Publications by authors named "Isidre Ferrer"

99Publications

SFPQ and Tau: critical factors contributing to rapid progression of Alzheimer's disease.

Acta Neuropathol 2020 Sep 23;140(3):317-339. Epub 2020 Jun 23.

Department of Neurology, University Medical Center Göttingen and the German Center for Neurodegenerative Diseases (DZNE), Robert-Koch-Straße 40, 37075, Göttingen, Germany.

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http://dx.doi.org/10.1007/s00401-020-02178-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7423812PMC
September 2020

Disease-Specific Changes in Reelin Protein and mRNA in Neurodegenerative Diseases.

Cells 2020 05 19;9(5). Epub 2020 May 19.

Molecular and Cellular Neurobiotechnology, Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), Science Park of Barcelona, 08028 Barcelona, Spain.

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http://dx.doi.org/10.3390/cells9051252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290479PMC
May 2020

In situ structural characterization of early amyloid aggregates in Alzheimer's disease transgenic mice and Octodon degus.

Sci Rep 2020 04 3;10(1):5888. Epub 2020 Apr 3.

Unitat de Biofísica i Centre d'Estudis en Biofísica, Departament de Bioquímica i de Biologia Molecular, Facultat de Medicina, Universitat Autònoma de Barcelona, 08193 Bellaterra, Catalonia, Spain.

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http://dx.doi.org/10.1038/s41598-020-62708-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125182PMC
April 2020

Succination of Protein Thiols in Human Brain Aging.

Front Aging Neurosci 2020 6;12:52. Epub 2020 Mar 6.

Department of Experimental Medicine, University of Lleida-Lleida Biomedical Research Institute (UdL-IRBLleida), Lleida, Spain.

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http://dx.doi.org/10.3389/fnagi.2020.00052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068737PMC
March 2020

The Quest for Cellular Prion Protein Functions in the Aged and Neurodegenerating Brain.

Cells 2020 03 2;9(3). Epub 2020 Mar 2.

Molecular and Cellular Neurobiotechnology, Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), Science Park of Barcelona, 08028 Barcelona, Spain.

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http://dx.doi.org/10.3390/cells9030591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140396PMC
March 2020

Disrupted functional connectivity of the locus coeruleus in healthy adults with parental history of Alzheimer's disease.

J Psychiatr Res 2020 04 30;123:81-88. Epub 2020 Jan 30.

Grupo de Investigación en Neurociencias Aplicadas a Las Alteraciones de La Conducta (INAAC), FLENI, Montañeses, 2325, Ciudad Autónoma de Buenos Aires, Argentina; National Council for Scientific and Technological Research (CONICET), Godoy Cruz, 2290, Ciudad Autónoma de Buenos Aires, Argentina; Department of Psychiatry, FLENI and Department of Psychiatry and Mental Health, School of Medicine, University of Buenos Aires, Montañeses, 2325, Ciudad Autónoma de Buenos Aires, Argentina. Electronic address:

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http://dx.doi.org/10.1016/j.jpsychires.2020.01.018DOI Listing
April 2020

Revealing Adenosine A-Dopamine D Receptor Heteromers in Parkinson's Disease Post-Mortem Brain through a New AlphaScreen-Based Assay.

Int J Mol Sci 2019 Jul 23;20(14). Epub 2019 Jul 23.

Unitat de Farmacologia, Departament de Patologia i Terapèutica Experimental, Facultat de Medicina i Ciències de la Salut, IDIBELL, Universitat de Barcelona, 08907 L'Hospitalet de Llobregat, Spain.

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http://dx.doi.org/10.3390/ijms20143600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678849PMC
July 2019

Plasma YKL-40 in the spectrum of neurodegenerative dementia.

J Neuroinflammation 2019 Jul 12;16(1):145. Epub 2019 Jul 12.

Department of Neurology, Clinical Dementia Center and National Reference Center for CJD Surveillance, University Medical School, Robert Koch 40, 37075, Göttingen, Germany.

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http://dx.doi.org/10.1186/s12974-019-1531-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624942PMC
July 2019

Historical setting and neuropathology of lathyrism: Insights from the neglected 1944 report by Oliveras de la Riva.

J Hist Neurosci 2019 Oct-Dec;28(4):361-386. Epub 2019 Jul 3.

