Publications by authors named "Isamu Okamoto"

100Publications

Integrated Immunohistochemical Study on Small-Cell Carcinoma of the Lung Focusing on Transcription and Co-Transcription Factors.

Diagnostics (Basel) 2020 Nov 13;10(11). Epub 2020 Nov 13.

Department of Pathology and Experimental Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan.

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http://dx.doi.org/10.3390/diagnostics10110949DOI Listing
November 2020

Phase I safety and pharmacokinetic study of YM155, a potent selective survivin inhibitor, in combination with erlotinib in patients with EGFR TKI refractory advanced non-small cell lung cancer.

Cancer Chemother Pharmacol 2020 Aug 8;86(2):211-219. Epub 2020 Jul 8.

Department of Medical Oncology, Kindai University Faculty of Medicine, 377-2 Ohnohigashi, Osakasayama City, Osaka, 5898511, Japan.

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http://dx.doi.org/10.1007/s00280-020-04112-1DOI Listing
August 2020

HTLV-1 seropositive patients with lung cancer treated with PD-1 inhibitors.

Cancer Sci 2020 09 18;111(9):3395-3396. Epub 2020 Jul 18.

Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

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http://dx.doi.org/10.1111/cas.14536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469807PMC
September 2020

NEUROD1 is highly expressed in extensive-disease small cell lung cancer and promotes tumor cell migration.

Lung Cancer 2020 08 24;146:97-104. Epub 2020 May 24.

Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

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http://dx.doi.org/10.1016/j.lungcan.2020.05.012DOI Listing
August 2020

Paired genetic analysis by next-generation sequencing of lung cancer and associated idiopathic pulmonary fibrosis.

Cancer Sci 2020 Jul 10;111(7):2482-2487. Epub 2020 Jun 10.

Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

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http://dx.doi.org/10.1111/cas.14488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385390PMC
July 2020

Expression of PD-L1, PD-L2, and IDO1 on tumor cells and density of CD8-positive tumor-infiltrating lymphocytes in early-stage lung adenocarcinoma according to histological subtype.

J Cancer Res Clin Oncol 2020 Oct 14;146(10):2639-2650. Epub 2020 May 14.

Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

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http://dx.doi.org/10.1007/s00432-020-03250-6DOI Listing
October 2020

Serum markers associated with treatment response and survival in non-small cell lung cancer patients treated with anti-PD-1 therapy.

Lung Cancer 2020 07 5;145:18-26. Epub 2020 May 5.

Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

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http://dx.doi.org/10.1016/j.lungcan.2020.04.034DOI Listing
July 2020

Immune Checkpoint Inhibitors for the Treatment of Unresectable Stage III Non-Small Cell Lung Cancer: Emerging Mechanisms and Perspectives.

Lung Cancer (Auckl) 2019 31;10:161-170. Epub 2019 Dec 31.

Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

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http://dx.doi.org/10.2147/LCTT.S184380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997215PMC
December 2019

Clinical impact of skeletal muscle area in patients with non-small cell lung cancer treated with anti-PD-1 inhibitors.

J Cancer Res Clin Oncol 2020 May 5;146(5):1217-1225. Epub 2020 Feb 5.

Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

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http://dx.doi.org/10.1007/s00432-020-03146-5DOI Listing
May 2020

Therapies after first-line afatinib in patients with m NSCLC in Japan: retrospective analysis of LUX-Lung 3.

Future Oncol 2020 Feb 10;16(4):49-60. Epub 2020 Jan 10.

Third Department of Internal Medicine, Wakayama Medical University, Wakayama 641-8509, Japan.

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http://dx.doi.org/10.2217/fon-2019-0659DOI Listing
February 2020

Multiclonality and Radiosensitivity of Granulocyte-colony Stimulating Factor-Producing Lung Adenocarcinoma Positive for an Activating EGFR Mutation.

Clin Lung Cancer 2020 01 26;21(1):e21-e24. Epub 2019 Sep 26.

Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

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http://dx.doi.org/10.1016/j.cllc.2019.09.001DOI Listing
January 2020

First-line afatinib for the treatment of mutation-positive non-small-cell lung cancer in the 'real-world' clinical setting.

Ther Adv Med Oncol 2019 15;11:1758835919836374. Epub 2019 Apr 15.

Department of Oncology, National Taiwan University Hospital and National Taiwan University Cancer Center, Taipei, Taiwan.

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http://dx.doi.org/10.1177/1758835919836374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466470PMC
April 2019

Safety and efficacy of PD-1 inhibitors in non-small cell lung cancer patients positive for antinuclear antibodies.

Lung Cancer 2019 04 29;130:5-9. Epub 2019 Jan 29.

Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2019.01.014DOI Listing
April 2019

Prognostic Impact of Programmed Death-Ligand 2 Expression in Primary Lung Adenocarcinoma Patients.

Ann Surg Oncol 2019 Jun 27;26(6):1916-1924. Epub 2019 Feb 27.

Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

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http://dx.doi.org/10.1245/s10434-019-07231-zDOI Listing
June 2019

Localized malignant pleural mesothelioma mimicking an anterior mediastinal tumor.

Eur J Radiol Open 2019 31;6:72-77. Epub 2019 Jan 31.

Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

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https://linkinghub.elsevier.com/retrieve/pii/S23520477193000
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http://dx.doi.org/10.1016/j.ejro.2019.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357286PMC
January 2019

Association of nephrotoxicity during platinum-etoposide doublet therapy with UGT1A1 polymorphisms in small cell lung cancer patients.

Lung Cancer 2018 12 5;126:156-161. Epub 2018 Nov 5.

Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01695002183062
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http://dx.doi.org/10.1016/j.lungcan.2018.11.002DOI Listing
December 2018

Sensitivity of epidermal growth factor receptor with single or double uncommon mutations to afatinib confirmed by a visual assay.

Cancer Sci 2018 Nov 25;109(11):3657-3661. Epub 2018 Sep 25.

Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

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http://dx.doi.org/10.1111/cas.13787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215868PMC
November 2018

CNS Response to Osimertinib Versus Standard Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Patients With Untreated EGFR-Mutated Advanced Non-Small-Cell Lung Cancer.

J Clin Oncol 2018 Aug 28:JCO2018783118. Epub 2018 Aug 28.

Thanyanan Reungwetwattana, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; Kazuhiko Nakagawa, Kindai University School of Medicine, Osaka; Naoyuki Nogami, National Hospital Organization Shikoku Cancer Center, Matsuyama; Isamu Okamoto, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Byoung Chul Cho, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul; Eun Kyung Cho, Gachon University Gil Medical Center, Incheon; Ki Hyeong Lee, Chungbuk National University Hospital, Cheong-ju, Republic of Korea; Manuel Cobo, Institute of Biomedical Research in Málaga, Málaga University Hospital Regional, Málaga, Spain; Alessandro Bertolini, Hospital of Sondrio, Sondrio, Italy; Sabine Bohnet, Universitätsklinik Schleswig-Holstein, Lübeck, Germany; Caicun Zhou, Pulmonary Hospital of Tongji University, Shanghai, People's Republic of China; Natasha Leighl, Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Rachel Hodge, Astrid McKeown, Andrew P. Brown, and Yuri Rukazenkov, AstraZeneca, Cambridge, United Kingdom; Suresh S. Ramalingam, Winship Cancer Institute, Emory University, Atlanta, GA; and Johan Vansteenkiste, University Hospital, Katholieke Universiteit Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1200/JCO.2018.78.3118DOI Listing
August 2018

Durable response to nivolumab in a lung adenocarcinoma patient with idiopathic pulmonary fibrosis.

Thorac Cancer 2018 11 28;9(11):1519-1521. Epub 2018 Aug 28.

Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

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http://dx.doi.org/10.1111/1759-7714.12853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209776PMC
November 2018

Anticancer drug treatment for advanced lung cancer with interstitial lung disease.

Respir Investig 2018 Jul 13;56(4):307-311. Epub 2018 Apr 13.

Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.resinv.2018.03.002DOI Listing
July 2018

Intrinsic and Extrinsic Regulation of PD-L2 Expression in Oncogene-Driven Non-Small Cell Lung Cancer.

J Thorac Oncol 2018 07 27;13(7):926-937. Epub 2018 Mar 27.

Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2018.03.012DOI Listing
July 2018

PD-L1 expression in lung adenocarcinoma harboring EGFR mutations or ALK rearrangements.

Lung Cancer 2018 04 2;118:36-40. Epub 2018 Feb 2.

Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2018.01.024DOI Listing
April 2018

Real world treatment and outcomes in EGFR mutation-positive non-small cell lung cancer: Long-term follow-up of a large patient cohort.

Lung Cancer 2018 03 9;117:14-19. Epub 2018 Jan 9.

Department of Medical Oncology, Izumi Municipal Hospital, 4-10-10 Fuchu, Izumi, 594-0071, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2018.01.005DOI Listing
March 2018

Combined therapy with epidermal growth factor receptor tyrosine kinase inhibitors for non-small cell lung cancer.

Expert Rev Anticancer Ther 2018 03 27;18(3):267-276. Epub 2018 Jan 27.

b Research Institute for Diseases of the Chest, Graduate School of Medical Sciences , Kyushu University , Fukuoka , Japan.

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http://dx.doi.org/10.1080/14737140.2018.1432356DOI Listing
March 2018

Prevalence of Delta-like protein 3 expression in patients with small cell lung cancer.

Lung Cancer 2018 01 22;115:116-120. Epub 2017 Nov 22.

Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01695002173058
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http://dx.doi.org/10.1016/j.lungcan.2017.11.018DOI Listing
January 2018

Metastatic Lung Adenocarcinoma Mimicking Meningioma.

