Publications by authors named "Isabelle Cleynen"

59Publications

Inflammatory bowel disease and Parkinson's disease: common pathophysiological links.

Gut 2020 Oct 16. Epub 2020 Oct 16.

Department of Human Genetics, KU Leuven, Leuven, Belgium

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/gutjnl-2020-322429DOI Listing
October 2020

Molecular Changes in the Non-Inflamed Terminal Ileum of Patients with Ulcerative Colitis.

Cells 2020 Jul 28;9(8). Epub 2020 Jul 28.

Laboratory of Complex Genetics, Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/cells9081793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464680PMC
July 2020

Genetic contributors to risk of schizophrenia in the presence of a 22q11.2 deletion.

Authors:
Isabelle Cleynen Worrawat Engchuan Matthew S Hestand Tracy Heung Aaron M Holleman H Richard Johnston Thomas Monfeuga Donna M McDonald-McGinn Raquel E Gur Bernice E Morrow Ann Swillen Jacob A S Vorstman Carrie E Bearden Eva W C Chow Marianne van den Bree Beverly S Emanuel Joris R Vermeesch Stephen T Warren Michael J Owen Pankaj Chopra David J Cutler Richard Duncan Alex V Kotlar Jennifer G Mulle Anna J Voss Michael E Zwick Alexander Diacou Aaron Golden Tingwei Guo Jhih-Rong Lin Tao Wang Zhengdong Zhang Yingjie Zhao Christian Marshall Daniele Merico Andrea Jin Brenna Lilley Harold I Salmons Oanh Tran Peter Holmans Antonio Pardinas James T R Walters Wolfram Demaerel Erik Boot Nancy J Butcher Gregory A Costain Chelsea Lowther Rens Evers Therese A M J van Amelsvoort Esther van Duin Claudia Vingerhoets Jeroen Breckpot Koen Devriendt Elfi Vergaelen Annick Vogels T Blaine Crowley Daniel E McGinn Edward M Moss Robert J Sharkus Marta Unolt Elaine H Zackai Monica E Calkins Robert S Gallagher Ruben C Gur Sunny X Tang Rosemarie Fritsch Claudia Ornstein Gabriela M Repetto Elemi Breetvelt Sasja N Duijff Ania Fiksinski Hayley Moss Maria Niarchou Kieran C Murphy Sarah E Prasad Eileen M Daly Maria Gudbrandsen Clodagh M Murphy Declan G Murphy Antonio Buzzanca Fabio Di Fabio Maria C Digilio Maria Pontillo Bruno Marino Stefano Vicari Karlene Coleman Joseph F Cubells Opal Y Ousley Miri Carmel Doron Gothelf Ehud Mekori-Domachevsky Elena Michaelovsky Ronnie Weinberger Abraham Weizman Leila Kushan Maria Jalbrzikowski Marco Armando Stéphan Eliez Corrado Sandini Maude Schneider Frédérique Sloan Béna Kevin M Antshel Wanda Fremont Wendy R Kates Raoul Belzeaux Tiffany Busa Nicole Philip Linda E Campbell Kathryn L McCabe Stephen R Hooper Kelly Schoch Vandana Shashi Tony J Simon Flora Tassone Celso Arango David Fraguas Sixto García-Miñaúr Jaume Morey-Canyelles Jordi Rosell Damià H Suñer Jasna Raventos-Simic Michael P Epstein Nigel M Williams Anne S Bassett

Mol Psychiatry 2020 Feb 3. Epub 2020 Feb 3.

Clinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41380-020-0654-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396297PMC
February 2020

How to approach understanding complex trait genetics - inflammatory bowel disease as a model complex trait.

United European Gastroenterol J 2019 12 1;7(10):1426-1430. Epub 2019 Dec 1.

Department of Gastroenterology, Örebro University, Örebro, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2050640619891120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893991PMC
December 2019

Quantitative microbiome profiling disentangles inflammation- and bile duct obstruction-associated microbiota alterations across PSC/IBD diagnoses.

Nat Microbiol 2019 11 17;4(11):1826-1831. Epub 2019 Jun 17.

Laboratory of Molecular Bacteriology, Department of Microbiology and Immunology, Rega Institute, KU Leuven, Leuven, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41564-019-0483-9DOI Listing
November 2019

Molecular Profiling of Inflammatory Bowel Disease: Is It Ready for Use in Clinical Decision-Making?

