Isabella Screpanti

Isabella Screpanti

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Isabella Screpanti

Isabella Screpanti

Publications by authors named "Isabella Screpanti"

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Broadening phenotype of adenylosuccinate lyase deficiency: A novel clinical pattern resembling neuronal ceroid lipofuscinosis.

Mol Genet Metab Rep 2019 Dec 21;21:100502. Epub 2019 Aug 21.

Division of Child Neurology and Infantile Psychiatry, Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy.

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http://dx.doi.org/10.1016/j.ymgmr.2019.100502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713842PMC
December 2019

PLK1 targets NOTCH1 during DNA damage and mitotic progression.

J Biol Chem 2019 Nov 9;294(47):17941-17950. Epub 2019 Oct 9.

Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 291, 00161 Rome, Italy

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http://dx.doi.org/10.1074/jbc.RA119.009881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879332PMC
November 2019

The Notch3 Receptor and Its Intracellular Signaling-Dependent Oncogenic Mechanisms.

Adv Exp Med Biol 2018 ;1066:205-222

Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.

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http://dx.doi.org/10.1007/978-3-319-89512-3_10DOI Listing
February 2019

Notch3 Targeting: A Novel Weapon against Ovarian Cancer Stem Cells.

Stem Cells Int 2019 6;2019:6264931. Epub 2019 Jan 6.

Department of Medico-Surgical Sciences and Biotechnology, Sapienza University, Latina, Italy.

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http://dx.doi.org/10.1155/2019/6264931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339748PMC
January 2019

Notch signaling as a therapeutic target for acute lymphoblastic leukemia.

Expert Opin Ther Targets 2018 04 21;22(4):331-342. Epub 2018 Mar 21.

e Department of Medico-Surgical Sciences and Biotechnology , Sapienza University , Latina , Italy.

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http://dx.doi.org/10.1080/14728222.2018.1451840DOI Listing
April 2018

A non-conserved amino acid variant regulates differential signalling between human and mouse CD28.

Nat Commun 2018 03 14;9(1):1080. Epub 2018 Mar 14.

Department of Biology and Biotechnology Charles Darwin, Laboratory Affiliated at Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University, 00185, Rome, Italy.

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http://dx.doi.org/10.1038/s41467-018-03385-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852078PMC
March 2018

The mazy case of Notch and immunoregulatory cells.

J Leukoc Biol 2017 08 14;102(2):361-368. Epub 2017 Mar 14.

Department of Molecular Medicine, Sapienza University, Rome, Italy; and

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http://dx.doi.org/10.1189/jlb.1VMR1216-505RDOI Listing
August 2017

CD3ε recruits Numb to promote TCR degradation.

Int Immunol 2016 Mar 27;28(3):127-37. Epub 2015 Oct 27.

Instituto de Parasitología y Biomedicina, CSIC, P. T. Ciencias de la Salud, 18100 Granada, Spain

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https://academic.oup.com/intimm/article-lookup/doi/10.1093/i
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http://dx.doi.org/10.1093/intimm/dxv060DOI Listing
March 2016

Proteomic analysis of human Sonic Hedgehog (SHH) medulloblastoma stem-like cells.

Mol Biosyst 2015 Jun;11(6):1603-11

Department of Medical, Oral and Biotechnological Sciences, University G. d'Annunzio of Chieti-Pescara, Chieti, Italy.

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http://dx.doi.org/10.1039/c5mb00034cDOI Listing
June 2015

The epigenetic factor BORIS/CTCFL regulates the NOTCH3 gene expression in cancer cells.

Biochim Biophys Acta 2014 Sep 28;1839(9):813-25. Epub 2014 Jun 28.

Department of Cellular Biotechnologies and Hematology, Faculty of Pharmacy & Medicine, Sapienza University of Rome, Rome, Italy; Pasteur Institute-Fondazione Cenci Bolognetti, Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bbagrm.2014.06.017DOI Listing
September 2014

The HMGA1 protoncogene frequently deregulated in cancer is a transcriptional target of E2F1.

