Publications by authors named "Isa An"

38 Publications

Evaluation of inner ear and hearing functions in lichen planus patients.

J Cosmet Dermatol 2021 Apr 2. Epub 2021 Apr 2.

Department of Dermatology, Harran University Faculty of Medicine, Sanliurfa, Turkey.

Background: Lichen planus (LP), which affects skin, nails, hair, and mucosal surfaces, is a chronic, autoimmune, and inflammatory disease, and autoimmune diseases may affect the inner ear.

Aims: This study aims to investigate hearing and inner ear functions of the LP patients.

Patients/methods: The present study was formed by 49 patients who were clinically and histopathologically diagnosed with LP and did not receive any treatment. The healthy group consisted of 52 healthy individuals. Pure tone audiometry (PTA) and distortion product otoacoustic emission tests were used in the hearing evaluation.

Results: At frequencies of 1, 2, 4, 6, and 8 kHz in the right ear and 0.5, 1, 2, 4, 6, and 8 kHz in the left ear in PTA, the lichen group's hearing thresholds were higher than the healthy group's. Upon comparing the hearing thresholds of LP patients with oral mucosa involvement and LP patients without oral mucosa involvement, there were significant differences between the groups at 1, 4, and 8 kHz in the right ear and at 0.25, 0.5, 2, 4, 6, and 8 kHz in the left ear.

Conclusion: Because of the increasing hearing thresholds, we think that hearing and inner ear functions of LP patients, particularly with oral mucosal involvement, are negatively affected.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/jocd.14124DOI Listing
April 2021

The effect of secukinumab treatment on inflammatory parameters in patients with psoriasis: A multicentre restrospective study.

Int J Clin Pract 2021 Feb 24:e14114. Epub 2021 Feb 24.

Department of Dermatology, Van Training and Research Hospital, Van, Turkey.

Aim: Psoriasis is a common chronic inflammatory disease of the skin with remission and relapses. The aim of this study was to investigate the change in inflammatory parameters such as neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and mean platelet volume (MPV) in patients receiving secukinumab treatment for psoriasis vulgaris (PV).

Materials And Methods: In this retrospective study, we evaluated the laboratory results of 40 patients who were followed up with a diagnosis of PV and received secukinumab treatment in three different dermatology clinics between July 2018 and September 2019.

Results: Neutrophil count and leukocyte count were significantly decreased after secukinumab treatment. (P < .001) There was no statistically significant difference between lymphocyte count, platelet count, MPV, NLR and PLR values before treatment and at the 4th month of treatment (P values .230, .065, .110, .915 and .365, respectively).

Conclusion: In conclusion, it can be concluded that parameters such as NLR, PLR and MPV are not suitable parameters for monitoring the effects of secukinumab treatment on inflammation.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/ijcp.14114DOI Listing
February 2021

Evaluation of thiol/disulphide balance in patients with cutaneous leishmaniasis.

Int J Clin Pract 2021 Feb 11:e14087. Epub 2021 Feb 11.

Department of Physiology, Harran University Medical Faculty, Şanlıurfa, Turkey.

Objective: The aim of this study was to evaluate serum thiol disulphide levels in patients with cutaneous leishmaniasis (CL) compared with a healthy control group and to investigate whether thiol/disulphide balance can be used as a new marker of oxidative stress in CL patients.

Material And Methods: This prospective study included 47 patients diagnosed with CL and 46 healthy individuals without any disease. Native thiol, disulphide and total thiol levels were used in plasma. Disulphide/total thiol, disulphide/native thiol and native thiol/total thiol levels were measured.

Results: Disulphide, native thiol disulphide and total thiol disulphide levels were significantly lower in CL patients compared with the control group. However, there was no statistically significant difference between CL patients and the control group in terms of disulphide/native thiol, disulphide/total thiol and native thiol/total thiol values.

Conclusion: Based on the data in our study, it can be said that the use of thiol/disulphide balance as a new oxidative stress marker in CL patients is not appropriate, but studies with a larger number of patients are needed.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/ijcp.14087DOI Listing
February 2021

Premature or nevoid sebaceous hyperplasia? Two case reports of a rare disease.

J Cosmet Dermatol 2021 Mar 23;20(3):835-837. Epub 2020 Dec 23.

Department of Pathology, University of Health Sciences Gazi Yaşargil Training and Research Hospital, Diyarbakır, Turkey.

Early or familial cases of sebaceous hyperplasia (SH) with multiple lesions, thought to be associated with genetic predisposition, have been reported in young individuals. Rarely reported variants include the giant, diffuse, zosteriform, and/or linear (nevoid) form. However, premature SH, defined as benign proliferation of sebaceous glands that occurs during or after puberty, is histologically similar to SH. Whether the definitions of nevoid SH or premature SH are the same remains unclear. We report two sporadic cases of premature SH.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/jocd.13906DOI Listing
March 2021

COVID-19 infection under omalizumab therapy for chronic spontaneous urticaria: three cases.