Cells 2019 06 4;8(6). Epub 2019 Jun 4.

Laboratory of Complex Genetics, Department of Human Genetics, KU Leuven, Herestraat 49 - box 610, 3000 Leuven, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/cells8060535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627070PMC
June 2019

Cellular diversity in the colon: another brick in the wall.

Nat Rev Gastroenterol Hepatol 2019 07;16(7):391-392

Department of Gastroenterology, Ghent University and VIB Center for Inflammation Research, Ghent, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41575-019-0161-7DOI Listing
July 2019

Butyrate Does Not Protect Against Inflammation-induced Loss of Epithelial Barrier Function and Cytokine Production in Primary Cell Monolayers From Patients With Ulcerative Colitis.

J Crohns Colitis 2019 Sep;13(10):1351-1361

Department of Chronic Diseases, Metabolism & Ageing [CHROMETA], Translational Research Center for Gastrointestinal Disorders [TARGID], KU Leuven, Leuven, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ecco-jcc/jjz064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764103PMC
September 2019

TREM-1, the ideal predictive biomarker for endoscopic healing in anti-TNF-treated Crohn's disease patients?

Gut 2019 08 14;68(8):1531-1533. Epub 2018 Jul 14.

Department of Gastroenterology and Hepatology, University Hospitals Leuven, KU Leuven, Leuven, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/gutjnl-2018-316845DOI Listing
August 2019

Genetic and Transcriptomic Bases of Intestinal Epithelial Barrier Dysfunction in Inflammatory Bowel Disease.

Inflamm Bowel Dis 2017 10;23(10):1718-1729

*Department of Clinical and Experimental Medicine, Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium; †Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium; ‡Laboratory of Complex Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium; §Gene Expression Unit, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium; ‖Faculty of Medicine and Life Sciences, Hasselt University, Hasselt, Belgium; and ¶Jessa Hospital, Hasselt, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MIB.0000000000001246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461205PMC
October 2017

Evolution of cytokines and inflammatory biomarkers during infliximab induction therapy and the impact of inflammatory burden on primary response in patients with Crohn's disease.

Scand J Gastroenterol 2017 Oct 16;52(10):1086-1092. Epub 2017 Jun 16.

a Department of Clinical and Experimental Medicine, Translational Research Center for GastroIntestinal Disorders (TARGID) , KU Leuven , Leuven , Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/00365521.2017.1339825DOI Listing
October 2017

Genetics of inflammatory bowel disease: beyond NOD2.

Lancet Gastroenterol Hepatol 2017 03 9;2(3):224-234. Epub 2017 Feb 9.

Department of Human Genetics, KU Leuven, Leuven, Belgium. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S2468-1253(16)30111-XDOI Listing
March 2017

RISK stratification in paediatric Crohn's disease.

Lancet 2017 04 2;389(10080):1672-1674. Epub 2017 Mar 2.

Laboratory for Complex Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S0140-6736(17)30634-7DOI Listing
April 2017

Effect of vedolizumab (anti-α4β7-integrin) therapy on histological healing and mucosal gene expression in patients with UC.

Gut 2018 01 7;67(1):43-52. Epub 2016 Oct 7.

Department of Clinical and Experimental Medicine, Translational Research Center for Gastrointestinal Disorders, KU Leuven, Leuven, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/gutjnl-2016-312293DOI Listing
January 2018

A Genetic Variation in the Neonatal Fc-Receptor Affects Anti-TNF Drug Concentrations in Inflammatory Bowel Disease.

Am J Gastroenterol 2016 Oct 2;111(10):1438-1445. Epub 2016 Aug 2.

Department of Gastroenterology, Universitair ziekenhuis Leuven, Leuven, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ajg.2016.306DOI Listing
October 2016

Genetic Influences on the Development of Fibrosis in Crohn's Disease.

Front Med (Lausanne) 2016 30;3:24. Epub 2016 May 30.

Laboratory of Complex Genetics, Department of Human Genetics, KU Leuven , Leuven , Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmed.2016.00024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885006PMC
June 2016

Genome-Wide Copy Number Variation Scan Identifies Complement Component C4 as Novel Susceptibility Gene for Crohn's Disease.

