Isabel Beerman

Isabel Beerman

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Isabel Beerman

Isabel Beerman

Publications by authors named "Isabel Beerman"

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DNA damage in aging, the stem cell perspective.

Hum Genet 2020 Mar 19;139(3):309-331. Epub 2019 Jul 19.

Epigenetics and Stem Cell Unit, Translational Gerontology Branch, National Institute on Aging, NIH, BRC, 251 Bayview Blvd, Suite 100/10C220, Baltimore, MD, 21224, USA.

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http://dx.doi.org/10.1007/s00439-019-02047-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980431PMC
March 2020

Biological implications of clonal hematopoiesis.

Exp Hematol 2019 09 28;77:1-5. Epub 2019 Aug 28.

Department of Immunology, Weizmann Institute of Science, Rehovot, Israel; Hematology Department, Rambam Healthcare Campus, Haifa, Israel.

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http://dx.doi.org/10.1016/j.exphem.2019.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6803101PMC
September 2019

Regenerative Medicine and the Biology of Aging.

J Gerontol A Biol Sci Med Sci 2019 Aug;74(9):1339-1340

Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, Maryland.

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http://dx.doi.org/10.1093/gerona/glz132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941207PMC
August 2019

Lineage Tracing Reveals a Subset of Reserve Muscle Stem Cells Capable of Clonal Expansion under Stress.

Cell Stem Cell 2019 Jun 18;24(6):944-957.e5. Epub 2019 Apr 18.

The Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Department of Orthopedic Surgery, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19345909193011
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http://dx.doi.org/10.1016/j.stem.2019.03.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597014PMC
June 2019

Loss of hematopoietic diversity with age.

Authors:
Isabel Beerman

Blood 2019 05;133(18):1921-1922

National Institute on Aging.

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http://dx.doi.org/10.1182/blood-2019-03-900902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497518PMC
May 2019

Set(d1a)-ing novel links between HSC regulators.

Authors:
Isabel Beerman

Blood 2018 03;131(12):1267-1269

National Institute on Aging.

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http://dx.doi.org/10.1182/blood-2018-02-829077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865237PMC
March 2018

ZFP521 regulates murine hematopoietic stem cell function and facilitates MLL-AF9 leukemogenesis in mouse and human cells.

Blood 2017 08 14;130(5):619-624. Epub 2017 Jun 14.

Program in Cellular and Molecular Medicine, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA.

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http://dx.doi.org/10.1182/blood-2016-09-738591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542850PMC
August 2017

The evolving view of the hematopoietic stem cell niche.

Exp Hematol 2017 06 9;50:22-26. Epub 2017 Feb 9.

Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute and Department of Haematology, University of Cambridge, and National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, UK.

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http://dx.doi.org/10.1016/j.exphem.2017.01.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466495PMC
June 2017

Accumulation of DNA damage in the aged hematopoietic stem cell compartment.

Authors:
Isabel Beerman

Semin Hematol 2017 01 18;54(1):12-18. Epub 2016 Nov 18.

Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD. Electronic address:

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http://dx.doi.org/10.1053/j.seminhematol.2016.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5242379PMC
January 2017

DNA Damage and Aging Around the Clock.

Trends Mol Med 2016 08 23;22(8):635-637. Epub 2016 Jun 23.

Program in Cellular and Molecular Medicine, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2016.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4969220PMC
August 2016

Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2.

Cancer Cell 2016 08 14;30(2):337-348. Epub 2016 Jul 14.

The Campbell Family Institute for Breast Cancer Research, University Health Network, Toronto, ON M5G 2C1, Canada; The Princess Margaret Cancer Centre and Ontario Cancer Institute, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.05.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5022794PMC
August 2016

Understanding hematopoiesis from a single-cell standpoint.

Exp Hematol 2016 06 18;44(6):447-50. Epub 2016 Mar 18.

Institut Curie, PSL Research University, Paris, France.

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http://dx.doi.org/10.1016/j.exphem.2016.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849462PMC
June 2016

Insulin-like growth factor 2 modulates murine hematopoietic stem cell maintenance through upregulation of p57.

