Isidro Ferrer

Isidro Ferrer

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Isidro Ferrer

Publications by authors named "Isidro Ferrer"

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Familial globular glial tauopathy linked to MAPT mutations: molecular neuropathology and seeding capacity of a prototypical mixed neuronal and glial tauopathy.

Acta Neuropathol 2020 Jan 6. Epub 2020 Jan 6.

CIBERNED (Network Centre of Biomedical Research of Neurodegenerative Diseases), Ministry of Economy and Competitiveness, Institute of Health Carlos III, Madrid, Spain.

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http://dx.doi.org/10.1007/s00401-019-02122-9DOI Listing
January 2020

Role of tau N-terminal motif in the secretion of human tau by End Binding proteins.

PLoS One 2019 22;14(1):e0210864. Epub 2019 Jan 22.

Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Madrid, Spain, CIEN Foundation, Queen Sofia Foundation Alzheimer Center, Madrid, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210864PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342323PMC
October 2019

Wnt Signaling Alterations in the Human Spinal Cord of Amyotrophic Lateral Sclerosis Cases: Spotlight on Fz2 and Wnt5a.

Mol Neurobiol 2019 Oct 28;56(10):6777-6791. Epub 2019 Mar 28.

Molecular Neurology Group, Hospital Nacional de Parapléjicos (HNP), Finca la Peraleda s/n, 45071, Toledo, Spain.

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http://dx.doi.org/10.1007/s12035-019-1547-9DOI Listing
October 2019

Brain pyrimidine nucleotide synthesis and Alzheimer disease.

Aging (Albany NY) 2019 Sep 27;11(19):8433-8462. Epub 2019 Sep 27.

Departamento de Bioquímica, Biología Molecular y Celular, Universidad de Zaragoza, Zaragoza, Spain.

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http://dx.doi.org/10.18632/aging.102328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814620PMC
September 2019

Relevance of host tau in tau seeding and spreading in tauopathies.

Brain Pathol 2019 Aug 9. Epub 2019 Aug 9.

CIBERNED (Network Centre of Biomedical Research of Neurodegenerative Diseases), Institute of Health Carlos III, Ministry of Economy and Competitiveness, Madrid, Spain.

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http://dx.doi.org/10.1111/bpa.12778DOI Listing
August 2019

Sisyphus in Neverland.

Authors:
Isidro Ferrer

J Alzheimers Dis 2018 ;62(3):1023-1047

Department of Pathology and Experimental Therapeutics, University of Barcelona; Service of Pathological Anatomy, Bellvitge University Hospital; CIBERNED; Hospitalet de Llobregat, Barcelona, Spain.

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http://www.medra.org/servlet/aliasResolver?alias=iospress&am
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http://dx.doi.org/10.3233/JAD-170609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870014PMC
May 2019

Lipids and lipoxidation in human brain aging. Mitochondrial ATP-synthase as a key lipoxidation target.

Redox Biol 2019 05 19;23:101082. Epub 2018 Dec 19.

Department of Experimental Medicine, University of Lleida-Institute for Research in Biomedicine of Lleida (UdL-IRBLleida), Lleida, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2018.101082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859548PMC
May 2019

Hereditary primary lateral sclerosis and progressive nonfluent aphasia.

J Neurol 2019 May 5;266(5):1079-1090. Epub 2019 Mar 5.

Department of Neurology, Hospital Universitario Marqués de Valdecilla (IDIVAL), University of Cantabria, CIBERNED, Santander, Spain.

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http://link.springer.com/10.1007/s00415-019-09235-x
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http://dx.doi.org/10.1007/s00415-019-09235-xDOI Listing
May 2019

Involvement of Oligodendrocytes in Tau Seeding and Spreading in Tauopathies.

Front Aging Neurosci 2019 28;11:112. Epub 2019 May 28.

CIBERNED (Network Centre of Biomedical Research of Neurodegenerative Diseases), Institute of Health Carlos III, Ministry of Economy and Competitiveness, Madrid, Spain.

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http://dx.doi.org/10.3389/fnagi.2019.00112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546889PMC
May 2019

Differential Aggregation and Phosphorylation of Alpha Synuclein in Membrane Compartments Associated With Parkinson Disease.

Front Neurosci 2019 24;13:382. Epub 2019 Apr 24.

Laboratory of Cellular Neurobiology, Department of Basic Medical Sciences, Section of Medicine, Faculty of Health Sciences, University of La Laguna, Santa Cruz de Tenerife, Spain.

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http://dx.doi.org/10.3389/fnins.2019.00382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491821PMC
April 2019

Altered gene transcription linked to astrocytes and oligodendrocytes in frontal cortex in Creutzfeldt-Jakob disease.

Prion 2018 27;12(3-4):216-225. Epub 2018 Jul 27.

a Department of Pathology and Experimental Therapeutics , University of Barcelona.

