Isabel Delany

Decorating the surface of Escherichia coli with bacterial lipoproteins: a comparative analysis of different display systems.

Authors:

Sonia Nicchi Maria Giuliani Fabiola Giusti Laura Pancotto Domenico Maione Isabel Delany Cesira L Galeotti Cecilia Brettoni

Microb Cell Fact 2021 Feb 2;20(1):33. Epub 2021 Feb 2.

GSK, via Fiorentina 1, 53100, Siena, Italy.

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February 2021

The meningococcal vaccine antigen GNA2091 is an analogue of YraP and plays key roles in outer membrane stability and virulence.

Authors:

Kate L Seib Andreas F Haag Francesca Oriente Laura Fantappiè Sara Borghi Evgeny A Semchenko Benjamin L Schulz Francesca Ferlicca Anna Rita Taddei Marzia M Giuliani Mariagrazia Pizza Isabel Delany

FASEB J 2019 11 23;33(11):12324-12335. Epub 2019 Aug 23.

GlaxoSmithKline (GSK) Vaccines, Siena, Italy.

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November 2019

Absence of Protein A Expression Is Associated With Higher Capsule Production in Staphylococcal Isolates.

Authors:

Tarcisio Brignoli Andrea G O Manetti Roberto Rosini Andreas F Haag Vincenzo Scarlato Fabio Bagnoli Isabel Delany

Front Microbiol 2019 10;10:863. Epub 2019 May 10.

GSK Vaccines, Siena, Italy.

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May 2019

Neisseria Heparin Binding Antigen is targeted by the human alternative pathway C3-convertase.

Authors:

Martina Di Fede Massimiliano Biagini Elena Cartocci Carlo Parillo Alessandra Greco Manuele Martinelli Sara Marchi Alfredo Pezzicoli Isabel Delany Silvia Rossi Paccani

PLoS One 2018 26;13(3):e0194662. Epub 2018 Mar 26.

GSK, Siena, Italy.

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July 2018

Outer Membrane Vesicles (OMV)-based and Proteomics-driven Antigen Selection Identifies Novel Factors Contributing to Adhesion to Epithelial Cells.

Authors:

Gianmarco Gasperini Massimiliano Biagini Vanessa Arato Claudia Gianfaldoni Alessandro Vadi Nathalie Norais Giuliano Bensi Isabel Delany Mariagrazia Pizza Beatrice Aricò Rosanna Leuzzi

Mol Cell Proteomics 2018 02 4;17(2):205-215. Epub 2017 Dec 4.

From the ‡GSK Vaccines, Siena, Italy

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February 2018

Analysis of Staphylococcus aureus-Infected Mice Reveals Differential Temporal and Spatial Expression Patterns of .

Authors:

Marta Bacconi Andreas F Haag Emiliano Chiarot Paolo Donato Fabio Bagnoli Isabel Delany Giuliano Bensi

Infect Immun 2017 10 20;85(10). Epub 2017 Sep 20.

GSK Vaccines Srl, Siena, Italy

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October 2017

Contribution of factor H-Binding protein sequence to the cross-reactivity of meningococcal native outer membrane vesicle vaccines with over-expressed fHbp variant group 1.

Authors:

Arianna Marini Omar Rossi Maria Grazia Aruta Francesca Micoli Simona Rondini Serafina Guadagnuolo Isabel Delany Ian R Henderson Adam F Cunningham Allan Saul Calman A MacLennan Oliver Koeberling

PLoS One 2017 25;12(7):e0181508. Epub 2017 Jul 25.

GSK Vaccines Institute for Global Health (GVGH), Siena, Italy.

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October 2017

Neisserial Heparin Binding Antigen (NHBA) Contributes to the Adhesion of Neisseria meningitidis to Human Epithelial Cells.

Authors:

Irene Vacca Elena Del Tordello Gianmarco Gasperini Alfredo Pezzicoli Martina Di Fede Silvia Rossi Paccani Sara Marchi Tsisti D Mubaiwa Lauren E Hartley-Tassell Michael P Jennings Kate L Seib Vega Masignani Mariagrazia Pizza Davide Serruto Beatrice Aricò Isabel Delany

PLoS One 2016 25;11(10):e0162878. Epub 2016 Oct 25.

GSK Vaccines, Siena, Italy.

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June 2017

The Phosphocarrier Protein HPr Contributes to Meningococcal Survival during Infection.

Authors:

Ana Antunes Meriem Derkaoui Aude Terrade Mélanie Denizon Ala-Eddine Deghmane Josef Deutscher Isabel Delany Muhamed-Kheir Taha

PLoS One 2016;11(9):e0162434. Epub 2016 Sep 21.

Institut Pasteur, Unité des Infections Bactériennes Invasives, Paris, France, 75724 Paris Cedex 15, France.

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September 2016

Molecular Basis of Ligand-Dependent Regulation of NadR, the Transcriptional Repressor of Meningococcal Virulence Factor NadA.

