Isabelle Plo

Isabelle Plo

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Isabelle Plo

Isabelle Plo

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The role of the thrombopoietin receptor MPL in myeloproliferative neoplasms: recent findings and potential therapeutic applications.

Expert Rev Hematol 2019 May 22:1-12. Epub 2019 May 22.

c Ludwig Institute for Cancer Research Brussels , Brussels , Belgium.

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http://dx.doi.org/10.1080/17474086.2019.1617129DOI Listing
May 2019

Disrupted filamin A/αβ interaction induces macrothrombocytopenia by increasing RhoA activity.

Blood 2019 Apr 2;133(16):1778-1788. Epub 2019 Jan 2.

Unité Mixte de Recherche (UMR) 1170, INSERM, Equipe Labelllisée Ligue Nationale Contre le Cancer, Gustave Roussy Cancer Campus, Université Paris-Sud, Université Paris-Saclay, Villejuif, France.

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http://dx.doi.org/10.1182/blood-2018-07-861427DOI Listing
April 2019

"Mixed" Myeloproliferative Neoplasm Due to Co-Occurrence of Different Driver Mutations.

Authors:
Isabelle Plo

Acta Haematol 2019 18;141(4):268-270. Epub 2019 Apr 18.

INSERM, UMR1170, Laboratory of Excellence GR-Ex, Villejuif, France,

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https://www.karger.com/Article/FullText/498979
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http://dx.doi.org/10.1159/000498979DOI Listing
April 2019

JAK inhibitors for the treatment of myeloproliferative neoplasms and other disorders.

F1000Res 2018 17;7:82. Epub 2018 Jan 17.

Signal Transduction & Molecular Hematology Unit, Ludwig Institute for Cancer Research, Brussels, Belgium.

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http://dx.doi.org/10.12688/f1000research.13167.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773931PMC
January 2018

Identification of R102P Mutation in Hereditary Thrombocytosis.

Front Endocrinol (Lausanne) 2017 20;8:235. Epub 2017 Sep 20.

INSERM UMR1170, Gustave Roussy, Villejuif, France.

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http://dx.doi.org/10.3389/fendo.2017.00235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5611484PMC
September 2017

Quantitative Proteome Heterogeneity in Myeloproliferative Neoplasm Subtypes and Association with Mutation Status.

Mol Cancer Res 2017 07 17;15(7):852-861. Epub 2017 Mar 17.

TheREx Team (Thérapeutique Recombinante Expérimentale), TIMC-IMAG Laboratory, (Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications de Grenoble), Grenoble Alpes University, Grenoble, France.

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http://mcr.aacrjournals.org/lookup/doi/10.1158/1541-7786.MCR
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http://dx.doi.org/10.1158/1541-7786.MCR-16-0495DOI Listing
July 2017

Uncoupling of the Hippo and Rho pathways allows megakaryocytes to escape the tetraploid checkpoint.

Haematologica 2016 12 11;101(12):1469-1478. Epub 2016 Aug 11.

Institut National de la Santé et la Recherche Médicale (INSERM) UMR1170, Equipe Labellisée par la Ligue Nationale Contre le Cancer, Villejuif, France

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http://dx.doi.org/10.3324/haematol.2016.149914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479626PMC
December 2016

Eltrombopag, a potent stimulator of megakaryopoiesis.

Haematologica 2016 12;101(12):1443-1445

INSERM, UMR1170, Gustave Roussy, Villejuif, France

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http://dx.doi.org/10.3324/haematol.2016.153668DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479610PMC
December 2016

Ph(-) myeloproliferative neoplasm red blood cells display deregulation of IQGAP1-Rho GTPase signaling depending on CALR/JAK2 status.

Biochim Biophys Acta 2016 11 24;1863(11):2758-2765. Epub 2016 Aug 24.

TheREx Team "Thérapeutique recombinante expérimentale", TIMC-IMAG Laboratory, "Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications de Grenoble", UMR, UJF, CNRS 5525, University of Grenoble Alpes, France; Laboratoire d'Hématologie cellulaire, Institut de Biologie et Pathologie, Grenoble Alpes University Hospital, France.