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http://dx.doi.org/10.1080/19336896.2018.1500076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277179PMC
February 2019

Cerebrospinal fluid neurofilament light in suspected sporadic Creutzfeldt-Jakob disease.

J Clin Neurosci 2019 Feb 9;60:124-127. Epub 2018 Oct 9.

Department of Neurology, University Medical School, Göttingen, Germany; Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Institute Carlos III, Ministry of Health, L'Hospitalet de Llobregat, Spain; Bellvitge Biomedical Research Institute (IDBELL), L'Hospitalet de Llobregat, Spain. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09675868183145
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http://dx.doi.org/10.1016/j.jocn.2018.09.031DOI Listing
February 2019

Patient-Specific iPSC-Derived Astrocytes Contribute to Non-Cell-Autonomous Neurodegeneration in Parkinson's Disease.

Stem Cell Reports 2019 02 10;12(2):213-229. Epub 2019 Jan 10.

Department of Pathology and Experimental Therapeutics, Bellvitge University Hospital-IDIBELL, Hospitalet de Llobregat, Barcelona 08908, Spain; Institute of Biomedicine of the University of Barcelona (IBUB), Barcelona 08028, Spain; Department of Molecular and Translational Medicine, University of Brescia, Brescia 25121, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2018.12.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372974PMC
February 2019

Combined Transcriptomics and Proteomics in Frontal Cortex Area 8 in Frontotemporal Lobar Degeneration Linked to C9ORF72 Expansion.

J Alzheimers Dis 2019 ;68(3):1287-1307

Neuropathology, Pathologic Anatomy Service, Bellvitge University Hospital - Bellvitge Biomedical Research Institute (IDIBELL), Hospitalet de Llobregat, Spain.

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http://dx.doi.org/10.3233/JAD-181123DOI Listing
January 2019

Purine-related metabolites and their converting enzymes are altered in frontal, parietal and temporal cortex at early stages of Alzheimer's disease pathology.

Brain Pathol 2018 11 21;28(6):933-946. Epub 2018 Feb 21.

Facultad de Ciencias y Tecnologías Químicas/Facultad de Medicina de Ciudad Real, Departamento de Química Inorgánica, Orgánica y Bioquímica, Centro Regional de Investigaciones Biomédicas, Universidad de Castilla-La Mancha, Ciudad Real, Spain.

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http://dx.doi.org/10.1111/bpa.12592DOI Listing
November 2018

Aging-related tau astrogliopathy (ARTAG): not only tau phosphorylation in astrocytes.

Brain Pathol 2018 11 25;28(6):965-985. Epub 2018 Feb 25.

Ministry of Economy and Competitiveness, CIBERNED (Network Centre of Biomedical Research of Neurodegenerative Diseases), Institute of Health Carlos III, Barcelona, Spain.

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http://dx.doi.org/10.1111/bpa.12593DOI Listing
November 2018

Regional vulnerability to lipoxidative damage and inflammation in normal human brain aging.

Exp Gerontol 2018 10 2;111:218-228. Epub 2018 Aug 2.

Institute of Neuropathology, Bellvitge University Hospital, Biomedical Research Institute of Bellvitge (IDIBELL), Hospitalet de Llobregat, Spain; Department of Pathology and Experimental Therapeutics, University of Barcelona, Hospitalet de Llobregat, Spain; Biomedical Research Network Center on Neurodegenerative Diseases (CIBERNED), Institute Carlos III, Spanish Ministry of Science and Innovation, Madrid, Spain; Institute of Neurosciences, University of Barcelona, Hospitalet de Llobregat, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.exger.2018.07.023DOI Listing
October 2018

Oligodendrogliopathy in neurodegenerative diseases with abnormal protein aggregates: The forgotten partner.

Authors:
Isidro Ferrer

Prog Neurobiol 2018 10 2;169:24-54. Epub 2018 Aug 2.

Department of Pathology and Experimental Therapeutics, University of Barcelona, Hospitalet de Llobregat, Spain; Service of Pathology, Bellvitge University Hospital, IDIBELL, Hospitalet de Llobregat, Spain; CIBERNED (Biomedical Network Research Centre of Neurodegenerative Diseases), Institute of Health Carlos III, Spain; Institute of Neurosciences, University of Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.pneurobio.2018.07.004DOI Listing
October 2018

Proteomics and lipidomics in the human brain.

Authors:
Isidro Ferrer

Handb Clin Neurol 2018 ;150:285-302

Pathologic Anatomy Service, Institute of Neuropathology, Bellvitge University Hospital; Department of Pathology and Experimental Therapeutics, Faculty of Medicine, University of Barcelona; and Network Center of Biomedical Research on Neurodegenerative Diseases, Institute Carlos III; Hospitalet de Llobregat, Llobregat, Spain. Electronic address:

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http://dx.doi.org/10.1016/B978-0-444-63639-3.00020-7DOI Listing
August 2018

Decreased generation of C-terminal fragments of ApoER2 and increased reelin expression in Alzheimer's disease.

