Publications by authors named "Isabelle Pin"

100Publications

Factors associated with asthma severity in children: data from the French COBRAPed Cohort.

J Allergy Clin Immunol Pract 2020 Dec 24. Epub 2020 Dec 24.

Université de Paris, Institut Necker Enfants Malades, Equipe Immunorégulation et Immunopathologie, Inserm UMR1151, CNRS UMR8253, F-75015, Paris France; Service de Pneumologie et Allergologie Pédiatriques, AP-HP, Hôpital Necker-Enfants Malades, F-75015, Paris, France. Electronic address:

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December 2020

Profile of exposures and lung function in adults with asthma: An exposome approach in the EGEA study.

Environ Res 2020 Nov 5:110422. Epub 2020 Nov 5.

Univ. Grenoble Alpes, Inserm, CNRS, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, IAB, 38000, Grenoble, France.

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November 2020

Use of bilevel positive pressure ventilation in patients with bronchiolitis.

Pediatr Pulmonol 2020 11 28;55(11):3134-3138. Epub 2020 Aug 28.

Pediatric Intensive Care Unit, Grenoble University Hospital, Grenoble, France.

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November 2020

Weaning from noninvasive ventilation and high flow nasal cannula in bronchiolitis: A survey of practice.

Pediatr Pulmonol 2020 11 14;55(11):3104-3109. Epub 2020 Sep 14.

Pediatric Intensive Care Unit, University Hospital of Grenoble-Alpes, La Tronche, France.

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November 2020

Use of personal care products during pregnancy in relation to urinary concentrations of select phenols: A longitudinal analysis from the SEPAGES feasibility study.

Int J Hyg Environ Health 2020 06 9;227:113518. Epub 2020 Apr 9.

University Grenoble Alpes, Inserm, CNRS, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, Institute for Advanced Biosciences (IAB), Grenoble, France. Electronic address:

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June 2020

Exposure to phenols during pregnancy and the first year of life in a new type of couple-child cohort relying on repeated urine biospecimens.

Environ Int 2020 06 2;139:105678. Epub 2020 Apr 2.

University Grenoble Alpes, Inserm, CNRS, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, Institute for Advanced Biosciences (IAB), Grenoble, France. Electronic address:

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June 2020

Non-infectious rhinitis is more strongly associated with early-rather than late-onset of COPD: data from the European Community Respiratory Health Survey (ECRHS).

Eur Arch Otorhinolaryngol 2020 May 11;277(5):1353-1359. Epub 2020 Feb 11.

Department of Otorhinolaryngology, Head and Neck Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gröna Stråket 9, 413 45, Gothenburg, Sweden.

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May 2020

Long-term air pollution exposure is associated with increased severity of rhinitis in 2 European cohorts.

J Allergy Clin Immunol 2020 03 23;145(3):834-842.e6. Epub 2020 Jan 23.

INSERM, U1168, VIMA: Aging and Chronic Diseases, Epidemiological and Public Health Approaches, Villejuif, France; University of Versailles St-Quentin-en-Yvelines, UMR 1168, Montigny le Bretonneux, France; ISGLobal, Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain. Electronic address:

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March 2020

Exposure to phthalate metabolites, phenols and organophosphate pesticide metabolites and blood pressure during pregnancy.

Int J Hyg Environ Health 2019 04 27;222(3):446-454. Epub 2018 Dec 27.

ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Spain. Electronic address:

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April 2019

Association between air pollution and rhinitis incidence in two European cohorts.

Environ Int 2018 06 30;115:257-266. Epub 2018 Mar 30.

INSERM, U1168, VIMA: Aging and Chronic Diseases, Epidemiological and Public Health Approaches, Villejuif, France; Univ Versailles St-Quentin-en-Yvelines, UMR-S 1168, F-78180 Montigny le Bretonneux, France; ISGLoBAL, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.

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June 2018

Multimorbidity medications and poor asthma prognosis.

Eur Respir J 2018 04 12;51(4). Epub 2018 Apr 12.

Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, Institute for Advanced Biosciences, INSERM U1209, CNRS UMR 5309, Université Grenoble Alpes, Grenoble, France.

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April 2018

Asthma Medication Ratio Phenotypes in Elderly Women.

J Allergy Clin Immunol Pract 2018 May - Jun;6(3):897-906.e5. Epub 2017 Sep 22.

Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, Institute for Advanced Biosciences, Institut National de la Santé et de la Recherche Médicale U1209, Centre National de la Recherche Scientifique - Unité Mixte de Recherche 5309, Université Grenoble Alpes, Grenoble, France.

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October 2019

Exposure to Select Phenols and Phthalates and Respiratory Health in Five-Year-Old Boys: A Prospective Study.

Environ Health Perspect 2017 09 8;125(9):097006. Epub 2017 Sep 8.

Inserm, CNRS, University Grenoble Alpes, Institute for Advanced Biosciences (IAB), U1209, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, Grenoble, France.

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September 2017

Propofol for sedation during less invasive surfactant administration in preterm infants.

Arch Dis Child Fetal Neonatal Ed 2017 Sep 8;102(5):F465. Epub 2017 May 8.

Neonatal Intensive Care Unit, CHU de Grenoble, Grenoble, 38 043 Grenoble Cedex 9, France.

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September 2017

Serum cytokine profiles as predictors of asthma control in adults from the EGEA study.

Respir Med 2017 04 6;125:57-64. Epub 2017 Mar 6.

INSERM, U1168, VIMA: Aging and Chronic Diseases, Epidemiological and Public Health Approaches, F-94807, Villejuif, France; Univ Versailles St-Quentin-en-Yvelines, UMR-S 1168, F-78180, Montigny le Bretonneux, France.

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April 2017

Mechanisms of the Development of Allergy (MeDALL): Introducing novel concepts in allergy phenotypes.

J Allergy Clin Immunol 2017 02;139(2):388-399

Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, GRIAC Research Institute, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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February 2017

Socioeconomic position and outdoor nitrogen dioxide (NO) exposure in Western Europe: A multi-city analysis.

Environ Int 2017 Apr 1;101:117-124. Epub 2017 Feb 1.

INSERM, U1168, VIMA: Aging and Chronic Diseases, Epidemiological and Public Health Approaches, F-94807 Villejuif, France; Univ Versailles St-Quentin-en-Yvelines, UMR-S 1168, F-78180 Montigny le Bretonneux, France; ISGlobal-Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain; CIBER Epidemiología y Salud Pública, Barcelona, Spain.

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April 2017

Blood granulocyte patterns as predictors of asthma phenotypes in adults from the EGEA study.

Eur Respir J 2016 10 4;48(4):1040-1051. Epub 2016 Aug 4.

INSERM, IAB, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, Grenoble, France Univ Grenoble Alpes, Grenoble, France CHU de Grenoble, Pédiatrie, Grenoble, France.

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October 2016

Women using bleach for home cleaning are at increased risk of non-allergic asthma.

Respir Med 2016 08 25;117:264-71. Epub 2016 Jun 25.

Inserm, U1168, VIMA: Aging and Chronic Diseases, Epidemiological and Public Health Approaches, F-94807, Villejuif, France; Univ Versailles St-Quentin-en-Yvelines, UMR-S 1168, F-78180, Montigny le Bretonneux, France.

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August 2016

Specific IgE and IgG measured by the MeDALL allergen-chip depend on allergen and route of exposure: The EGEA study.

J Allergy Clin Immunol 2017 02 22;139(2):643-654.e6. Epub 2016 Jun 22.

INSERM U1168, VIMA (Aging and chronic diseases. Epidemiological and public health approaches), Villejuif, France; Univ Versailles St-Quentin-en-Yvelines, Montigny le Bretonneux, France; University Hospital, Montpellier, France.

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February 2017

Forced midexpiratory flow between 25% and 75% of forced vital capacity is associated with long-term persistence of asthma and poor asthma outcomes.

