Dr. Isabelle Royal, Ph.D. - Université de Montréal - Adjunct Professor

Dr. Isabelle Royal

Ph.D.

Université de Montréal

Adjunct Professor

Montreal, Quebec | Canada

Main Specialties: Biology

Additional Specialties: Molecular and Cellular Biology

Dr. Isabelle Royal, Ph.D. - Université de Montréal - Adjunct Professor

Dr. Isabelle Royal

Ph.D.

Introduction

Primary Affiliation: Université de Montréal - Montreal, Quebec , Canada

Specialties:

Additional Specialties:

Research Interests:

Publications

22Publications

215Reads

2Profile Views

548PubMed Central Citations

Tyrosine Phosphatase PTPRJ/DEP-1 Is an Essential Promoter of Vascular Permeability, Angiogenesis, and Tumor Progression.

Cancer Res 2016 09 30;76(17):5080-91. Epub 2016 Jun 30.

CRCHUM - Centre de recherche du Centre Hospitalier de l'Université de Montréal, Montréal, Quebec, Canada. Institut du cancer de Montréal, Montréal, Quebec, Canada. Département de Médecine, Université de Montréal, Montréal, Quebec, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-1071DOI Listing
September 2016
4 Reads
4 Citations
9.330 Impact Factor

CdGAP/ARHGAP31, a Cdc42/Rac1 GTPase regulator, is critical for vascular development and VEGF-mediated angiogenesis.

Sci Rep 2016 06 7;6:27485. Epub 2016 Jun 7.

CRCHUM - Centre de recherche du Centre Hospitalier de l'Université de Montréal and Institut du Cancer de Montréal, Montréal, Québec, Canada.

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http://dx.doi.org/10.1038/srep27485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895392PMC
June 2016
28 Reads
5 Citations
5.080 Impact Factor

The protein tyrosine phosphatase DEP-1/PTPRJ promotes breast cancer cell invasion and metastasis.

Oncogene 2015 Oct 16;34(44):5536-47. Epub 2015 Mar 16.

CRCHUM - Centre de recherche du Centre Hospitalier de l'Université de Montréal, Institut du Cancer de Montréal, Montréal, QC, Canada.

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http://dx.doi.org/10.1038/onc.2015.9DOI Listing
October 2015
22 Reads
5 Citations
8.460 Impact Factor

Phosphorylation of DEP-1/PTPRJ on threonine 1318 regulates Src activation and endothelial cell permeability induced by vascular endothelial growth factor.

Cell Signal 2014 Jun 28;26(6):1283-93. Epub 2014 Feb 28.

CRCHUM - Centre de recherche du Centre Hospitalier de l'Université de Montréal and Institut du Cancer de Montréal, Montréal, Québec, Canada; Department of Medicine, Université de Montréal, Montréal, Québec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2014.02.008DOI Listing
June 2014
3 Reads
2 Citations
4.320 Impact Factor

Anti-CD73 therapy impairs tumor angiogenesis.

Int J Cancer 2014 Mar 18;134(6):1466-73. Epub 2013 Sep 18.

Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Faculté de Pharmacie et Institut du Cancer de Montréal, Montréal, Québec, H2L 4M1, Canada.

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http://dx.doi.org/10.1002/ijc.28456DOI Listing
March 2014
19 Reads
27 Citations
5.085 Impact Factor

Tyrosine phosphorylation of DEP-1/CD148 as a mechanism controlling Src kinase activation, endothelial cell permeability, invasion, and capillary formation.

Blood 2012 Sep 16;120(13):2745-56. Epub 2012 Aug 16.

Centre de recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM) and Institut du Cancer de Montréal, Montréal, QC, Canada.

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http://dx.doi.org/10.1182/blood-2011-12-398040DOI Listing
September 2012
19 Reads
16 Citations
10.452 Impact Factor

Annexin-1-mediated endothelial cell migration and angiogenesis are regulated by vascular endothelial growth factor (VEGF)-induced inhibition of miR-196a expression.