FASEB J 2018 07 9;32(7):3536-3546. Epub 2018 Feb 9.

Instituto de Neurociencias de Alicante, Universidad Miguel Hernández-Consejo Superior de Investigaciones Cientificas (CSIC), Sant Joan d'Alacant, Alicante, Spain.

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http://dx.doi.org/10.1096/fj.201700736RRDOI Listing
July 2018

Gene Expression Profile in Frontal Cortex in Sporadic Frontotemporal Lobar Degeneration-TDP.

J Neuropathol Exp Neurol 2018 07;77(7):608-627

Neuropathology, Pathologic Anatomy Service, Bellvitge University Hospital, IDIBELL, Hospitalet de Llobregat, Spain.

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http://dx.doi.org/10.1093/jnen/nly037DOI Listing
July 2018

Reduced Mitochondrial Activity is Early and Steady in the Entorhinal Cortex but it is Mainly Unmodified in the Frontal Cortex in Alzheimer's Disease.

Curr Alzheimer Res 2017 ;14(12):1327-1334

Institute of Neuropathology, Service of Pathologic Anatomy, Bellvitge University Hospital, carrer Feixa Llarga s/n, 08907 Hospitalet de Llobregat, Barcelona. Spain.

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http://dx.doi.org/10.2174/1567205014666170505095921DOI Listing
June 2018

Transcriptional network analysis in frontal cortex in Lewy body diseases with focus on dementia with Lewy bodies.

Brain Pathol 2018 05 6;28(3):315-333. Epub 2017 Apr 6.

Department of Pathology and Experimental Therapeutics, University of Barcelona, L'Hospitalet de Llobregat, Spain.

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http://dx.doi.org/10.1111/bpa.12511DOI Listing
May 2018

Lipid Profile in Human Frontal Cortex Is Sustained Throughout Healthy Adult Life Span to Decay at Advanced Ages.

J Gerontol A Biol Sci Med Sci 2018 05;73(6):703-710

Department of Experimental Medicine, University of Lleida-Institute for Research in Biomedicine of Lleida (UdL-IRBLleida), Spain.

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http://dx.doi.org/10.1093/gerona/glx164DOI Listing
May 2018

Altered Regulation of KIAA0566, and Katanin Signaling Expression in the Locus Coeruleus With Neurofibrillary Tangle Pathology.

Front Cell Neurosci 2018 17;12:131. Epub 2018 May 17.

Neuropathology, Pathologic Anatomy Service, Bellvitge Biomedical Research Institute, Hospitalet de Llobregat, Bellvitge University Hospital, Barcelona, Spain.

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http://journal.frontiersin.org/article/10.3389/fncel.2018.00
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http://dx.doi.org/10.3389/fncel.2018.00131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966574PMC
May 2018

Glutamate Transporter GLT1 Expression in Alzheimer Disease and Dementia With Lewy Bodies.

Front Aging Neurosci 2018 26;10:122. Epub 2018 Apr 26.

Department of Pathology and Experimental Therapeutics, University of Barcelona, Hospitalet de Llobregat, Barcelona, Spain.

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http://journal.frontiersin.org/article/10.3389/fnagi.2018.00
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http://dx.doi.org/10.3389/fnagi.2018.00122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932187PMC
April 2018

Involvement of Cellular Prion Protein in α-Synuclein Transport in Neurons.

Mol Neurobiol 2018 03 22;55(3):1847-1860. Epub 2017 Feb 22.

Molecular and Cellular Neurobiotechnology, Institute of Bioengineering of Catalonia (IBEC), Parc Científic de Barcelona, Baldiri Reixac 15-21, E-08028, Barcelona, Spain.

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http://dx.doi.org/10.1007/s12035-017-0451-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840251PMC
March 2018

Kidins220 Correlates with Tau in Alzheimer's Disease Brain and Cerebrospinal Fluid.

J Alzheimers Dis 2017 ;55(4):1327-1333

Instituto de Investigaciones Biomédicas "Alberto Sols", Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM), Madrid, Spain.

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http://dx.doi.org/10.3233/JAD-160639DOI Listing
February 2018

Mitochondrial activity in the frontal cortex area 8 and angular gyrus in Parkinson's disease and Parkinson's disease with dementia.

Brain Pathol 2018 Jan 16;28(1):43-57. Epub 2017 Mar 16.

Institute of Neuropathology, Bellvitge University Hospital, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Hospitalet de LLobregat, Catalonia, Spain.

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http://dx.doi.org/10.1111/bpa.12474DOI Listing
January 2018

Neuropathology of cerebrovascular diseases.