Mol Carcinog 2013 Jul 2;52(7):526-34. Epub 2012 Mar 2.

Department of Experimental Medicine, Sapienza University, Rome, Italy.

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http://dx.doi.org/10.1002/mc.21887DOI Listing
July 2013

Scleroderma Mesenchymal Stem Cells display a different phenotype from healthy controls; implications for regenerative medicine.

Angiogenesis 2013 Jul 15;16(3):595-607. Epub 2013 Feb 15.

Department of Biotechnological and Applied Clinical Science, Rheumatology Unit, School of Medicine, University of L'Aquila, Delta 6 Building, Via dell'Ospedale, 67100 L'Aquila, Italy.

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http://dx.doi.org/10.1007/s10456-013-9338-9DOI Listing
July 2013

Hedgehog/Gli control by ubiquitination/acetylation interplay.

Vitam Horm 2012 ;88:211-27

Department of Molecular Medicine, Sapienza University, Rome, Italy.

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http://dx.doi.org/10.1016/B978-0-12-394622-5.00009-2DOI Listing
August 2012

MYCN sensitizes human neuroblastoma to apoptosis by HIPK2 activation through a DNA damage response.

Mol Cancer Res 2011 Jan 20;9(1):67-77. Epub 2010 Dec 20.

Department of Experimental Medicine, Sapienza University of Rome, Policlinico Umberto I, Viale Regina Elena, 324, 00161, Rome, Italy.

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http://dx.doi.org/10.1158/1541-7786.MCR-10-0227DOI Listing
January 2011

Novel targets for endoplasmic reticulum stress-induced apoptosis in B-CLL.

Blood 2010 Oct 13;116(15):2713-23. Epub 2010 Jul 13.

Department of Clinical and Experimental Medicine, General Pathology and Immunology Section, University of Perugia, Perugia, Italy.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2010-03-27
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http://dx.doi.org/10.1182/blood-2010-03-275628DOI Listing
October 2010

The multiple functions of Numb.

Exp Cell Res 2010 Apr 26;316(6):900-6. Epub 2009 Nov 26.

Department of Experimental Medicine, Sapienza University, 324 viale Regina Elena, 00161 Rome, Italy.

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http://linkinghub.elsevier.com/retrieve/pii/S001448270900516
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http://dx.doi.org/10.1016/j.yexcr.2009.11.017DOI Listing
April 2010

The chemokine Bv8/prokineticin 2 is up-regulated in inflammatory granulocytes and modulates inflammatory pain.

Proc Natl Acad Sci U S A 2009 Aug 10;106(34):14646-51. Epub 2009 Aug 10.

Department of Physiology and Pharmacology Vittorio Erspamer, Sapienza University of Rome, I-00185 Rome, Italy.

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http://dx.doi.org/10.1073/pnas.0903720106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2731841PMC
August 2009

The coactivator CRTC1 promotes cell proliferation and transformation via AP-1.

Proc Natl Acad Sci U S A 2009 Feb 21;106(5):1445-50. Epub 2009 Jan 21.

Department of Experimental Medicine and Pasteur Institute, Cenci Bolognetti Foundation, Sapienza University, Rome, Italy.

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http://dx.doi.org/10.1073/pnas.0808749106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635810PMC
February 2009

Constitutively activated Notch signaling is involved in survival and apoptosis resistance of B-CLL cells.

Blood 2009 Jan 16;113(4):856-65. Epub 2008 Sep 16.

Department of Clinical and Experimental Medicine, General Pathology and Immunology Section, University of Perugia, Perugia.

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http://dx.doi.org/10.1182/blood-2008-02-139725DOI Listing
January 2009

Notch signaling and diseases: an evolutionary journey from a simple beginning to complex outcomes.

Biochim Biophys Acta 2008 Sep 24;1782(9):489-97. Epub 2008 Jun 24.

Department of Experimental Medicine, Sapienza University of Rome, Roma, Italy.