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http://dx.doi.org/10.1016/j.bbamcr.2016.08.012DOI Listing
November 2016

TET2-mediated 5-hydroxymethylcytosine induces genetic instability and mutagenesis.

DNA Repair (Amst) 2016 07 24;43:78-88. Epub 2016 May 24.

INSERM, UMR 1170, Laboratory of Excellence GR-Ex, Villejuif, France; Université Paris XI, UMR 1170, Gustave Roussy, Villejuif, France; Gustave Roussy, Villejuif, France; Laboratory of Excellence GR-Ex, Villejuif, France. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2016.05.031DOI Listing
July 2016

EZH2: a molecular switch of the MPN phenotype.

Blood 2016 06;127(26):3297-8

INSERM.

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http://dx.doi.org/10.1182/blood-2016-04-711770DOI Listing
June 2016

[Not Available].

Bull Cancer 2016 Jun;103(6 Suppl 1):S16-28

Inserm UMR 1170, Gustave Roussy, Villejuif, 94805, France; Université Paris-Saclay, UMR 1170, Gustave Roussy, Villejuif, 94805, France; Gustave Roussy, UMR 1170, Villejuif, 94805, France. Electronic address:

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http://dx.doi.org/10.1016/S0007-4551(16)30142-4DOI Listing
June 2016

Recent advances in understanding myelofibrosis and essential thrombocythemia.

F1000Res 2016 19;5. Epub 2016 Apr 19.

Gustave Roussy, Paris, France; Universite Paris-Saclay, Gustave Roussy, Paris, France.

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http://dx.doi.org/10.12688/f1000research.8081.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4841197PMC
May 2016

ATG2B and GSKIP: 2 new genes predisposing to myeloid malignancies.

Mol Cell Oncol 2016 Mar 29;3(2):e1094564. Epub 2015 Oct 29.

INSERM, UMR 1170, Gustave Roussy, Villejuif, France; Université Paris-Sud, UMR1170, Gustave Roussy, Villejuif, France; Gustave Roussy, Villejuif France.

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http://dx.doi.org/10.1080/23723556.2015.1094564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905402PMC
March 2016

Presence of atypical thrombopoietin receptor (MPL) mutations in triple-negative essential thrombocythemia patients.

Blood 2016 Jan 8;127(3):333-42. Epub 2015 Oct 8.

INSERM, Unité Mixte de Recherche (UMR) 1170, Gustave Roussy, Villejuif, France; Université Paris-Saclay, UMR1170, Gustave Roussy, Villejuif, France; UMR1170, Gustave Roussy, Villejuif, France; Consultation d'Hématologie-Immunologie, Hôpital Saint Louis, Assistance Publique-Hôpitaux de Paris, Paris, France.

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http://dx.doi.org/10.1182/blood-2015-07-661983DOI Listing
January 2016

Tuning cytokine receptor signaling by re-orienting dimer geometry with surrogate ligands.

Cell 2015 Mar 26;160(6):1196-208. Epub 2015 Feb 26.

Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305-5345, USA; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305-5345, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.02.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766813PMC
March 2015

[Properties and biological roles of TET proteins during embryogenesis and in hematopoiesis].

Med Sci (Paris) 2015 Mar 8;31(3):268-74. Epub 2015 Apr 8.

Inserm 1170, Institut Gustave Roussy, 114, rue Edouard Vaillant, 94805 Villejuif, France - Institut Gustave Roussy, Villejuif, France - Université Paris XI, Orsay, France.

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http://dx.doi.org/10.1051/medsci/20153103012DOI Listing
March 2015

TET2 loss, a rescue of JAK2V617F HSCs.

Blood 2015 Jan;125(2):212-3

INSTITUT DE CANCÉROLOGIE GUSTAVE ROUSSY.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2014-10-60
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http://dx.doi.org/10.1182/blood-2014-10-606624DOI Listing
January 2015

p19 INK4d controls hematopoietic stem cells in a cell-autonomous manner during genotoxic stress and through the microenvironment during aging.

Stem Cell Reports 2014 Dec 20;3(6):1085-102. Epub 2014 Nov 20.