J Allergy Clin Immunol 2016 06 11;137(6):1709-1716.e6. Epub 2015 Dec 11.

Université Grenoble Alpes, IAB, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, Grenoble, France; Inserm, IAB, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, Grenoble, France; CHU de Grenoble, IAB, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Grenoble, France.

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June 2016

Characterization of Rhinitis According to the Asthma Status in Adults Using an Unsupervised Approach in the EGEA Study.

PLoS One 2015 26;10(8):e0136191. Epub 2015 Aug 26.

INSERM, U1168, VIMA: Aging and chronic diseases, Epidemiological and Public health approaches, F-94807, Villejuif, France; Univ Versailles St-Quentin-en-Yvelines, UMR-S 1168, F-78180, Montigny le Bretonneux, France.

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May 2016

Estimation of exposure to atmospheric pollutants during pregnancy integrating space-time activity and indoor air levels: Does it make a difference?

Environ Int 2015 Nov 24;84:161-73. Epub 2015 Aug 24.

Inserm and Univ. Grenoble Alpes, IAB, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Grenoble, France. Electronic address:

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November 2015

Real-life long-term omalizumab therapy in children with severe allergic asthma.

Eur Respir J 2015 Sep 28;46(3):856-9. Epub 2015 May 28.

Centre de l'Asthme et des Allergies, Hôpital d'Enfants Armand-Trousseau, Paris, France INSERM, UMR_S 1136, Sorbonne Universités, UPMC Université Paris 06, Paris, France Institut Pierre Louis d'Epidémiologie et de Santé Publique, Equipe EPAR, Paris, France.

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September 2015

Comparing Mycobacterium massiliense and Mycobacterium abscessus lung infections in cystic fibrosis patients.

J Cyst Fibros 2015 Jan 30;14(1):63-9. Epub 2014 Jul 30.

EA3647, UFR des Sciences de la Santé Simone Veil, Université de Versailles Saint Quentin en Yvelines (UVSQ), Guyancourt, France; Laboratoire de Microbiologie, Hôpital Raymond Poincaré, Assistance Publique Hôpitaux de Paris (AP-HP), Garches, France; Laboratoire de Microbiologie, Hôpital Ambroise Paré, AP-HP, Boulogne-Billancourt, France.

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January 2015

Long-term benefits of inhaled corticosteroids in asthma: the propensity score method.

Pharmacoepidemiol Drug Saf 2015 Mar 26;24(3):246-55. Epub 2014 Jun 26.

INSERM, Institut Albert Bonniot, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, F-38000, Grenoble, France; Université Grenoble Alpes, Institut Albert Bonniot, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, F-38000, Grenoble, France; CHU de Grenoble, Institut Albert Bonniot, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, F-38000, Grenoble, France; Université Grenoble Alpes, School of Pharmacy, F-38000, Grenoble, France; CHU de Grenoble, Pharmacy Department, F-38000, Grenoble, France.

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March 2015

Genome-wide association analysis identifies six new loci associated with forced vital capacity.