Department of Neurology, School of Medicine, and Oregon Institute of Occupational Health Sciences, Oregon Health & Science University , Portland , Oregon , USA.

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http://dx.doi.org/10.1080/0964704X.2019.1600357DOI Listing
June 2020

Differences in structure and function between human and murine tau.

Biochim Biophys Acta Mol Basis Dis 2019 08 12;1865(8):2024-2030. Epub 2018 Aug 12.

Department of Molecular Neuropathology, Centro de Biología Molecular "Severo Ochoa" (CBMSO), CSIC-UAM, Madrid, Spain; Network Center for Biomedical Research on Neurodegenerative Diseases (CIBERNED), Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2018.08.010DOI Listing
August 2019

Redox lipidomics to better understand brain aging and function.

Free Radic Biol Med 2019 11 18;144:310-321. Epub 2019 Mar 18.

Freshage Research Group-Department of Physiology, Faculty of Medicine, University of Valencia, CIBERFES, INCLIVA, Spain.

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http://dx.doi.org/10.1016/j.freeradbiomed.2019.03.016DOI Listing
November 2019

Poly(propylene imine) dendrimers with histidine-maltose shell as novel type of nanoparticles for synapse and memory protection.

Nanomedicine 2019 04 30;17:198-209. Epub 2019 Jan 30.

Institute of Neuropathology, IDIBELL-University Hospital Bellvitge, L'Hospitalet de Llobregat, Spain; Wallenberg Neuroscience Center, Lund University, Lund, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.nano.2019.01.010DOI Listing
April 2019

Neuroinflammation in the dorsolateral prefrontal cortex in elderly chronic schizophrenia.

Eur Neuropsychopharmacol 2019 03 7;29(3):384-396. Epub 2019 Jan 7.

Psiquiatria Molecular, Institut de Recerca Sant Joan de Déu, Santa Rosa 39-57, 08950 Esplugues de Llobregat, Spain; Parc Sanitari Sant Joan de Déu, Dr. Antoni Pujadas, 42, 08830 Sant Boi de Llobregat, Spain; Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM (Biomedical Network Research Center of Mental Health), Ministry of Economy, Industry and Competitiveness Institute of Health Carlos III, Madrid, Spain; Dept. de Bioquímica i Biologia Molecular, Facultat de Medicina, Universitat Autònoma de Barcelona, Bellaterra, 08193 Barcelona, Spain. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0924977X183200
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http://dx.doi.org/10.1016/j.euroneuro.2018.12.011DOI Listing
March 2019

Adenosine A-Cannabinoid CB Receptor Heteromers in the Hippocampus: Cannabidiol Blunts Δ-Tetrahydrocannabinol-Induced Cognitive Impairment.

Mol Neurobiol 2019 Aug 4;56(8):5382-5391. Epub 2019 Jan 4.

Unitat de Farmacologia, Departament de Patologia i Terapèutica Experimental, Facultat de Medicina i Ciències de la Salut, IDIBELL-Universitat de Barcelona, C/Feixa Llarga s/n, 08907, L'Hospitalet de Llobregat, Spain.

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http://link.springer.com/10.1007/s12035-018-1456-3
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http://dx.doi.org/10.1007/s12035-018-1456-3DOI Listing
August 2019

Variably protease-sensitive prionopathy presenting within ALS/FTD spectrum.

Ann Clin Transl Neurol 2018 Oct 21;5(10):1297-1302. Epub 2018 Sep 21.

Neurological Tissue Bank of the Biobanc-Hospital Clínic Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) Barcelona Spain.

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http://doi.wiley.com/10.1002/acn3.632
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http://dx.doi.org/10.1002/acn3.632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186932PMC
October 2018

Unveiling the olfactory proteostatic disarrangement in Parkinson's disease by proteome-wide profiling.

Neurobiol Aging 2019 01 25;73:123-134. Epub 2018 Sep 25.

Clinical Neuroproteomics Group, Navarrabiomed, Complejo Hospitalario de Navarra (CHN), Universidad Pública de Navarra (UPNA), IdiSNA, Pamplona, Spain; Proteored-ISCIII, Proteomics Unit, Navarrabiomed, Complejo Hospitalario de Navarra (CHN), Universidad Pública de Navarra (UPNA), IdiSNA, Pamplona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.09.018DOI Listing
January 2019

YKL40 in sporadic amyotrophic lateral sclerosis: cerebrospinal fluid levels as a prognosis marker of disease progression.