Handb Clin Neurol 2017 ;145:79-114

Pathologic Anatomy Service, Institute of Neuropathology, Bellvitge University Hospital, University of Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1016/B978-0-12-802395-2.00007-9DOI Listing
January 2018

Wnts Are Expressed in the Ependymal Region of the Adult Spinal Cord.

Mol Neurobiol 2017 Oct 8;54(8):6342-6355. Epub 2016 Oct 8.

Laboratory of Neuroinflammation, Hospital Nacional de Paraplejicos (SESCAM), Finca La Peraleda s/n, 45071, Toledo, Spain.

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http://dx.doi.org/10.1007/s12035-016-0132-8DOI Listing
October 2017

Reelin Expression in Creutzfeldt-Jakob Disease and Experimental Models of Transmissible Spongiform Encephalopathies.

Mol Neurobiol 2017 Oct 10;54(8):6412-6425. Epub 2016 Oct 10.

Molecular and Cellular Neurobiotechnology, Institute of Bioengineering of Catalonia (IBEC), Parc Científic de Barcelona, Baldiri Reixac 15-21, 08028, Barcelona, Spain.

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http://dx.doi.org/10.1007/s12035-016-0177-8DOI Listing
October 2017

MicroRNA Expression in the Locus Coeruleus, Entorhinal Cortex, and Hippocampus at Early and Middle Stages of Braak Neurofibrillary Tangle Pathology.

J Mol Neurosci 2017 Oct 5;63(2):206-215. Epub 2017 Sep 5.

CIBERNED (Network Centre for Biomedical Research of Neurodegenerative Diseases), Institute Carlos III, Ministry of Health, Madrid, Spain.

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http://dx.doi.org/10.1007/s12031-017-0971-4DOI Listing
October 2017

Inflammatory Gene Expression in Whole Peripheral Blood at Early Stages of Sporadic Amyotrophic Lateral Sclerosis.

Front Neurol 2017 13;8:546. Epub 2017 Oct 13.

Neuropathology, Pathologic Anatomy Service, Bellvitge University Hospital, IDIBELL, Hospitalet de Llobregat, Spain.

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http://dx.doi.org/10.3389/fneur.2017.00546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645505PMC
October 2017

Diversity of astroglial responses across human neurodegenerative disorders and brain aging.

Authors:
Isidro Ferrer

Brain Pathol 2017 Sep;27(5):645-674

Department of Pathology and Experimental Therapeutics, University of Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1111/bpa.12538DOI Listing
September 2017

Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG).

J Neuropathol Exp Neurol 2017 Jul;76(7):605-619

Institute of Neurology, Medical University of Vienna, Vienna, Austria; Center for Neurodegenerative Disease Research, Institute on Aging and Department of Pathology and Laboratory Medicine of the Perelman School of Medicine at the University of Pennsylvania; and Department of Biostatistics and Epidemiology; and Department of Neurosurgery, Center for Brain Injury and Repair, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden; Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK; Department of Neuropathology, Institute of Pathology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida; Northwestern University Feinberg School of Medicine, Northwestern ADC Neuropathology Core, Chicago, Illinois; Clinical Neuropathology, King's College Hospital and London Neurodegenerative Brain Bank, London, UK; Institute of Neuropathology, University Hospital Zurich, Zurich, Switzerland; University of California San Francisco, Institute for Neurodegenerative Diseases, San Francisco, California; Neuropathology Department, Hôpital de La Salpetrière, AP-HP, UPMC-Sorbonne-University, Paris, France; Institute of Neuropathology, Bellvitge University Hospital, University of Barcelona, CIBERNED, Hospitalet de Llobregat, Barcelona, Spain; Discipline of Pathology, Sydney Medical School, The University of Sydney, Sydney, Australia; Neurological Tissue Bank of the Biobank-Hospital Clinic-IDIBAPS, Institut d'Investigacions Biomediques Pi i, Barcelona, Spain; Department of Medicine, Imperial College London, London, UK; IRCCS Foundation "Carlo Besta" Neurological Institute, Milan, Italy; Memory and Aging Center, Department of Neurology, University of California, San Francisco, California; Department of Pathology, University of Sao Paulo Medical School, LIM, São Paulo, Brazil; Brain & Mind Centre, Sydney Medical School, The University of Sydney, and UNSW Medicine & NeuRA, Sydney, Australia; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas; Fishberg Department of Neuroscience, Friedman Brain Institute, and Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Neuropathology, John Radcliffe Hospital, Oxford, UK; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Mental Health and Psychiatry, University Hospitals and University of Geneva School of Medicine, Geneva, Switzerland; Institute of Clinical Neurosciences, University of Bristol, Learning & Research Level 2, Southmead Hospital, Bristol, UK; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada; Department of Pathology and Molecular Medicine, Thomayer Hospital, Prague, Czech Republic; Department of Pathology, First Medical Faculty, Charles University, Prague, Czech Republic; Department of Anatomical Pathology, Alfred Hospital , Prahran, Victoria, Australia; Division of Pathology, St. Michael's Hospital, Toronto, Ontario, Canada; Department of Pathology and Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky; Physiopathology in Aging Lab/Brazilian Aging Brain Study Group-LIM22, University of Sao Paulo Medical School, Sao Paulo, Brazil; Behavioral and Cognitive Neurology Unit, Department of Neurology, University of São Paulo , São Paulo, Brazil; Netherlands Brainbank, Amsterdam and Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands; Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan; Institute of Neuroanatomy, Centre for Biomedicine and Medical Technology Mannheim, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany; Department of Neurodegenerative Diseases and Gerontopsychiatry at the University of Bonn Medical Center, Bonn, Germany; Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan; Department of Neurology, Saitama Medical University International Medical Center, Saitama, Japan; Department of Neuroscience, Katholieke Universiteit-Leuven; and Department of Pathology, Universitaire Ziekenhuizen-Leuven, Leuven, Belgium; Laboratory of Neuropathology, Department of Pathology and Neuropathology, Kepler University Hospital, Medical School, Johannes Kepler University, Linz, Austria; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK; and Department of Pathology and Laboratory Medicine, Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, University of Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1093/jnen/nlx041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251511PMC
July 2017