Authors:
Daan W Loth María Soler Artigas Sina A Gharib Louise V Wain Nora Franceschini Beate Koch Tess D Pottinger Albert Vernon Smith Qing Duan Chris Oldmeadow Mi Kyeong Lee David P Strachan Alan L James Jennifer E Huffman Veronique Vitart Adaikalavan Ramasamy Nicholas J Wareham Jaakko Kaprio Xin-Qun Wang Holly Trochet Mika Kähönen Claudia Flexeder Eva Albrecht Lorna M Lopez Kim de Jong Bharat Thyagarajan Alexessander Couto Alves Stefan Enroth Ernst Omenaas Peter K Joshi Tove Fall Ana Viñuela Lenore J Launer Laura R Loehr Myriam Fornage Guo Li Jemma B Wilk Wenbo Tang Ani Manichaikul Lies Lahousse Tamara B Harris Kari E North Alicja R Rudnicka Jennie Hui Xiangjun Gu Thomas Lumley Alan F Wright Nicholas D Hastie Susan Campbell Rajesh Kumar Isabelle Pin Robert A Scott Kirsi H Pietiläinen Ida Surakka Yongmei Liu Elizabeth G Holliday Holger Schulz Joachim Heinrich Gail Davies Judith M Vonk Mary Wojczynski Anneli Pouta Asa Johansson Sarah H Wild Erik Ingelsson Fernando Rivadeneira Henry Völzke Pirro G Hysi Gudny Eiriksdottir Alanna C Morrison Jerome I Rotter Wei Gao Dirkje S Postma Wendy B White Stephen S Rich Albert Hofman Thor Aspelund David Couper Lewis J Smith Bruce M Psaty Kurt Lohman Esteban G Burchard André G Uitterlinden Melissa Garcia Bonnie R Joubert Wendy L McArdle A Bill Musk Nadia Hansel Susan R Heckbert Lina Zgaga Joyce B J van Meurs Pau Navarro Igor Rudan Yeon-Mok Oh Susan Redline Deborah L Jarvis Jing Hua Zhao Taina Rantanen George T O'Connor Samuli Ripatti Rodney J Scott Stefan Karrasch Harald Grallert Nathan C Gaddis John M Starr Cisca Wijmenga Ryan L Minster David J Lederer Juha Pekkanen Ulf Gyllensten Harry Campbell Andrew P Morris Sven Gläser Christopher J Hammond Kristin M Burkart John Beilby Stephen B Kritchevsky Vilmundur Gudnason Dana B Hancock O Dale Williams Ozren Polasek Tatijana Zemunik Ivana Kolcic Marcy F Petrini Matthias Wjst Woo Jin Kim David J Porteous Generation Scotland Blair H Smith Anne Viljanen Markku Heliövaara John R Attia Ian Sayers Regina Hampel Christian Gieger Ian J Deary H Marike Boezen Anne Newman Marjo-Riitta Jarvelin James F Wilson Lars Lind Bruno H Stricker Alexander Teumer Timothy D Spector Erik Melén Marjolein J Peters Leslie A Lange R Graham Barr Ken R Bracke Fien M Verhamme Joohon Sung Pieter S Hiemstra Patricia A Cassano Akshay Sood Caroline Hayward Josée Dupuis Ian P Hall Guy G Brusselle Martin D Tobin Stephanie J London

Nat Genet 2014 Jul 15;46(7):669-77. Epub 2014 Jun 15.

1] Epidemiology Branch, National Institute of Environmental Health Sciences, US National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, North Carolina, USA. [2].

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July 2014

Virus and cystic fibrosis: rhinoviruses are associated with exacerbations in adult patients.

J Clin Virol 2014 Jun 25;60(2):147-53. Epub 2014 Feb 25.

Department of Microbiology, Lille Hospital, Faculty of Medicine, Lille, France; Center of Infection and Immunology of Lille (CIIL), Institut Pasteur, Biology and Diversity of Emerging Eukaryotic Pathogens (BDEEP - EA4547), Lille, France; INSERM U1019, Lille, France.

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June 2014

Does consideration of larger study areas yield more accurate estimates of air pollution health effects? An illustration of the bias-variance trade-off in air pollution epidemiology.

Environ Int 2013 Oct 28;60:23-30. Epub 2013 Aug 28.

Centre for Research in Environmental Epidemiology (CREAL), Parc de Recerca Biomèdica de Barcelona, Doctor Aiguader 88, 08003 Barcelona, Spain; IMIM (Hospital del Mar Research Institute), Passeig Marítim 25-29, 08003 Barcelona, Spain; CIBER Epidemiologia y Salud Pública (CIBERESP), Spain; INSERM, U823, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, Institute Albert Bonniot, 38042 Grenoble, France.

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October 2013

Impact of geocoding methods on associations between long-term exposure to urban air pollution and lung function.

