.2013.03.001DOI Listing
June 2013

Involvement of heparanase in atherosclerosis and other vessel wall pathologies.

Matrix Biol 2013 Jun 13;32(5):241-51. Epub 2013 Mar 13.

Cancer and Vascular Biology Research Center, The Rappaport Faculty of Medicine and Research Institute, Technion, Haifa, Israel.

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http://dx.doi.org/10.1016/j.matbio.2013.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959806PMC
June 2013

The heparanase/syndecan-1 axis in cancer: mechanisms and therapies.

FEBS J 2013 May 4;280(10):2294-306. Epub 2013 Mar 4.

Department of Pathology, University of Alabama at Birmingham, AL 35294, USA.

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http://dx.doi.org/10.1111/febs.12168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651779PMC
May 2013

Endothelial heparanase regulates heart metabolism by stimulating lipoprotein lipase secretion from cardiomyocytes.

Arterioscler Thromb Vasc Biol 2013 May 7;33(5):894-902. Epub 2013 Mar 7.

Faculty of Pharmaceutical Sciences, The University of British Columbia, 2405 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 1Z3.

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http://dx.doi.org/10.1161/ATVBAHA.113.301309DOI Listing
May 2013

Heparanase regulates secretion, composition, and function of tumor cell-derived exosomes.

J Biol Chem 2013 Apr 21;288(14):10093-9. Epub 2013 Feb 21.

Department of Pathology, University of Alabama, Birmingham, Alabama 35294, USA.

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http://dx.doi.org/10.1074/jbc.C112.444562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617250PMC
April 2013

Characterization of heparanase-induced phosphatidylinositol 3-kinase-AKT activation and its integrin dependence.

J Biol Chem 2013 Apr 15;288(17):12366-75. Epub 2013 Mar 15.

Department of Medical Biochemistry and Microbiology, Uppsala University, 75123 Uppsala, Sweden.

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http://dx.doi.org/10.1074/jbc.M112.435172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636920PMC
April 2013

Inhibition of matrix metalloproteinase-2 by halofuginone is mediated by the Egr1 transcription factor.

Anticancer Drugs 2012 Nov;23(10):1022-31

Sharett Institute, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

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http://dx.doi.org/10.1097/CAD.0b013e328357d186DOI Listing
November 2012

Heparanase overexpression impairs inflammatory response and macrophage-mediated clearance of amyloid-β in murine brain.

Acta Neuropathol 2012 Oct 13;124(4):465-78. Epub 2012 Jun 13.

Department of Public Health and Caring Sciences, Molecular Geriatrics, Rudbeck Laboratory, University of Uppsala, Sweden.

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http://dx.doi.org/10.1007/s00401-012-0997-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444710PMC
October 2012

Dissociation between mature phenotype and impaired transmigration in dendritic cells from heparanase-deficient mice.

PLoS One 2012 10;7(5):e35602. Epub 2012 May 10.

The Laboratory for Cellular and Molecular Immunology, Department of Medicine, Rheumatology Research Center, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0035602PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349677PMC
September 2012

Significance of heparanase in cancer and inflammation.

Cancer Microenviron 2012 Aug 3;5(2):115-32. Epub 2011 Aug 3.

Cancer and Vascular Biology Research Center, The Rappaport Faculty of Medicine, Technion, P. O. Box 9649, Haifa, 31096, Israel,

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http://link.springer.com/10.1007/s12307-011-0082-7
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http://dx.doi.org/10.1007/s12307-011-0082-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399068PMC
August 2012

Heparanase overexpression reduces carrageenan-induced mechanical and cold hypersensitivity in mice.

Neurosci Lett 2012 Mar 31;511(1):4-7. Epub 2011 Dec 31.

Department of Physiology and Pharmacology, Section of Integrative Pain Research, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.neulet.2011.12.038DOI Listing
March 2012

Heparanase affects secretory granule homeostasis of murine mast cells through degrading heparin.

J Allergy Clin Immunol 2011 Dec 14;128(6):1310-1317.e8. Epub 2011 May 14.

Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1016/j.jaci.2011.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160500PMC
December 2011

Heparanase is highly expressed and regulates proliferation in GH-secreting pituitary tumor cells.

Endocrinology 2011 Dec 18;152(12):4562-70. Epub 2011 Oct 18.

Institute of Endocrinology, Felsenstein Medical Research Center, Rabin Medical Center, Beilinson Campus, Petach Tikva 49100, Israel.

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http://dx.doi.org/10.1210/en.2011-0273DOI Listing
December 2011

Sulfated hexasaccharides attenuate metastasis by inhibition of P-selectin and heparanase.

Neoplasia 2011 May;13(5):445-52

Zürich Center for Integrative Human Physiology, Institute of Physiology, University of Zürich, Zürich, Switzerland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084621PMC
http://dx.doi.org/10.1593/neo.101734DOI Listing
May 2011