J Biol Chem 2012 Aug 6;287(36):30541-51. Epub 2012 Jul 6.

Le Centre de recherche en cancérologie de l'Université Laval and Centre de recherche du CHUQ, l'Hôtel-Dieu de Québec, 9 rue McMahon, Québec G1R 2J6, Canada.

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http://dx.doi.org/10.1074/jbc.M112.393561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436302PMC
August 2012
12 Reads
22 Citations
4.573 Impact Factor

Non-redundant roles of the Gab1 and Gab2 scaffolding adapters in VEGF-mediated signalling, migration, and survival of endothelial cells.

Cell Signal 2009 Jun 20;21(6):943-53. Epub 2009 Feb 20.

Centre de recherche du Centre Hospitalier de l'Université de Montréal, 1560 rue Sherbrooke est, Montréal, Québec, Canada.

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http://dx.doi.org/10.1016/j.cellsig.2009.02.004DOI Listing
June 2009
5 Reads
18 Citations
4.320 Impact Factor

New role for the protein tyrosine phosphatase DEP-1 in Akt activation and endothelial cell survival.

Mol Cell Biol 2009 Jan 20;29(1):241-53. Epub 2008 Oct 20.

CRCHUM-Centre Hospitalier de l'Université de Montréal and Institut du Cancer de Montréal, Montréal, Québec, Canada H2L 4M1.

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http://dx.doi.org/10.1128/MCB.01374-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2612487PMC
January 2009
5 Reads
29 Citations
4.780 Impact Factor

The scaffolding adapter Gab1 mediates vascular endothelial growth factor signaling and is required for endothelial cell migration and capillary formation.

J Biol Chem 2007 Mar 17;282(11):7758-69. Epub 2006 Dec 17.

Centre de Recherche du Centre Hospitalier de l'Université de Montréal/Institut du Cancer de Montréal and Département de Médecine de l'Université de Montréal, Montréal, Québec H2L 4M1, Canada.

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http://dx.doi.org/10.1074/jbc.M611327200DOI Listing
March 2007
8 Reads
37 Citations
4.573 Impact Factor

Regulation of vascular endothelial growth factor receptor-2 activity by caveolin-1 and plasma membrane cholesterol.

Mol Biol Cell 2003 Jan;14(1):334-47

Centre de Cancérologie Charles-Bruneau, Hôpital Sainte-Justine, Montréal, Quebec, Canada H3T 1C5.

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http://dx.doi.org/10.1091/mbc.e02-07-0379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC140249PMC
January 2003
4 Reads
73 Citations
4.470 Impact Factor

Crk adapter proteins promote an epithelial-mesenchymal-like transition and are required for HGF-mediated cell spreading and breakdown of epithelial adherens junctions.

Mol Biol Cell 2002 May;13(5):1449-61

Department of Biochemistry, McGill University, Montreal, Quebec, Canada H3A 1A1.

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http://dx.doi.org/10.1091/mbc.01-10-0477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC111118PMC
May 2002
5 Reads
39 Citations
4.470 Impact Factor

Identification of an atypical Grb2 carboxyl-terminal SH3 domain binding site in Gab docking proteins reveals Grb2-dependent and -independent recruitment of Gab1 to receptor tyrosine kinases.

J Biol Chem 2000 Oct;275(40):31536-45

Departments of Biochemistry, Medicine, and Oncology, Molecular Oncology Group, McGill University Health Centre, Montreal, Quebec H3A 1A1, Canada.

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http://dx.doi.org/10.1074/jbc.M003597200DOI Listing
October 2000
4 Reads
58 Citations
4.573 Impact Factor

Activation of cdc42, rac, PAK, and rho-kinase in response to hepatocyte growth factor differentially regulates epithelial cell colony spreading and dissociation.