Authors:

Alessia Liguori Enrico Malito Paola Lo Surdo Luca Fagnocchi Francesca Cantini Andreas F Haag Sébastien Brier Mariagrazia Pizza Isabel Delany Matthew J Bottomley

PLoS Pathog 2016 04 22;12(4):e1005557. Epub 2016 Apr 22.

GSK Vaccines Srl, Siena, Italy.

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April 2016

Expression of factor H binding protein in meningococcal strains can vary at least 15-fold and is genetically determined.

Proc Natl Acad Sci U S A 2016 Mar 17;113(10):2714-9. Epub 2016 Feb 17.

GSK Vaccines, 53100 Siena, Italy

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March 2016

A stable luciferase reporter plasmid for in vivo imaging in murine models of Staphylococcus aureus infections.

Authors:

Marta Bacconi Andreas F Haag Antonina Torre Andrea Castagnetti Emiliano Chiarot Isabel Delany Giuliano Bensi

Appl Microbiol Biotechnol 2016 Apr 21;100(7):3197-206. Epub 2015 Dec 21.

, GSK Vaccines S.r.l., Via Fiorentina 1, 53100, Siena, Italy.

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April 2016

HexR Controls Glucose-Responsive Genes and Central Carbon Metabolism in Neisseria meningitidis.

Authors:

Ana Antunes Giacomo Golfieri Francesca Ferlicca Marzia M Giuliani Vincenzo Scarlato Isabel Delany

J Bacteriol 2015 Dec 7;198(4):644-54. Epub 2015 Dec 7.

GSK Vaccines s.r.l., Siena, Italy

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December 2015

Global transcriptome analysis reveals small RNAs affecting Neisseria meningitidis bacteremia.

Authors:

Luca Fagnocchi Silvia Bottini Giacomo Golfieri Laura Fantappiè Francesca Ferlicca Ana Antunes Serafina Guadagnuolo Elena Del Tordello Emilio Siena Davide Serruto Vincenzo Scarlato Alessandro Muzzi Isabel Delany

PLoS One 2015 7;10(5):e0126325. Epub 2015 May 7.

Novartis Vaccines and Diagnotics, Siena, Italy.

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April 2016

Neisseria meningitis GNA1030 is a ubiquinone-8 binding protein.

Authors:

Danilo Donnarumma Giacomo Golfieri Sébastien Brier Marta Castagnini Daniele Veggi Matthew James Bottomley Isabel Delany Nathalie Norais

FASEB J 2015 Jun 20;29(6):2260-7. Epub 2015 Feb 20.

Novartis Vaccines, Siena, Italy

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June 2015

Vaccines for the 21st century.

Authors:

Isabel Delany Rino Rappuoli Ennio De Gregorio

EMBO Mol Med 2014 Jun 6;6(6):708-20. Epub 2014 Apr 6.

Novartis Vaccines, Siena, Italy

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June 2014

Vaccines, reverse vaccinology, and bacterial pathogenesis.

Authors:

Isabel Delany Rino Rappuoli Kate L Seib

Cold Spring Harb Perspect Med 2013 May 1;3(5):a012476. Epub 2013 May 1.

Novartis Vaccines and Diagnostics, 53100 Siena, Italy.

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May 2013

Transcriptional regulation of the nadA gene in Neisseria meningitidis impacts the prediction of coverage of a multicomponent meningococcal serogroup B vaccine.

Authors:

Luca Fagnocchi Alessia Biolchi Francesca Ferlicca Giuseppe Boccadifuoco Brunella Brunelli Sébastien Brier Nathalie Norais Emiliano Chiarot Giuliano Bensi J Simon Kroll Mariagrazia Pizza John Donnelly Marzia Monica Giuliani Isabel Delany

Infect Immun 2013 Feb 10;81(2):560-9. Epub 2012 Dec 10.

Novartis Vaccines and Diagnotics, Research Center, Siena, Italy.

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February 2013

Structural insight into the mechanism of DNA-binding attenuation of the Neisserial adhesin repressor NadR by the small natural ligand 4-hydroxyphenylacetic acid.

Authors:

Sébastien Brier Luca Fagnocchi Danilo Donnarumma Maria Scarselli Rino Rappuoli Mikkel Nissum Isabel Delany Nathalie Norais

Biochemistry 2012 Aug 15;51(34):6738-52. Epub 2012 Aug 15.

Research Center, Novartis Vaccines and Diagnostics, via Fiorentina 1, 53100, Siena, Italy.

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August 2012

In the NadR regulon, adhesins and diverse meningococcal functions are regulated in response to signals in human saliva.

Authors:

Luca Fagnocchi Eva Pigozzi Vincenzo Scarlato Isabel Delany

J Bacteriol 2012 Jan 11;194(2):460-74. Epub 2011 Nov 11.