Environ Health Perspect 2013 Sep 3;121(9):1054-60. Epub 2013 Jul 3.

Inserm (Institut National de la Santé et de la Recherche Médicale), CESP (Centre de recherche en Épidémiologie et Santé des Populations), U1018, Respiratory and Environmental Epidemiology Team, Villejuif, France.

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September 2013

Long-term mechanical ventilation equipment for neuromuscular patients: meeting the expectations of patients and prescribers.

Respir Care 2014 Jan 13;59(1):97-106. Epub 2013 Jun 13.

Physiologie-Explorations Fonctionnelles, et Le Centre d'Investigation Clinique et d'Innovation Technologique Unité Mixte de Recherche 805, Hôpital Raymond Poincaré, Assistance Publique Hôpitaux de Paris, Garches, France.

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January 2014

Domestic use of cleaning sprays and asthma activity in females.

Eur Respir J 2012 Dec 10;40(6):1381-9. Epub 2012 Apr 10.

INSERM, CESP Centre for Research in Epidemiology and Population Health, U1018, Respiratory and Environmental Epidemiology Team, Universite´ Paris Sud 11, UMRS1018, Villejuif, France.

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December 2012

The impact of cigarette smoking on asthma: a population-based international cohort study.

Int Arch Allergy Immunol 2012 26;158(2):175-83. Epub 2012 Jan 26.

Division of Respiratory Diseases, IRCCS San Matteo Hospital Foundation, University of Pavia, Pavia, Italy.

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August 2012

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.

Authors:
María Soler Artigas Daan W Loth Louise V Wain Sina A Gharib Ma'en Obeidat Wenbo Tang Guangju Zhai Jing Hua Zhao Albert Vernon Smith Jennifer E Huffman Eva Albrecht Catherine M Jackson David M Evans Gemma Cadby Myriam Fornage Ani Manichaikul Lorna M Lopez Toby Johnson Melinda C Aldrich Thor Aspelund Inês Barroso Harry Campbell Patricia A Cassano David J Couper Gudny Eiriksdottir Nora Franceschini Melissa Garcia Christian Gieger Gauti Kjartan Gislason Ivica Grkovic Christopher J Hammond Dana B Hancock Tamara B Harris Adaikalavan Ramasamy Susan R Heckbert Markku Heliövaara Georg Homuth Pirro G Hysi Alan L James Stipan Jankovic Bonnie R Joubert Stefan Karrasch Norman Klopp Beate Koch Stephen B Kritchevsky Lenore J Launer Yongmei Liu Laura R Loehr Kurt Lohman Ruth J F Loos Thomas Lumley Khalid A Al Balushi Wei Q Ang R Graham Barr John Beilby John D Blakey Mladen Boban Vesna Boraska Jonas Brisman John R Britton Guy G Brusselle Cyrus Cooper Ivan Curjuric Santosh Dahgam Ian J Deary Shah Ebrahim Mark Eijgelsheim Clyde Francks Darya Gaysina Raquel Granell Xiangjun Gu John L Hankinson Rebecca Hardy Sarah E Harris John Henderson Amanda Henry Aroon D Hingorani Albert Hofman Patrick G Holt Jennie Hui Michael L Hunter Medea Imboden Karen A Jameson Shona M Kerr Ivana Kolcic Florian Kronenberg Jason Z Liu Jonathan Marchini Tricia McKeever Andrew D Morris Anna-Carin Olin David J Porteous Dirkje S Postma Stephen S Rich Susan M Ring Fernando Rivadeneira Thierry Rochat Avan Aihie Sayer Ian Sayers Peter D Sly George Davey Smith Akshay Sood John M Starr André G Uitterlinden Judith M Vonk S Goya Wannamethee Peter H Whincup Cisca Wijmenga O Dale Williams Andrew Wong Massimo Mangino Kristin D Marciante Wendy L McArdle Bernd Meibohm Alanna C Morrison Kari E North Ernst Omenaas Lyle J Palmer Kirsi H Pietiläinen Isabelle Pin Ozren Pola Sbreve Ek Anneli Pouta Bruce M Psaty Anna-Liisa Hartikainen Taina Rantanen Samuli Ripatti Jerome I Rotter Igor Rudan Alicja R Rudnicka Holger Schulz So-Youn Shin Tim D Spector Ida Surakka Veronique Vitart Henry Völzke Nicholas J Wareham Nicole M Warrington H-Erich Wichmann Sarah H Wild Jemma B Wilk Matthias Wjst Alan F Wright Lina Zgaga Tatijana Zemunik Craig E Pennell Fredrik Nyberg Diana Kuh John W Holloway H Marike Boezen Debbie A Lawlor Richard W Morris Nicole Probst-Hensch Jaakko Kaprio James F Wilson Caroline Hayward Mika Kähönen Joachim Heinrich Arthur W Musk Deborah L Jarvis Sven Gläser Marjo-Riitta Järvelin Bruno H Ch Stricker Paul Elliott George T O'Connor David P Strachan Stephanie J London Ian P Hall Vilmundur Gudnason Martin D Tobin