Institut National de la Santé et de la Recherche Médicale, U1009, Equipe labellisée Ligue Nationale contre le Cancer, 114 rue Edouard Vaillant, 94805 Villejuif, France; University Paris Sud, 114, rue Edouard Vaillant, 94805 Villejuif, France; Gustave Roussy, IFR54, 114, rue Edouard Vaillant, 94805 Villejuif, France. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2014.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264042PMC
December 2014

Myeloproliferative neoplasms: JAK2 signaling pathway as a central target for therapy.

Clin Lymphoma Myeloma Leuk 2014 Sep;14 Suppl:S23-35

INSERM 1009, Institut Gustave Roussy, Villejuif, France; Institut Gustave Roussy, Villejuif, France; Université Paris XI, Institut Gustave Roussy, Villejuif, France; Ligue Nationale contre le Cancer, équipe labellisée, Villejuif, France. Electronic address:

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http://dx.doi.org/10.1016/j.clml.2014.06.014DOI Listing
September 2014

TET2 deficiency inhibits mesoderm and hematopoietic differentiation in human embryonic stem cells.

Stem Cells 2014 Aug;32(8):2084-97

Institut National de la Santé et de la Recherche Médicale, UMR 1009, Laboratory of Excellence GR-Ex, 114 rue Edouard Vaillant, Villejuif, Paris, France; Institut Gustave Roussy, Villejuif, Paris, France; Université Paris Sud 11, Orsay, France.

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http://dx.doi.org/10.1002/stem.1718DOI Listing
August 2014

Emergence of a BCR-ABL translocation in a patient with the JAK2V617F mutation: evidence for secondary acquisition of BCR-ABL in the JAK2V617F clone.

J Clin Oncol 2014 Jul 10;32(21):e76-9. Epub 2014 Feb 10.

INSERM, UMR 1009, Institut Gustave Roussy, Université Paris XI; INSERM, UMR 1009, Laboratoire d'Excellence du Globule Rouge, Villejuif, France.

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http://dx.doi.org/10.1200/JCO.2012.47.8669DOI Listing
July 2014

p53 at the crossroads of MPN treatment.

Authors:
Isabelle Plo

Blood 2014 Jul;124(5):668-9

INSERM, UNITÉ MIXTE DE RECHERCHE 1009.

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http://dx.doi.org/10.1182/blood-2014-06-579623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118478PMC
July 2014

Heterozygous and homozygous JAK2(V617F) states modeled by induced pluripotent stem cells from myeloproliferative neoplasm patients.

PLoS One 2013 16;8(9):e74257. Epub 2013 Sep 16.

Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche 1009, Laboratory of Excellence, Globule rouge-Excellence (GR-Ex), Villejuif, France ; University Paris-Sud 11, Le Kremlin-Bicêtre, France ; Institut Gustave Roussy, Villejuif, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0074257PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774801PMC
May 2014

DNA binding of the p21 repressor ZBTB2 is inhibited by cytosine hydroxymethylation.

Biochem Biophys Res Commun 2014 Mar 4;446(1):341-6. Epub 2014 Mar 4.

Laboratoire Lésions des Acides Nucléiques, Service de Chimie Inorganique et Biologique, UMR E_3 CEA/UJF-Grenoble 1, INAC, 17 rue des Martyrs, Grenoble F-38054, France. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2014.02.122DOI Listing
March 2014

BRCA1-Ku80 protein interaction enhances end-joining fidelity of chromosomal double-strand breaks in the G1 phase of the cell cycle.

J Biol Chem 2013 Mar 23;288(13):8966-76. Epub 2013 Jan 23.

Department of Radiation Oncology, The Ohio State University Medical Center, Arthur G. James Comprehensive Cancer Center, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1074/jbc.M112.412650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610969PMC
March 2013

Molecular and genetic bases of myeloproliferative disorders: questions and perspectives.

Clin Lymphoma Myeloma 2009 ;9 Suppl 3:S329-39

INSERM U790, Villejuif, France Institut Gustave Roussy, 94805 Villejuif, France.

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http://dx.doi.org/10.3816/CLM.2009.s.032DOI Listing
January 2010

An activating mutation in the CSF3R gene induces a hereditary chronic neutrophilia.

J Exp Med 2009 Aug 20;206(8):1701-7. Epub 2009 Jul 20.

Research Laboratory on Hematopoiesis and Normal and Leukemic Stem Cells, U790, Institut National de la Santé et de la Recherche Médicale, 94805 Villejuif, France.