Mol Biol Cell 2000 May;11(5):1709-25

Molecular Oncology Group, McGill University Hospital Center, McGill University, Montreal, Quebec, Canada, H3A 1A1.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC14878PMC
http://dx.doi.org/10.1091/mbc.11.5.1709DOI Listing
May 2000
2 Reads
76 Citations
4.470 Impact Factor

The Gab1 PH domain is required for localization of Gab1 at sites of cell-cell contact and epithelial morphogenesis downstream from the met receptor tyrosine kinase.

Mol Cell Biol 1999 Mar;19(3):1784-99

Departments of Medicine, Molecular Oncology Group, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada H3A 1A1.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC83972PMC
http://dx.doi.org/10.1128/mcb.19.3.1784DOI Listing
March 1999
1 Read
57 Citations
4.780 Impact Factor

Differential requirement of Grb2 and PI3-kinase in HGF/SF-induced cell motility and tubulogenesis.

J Cell Physiol 1997 Nov;173(2):196-201

Royal Victoria Hospital, Department of Medicine, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1002/(SICI)1097-4652(199711)173:2<196::AID-JCP20>3.0.CO;2-DDOI Listing
November 1997
1 Read
11 Citations
3.840 Impact Factor

Down-regulation of cytokeratin 14 gene expression by the polyoma virus middle T antigen is dependent on c-Src association but independent of full transformation in rat liver nonparenchymal epithelial cells.

Cell Growth Differ 1996 Jun;7(6):737-43

Centre de Recherche en Cancérologie de l'Université Laval, L'Hôtel-Dieu de Québec, Canada.

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June 1996
2 Reads
2 Citations

Hepatocyte growth factor-induced scatter of Madin-Darby canine kidney cells requires phosphatidylinositol 3-kinase.

Authors:
I Royal M Park

J Biol Chem 1995 Nov;270(46):27780-7

Molecular Oncology Laboratory, Royal Victoria Hospital, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1074/jbc.270.46.27780DOI Listing
November 1995
1 Read
54 Citations
4.573 Impact Factor

Polyomavirus middle T selective action on cytokeratin 14 gene expression in liver nonparenchymal epithelial cells.

Exp Cell Res 1995 Sep;220(1):171-7

Centre de Recherche en Cancérologie de l'Université Laval, L'Hôtel-Dieu de Québec, Canada.

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http://dx.doi.org/10.1006/excr.1995.1303DOI Listing
September 1995
1 Read
1 Citation
3.250 Impact Factor

Cytokeratin 14 expression in rat liver cells in culture and localization in vivo.

Differentiation 1992 Dec;52(1):45-54

Laval University Cancer Research Center, L'Hôtel-Dieu de Québec, Canada.

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http://dx.doi.org/10.1111/j.1432-0436.1992.tb00498.xDOI Listing
December 1992
1 Read
9 Citations
3.440 Impact Factor

Down-regulation of cytokeratin 14 mRNA in polyoma virus middle T-transformed rat liver epithelial cells.

Cell Growth Differ 1992 Sep;3(9):589-96

Centre de Recherche en Cancérologie, Université Laval, Hôtel-Dieu de Québec, Canada.

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September 1992
1 Read
1 Citation

Top co-authors

Kathleen Spring
Kathleen Spring

CRCHUM-Centre Hospitalier de l'Université de Montréal and Institut du Cancer de Montréal

5
Catherine Chabot
Catherine Chabot

Montreal Cancer Institute

4
Christine Caron
Christine Caron

Shriners Hospitals for Children

4
Patrick Fournier
Patrick Fournier

Centre Hospitalier Universitaire de Sherbrooke

3
Simon Langlois
Simon Langlois

Centre de recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM) and Institut du Cancer de Montréal

2
Line Lapointe
Line Lapointe

Université Laval

2
Monikca Cloutier
Monikca Cloutier

Natural Resources Canada

2
Mounib Elchebly
Mounib Elchebly

Université de Montréal

2