Exp Hematol 2016 May 10;44(5):422-433.e1. Epub 2016 Feb 10.

Section of Gastroenterology, Department of Medicine, Boston University School of Medicine, Boston, MA; Center for Regenerative Medicine (CReM), Boston University and Boston Medical Center, Boston, MA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0301472X160003
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http://dx.doi.org/10.1016/j.exphem.2016.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555112PMC
May 2016

Epigenetic Control of Stem Cell Potential during Homeostasis, Aging, and Disease.

Cell Stem Cell 2015 Jun;16(6):613-25

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA; Program in Cellular and Molecular Medicine, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02116, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2015.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4469343PMC
June 2015

Epigenetic regulation of hematopoietic stem cell aging.

Exp Cell Res 2014 Dec 28;329(2):192-9. Epub 2014 Sep 28.

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA; Program in Cellular and Molecular Medicine, Division of Hematology/Oncology, Boston Children׳s Hospital, MA 02116, USA.

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http://dx.doi.org/10.1016/j.yexcr.2014.09.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250347PMC
December 2014

Growth hormone receptor signaling is dispensable for HSC function and aging.

Blood 2014 Nov 1;124(20):3076-80. Epub 2014 Oct 1.

Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA; Department of Stem Cell and Regenerative Medicine, Harvard University, Cambridge, MA; and.

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http://www.bloodjournal.org/content/early/2014/10/01/blood-2
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http://www.bloodjournal.org/content/124/20/3076.full.pdf
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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2014-05-57
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http://dx.doi.org/10.1182/blood-2014-05-575308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231418PMC
November 2014

Quiescent hematopoietic stem cells accumulate DNA damage during aging that is repaired upon entry into cell cycle.

Cell Stem Cell 2014 Jul 8;15(1):37-50. Epub 2014 May 8.

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1016/j.stem.2014.04.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082747PMC
July 2014

Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging.

Cell Stem Cell 2013 Apr 14;12(4):413-25. Epub 2013 Feb 14.

Program in Cellular and Molecular Medicine, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02116, USA.

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http://www.idi.harvard.edu/uploads/investigators/Beerman_et_
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http://linkinghub.elsevier.com/retrieve/pii/S193459091300020
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http://dx.doi.org/10.1016/j.stem.2013.01.017DOI Listing
April 2013

Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age.

Proc Natl Acad Sci U S A 2011 Dec 28;108(50):20012-7. Epub 2011 Nov 28.

Institute for Stem Cell Biology and Regenerative Medicine, Ludwig Center for Stem Cell Research, and Department of Pathology, Stanford University, Stanford, CA 94305, USA.

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http://www.pnas.org/content/108/50/20012.full.pdf
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http://www.pnas.org/cgi/doi/10.1073/pnas.1116110108
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http://dx.doi.org/10.1073/pnas.1116110108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250139PMC
December 2011

Stem cells and the aging hematopoietic system.

Curr Opin Immunol 2010 Aug 23;22(4):500-6. Epub 2010 Jul 23.

Department of Pathology, Harvard Medical School, Harvard Stem Cell Institute, Immune Disease Institute, Program in Cellular and Molecular Medicine, Children's Hospital Boston, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.coi.2010.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817978PMC
August 2010

Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion.

Proc Natl Acad Sci U S A 2010 Mar 18;107(12):5465-70. Epub 2010 Mar 18.

Immune Disease Institute, Program in Cellular and Molecular Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1000834107
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http://dx.doi.org/10.1073/pnas.1000834107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851806PMC
March 2010

The genetics of IgA nephropathy.

Nat Clin Pract Nephrol 2007 Jun;3(6):325-38

Department of Genetics, Yale University, New Haven, CT, USA.

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http://dx.doi.org/10.1038/ncpneph0492DOI Listing
June 2007

Haplotype analysis in the presence of informatively missing genotype data.

Genet Epidemiol 2006 May;30(4):290-300

Department of Biostatistics, University of Alabama at Birmingham, Birmingham, USA.

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http://dx.doi.org/10.1002/gepi.20144DOI Listing
May 2006