Nat Genet 2011 Sep 25;43(11):1082-90. Epub 2011 Sep 25.

Department of Health Sciences, University of Leicester, Leicester, UK.

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September 2011

Exposure to phthalates and phenols during pregnancy and offspring size at birth.

Environ Health Perspect 2012 Mar 7;120(3):464-70. Epub 2011 Sep 7.

Institut National de la Santé et de la Recherche Médicale, Institut Albert Bonniot (U823), Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, Grenoble, France.

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March 2012

Smoking and asthma: disentangling their mutual influences using a longitudinal approach.

Respir Med 2011 Dec 27;105(12):1805-14. Epub 2011 Aug 27.

Centre de Recherche INSERM/UJF U823, Institut Albert Bonniot, BP 170, 38042 Grenoble Cedex 9, La Tronche, France.

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December 2011

Air pollution and asthma control in the Epidemiological study on the Genetics and Environment of Asthma.

J Epidemiol Community Health 2012 Sep 20;66(9):796-802. Epub 2011 Jun 20.

Epidémiologie respiratoire et environnementale, CESP/UMRS 1018 Inserm, UPS11, 16, avenue Paul Vaillant Couturier, 94807 Villejuif Cedex, France.

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September 2012

Mold allergen sensitization in adult asthma according to integrin β3 polymorphisms and Toll-like receptor 2/+596 genotype.

J Allergy Clin Immunol 2011 Jul 13;128(1):185-191.e7. Epub 2011 May 13.

Institute for Risk Assessment Sciences, Division of Environmental Epidemiology, Utrecht University, Utrecht, The Netherlands.

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July 2011

Passive and active smoking and exhaled nitric oxide levels according to asthma and atopy in adults.

Ann Allergy Asthma Immunol 2010 May;104(5):385-93

Inserm, CESP Centre for Research in Epidemiology and Population Health, Respiratory and Environmental Epidemiology Team U1018, Villejuif, France.

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May 2010

Prevalence and risk factors of suppurative complications in children with pneumonia.

Acta Paediatr 2010 Jun 19;99(6):861-6. Epub 2010 Feb 19.

Quality of Care Unit, Centre Hospitalier Universitaire de Grenoble, Grenoble, France.

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June 2010

Asthma severity according to Global Initiative for Asthma and its determinants: an international study.

Int Arch Allergy Immunol 2010 7;151(1):70-9. Epub 2009 Aug 7.

Unit of Epidemiology and Medical Statistics, Department of Medicine and Public Health, University of Verona, Verona, Italy.

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December 2009

Body mass index, weight gain, and other determinants of lung function decline in adult asthma.

J Allergy Clin Immunol 2009 May 24;123(5):1069-74, 1074.e1-4. Epub 2009 Mar 24.

Department of Medicine and Public Health, Unit of Epidemiology and Medical Statistics, University of Verona, Verona, Italy.

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May 2009