Aging (Albany NY) 2018 09;10(9):2367-2382

Department of Pathology and Experimental Therapeutics, University of Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain.

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http://dx.doi.org/10.18632/aging.101551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188478PMC
September 2018

Cannabinoid pharmacology/therapeutics in chronic degenerative disorders affecting the central nervous system.

Biochem Pharmacol 2018 11 17;157:67-84. Epub 2018 Aug 17.

CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Spain; Instituto Universitario de Investigación en Neuroquímica, Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad Complutense, Madrid, Spain; IRYCIS, Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain.

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http://dx.doi.org/10.1016/j.bcp.2018.08.016DOI Listing
November 2018

Genetic deletion of CB cannabinoid receptors exacerbates the Alzheimer-like symptoms in a transgenic animal model.

Biochem Pharmacol 2018 11 7;157:210-216. Epub 2018 Aug 7.

Department of Pathology and Experimental Therapeutics, University of Barcelona-IDIBELL, L'Hospitalet de Llobregat, Spain; CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Spain.

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http://dx.doi.org/10.1016/j.bcp.2018.08.007DOI Listing
November 2018

PM20D1 is a quantitative trait locus associated with Alzheimer's disease.

Nat Med 2018 05 7;24(5):598-603. Epub 2018 May 7.

Laboratory of Neuroepigenetics, Brain Mind Institute, Faculty of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.1038/s41591-018-0013-yDOI Listing
May 2018

"Lipid raft aging" in the human frontal cortex during nonpathological aging: gender influences and potential implications in Alzheimer's disease.

Neurobiol Aging 2018 07 10;67:42-52. Epub 2018 Mar 10.

Departamento de Ciencias Médicas Básicas, Universidad de La Laguna, Tenerife, Spain; Associate Research Unit CSIC-ULL "Fisiología y Biofísica de la membrana celular en patologías neurodegenerativas y tumorales", Tenerife, Spain.

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.02.022DOI Listing
July 2018

Role of cellular prion protein in interneuronal amyloid transmission.

Prog Neurobiol 2018 Jun - Aug;165-167:87-102. Epub 2018 Mar 9.

Molecular and Cellular Neurobiotechnology, Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology, Barcelona, Spain; Department of Cell Biology, Physiology and Immunology, University of Barcelona, Barcelona, Spain; Center for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED), Barcelona, Spain; Institute of Neuroscience, University of Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1016/j.pneurobio.2018.03.001DOI Listing
February 2019

Tau hyperphosphorylation induces oligomeric insulin accumulation and insulin resistance in neurons.

Brain 2017 Dec;140(12):3269-3285

Karolinska Institutet, Center for Alzheimer Research, Department of Neurobiology Care Sciences and Society, Division of Neurogeriatrics, Stockholm, Sweden.

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http://dx.doi.org/10.1093/brain/awx256DOI Listing
December 2017

Aging dependent effect of nuclear tau.

Brain Res 2017 Dec 30;1677:129-137. Epub 2017 Sep 30.

Department of Biological, Geological and Environmental Sciences, University of Catania, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.brainres.2017.09.030DOI Listing
December 2017

Prion Protein Interactome: Identifying Novel Targets in Slowly and Rapidly Progressive Forms of Alzheimer's Disease.

J Alzheimers Dis 2017 ;59(1):265-275

Department of Neurology, Clinical Dementia Center and DZNE, Georg-August University, University Medical Center Göttingen (UMG), Göttingen, Germany.

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http://dx.doi.org/10.3233/JAD-170237DOI Listing
April 2018

Cytoskeleton-Associated Risk Modifiers Involved in Early and Rapid Progression of Sporadic Creutzfeldt-Jakob Disease.

Mol Neurobiol 2018 May 1;55(5):4009-4029. Epub 2017 Jun 1.

Department of Neurology, Clinical Dementia Center, and DZNE, Georg-August University, University Medical Center Goettingen (UMG), Robert-Koch-Str. 40, 37075, Goettingen, Germany.