Int J Dermatol 2021 Feb 17;60(2):253-254. Epub 2020 Dec 17.

Department of Infectious Diseases and Clinical Microbiology, Bismil State Hospital, Diyarbakır, Turkey.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/ijd.15379DOI Listing
February 2021

Retinal nerve fibre layer thickness and choroidal thickness: An evaluation in psoriasis patients.

Int J Clin Pract 2021 Apr 18;75(4):e13904. Epub 2020 Dec 18.

Department of Dermatolog, Sanlıurfa Training and Research Hospital, Sanlıurfa, Turkey.

Background/objectives: To conduct a comparative study of retinal nerve fibre layer (RNFL) thickness and choroidal thickness of psoriasis patients and healthy volunteers.

Methods: This study included 35 severe psoriasis patients, 35 mild psoriasis patients and 35 healthy individuals. RNFL and choroidal thickness analysis were performed by spectral field optical coherence tomography (SD-OCT). Only patients with psoriasis vulgaris who have not used systemic therapy for the last 3 months were included in the study.

Results: In the severe psoriasis group, the RSLT thickness was found to be statistically significantly thinner and the choroid thickness was thicker than the mild psoriasis and control group (P < .001). There was no significant difference in terms of RNLF and choroid thickness compared to mild psoriasis and the control group (P > .05). The correlation between length of the disease duration, RNFL and choroidal thickness was not significant (P > 0,05).

Conclusion: The increase in choroidal thickness was found to be significant, while with respect to RNFL thickness, a decrease was evident, a possible indicator of damage to microvascular structures in the choroid and ganglion cells, especially in patients with severe psoriasis. Therefore, choroidal and RSLT thickness measurement with OCT device can assist in the detection of damage to psoriasis.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/ijcp.13904DOI Listing
April 2021

Evaluation of inflammatory parameters in patients with cutaneous leishmaniasis.

Dermatol Ther 2021 Jan 7;34(1):e14603. Epub 2020 Dec 7.

Department of Microbiology, Harran University Medical Faculty, Sanlıurfa, Turkey.

Cutaneous leishmaniasis (CL) is a vector-borne parasitic disease characterized by various skin lesions that can cause deformities when healed. Our aim in this study is to show the utility of parameters such as neutrophil/lymphocyte ratio (NLR), thrombocyte/lymphocyte ratio (TLR), and mean thrombocyte volume (MTV) as auxiliary laboratory methods in CL patients. About 107 patients who were admitted to our dermatological and venereal diseases outpatient clinic between January 2018 and January 2019 and were diagnosed with CL by microscopic examination and 74 healthy individuals were included in the study. There were no significant differences between the patient and control group in terms of neutrophil counts, leukocyte counts, platelet counts, and NLR values (P values: .271, .053, .263, and .459, respectively). When the TLR and MTV values of patients with CL and those of the healthy controls were compared, it was found that TLR and MTV values were statistically higher in patients with CL (P values of .010 and .044, respectively). Based on these data, NLR was not considered to be a suitable parameter for demonstrating inflammation in CL patients, but TLR and MTV were held to be an appropriate parameter for demonstrating inflammation in CL patients. In addition, we think that the increase in MTV and TLR, can be used as an auxiliary laboratory test in the diagnosis of CL disease.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/dth.14603DOI Listing
January 2021

Evaluation of cochlear involvement and hearing function in lipoid proteinosis patients.

J Cosmet Dermatol 2020 Nov 11. Epub 2020 Nov 11.

Department of Otorhinolaryngology, Sanliurfa Training and Research Hospital, Sanliurfa, Turkey.

Background: Lipoid proteinosis (LP) is a rare genodermatosis involving amorphous hyaline accumulation in the skin, oral mucosa, larynx, mucous membranes, and viscera.

Aims: In this study, we aimed to investigate the effects of hyaline accumulation on cochlear function and hearing in LP patients.

Patients/methods: In this prospective study, 20 patients who were followed up with a diagnosis of LP between October 2016 and April 2020 in our clinic and 20 healthy individuals of the same age and gender, as a control group, were included. Pure-tone audiometry, tympanometry, and distortion-product otoacoustic emission tests of the patient and control groups were performed. The audiological results of the LP and control groups were compared statistically.

Results: In the comparison of air-conduction thresholds between groups in pure-tone audiometry, hearing thresholds in the patient group were found to be higher than the control group at frequencies of 250, 4000, 6000, and 8000 Hz for the right ear, and 500 and 4000 Hz for the left ear. In the comparison of signal-noise responses between groups in distortion-product otoacoustic emission (DP-OAE) test, signal-noise responses in the right and left ear at frequencies of 1000, 2000, 4000, and 6000 Hz were lower in the patient group than in the control group.