The cellular prion protein (PrP) as neuronal receptor for α-synuclein.

Prion 2017 07 31;11(4):226-233. Epub 2017 Jul 31.

a Molecular and Cellular Neurobiotechnology , Institute of Bioengineering of Catalonia (IBEC) , Parc Científic de Barcelona, Barcelona , Spain.

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https://www.tandfonline.com/doi/full/10.1080/19336896.2017.1
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http://dx.doi.org/10.1080/19336896.2017.1334748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553301PMC
July 2017

Altered mechanisms of protein synthesis in frontal cortex in Alzheimer disease and a mouse model.

Am J Neurodegener Dis 2017 15;6(2):15-25. Epub 2017 Jun 15.

Institute of Neuropathology, Pathologic Anatomy Service, Bellvitge University HospitalIDIBELL, Spain.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498849PMC
June 2017

Tau-positive nuclear indentations in P301S tauopathy mice.

Brain Pathol 2017 05 2;27(3):314-322. Epub 2016 Aug 2.

Center for Molecular Biology "Severo Ochoa" (CBMSO) CSIC/UAM, 28049, Madrid, Spain.

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http://dx.doi.org/10.1111/bpa.12407DOI Listing
May 2017

Fatal Familial Insomnia: Clinical Aspects and Molecular Alterations.

Curr Neurol Neurosci Rep 2017 04;17(4):30

Institute of Neuropathology, Bellvitge University Hospital-IDIBELL, L'Hospitalet de Llobregat, c/Feixa Llarga sn, 08907, Barcelona, Spain.

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http://dx.doi.org/10.1007/s11910-017-0743-0DOI Listing
April 2017

Dementia with Lewy Bodies: Molecular Pathology in the Frontal Cortex in Typical and Rapidly Progressive Forms.

Front Neurol 2017 13;8:89. Epub 2017 Mar 13.

Institute of Neuropathology, Service of Pathologic Anatomy, IDIBELL-Hospital Universitari de Bellvitge, Hospitalet de Llobregat, Barcelona, Spain; CIBERNED, Network Centre for Biomedical Research of Neurodegenerative Diseases, Institute Carlos III, Madrid, Spain; Department of Pathology and Experimental Therapeutics, L'Hospitalet de Llobregat, University of Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.3389/fneur.2017.00089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346561PMC
March 2017

Biomonitorization of iron accumulation in the substantia nigra from Lewy body disease patients.

Toxicol Rep 2017 31;4:188-193. Epub 2017 Mar 31.

Institute of Parasitology and Biomedicine "López-Neyra", Consejo Superior de Investigaciones Científicas (CSIC), Avda del Conocimiento s/n, 18016 Granada, Spain.

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http://dx.doi.org/10.1016/j.toxrep.2017.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436624PMC
March 2017

Fatal familial insomnia: mitochondrial and protein synthesis machinery decline in the mediodorsal thalamus.

Brain Pathol 2017 01 2;27(1):95-106. Epub 2016 Aug 2.

Institute of Neuropathology, Bellvitge University Hospital, University of Barcelona, Bellvitge Biomedical Research Institute (IDIBELL), Hospitalet de Llobregat, Spain.

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http://dx.doi.org/10.1111/bpa.12408DOI Listing
January 2017

Regional Gene Expression of Inflammation and Oxidative Stress Responses Does Not Predict Neurodegeneration in Aging.

J Neuropathol Exp Neurol 2017 01 23. Epub 2017 Jan 23.

Institute of Neuropathology, Service of Pathologic Anatomy, Bellvitge University Hospital.