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http://dx.doi.org/10.1007/s12035-017-0589-0DOI Listing
May 2018

Region-specific vulnerability to lipid peroxidation and evidence of neuronal mechanisms for polyunsaturated fatty acid biosynthesis in the healthy adult human central nervous system.

Biochim Biophys Acta Mol Cell Biol Lipids 2017 May 7;1862(5):485-495. Epub 2017 Feb 7.

Department of Experimental Medicine, University of Lleida-Institute for Research in Biomedicine of Lleida (UdL-IRBLleida), E-25198 Lleida, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2017.02.001DOI Listing
May 2017

GSK3β 5'-flanking DNA Methylation and Expression in Alzheimer's Disease Patients.

Curr Alzheimer Res 2017 ;14(7):753-759

European Center for Brain Research (CERC)/IRCCS Santa Lucia Foundation, Via del Fosso di Fiorano 64-65, 00143 Rome. Italy.

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http://dx.doi.org/10.2174/1567205014666170203153325DOI Listing
April 2018

Whole genome grey and white matter DNA methylation profiles in dorsolateral prefrontal cortex.

Synapse 2017 06 6;71(6). Epub 2017 Feb 6.

School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Brain Mind Institute, Lausanne, CH-1015, Switzerland.

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http://dx.doi.org/10.1002/syn.21959DOI Listing
June 2017

DNA Methylation Profiles of Selected Pro-Inflammatory Cytokines in Alzheimer Disease.

J Neuropathol Exp Neurol 2017 01;76(1):27-31

European Center for Brain Research (CERC)/IRCCS Santa Lucia Foundation, Rome, Italy.

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http://dx.doi.org/10.1093/jnen/nlw099DOI Listing
January 2017

Tauroursodeoxycholic bile acid arrests axonal degeneration by inhibiting the unfolded protein response in X-linked adrenoleukodystrophy.

Acta Neuropathol 2017 02 21;133(2):283-301. Epub 2016 Dec 21.

Neurometabolic Diseases Laboratory, Institut de Neuropatologia de Bellvitge, IDIBELL, Gran Via, 199, L'Hospitalet de Llobregat, 08908, Barcelona, Spain.

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http://dx.doi.org/10.1007/s00401-016-1655-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5250669PMC
February 2017

Sixty years old is the breakpoint of human frontal cortex aging.

Free Radic Biol Med 2017 02 13;103:14-22. Epub 2016 Dec 13.

Department of Experimental Medicine, University of Lleida-Institute for Research in Biomedicine of Lleida (UdL-IRBLleida), E-25198 Lleida, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2016.12.010DOI Listing
February 2017

Molecular Alterations in the Cerebellum of Sporadic Creutzfeldt-Jakob Disease Subtypes with DJ-1 as a Key Regulator of Oxidative Stress.

Mol Neurobiol 2018 01 14;55(1):517-537. Epub 2016 Dec 14.

Department of Neurology, University Medical Center Goettingen (UMG) and German Center for Neurodegenerative Diseases (DZNE) Goettingen, Robert-Koch-Str., 40, 37075, Goettingen, Germany.

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http://dx.doi.org/10.1007/s12035-016-0294-4DOI Listing
January 2018

Regulation of human cerebrospinal fluid malate dehydrogenase 1 in sporadic Creutzfeldt-Jakob disease patients.

Aging (Albany NY) 2016 11;8(11):2927-2935

From the Department of Neurology, University Medical Center Göttingen, Göttingen, Germany.

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http://dx.doi.org/10.18632/aging.101101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5191879PMC
November 2016

Lipid raft ER signalosome malfunctions in menopause and Alzheimer's disease.

Front Biosci (Schol Ed) 2017 01 1;9:111-126. Epub 2017 Jan 1.

Laboratory of Cellular Neurobiology, Department of Physiology, School of Medicine, La Laguna University, Tenerife, Spain,

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http://dx.doi.org/10.2741/s476DOI Listing
January 2017

Amyloid-β Precursor Protein Modulates the Sorting of Testican-1 and Contributes to Its Accumulation in Brain Tissue and Cerebrospinal Fluid from Patients with Alzheimer Disease.

J Neuropathol Exp Neurol 2016 09 2;75(9):903-16. Epub 2016 Aug 2.