Intern Med 2018 Apr 21;57(7):1057-1058. Epub 2017 Dec 21.

Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Japan.

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http://dx.doi.org/10.2169/internalmedicine.9472-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919874PMC
April 2018

Osimertinib in Untreated EGFR-Mutated Advanced Non-Small-Cell Lung Cancer.

N Engl J Med 2018 01 18;378(2):113-125. Epub 2017 Nov 18.

From Gustave Roussy Cancer Campus and University Paris-Sud, Orsay, France (J.-C.S., D.P.); the Department of Thoracic Oncology, National Cancer Center Hospital, Tokyo (Y.O.), the Department of Thoracic Oncology, Osaka International Cancer Institute (F.I.), and the Department of Thoracic Oncology, Kansai Medical University Hospital (T.K.), Osaka, the Department of Thoracic Oncology, National Hospital Organization Shikoku Cancer Center, Matsuyama (N.N.), and the Research Institute for Diseases of the Chest, Graduate School of Medical Science, Kyushu University, Fukuoka (I.O.) - all in Japan; the Respiratory Oncology Unit, University Hospital KU Leuven, Leuven, Belgium (J.V.); Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok (T.R.), the Oncology Unit, Department of Medicine, Chiang Mai University, Chiang Mai (B.C.), and the Division of Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai (A.D.) - all in Thailand; the Division of Medical Oncology, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheong-ju (K.H.L.), the Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul (B.C.C.), and the Division of Hematology and Oncology, Department of Internal Medicine, Gachon University Gil Medical Center, Incheon (E.K.C.) - all in South Korea; Pulmonary Hospital of Tongji University, Shanghai (C.Z.), and Jilin Provincial Cancer Hospital, Changchun (Y.C.) - both in China; Hospital Umum Sarawak, Kuching, Malaysia (P.J.V.); National Cheng Kung University, Tainan, Taiwan (W.-C.S.); the Department of Thoracic Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL (J.E.G.); the Department of Oncology, University College London Hospitals Biomedical Research Centre, and the Cancer Research UK Lung Cancer Centre of Excellence, London (S.-M.L.), and AstraZeneca, Cambridge (R.H., M.M., Y.R.) - all in the United Kingdom; and Emory University School of Medicine, Winship Cancer Institute, Atlanta (S.S.R.).

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http://dx.doi.org/10.1056/NEJMoa1713137DOI Listing
January 2018

CD44 variant-dependent regulation of redox balance in EGFR mutation-positive non-small cell lung cancer: A target for treatment.

Lung Cancer 2017 11 14;113:72-78. Epub 2017 Sep 14.

Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2017.09.008DOI Listing
November 2017

Visualization and quantitation of epidermal growth factor receptor homodimerization and activation with a proximity ligation assay.

Oncotarget 2017 Sep 25;8(42):72127-72132. Epub 2017 Jul 25.

Research Institute for Diseases of The Chest, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan.

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http://dx.doi.org/10.18632/oncotarget.19552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641116PMC
September 2017

Prediction of Therapeutic Effect of Chemotherapy for NSCLC Using Dual-Input Perfusion CT Analysis: Comparison among Bevacizumab Treatment, Two-Agent Platinum-based Therapy without Bevacizumab, and Other Non-Bevacizumab Treatment Groups.

Radiology 2018 Feb 23;286(2):685-695. Epub 2017 Oct 23.

From the Department of Health Sciences (H.Y.), Department of Clinical Radiology (S.K., T.K., K.S., Y.Y., H.H.), and Research Institute for Diseases of the Chest (E.I., I.O.), Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

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http://dx.doi.org/10.1148/radiol.2017162204DOI Listing
February 2018

Marked response to pembrolizumab in a patient with pulmonary pleomorphic carcinoma highly positive for PD-L1.

Lung Cancer 2017 10 21;112:230-231. Epub 2017 Jul 21.

Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2017.07.020DOI Listing
October 2017

Most T790M mutations are present on the same EGFR allele as activating mutations in patients with non-small cell lung cancer.

Lung Cancer 2017 06 1;108:75-82. Epub 2017 Mar 1.

Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka 8128582, Japan.

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http://dx.doi.org/10.1016/j.lungcan.2017.02.019DOI Listing
June 2017

Severe Aplastic Anemia during Osimertinib Therapy in a Patient with EGFR Tyrosine Kinase Inhibitor-Resistant Non-Small Cell Lung Cancer.

J Thorac Oncol 2017 05;12(5):e46-e47

Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

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http://dx.doi.org/10.1016/j.jtho.2016.12.023DOI Listing
May 2017

Chronic myelomonocytic leukemia blast crisis in a patient with advanced non-small cell lung cancer treated with EGFR tyrosine kinase inhibitors.

Respir Investig 2017 Mar 12;55(2):181-183. Epub 2017 Jan 12.

Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

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http://dx.doi.org/10.1016/j.resinv.2016.12.002DOI Listing
March 2017