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http://dx.doi.org/10.1093/jnen/nlw117DOI Listing
January 2017

CSF biomarkers in neurodegenerative and vascular dementias.

Prog Neurobiol 2016 Mar-May;138-140:36-53. Epub 2016 Mar 22.

Department of Neurology, University Medical Center Göttingen, Göttingen, Germany; German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.

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http://dx.doi.org/10.1016/j.pneurobio.2016.03.003DOI Listing
December 2016

Mini-symposium: Huntington's disease - introduction.

Authors:
Isidro Ferrer

Brain Pathol 2016 11;26(6):724-725

Institute of Neuropathology, Bellvitge University Hospital, IDIBELL, Barcelona, Spain.

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http://dx.doi.org/10.1111/bpa.12431DOI Listing
November 2016

Potential Role of Aminoprocalcitonin in the Pathogenesis of Alzheimer Disease.

Am J Pathol 2016 10 4;186(10):2723-35. Epub 2016 Aug 4.

Group of Neurodegenerative Diseases, Instituto de Investigacion Hospital 12 de Octubre (i+12), Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Neurodegenerative Diseases Biomedical Research Center (CIBERNED), Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2016.06.006DOI Listing
October 2016

An early dysregulation of FAK and MEK/ERK signaling pathways precedes the β-amyloid deposition in the olfactory bulb of APP/PS1 mouse model of Alzheimer's disease.

J Proteomics 2016 10 3;148:149-58. Epub 2016 Aug 3.

Clinical Neuroproteomics Group, Navarrabiomed Biomedical Research Center, Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain; Proteomics Unit, Navarrabiomed Biomedical Research Center, Proteored-ISCIII, Instituto de investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.jprot.2016.07.032DOI Listing
October 2016

Delineating the Efficacy of a Cannabis-Based Medicine at Advanced Stages of Dementia in a Murine Model.

J Alzheimers Dis 2016 10;54(3):903-912

Institut de Neuropatologia, Servei d'Anatomia Patològica, IDIBELL-Hospital Universitari de Bellvitge, Universitat de Barcelona, L'Hospitalet de Llobregat, Spain.

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http://dx.doi.org/10.3233/JAD-160533DOI Listing
October 2016

Clinicopathological Correlations and Concomitant Pathologies in Rapidly Progressive Dementia: A Brain Bank Series.

Neurodegener Dis 2015 31;15(6):350-60. Epub 2015 Oct 31.

Alzheimer's Disease and Other Cognitive Disorders Unit, Department of Neurology, Hospital Clx00ED;nic, Barcelona, Spain.

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http://dx.doi.org/10.1159/000439251DOI Listing
September 2016

Iron overload causes endolysosomal deficits modulated by NAADP-regulated 2-pore channels and RAB7A.

Autophagy 2016 09 6;12(9):1487-506. Epub 2016 Jul 6.

a Institute of Parasitology and Biomedicine "López-Neyra," Consejo Superior de Investigaciones Científicas (CSIC) , Granada , Spain.

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http://dx.doi.org/10.1080/15548627.2016.1190072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082776PMC
September 2016

FOXP2 Expression in Frontotemporal Lobar Degeneration-Tau.

J Alzheimers Dis 2016 09;54(2):471-5

Institute of Neuropathology, Bellvitge University Hospital-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.

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http://dx.doi.org/10.3233/JAD-160274DOI Listing
September 2016

Altered Mitochondria, Protein Synthesis Machinery, and Purine Metabolism Are Molecular Contributors to the Pathogenesis of Creutzfeldt-Jakob Disease.

J Neuropathol Exp Neurol 2016 08 12;75(8):755-769. Epub 2016 Jun 12.

From the Institute of Neuropathology, Service of Pathologic Anatomy, Hospital Universitari de Bellvitge, Hospitalet de Llobregat, Spain (BA, PG-E, KH-O, MC, IF); CIBERNED, Network Centre for Biomedical Research of Neurodegenerative Diseases, Institute Carlos III, Spain (PG-E, KH-O, MC, JAR, IF); Department of Neurology, Clinical Dementia Center, University Medical School, Georg-August University and German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany (FL, IZ); Molecular and Cellular Neurobiotechnology, Institute of Bioengineering of Catalonia (IBEC), Parc Científic de Barcelona, Department of Cell Biology, University of Barcelona, Barcelona, Spain (JAR); and Department of Pathology and Experimental Therapeutics, University of Barcelona, L'Hospitalet de Llobregat, Spain (IF).

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http://dx.doi.org/10.1093/jnen/nlw048DOI Listing
August 2016

Fibrinogen-Derived γ377-395 Peptide Improves Cognitive Performance and Reduces Amyloid-β Deposition, without Altering Inflammation, in AβPP/PS1 Mice.

J Alzheimers Dis 2015 ;47(2):403-12

Institut de Neuropatologia, Servei d'Anatomia Patològica, IDIBELL-Hospital Universitari de Bellvitge, Universitat de Barcelona, L'Hospitalet de Llobregat, Spain.