From the Institute of Neuropathology (AB-O, JM, BP, MG, DS-F), Department of Psychiatry and Psychotherapy (SA, HJ), University Medical Center Hamburg-Eppendorf, Hamburg, Germany, Center for Biochemistry, Medical Faculty, University of Cologne, Cologne, Germany (UH), Institute of Neuropathology, Bellvitge University Hospital, CIBERNED, Hospitalet de Llobregat, University of Barcelona, Spain (IF), Mosaiques Diagnostics and Therapeutics AG, Hannover, Germany (PZ), and Department of Pharmaceutical Sciences, Natura Research Group, Faculty of Natural Sciences, ICESI University, Cali, Colombia (AB-O).

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https://academic.oup.com/jnen/article-lookup/doi/10.1093/jne
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http://dx.doi.org/10.1093/jnen/nlw065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015660PMC
September 2016

Hereditary Human Prion Diseases: an Update.

Mol Neurobiol 2017 08 20;54(6):4138-4149. Epub 2016 Jun 20.

Department of Neurology, University Medical Center Göttingen and the German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.

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http://dx.doi.org/10.1007/s12035-016-9918-yDOI Listing
August 2017

Altered CSNK1E, FABP4 and NEFH protein levels in the dorsolateral prefrontal cortex in schizophrenia.

Schizophr Res 2016 11 25;177(1-3):88-97. Epub 2016 May 25.

Unitat de recerca, Parc Sanitari Sant Joan de Déu, Fundació Sant Joan de Déu, Universitat de Barcelona, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM. Dr. Antoni Pujadas, 42, Sant Boi de Llobregat, 08830 Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.schres.2016.04.050DOI Listing
November 2016

The glial phosphorylase of glycogen isoform is reduced in the dorsolateral prefrontal cortex in chronic schizophrenia.

Schizophr Res 2016 11 5;177(1-3):37-43. Epub 2016 May 5.

Unitat de recerca, Parc Sanitari Sant Joan de Déu, Fundació Sant Joan de Déu, Universitat de Barcelona, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM. Dr. Antoni Pujadas, 42, 08830, Sant Boi de Llobregat, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.schres.2016.04.024DOI Listing
November 2016

Inflammation in Lafora Disease: Evolution with Disease Progression in Laforin and Malin Knock-out Mouse Models.

Mol Neurobiol 2017 07 4;54(5):3119-3130. Epub 2016 Apr 4.

Institut de Neuropatologia, Servei Anatomia Patologica, Hospital Universitari de Bellvitge, Carrer Feixa Llarga sn, Hospitalet de Llobregat, 08907, Barcelona, Spain.

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http://dx.doi.org/10.1007/s12035-016-9884-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472678PMC
July 2017

Cannabinoid Receptor 2 Participates in Amyloid-β Processing in a Mouse Model of Alzheimer's Disease but Plays a Minor Role in the Therapeutic Properties of a Cannabis-Based Medicine.

J Alzheimers Dis 2016 ;51(2):489-500

Institut de Neuropatologia, Servei d'Anatomia Patològica, IDIBELL-Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Spain.

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http://dx.doi.org/10.3233/JAD-150913DOI Listing
December 2016

Altered Mitochondrial DNA Methylation Pattern in Alzheimer Disease-Related Pathology and in Parkinson Disease.

Am J Pathol 2016 Feb;186(2):385-97

Institute of Neuropathology, Bellvitge University Hospital (Bellvitge Biomedical Research Institute) IDIBELL, L'Hospitalet de Llobregat, Spain; Networked Biomedical Research Centre for NeuroDegenerative Disorders (CIBERNED), Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2015.10.004DOI Listing
February 2016

Strain-Specific Altered Regulatory Response of Rab7a and Tau in Creutzfeldt-Jakob Disease and Alzheimer's Disease.

Mol Neurobiol 2017 01 14;54(1):697-709. Epub 2016 Jan 14.

Department of Neurology, Clinical Dementia Center and DZNE, University Medical Centre Goettingen, 37075, Goettingen, Germany.

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http://dx.doi.org/10.1007/s12035-016-9694-8DOI Listing
January 2017

Early and gender-specific differences in spinal cord mitochondrial function and oxidative stress markers in a mouse model of ALS.

Acta Neuropathol Commun 2016 Jan 13;4. Epub 2016 Jan 13.