Novartis Vaccines, Microbial Molecular Biology, Siena, Italy.

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January 2012

The Streptococcus pneumoniae pilus-1 displays a biphasic expression pattern.

Authors:

Gabriella De Angelis Monica Moschioni Alessandro Muzzi Alfredo Pezzicoli Stefano Censini Isabel Delany Morena Lo Sapio Antonia Sinisi Claudio Donati Vega Masignani Michèle A Barocchi

PLoS One 2011 22;6(6):e21269. Epub 2011 Jun 22.

Novartis Vaccines and Diagnostics, Siena, Italy.

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November 2011

A novel epigenetic regulator associated with the hypervirulent Neisseria meningitidis clonal complex 41/44.

Authors:

Kate L Seib Eva Pigozzi Alessandro Muzzi Jayde A Gawthorne Isabel Delany Michael P Jennings Rino Rappuoli

FASEB J 2011 Oct 16;25(10):3622-33. Epub 2011 Jun 16.

Microbial Molecular Biology, Novartis Vaccines, Via Fiorentina, 1, 53100 Siena, Italy.

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October 2011

Identification of the in vitro target of an iron-responsive AraC-like protein from Neisseria meningitidis that is in a regulatory cascade with Fur.

Authors:

Laura Fantappiè Vincenzo Scarlato Isabel Delany

Microbiology (Reading) 2011 Aug 20;157(Pt 8):2235-2247. Epub 2011 May 20.

Novartis Vaccines, Microbial Molecular Biology, Via Fiorentina 1, 53100 Siena, Italy.

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August 2011

A critical threshold of meningococcal factor H binding protein expression is required for increased breadth of protective antibodies elicited by native outer membrane vesicle vaccines.

Authors:

Oliver Koeberling Isabel Delany Dan M Granoff

Clin Vaccine Immunol 2011 May 2;18(5):736-42. Epub 2011 Mar 2.

Novartis Vaccines, Siena, Italy.

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May 2011

A novel Hfq-dependent sRNA that is under FNR control and is synthesized in oxygen limitation in Neisseria meningitidis.

Authors:

Laura Fantappiè Francesca Oriente Alessandro Muzzi Davide Serruto Vincenzo Scarlato Isabel Delany

Mol Microbiol 2011 Apr 7;80(2):507-23. Epub 2011 Mar 7.

Novartis Vaccines, Microbial Molecular Biology, Via Fiorentina 1, 53100 Siena, Italy.

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April 2011

Influence of serogroup B meningococcal vaccine antigens on growth and survival of the meningococcus in vitro and in ex vivo and in vivo models of infection.

Authors:

Kate L Seib Francesca Oriente Jeannette Adu-Bobie Paolo Montanari Francesca Ferlicca Marzia M Giuliani Rino Rappuoli Mariagrazia Pizza Isabel Delany

Vaccine 2010 Mar 10;28(12):2416-27. Epub 2010 Jan 10.

Novartis Vaccines, Via Fiorentina 1, 53100 Siena, Italy.

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March 2010

A novel phase variation mechanism in the meningococcus driven by a ligand-responsive repressor and differential spacing of distal promoter elements.

Authors:

Matteo M E Metruccio Eva Pigozzi Davide Roncarati Francesco Berlanda Scorza Nathalie Norais Stuart A Hill Vincenzo Scarlato Isabel Delany

PLoS Pathog 2009 Dec 24;5(12):e1000710. Epub 2009 Dec 24.

Novartis Vaccines and Diagnostics, Siena, Italy.

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December 2009

Expression of factor H binding protein of meningococcus responds to oxygen limitation through a dedicated FNR-regulated promoter.

Authors:

Francesca Oriente Vincenzo Scarlato Isabel Delany

J Bacteriol 2010 Feb 30;192(3):691-701. Epub 2009 Nov 30.

Novartis Vaccines, Microbial Molecular Biology, 53100 Siena, Italy.

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February 2010

Growth phase and metal-dependent transcriptional regulation of the fecA genes in Helicobacter pylori.

Authors:

Alberto Danielli Simona Romagnoli Davide Roncarati Lorenzo Costantino Isabel Delany Vincenzo Scarlato

J Bacteriol 2009 Jun 3;191(11):3717-25. Epub 2009 Apr 3.

Department of Biology, University of Bologna, Via Selmi 3, 40126 Bologna, Italy.

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June 2009

The RNA chaperone Hfq is involved in stress response and virulence in Neisseria meningitidis and is a pleiotropic regulator of protein expression.

Authors:

Laura Fantappiè Matteo M E Metruccio Kate L Seib Francesca Oriente Elena Cartocci Francesca Ferlicca Marzia M Giuliani Vincenzo Scarlato Isabel Delany

Infect Immun 2009 May 17;77(5):1842-53. Epub 2009 Feb 17.

Novartis Vaccines, Via Fiorentina 1, 53100 Siena, Italy.

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May 2009

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