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http://dx.doi.org/10.3233/JAD-142928DOI Listing
July 2016

Abnormal Expression and Distribution of MMP2 at Initial Stages of Alzheimer's Disease-Related Pathology.

J Alzheimers Dis 2015 ;46(2):461-9

Institute of Neuropathology, Bellvitge University Hospital, Hospitalet de Llobregat, Spain.

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http://dx.doi.org/10.3233/JAD-142460DOI Listing
July 2016

Olfactory Receptors in Non-Chemosensory Organs: The Nervous System in Health and Disease.

Front Aging Neurosci 2016 5;8:163. Epub 2016 Jul 5.

Scuola Internazionale Superiore di Studi Avanzati (SISSA), Area of Neuroscience Trieste, Italy.

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http://dx.doi.org/10.3389/fnagi.2016.00163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932117PMC
July 2016

Redox proteomic profiling of neuroketal-adducted proteins in human brain: Regional vulnerability at middle age increases in the elderly.

Free Radic Biol Med 2016 06 8;95:1-15. Epub 2016 Mar 8.

Institute of Neuropathology, University Hospital of Bellvitge, IDIBELL (Biomedical Research Institute of Bellvitge), Carrer Feixa Llarga sn, 08907 Hospitalet de Llobregat, Spain; Department of Pathology and Experimental Therapeutics, University of Barcelona, Carrer Feixa Llarga sn, 08907 Hospitalet de Llobregat, Spain; CIBERNED (Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas), Spain. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2016.02.034DOI Listing
June 2016

Identification of new molecular alterations in fatal familial insomnia.

Hum Mol Genet 2016 06 7;25(12):2417-2436. Epub 2016 Apr 7.

Institute of Neuropathology, Service of Pathological Anatomy, Bellvitge University Hospital, University of Barcelona, Bellvitge Biomedical Research Institute (IDIBELL), Hospitalet de Llobregat, and Biomedical Research Center of Neurodegenerative Diseases (CIBERNED) Hospitalet del Llobregat 08907, Spain

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http://dx.doi.org/10.1093/hmg/ddw108DOI Listing
June 2016

CB2 Cannabinoid Receptor As Potential Target against Alzheimer's Disease.

Front Neurosci 2016 31;10:243. Epub 2016 May 31.

Institut de Neuropatologia, Servei d'Anatomia Patològica, Bellvitge Biomedical Research Institute (IDIBELL)-Hospital Universitari de Bellvitge, Universitat de BarcelonaL'Hospitalet de Llobregat, Spain; CIBERNED - Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto Carlos IIIMadrid, Spain.

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http://dx.doi.org/10.3389/fnins.2016.00243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885828PMC
June 2016

74 Year-Old Woman with Progressive Weakness.

Brain Pathol 2016 05;26(3):423-4

Service of Neurosurgery, Bellvitge University Hospital, Hospitalet de Llobregat, Spain.

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http://dx.doi.org/10.1111/bpa.12380DOI Listing
May 2016

Sporadic adult-onset leucodystrophy with axonal spheroids and pigmented glia with no mutations in the known targeted genes.

Histopathology 2016 Jan 6;68(2):308-12. Epub 2015 Jul 6.

Institute of Neuropathology, Bellvitge University Hospital, University of Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1111/his.12741DOI Listing
January 2016

Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy.

Acta Neuropathol 2016 Jan 10;131(1):87-102. Epub 2015 Dec 10.

Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.

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http://dx.doi.org/10.1007/s00401-015-1509-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879001PMC
January 2016

CB1 cannabinoid receptor enrichment in the ependymal region of the adult human spinal cord.

Sci Rep 2015 Dec 4;5:17745. Epub 2015 Dec 4.

Laboratory of Neuroinflammation, Hospital Nacional de Paraplejicos (SESCAM), Toledo, Spain.

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http://dx.doi.org/10.1038/srep17745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669459PMC
December 2015

High-fat diet-induced deregulation of hippocampal insulin signaling and mitochondrial homeostasis deficiences contribute to Alzheimer disease pathology in rodents.

Biochim Biophys Acta 2015 Sep 21;1852(9):1687-99. Epub 2015 May 21.

Unitat de Farmacologia i Farmacognòsia, Facultat de Farmàcia, Institut de Biomedicina de la UB (IBUB), Universitat de Barcelona, Barcelona, Spain; Biomedical Research Networking Center in Neurodegenerative Diseases (CIBERNED), Madrid, Spain; Universidad Nacional de Loja, Department of Biotechnology, Ecuador. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09254439150014
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http://dx.doi.org/10.1016/j.bbadis.2015.05.004DOI Listing
September 2015

Type-1 cannabinoid receptor activity during Alzheimer's disease progression.