The Metabolic Pathophysiology Research Group, Deparment Experimental Medicine, University of Lleida-Institute for Research in Biomedicine of Lleida (UdL- IRBLleida), Avda Rovira Roure, 80, E-25198, Lleida, Spain.

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http://dx.doi.org/10.1186/s40478-015-0271-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4711180PMC
January 2016

Impaired PLP-dependent metabolism in brain samples from Huntington disease patients and transgenic R6/1 mice.

Metab Brain Dis 2016 06 14;31(3):579-86. Epub 2015 Dec 14.

Departament de Ciències Mèdiques Bàsiques, Universitat de Lleida, IRBLleida, Av. Rovira Roure 80, 25198, Lleida, Catalonia, Spain.

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http://dx.doi.org/10.1007/s11011-015-9777-7DOI Listing
June 2016

Nuclear phosphorylated Y142 β-catenin accumulates in astrocytomas and glioblastomas and regulates cell invasion.

Cell Cycle 2015 ;14(22):3644-55

a Departments of Basic Medical Sciences & Experimental Medicine ; University of Lleida & IRBLleida ; Lleida , Spain.

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http://dx.doi.org/10.1080/15384101.2015.1104443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825709PMC
September 2016

Altered machinery of protein synthesis is region- and stage-dependent and is associated with α-synuclein oligomers in Parkinson's disease.

Acta Neuropathol Commun 2015 Dec 1;3:76. Epub 2015 Dec 1.

Institute of Neuropathology, Bellvitge University Hospital, University of Barcelona, Bellvitge Biomedical Research Institute (IDIBELL), Hospitalet de Llobregat; Biomedical Research Center of Neurodegenerative Diseases (CIBERNED), Barcelona, Spain.

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http://dx.doi.org/10.1186/s40478-015-0257-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666041PMC
December 2015

Sporadic MM2-thalamic + cortical Creutzfeldt-Jakob disease: Utility of diffusion tensor imaging in the detection of cortical involvement in vivo.

Neuropathology 2016 Apr 6;36(2):199-204. Epub 2015 Nov 6.

Neurological Tissue Bank of the Biobanc-Hospital Clínic-Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain.

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http://dx.doi.org/10.1111/neup.12261DOI Listing
April 2016

Specific small-RNA signatures in the amygdala at premotor and motor stages of Parkinson's disease revealed by deep sequencing analysis.

Bioinformatics 2016 03 2;32(5):673-81. Epub 2015 Nov 2.

Genomics and Disease Group, Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology, Barcelona 08003, Spain, Universitat Pompeu Fabra (UPF), Barcelona 08003, Spain, IMIM, Hospital del Mar Medical Research Institute, Barcelona 08003, Spain, CIBER de Epidemiología y Salud Pública (CIBERESP), CRG, Instituto Carlos III Barcelona 08003, Spain.

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http://dx.doi.org/10.1093/bioinformatics/btv632DOI Listing
March 2016

Altered Machinery of Protein Synthesis in Alzheimer's: From the Nucleolus to the Ribosome.

Brain Pathol 2016 09 14;26(5):593-605. Epub 2015 Dec 14.

Institute of Neuropathology, Service of Pathologic Anatomy, IDIBELL-Bellvitge University Hospital, University of Barcelona, Hospitalet de Llobregat, Spain.

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http://dx.doi.org/10.1111/bpa.12335DOI Listing
September 2016

Neuroinflammatory Gene Regulation, Mitochondrial Function, Oxidative Stress, and Brain Lipid Modifications With Disease Progression in Tau P301S Transgenic Mice as a Model of Frontotemporal Lobar Degeneration-Tau.

J Neuropathol Exp Neurol 2015 Oct;74(10):975-99

From the Institut de Neuropatologia, IDIBELL-Hospital Universitari de Bellvitge (ILG, EA, MC, MAU, RB, IF); and Universitat de Barcelona (IF), Hospitalet de Llobregat, Barcelona; and CIBERNED (Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas) (IF); and Department of Experimental Medicine, University of Lleida-Biomedical Research Institute of Lleida (AN, RC, MPO, RP), Lleida, Spain.

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http://dx.doi.org/10.1097/NEN.0000000000000241DOI Listing
October 2015

Lipidomics of human brain aging and Alzheimer's disease pathology.