Inflamm Bowel Dis 2016 Mar;22(3):505-15

*Department of Clinical and Experimental Medicine, TARGID, KU Leuven, Leuven, Belgium; †Department of Electrical Engineering (ESAT), STADIUS Center for Dynamical Systems, Signal Processing and Data Analytics, KU Leuven, Leuven, Belgium; ‡iMinds Department of Medical Information Technologies, KU Leuven, Leuven, Belgium; §Department of Human Genetics, KU Leuven, Leuven, Belgium; ‖Department of Gastroenterology, Ghent University Hospital, Gent, Belgium; ¶Erasmus Hospital, Free University of Brussels, Department of Gastroenterology, Brussels, Belgium; **Unit of Animal Genomics, Groupe Interdisciplinaire de Genoproteomique Appliquee (GIGA-R) and Faculty of Veterinary Medicine, University of Liege, Liege, Belgium; ††Division of Gastroenterology, Centre Hospitalier Universitaire, Université de Liege, Liège, Belgium; ‡‡Division of Gastroenterology, UZ Leuven, Leuven, Belgium; and §§Department of Electrical Engineering and Computer Science, Bioinformatics-Statistical Genetics, Montefiore Institute, Universty of Liège, Liège, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MIB.0000000000000623DOI Listing
March 2016

The genetic architecture of inflammatory bowel disease: past, present and future.

Curr Opin Gastroenterol 2015 Nov;31(6):456-63

aDepartment of Human Genetics, KU Leuven bDepartment of Clinical and Experimental Medicine, KU Leuven cDivision of Gastroenterology, UZ Leuven, Leuven, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MOG.0000000000000215DOI Listing
November 2015

Strong Upregulation of AIM2 and IFI16 Inflammasomes in the Mucosa of Patients with Active Inflammatory Bowel Disease.

Inflamm Bowel Dis 2015 Nov;21(11):2673-82

*Department of Clinical and Experimental Medicine, Translational Research Center for Gastrointestinal Disorders, KU Leuven, Leuven, Belgium; †Department of Respiratory Medicine, Maastricht University Medical Centre+, Maastricht University, Maastricht, the Netherlands; ‡IUF - Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany; §Gene Expression Unit, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium; and ‖Translational Cell & Tissue Research, Department of Imaging & Pathology, KU Leuven, Leuven, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MIB.0000000000000535DOI Listing
November 2015

Immunogenicity to infliximab is associated with HLA-DRB1.

Gut 2015 Aug 15;64(8):1344-5. Epub 2015 Apr 15.

Department of Gastroenterology, UZ Leuven, Leuven, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/gutjnl-2015-309698DOI Listing
August 2015

Polymorphisms near TBX5 and GDF7 are associated with increased risk for Barrett's esophagus.

Gastroenterology 2015 Feb 5;148(2):367-78. Epub 2014 Nov 5.

University Hospitals Coventry & Warwickshire NHS Trust, Warwickshire, England; Warwick Medical School, University of Warwick, Warwickshire, England. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.gastro.2014.10.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315134PMC
February 2015

The role of Haptoglobin and its related protein, Zonulin, in inflammatory bowel disease.

Tissue Barriers 2013 Dec 10;1(5):e27321. Epub 2013 Dec 10.

Department of Clinical and Experimental Medicine; TARGID; KU Leuven.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/tisb.27321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943850PMC
December 2013

Genetic association and functional role of Crohn disease risk alleles involved in microbial sensing, autophagy, and endoplasmic reticulum (ER) stress.

Autophagy 2013 Dec 14;9(12):2046-55. Epub 2013 Nov 14.

Department of Clinical and Experimental Medicine; Translational Research Center for Gastrointestinal Disorders (TARGID); KU Leuven; Leuven, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/auto.26337DOI Listing
December 2013

Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis.

Nat Genet 2013 Jun 21;45(6):670-5. Epub 2013 Apr 21.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.

View Article

Download full-text PDF

Source
http://petercroucher.com/wp-content/uploads/2013/10/51_Natur
Web Search
http://www.nature.com/doifinder/10.1038/ng.2616
Publisher Site
http://dx.doi.org/10.1038/ng.2616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667736PMC
June 2013

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.