J Alzheimers Dis 2014 ;42(3):761-6

Department of Pharmacology, Faculty of Medicine and Odontology, University of the Basque Country, Leioa, Spain.

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http://dx.doi.org/10.3233/JAD-140492DOI Listing
August 2015

Cannabis-based medicine reduces multiple pathological processes in AβPP/PS1 mice.

J Alzheimers Dis 2015 ;43(3):977-91

Institut de Neuropatologia, Servei d'Anatomia Patològica, IDIBELL-Hospital Universitari de Bellvitge, Universitat de Barcelona, L'Hospitalet de Llobregat, Spain CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto Carlos III, Spain.

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http://dx.doi.org/10.3233/JAD-141014DOI Listing
August 2015

Novel Levetiracetam Derivatives That Are Effective against the Alzheimer-like Phenotype in Mice: Synthesis, in Vitro, ex Vivo, and in Vivo Efficacy Studies.

J Med Chem 2015 Aug 27;58(15):6018-32. Epub 2015 Jul 27.

†Laboratori de Química Farmacèutica (Unitat Associada al CSIC), Facultat de Farmàcia, and Institut de Biomedicina (IBUB), Universitat de Barcelona, Av. Joan XXIII 27-31, E-08028, Barcelona, Spain.

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http://pubs.acs.org/doi/10.1021/acs.jmedchem.5b00624
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August 2015

New cardiac and skeletal protein aggregate myopathy associated with combined MuRF1 and MuRF3 mutations.

Hum Mol Genet 2015 Jul 23;24(13):3638-50. Epub 2015 Mar 23.

Department of Pathology, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg SE-413 45, Sweden, Department of Clinical and Medical Genetics, University of Gothenburg, Gothenburg SE-405 30, Sweden and Systems Biology Research Centre, School of Biomedicine, University of Skövde, Skövde SE-541 28, Sweden

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http://dx.doi.org/10.1093/hmg/ddv108DOI Listing
July 2015

Expression of regulatory proteins in choroid plexus changes in early stages of Alzheimer disease.

J Neuropathol Exp Neurol 2015 Apr;74(4):359-69

From the Neuroscience Group, Research Institute Hospital; Biomedical Research Networking Center on Neurodegenerative Diseases (CIBERNED); and Proteomic Unit, Research Institute Hospital, Madrid; and Institut de Neuropatologia, IDIBELL-Hospital Universitari de Bellvitge; and Universitat de Barcelona, Hospitalet de Llobregat, Barcelona, Spain.

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http://jnen.oxfordjournals.org/content/jnen/74/4/359.full.pd
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http://jnen.oxfordjournals.org/lookup/doi/10.1097/NEN.000000
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http://dx.doi.org/10.1097/NEN.0000000000000181DOI Listing
April 2015

Traumatic functional pathology of the masticatory system as being responsible for headaches: an odontologic standpoint.

Clin J Pain 2015 Mar;31(3):280-1

*Clínica Dental Ferrer, Valencia, Spain †Associated Dental Clinics for treatment of Headaches, Spain ‡Clínica Ferreiro, Madrid, Spain §University of Alfonso X el Sabio Madrid, Spain.

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https://insights.ovid.com/crossref?an=00002508-201503000-000
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http://dx.doi.org/10.1097/AJP.0000000000000074DOI Listing
March 2015

LRRK2 delays degradative receptor trafficking by impeding late endosomal budding through decreasing Rab7 activity.

Hum Mol Genet 2014 Dec 30;23(25):6779-96. Epub 2014 Jul 30.

Institute of Parasitology and Biomedicine 'López-Neyra', Consejo Superior de Investigaciones Científicas (CSIC), Avda del Conocimiento s/n, 18016 Granada, Spain

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https://academic.oup.com/hmg/article-lookup/doi/10.1093/hmg/
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http://dx.doi.org/10.1093/hmg/ddu395DOI Listing
December 2014

Huntington's disease is a four-repeat tauopathy with tau nuclear rods.

Nat Med 2014 Aug 20;20(8):881-5. Epub 2014 Jul 20.

1] Center for Molecular Biology "Severo Ochoa" (CBMSO) Consejo Superior de Investigaciones Científicas y Universidad Autónoma de Madrid (CSIC/UAM), Madrid, Spain. [2] Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Spain.

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http://dx.doi.org/10.1038/nm.3617DOI Listing
August 2014

Crtc1 activates a transcriptional program deregulated at early Alzheimer's disease-related stages.

J Neurosci 2014 Apr;34(17):5776-87

Institut de Neurociències, Department de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Barcelona 08193, Spain, and Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED) and Institut de Neuropatologia, IDIBELL-Hospital Universitari de Bellvitge, Universitat de Barcelona, Barcelona 08907, Spain.

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http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.5288-13.2
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http://dx.doi.org/10.1523/JNEUROSCI.5288-13.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6608295PMC
April 2014