Int Rev Neurobiol 2015 19;122:133-89. Epub 2015 Jun 19.

Department of Experimental Medicine, University of Lleida-Biomedical Research Institute of Lleida, Lleida, Spain. Electronic address:

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http://dx.doi.org/10.1016/bs.irn.2015.05.008DOI Listing
June 2016

Complex Inflammation mRNA-Related Response in ALS Is Region Dependent.

Neural Plast 2015 2;2015:573784. Epub 2015 Aug 2.

Institute of Neuropathology, Bellvitge University Hospital, University of Barcelona, CIBERNED (Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas), 08907 L'Hospitalet de Llobregat, Spain.

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http://dx.doi.org/10.1155/2015/573784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537753PMC
April 2016

Involvement of PrP(C) in kainate-induced excitotoxicity in several mouse strains.

Sci Rep 2015 Jul 9;5:11971. Epub 2015 Jul 9.

1] Molecular and Cellular Neurobiotechnology, Institute of Bioengineering of Catalonia (IBEC), Parc Científic de Barcelona, Barcelona, Spain [2] Department of Cell Biology, Universitat de Barcelona, Barcelona, Spain [3] Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648388PMC
July 2015

Oxidative stress, mitochondrial and proteostasis malfunction in adrenoleukodystrophy: A paradigm for axonal degeneration.

Free Radic Biol Med 2015 Nov 12;88(Pt A):18-29. Epub 2015 Jun 12.

Neurometabolic Diseases Laboratory, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Hospitalet de Llobregat, 08908 Barcelona, Spain; Institut of Neuropathology, Pathologic Anatomy Service, Bellvitge Biomedical Research Institute, IDIBELL-Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, 08908 Barcelona, Spain; Center for Biomedical Research on Rare Diseases (CIBERER), U759, ISCIII, Spain; Catalan Institution of Research and Advanced Studies (ICREA), Barcelona 08010, Catalonia, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2015.05.041DOI Listing
November 2015

Creutzfeldt-Jakob Disease Subtype-Specific Regional and Temporal Regulation of ADP Ribosylation Factor-1-Dependent Rho/MLC Pathway at Pre-Clinical Stage.

J Mol Neurosci 2015 Jun 21;56(2):329-48. Epub 2015 Apr 21.

Department of Neurology, Clinical Dementia Center and DZNE, Georg-August University, University Medical Center Goettingen (UMG), Robert-Koch-Str. 40, 37075, Goettingen, Germany,

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http://dx.doi.org/10.1007/s12031-015-0544-3DOI Listing
June 2015

Memory Improvement in the AβPP/PS1 Mouse Model of Familial Alzheimer’s Disease Induced by Carbamylated-Erythropoietin is Accompanied by Modulation of Synaptic Genes.

J Alzheimers Dis 2015 ;45(2):407-21

Institut de Neuropatologia, IDIBELL-Hospital Universitari de Bellvitge, Universitat de Barcelona, L’Hospitalet de Llobregat, Spain.

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http://dx.doi.org/10.3233/JAD-150002DOI Listing
January 2016

Mutation loads in different tissues from six pathogenic mtDNA point mutations.

Mitochondrion 2015 May 10;22:17-22. Epub 2015 Mar 10.

Departamentos de Neurología, Bioquímica Clínica y de Patología, Hospital Sant Joan de Déu, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.mito.2015.03.001DOI Listing
May 2015

Neuroinflammatory signals in Alzheimer disease and APP/PS1 transgenic mice: correlations with plaques, tangles, and oligomeric species.

J Neuropathol Exp Neurol 2015 Apr;74(4):319-44

From the Institut de Neuropatologia, Institut d'Investigació Biomèdica de Bellvitge-Hospital Universitari de Bellvitge (IL-G, EA, PG-E, BA, FL, MC, JM, AP, IF); Universitat de Barcelona (IF); and Neurometabolic Diseases Laboratory, Institut d'Investigació Biomèdica de Bellvitge (AS, AP), Hospitalet de Llobregat; Catalan Institution for Research and Advanced Studies (AP), Barcelona; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (IF) and Center for Biomedical Research on Rare Diseases (AS, AP), Madrid; and Department of Experimental Medicine, University of Lleida-Biomedical Research Institute of Lleida, Lleida (MP-O, RP), Spain; and Section Neuroscience, Department of Psychology, Sapienza University of Rome (AF); and European Center for Brain Research/IRCCS Santa Lucia Foundation (AF), Rome, Italy.