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http://dx.doi.org/10.1084/jem.20090693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722170PMC
August 2009

Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells.

Nat Struct Mol Biol 2009 Aug 26;16(8):819-24. Epub 2009 Jul 26.

Unité mixte de recherche 217, Centre National de la Recherche Scientifique-Commissariat à l'Energie Atomique, Equipe labellisée LA LIGUE 2008, Institut de Radiobiologie Cellulaire et Moléculaire, Fontenay-aux-Roses, France.

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http://www.nature.com/articles/nsmb.1641
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http://dx.doi.org/10.1038/nsmb.1641DOI Listing
August 2009

AKT1 inhibits homologous recombination by inducing cytoplasmic retention of BRCA1 and RAD51.

Cancer Res 2008 Nov;68(22):9404-12

Unité Mixte de Recherche Commissariat à l'Energie Atomique (CEA)-Centre National de la Recherche Scientifique (CNRS) 217, Fontenay aux Roses, 92265, France.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-0861DOI Listing
November 2008

Defects in XRCC4 and KU80 differentially affect the joining of distal nonhomologous ends.

Proc Natl Acad Sci U S A 2007 Dec 18;104(52):20902-7. Epub 2007 Dec 18.

Commissariat à l'Energie Atomique, Unité Mixte de Recherche 217, Centre National de la Recherche Scientifique/Commissariat à l'Energie Atomique, Institut de Radiobiologie Cellulaire et Moléculaire, Fontenay aux Roses, France.

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http://dx.doi.org/10.1073/pnas.0708541104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409239PMC
December 2007

Apoptotic topoisomerase I-DNA complexes induced by staurosporine-mediated oxygen radicals.

J Biol Chem 2004 Nov 22;279(48):50499-504. Epub 2004 Sep 22.

Laboratory of Molecular Pharmacology, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892-4255, USA.

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http://dx.doi.org/10.1074/jbc.M410277200DOI Listing
November 2004

Phosphatidylcholine-derived phosphatidic acid and diacylglycerol are involved in the signaling pathways activated by docetaxel.

J Exp Ther Oncol 2003 Jan-Feb;3(1):36-46

INSERM E9910, Institut Claudius Regaud, 20 rue du Pont St Pierre, Toulouse 31052, France.

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February 2004

Association of XRCC1 and tyrosyl DNA phosphodiesterase (Tdp1) for the repair of topoisomerase I-mediated DNA lesions.

DNA Repair (Amst) 2003 Oct;2(10):1087-100

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institute of Health, Building 37, Room 5068, Bethesda, MD, USA.

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October 2003

Protein kinase Czeta mediated Raf-1/extracellular-regulated kinase activation by daunorubicin.

Blood 2003 Feb 24;101(4):1543-50. Epub 2002 Oct 24.

Institut National de la Santé et de la Recherche Médicale U563, Institut Claudius Régaud, Toulouse, France.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2002-05-15
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http://dx.doi.org/10.1182/blood-2002-05-1585DOI Listing
February 2003

Overexpression of the atypical protein kinase C zeta reduces topoisomerase II catalytic activity, cleavable complexes formation, and drug-induced cytotoxicity in monocytic U937 leukemia cells.

J Biol Chem 2002 Aug 24;277(35):31407-15. Epub 2002 Jun 24.

INSERM E9910, Institut Claudius Régaud, 20 rue du Pont Saint Pierre, 31052 Toulouse cedex, France.

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http://dx.doi.org/10.1074/jbc.M204654200DOI Listing
August 2002

Influence of ceramide metabolism on P-glycoprotein function in immature acute myeloid leukemia KG1a cells.

Mol Pharmacol 2002 Aug;62(2):304-12

Institut National de la Santé et de la Recherche Médicale (INSERM) E9910, Institut Claudius Régaud, Toulouse, France.

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August 2002

Kit signaling inhibits the sphingomyelin-ceramide pathway through PLC gamma 1: implication in stem cell factor radioprotective effect.

Blood 2002 Aug;100(4):1294-301

Institut Nationale de la Santé et de la Recherche Médicale E9910, Institut Claudius Régaud, Toulouse, France.

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August 2002