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http://linkinghub.elsevier.com/retrieve/pii/S092544390800129
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http://dx.doi.org/10.1016/j.bbadis.2008.06.008DOI Listing
September 2008

Notch and Ikaros: not only converging players in T cell leukemia.

Cell Cycle 2007 Nov 15;6(22):2730-4. Epub 2007 Aug 15.

Department of Experimental Medicine, University La Sapienza, Roma, taly.

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http://dx.doi.org/10.4161/cc.6.22.4894DOI Listing
November 2007

Hedgehog signaling pathway in neural development and disease.

Psychoneuroendocrinology 2007 Aug 9;32 Suppl 1:S52-6. Epub 2007 Jul 9.

Department of Experimental Medicine and Pathology, University La Sapienza, 324 Viale Regina Elena, 00161 Roma, Italy.

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http://dx.doi.org/10.1016/j.psyneuen.2007.03.017DOI Listing
August 2007

TrkAIII expression in the thymus.

J Neuroimmunol 2007 Feb 22;183(1-2):151-61. Epub 2007 Jan 22.

Department of Experimental Medicine, University of L'Aquila, Coppito 2, Via Vetoio, 67100 L'Aquila, Italy.

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http://dx.doi.org/10.1016/j.jneuroim.2006.12.005DOI Listing
February 2007

Multiple ubiquitin-dependent processing pathways regulate hedgehog/gli signaling: implications for cell development and tumorigenesis.

Cell Cycle 2007 Feb 3;6(4):390-3. Epub 2007 Feb 3.

Department of Experimental Medicine and Pathology, Cenci Bolognetti Foundation, University La Sapienza, Roma, Italy.

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http://dx.doi.org/10.4161/cc.6.4.3809DOI Listing
February 2007

Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination.

Nat Cell Biol 2006 Dec 19;8(12):1415-23. Epub 2006 Nov 19.

Department of Experimental Medicine and Pathology, University La Sapienza, Roma, 324 Viale Regina Elena, 00161 Roma, Italy.

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http://dx.doi.org/10.1038/ncb1510DOI Listing
December 2006

Suppressors of hedgehog signaling: Linking aberrant development of neural progenitors and tumorigenesis.

Mol Neurobiol 2006 Dec;34(3):193-204

Department of Experimental Medicine and Pathology, University La Sapienza, Rome, Italy.

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http://link.springer.com/10.1385/MN:34:3:193
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http://dx.doi.org/10.1385/MN:34:3:193DOI Listing
December 2006

Novel BRCA1 and BRCA2 germline mutations and assessment of mutation spectrum and prevalence in Italian breast and/or ovarian cancer families.

Breast Cancer Res Treat 2006 Nov 9;100(1):83-91. Epub 2006 May 9.

Department of Experimental Medicine and Pathology, University La Sapienza, Policlinico Umberto I Viale Regina Elena, 324, 00161 Rome, Italy.

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http://dx.doi.org/10.1007/s10549-006-9225-9DOI Listing
November 2006

Cross talk among Notch3, pre-TCR, and Tal1 in T-cell development and leukemogenesis.

Blood 2006 Apr 20;107(8):3313-20. Epub 2005 Dec 20.

Dipartimento di Medicina Sperimentale e Patologia, University La Sapienza, Viale Regina Elena 32400161 Roma, Italy.

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http://dx.doi.org/10.1182/blood-2005-07-2823DOI Listing
April 2006

Hedgehog checkpoints in medulloblastoma: the chromosome 17p deletion paradigm.

Trends Mol Med 2005 Dec 14;11(12):537-45. Epub 2005 Nov 14.

Department of Experimental Medicine and Pathology, La Sapienza University, Viale Regina Elena 324, 00161 Rome, Italy.

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http://dx.doi.org/10.1016/j.molmed.2005.10.005DOI Listing
December 2005

High mobility group A1 is a molecular target for MYCN in human neuroblastoma.

Cancer Res 2005 Sep;65(18):8308-16

Department of Experimental Medicine and Pathology, University La Sapienza, Rome, Italy.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-0607DOI Listing
September 2005