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http://dx.doi.org/10.1097/NEN.0000000000000176DOI Listing
April 2015

Familial behavioral variant frontotemporal dementia associated with astrocyte-predominant tauopathy.

J Neuropathol Exp Neurol 2015 Apr;74(4):370-9

From the Institute of Neuropathology, IDIBELL-Bellvitge University Hospital, University of Barcelona, Hospitalet de Llobregat; CIBERNED (Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas), Spain (IF, MC, RB); Department of Neurology and Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, California (AL, GC); Service of Neurology, Hospital Galdakao-Usansolo, Vizcaya, Spain (JCG-M, MG-B); and Department of Neurology and Pathology, Memory and Aging Center, University of California, San Francisco, California (WWS).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366320PMC
April 2015

Disclosing bias in bisulfite assay: MethPrimers underestimate high DNA methylation.

PLoS One 2015 18;10(2):e0118318. Epub 2015 Feb 18.

Dept. of Cellular Biotechnologies and Hematology, Sapienza University of Rome, Rome, Italy; Pasteur Institute, Cenci Bolognetti Foundation, Sapienza University of Rome, Rome, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333220PMC
December 2015

Purine metabolism gene deregulation in Parkinson's disease.

Neuropathol Appl Neurobiol 2015 Dec 2;41(7):926-40. Epub 2015 May 2.

Institute of Neuropathology, Bellvitge University Hospital-Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.

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http://dx.doi.org/10.1111/nan.12221DOI Listing
December 2015

Autophagy induction halts axonal degeneration in a mouse model of X-adrenoleukodystrophy.

Acta Neuropathol 2015 Mar 31;129(3):399-415. Epub 2014 Dec 31.

Neurometabolic Diseases Laboratory, Bellvitge Biomedical Research Institute (IDIBELL), L' Hospitalet de Llobregat, 08908, Barcelona, Catalonia, Spain.

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http://dx.doi.org/10.1007/s00401-014-1378-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4331612PMC
March 2015

Microspectroscopy (μFTIR) reveals co-localization of lipid oxidation and amyloid plaques in human Alzheimer disease brains.

Anal Chem 2014 Dec 4;86(24):12047-54. Epub 2014 Dec 4.

European Synchrotron Radiation Facility, 71 Avenue des Martyrs, F-38000 Grenoble, France.

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http://dx.doi.org/10.1021/ac502667bDOI Listing
December 2014

Deregulation of purine metabolism in Alzheimer's disease.

Neurobiol Aging 2015 Jan 8;36(1):68-80. Epub 2014 Aug 8.

Institute of Neuropathology, Bellvitge University Hospital-Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Spain; University of Barcelona, Bellvitge Campus, L'Hospitalet de Llobregat, Spain; Centre for Networked Biomedical Research in Neurodegenerative Diseases (CIBERNED), Institute Carlos III, Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2014.08.004DOI Listing
January 2015

Decrease in olfactory and taste receptor expression in the dorsolateral prefrontal cortex in chronic schizophrenia.

J Psychiatr Res 2015 Jan 2;60:109-16. Epub 2014 Oct 2.

Institut de Neuropatologia, IDIBELL-Hospital Universitari de Bellvitge, Hospitalet de Llobregat, Barcelona, Spain; Universitat de Barcelona, Hospitalet de Llobregat, Barcelona, Spain; CIBERNED (Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas), Spain. Electronic address:

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http://dx.doi.org/10.1016/j.jpsychires.2014.09.012DOI Listing
January 2015

Increased SP4 and SP1 transcription factor expression in the postmortem hippocampus of chronic schizophrenia.

J Psychiatr Res 2014 Nov 19;58:189-96. Epub 2014 Aug 19.

Unitat de recerca, Parc Sanitari Sant Joan de Déu, Fundació Sant Joan de Déu, Universitat de Barcelona, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM. Dr. Antoni Pujadas, 42, 08830 Sant Boi de Llobregat, Barcelona, Spain. Electronic address:

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November 2014