Authors:
Luke Jostins Stephan Ripke Rinse K Weersma Richard H Duerr Dermot P McGovern Ken Y Hui James C Lee L Philip Schumm Yashoda Sharma Carl A Anderson Jonah Essers Mitja Mitrovic Kaida Ning Isabelle Cleynen Emilie Theatre Sarah L Spain Soumya Raychaudhuri Philippe Goyette Zhi Wei Clara Abraham Jean-Paul Achkar Tariq Ahmad Leila Amininejad Ashwin N Ananthakrishnan Vibeke Andersen Jane M Andrews Leonard Baidoo Tobias Balschun Peter A Bampton Alain Bitton Gabrielle Boucher Stephan Brand Carsten Büning Ariella Cohain Sven Cichon Mauro D'Amato Dirk De Jong Kathy L Devaney Marla Dubinsky Cathryn Edwards David Ellinghaus Lynnette R Ferguson Denis Franchimont Karin Fransen Richard Gearry Michel Georges Christian Gieger Jürgen Glas Talin Haritunians Ailsa Hart Chris Hawkey Matija Hedl Xinli Hu Tom H Karlsen Limas Kupcinskas Subra Kugathasan Anna Latiano Debby Laukens Ian C Lawrance Charlie W Lees Edouard Louis Gillian Mahy John Mansfield Angharad R Morgan Craig Mowat William Newman Orazio Palmieri Cyriel Y Ponsioen Uros Potocnik Natalie J Prescott Miguel Regueiro Jerome I Rotter Richard K Russell Jeremy D Sanderson Miquel Sans Jack Satsangi Stefan Schreiber Lisa A Simms Jurgita Sventoraityte Stephan R Targan Kent D Taylor Mark Tremelling Hein W Verspaget Martine De Vos Cisca Wijmenga David C Wilson Juliane Winkelmann Ramnik J Xavier Sebastian Zeissig Bin Zhang Clarence K Zhang Hongyu Zhao Mark S Silverberg Vito Annese Hakon Hakonarson Steven R Brant Graham Radford-Smith Christopher G Mathew John D Rioux Eric E Schadt Mark J Daly Andre Franke Miles Parkes Severine Vermeire Jeffrey C Barrett Judy H Cho

Nature 2012 Nov;491(7422):119-24

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature11582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491803PMC
November 2012

Paradoxical inflammation induced by anti-TNF agents in patients with IBD.

Nat Rev Gastroenterol Hepatol 2012 Sep 3;9(9):496-503. Epub 2012 Jul 3.

Gastroenterology Department, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrgastro.2012.125DOI Listing
September 2012

Genetic variation in the autophagy gene ULK1 and risk of Crohn's disease.

Inflamm Bowel Dis 2011 Jun 28;17(6):1392-7. Epub 2010 Nov 28.

Department of Gastroenterology, University Hospitals Leuven, Leuven, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ibd.21486DOI Listing
June 2011

Genetic risk profiling and prediction of disease course in Crohn's disease patients.

Clin Gastroenterol Hepatol 2009 Sep 5;7(9):972-980.e2. Epub 2009 May 5.

Department of Medicine, Gastroenterology Section, Catholic University of Leuven, Leuven, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cgh.2009.05.001DOI Listing
September 2009

Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort.

Am J Gastroenterol 2009 Mar 27;104(3):630-8. Epub 2009 Jan 27.

Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ajg.2008.112DOI Listing
March 2009

The HMGA proteins: a myriad of functions (Review).

Int J Oncol 2008 Feb;32(2):289-305

Laboratory of Molecular Oncology, Department of Human Genetics, University of Leuven, Herestraat 49/bus 602, Leuven, Belgium.

View Article

Download full-text PDF

Source
February 2008

Transcriptional control of the human high mobility group A1 gene: basal and oncogenic Ras-regulated expression.

Cancer Res 2007 May;67(10):4620-9

Laboratory of Molecular Oncology, Department of Human Genetics, University of Leuven, Flanders Interuniversity Institute for Biotechnology, Herestraat, Leuven, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-06-4325DOI Listing
May 2007

HMGA2 regulates transcription of the Imp2 gene via an intronic regulatory element in cooperation with nuclear factor-kappaB.

Mol Cancer Res 2007 Apr;5(4):363-72

Department of Human Genetics, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Herestraat 49, Box 602, B-3000 Leuven, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1541-7786.MCR-06-0331DOI Listing
April 2007