Conclusion: We found that the cochlear functions of patients with LP were affected due to the increase in hearing thresholds and decreased signal-noise responses. We think that LP patients are candidates for hearing loss in their later life.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/jocd.13839DOI Listing
November 2020

Evaluation of inflammatory parameters in lipoid proteinosis patients.

Dermatol Ther 2020 11 8;33(6):e14495. Epub 2020 Nov 8.

Sanlıurfa Training and Research Hospital, Department of Dermatology, Sanlıurfa, Turkey.

Lipoid proteinosis (LP) is a rare metabolic storage disease characterized by the storage of hyaline-like substances in the skin, mucosa, and many other organs. The aim of this study was to compare the neutrophil/lymphocyte ratio (NLR), platelets/lymphocyte ratio (PLR), and mean platelet volume (MPV) values of LP patients with healthy control group and to determine the usefulness of these parameters in determining the inflammatory status in LP patients. This study included 14 patients who were admitted to our clinic between March 2013 and January 2017 and diagnosed as LP with clinical, radiological, and histopathological examinations with 14 individuals who had no systemic inflammatory disease or malignancy and has a hemogram result. There was no statistically significant difference between the two groups in comparison to the MPV and PLR values of the patients with LP and healthy controls (P values 0.666 and 0.654, respectively). When the NLR values of the patients with LP and healthy controls were compared, it was found that the LP-diagnosed NLR values were statistically higher. (P: 0.019). In conclusion, it can be said that NLR is an appropriate parameter in demonstrating inflammation in LP patients, but PLR and MPV are not a suitable parameter in demonstrating inflammation in LP patients. Prospective studies with more patients are needed.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/dth.14495DOI Listing
November 2020

Atypical and unusual morphological variants of cutaneous leishmaniasis.

Int J Clin Pract 2020 Oct 26:e13730. Epub 2020 Oct 26.

Department of Pathology, Harran University Medical Faculty, Sanliurfa, Turkey.

Objective: Cutaneous leishmaniasis (CL) is a skin disease characterised by prolonged nodulo-ulcerative lesions of the skin that heals with atrophic scar. Clinical features of CL vary depending on the type of parasite and host immune resistance. The aim of this study was to investigate the clinical features of atypical and unusual morphological variants of CL patients diagnosed in our clinic.

Materials And Methods: In this prospective study, 27 CL patients with atypical clinical features among 486 patients admitted to our clinic between July 2018 and September 2019 and diagnosed as CL by slit-skin smear examination or histopathological examination were included.

Results: Of 27 patients, 15 (55.5%) were male and 12 (44.5%) were female. The mean age of the patients was 25.8 ± 7.62 years. Seven (25.9%) patients had lupoid lesions, five (18.6%) patients had eczematoid lesions, four (14.8%) patients had lip lesions, three (11.1%) patients had erysipelas-like lesions, two (7.4%) patients had eyelid lesions, two (7.4%) patients had sporotrichoid lesions, two (7.4%) patients had verrucous lesions, one (3.7%) patient had psoriasiform lesion and one (3.7%) patient had paronychial lesion.

Conclusion: In conclusion, rare clinical forms of CL are presented in this study. It should be kept in mind that CL may have very different clinical features and should be considered in the differential diagnosis of eczema, psoriasis, erysipelas, sporotrichosis, paronychia and verrucous lesions.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/ijcp.13730DOI Listing
October 2020

H syndrome: A rare genodermatosis.

J Cosmet Dermatol 2020 Sep 12;19(9):2449-2450. Epub 2020 Jul 12.

Department of Pathology, Dicle University Medical Faculty, Diyarbakır, Turkey.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/jocd.13572DOI Listing
September 2020

The effect of biological agent treatment on neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, mean platelet volume, and C-reactive protein in psoriasis patients.

Postepy Dermatol Alergol 2020 Apr 5;37(2):202-206. Epub 2020 May 5.

Department of Dermatology, Van Training and Research Hospital, Van, Turkey.

Introduction: In recent years, the neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), mean platelet volume (MPV) and C reactive protein (CRP) have been shown to be important indicators of systemic inflammation. Studies have shown that NLR, PLR, MPV and CRP are higher in psoriasis patients than in the control group.

Aim: To investigate the NLR, PLR, MPV and serum CRP levels in patients who were treated with biological agents for psoriasis.

Material And Methods: In our study, 75 patients who were followed up and had a diagnosis of psoriasis vulgaris and took a biological agent therapy between January 2014 and December 2017 in the Dermatology Clinic of the Dicle University Medical Faculty Hospital were evaluated before treatment, and 3 and 6 months after treatment.

Results: Neutrophil count, lymphocyte count, thrombocyte count, NLR, PLR, MPV and CRP values before the biological agent treatment were statistically higher than the values at 3 and 6 months of treatment. There was no statistically significant difference between pre-treatment neutrophil, lymphocyte, leukocyte, platelet, NLR, PLR, MPV, CRP values and values at 3 and 6 months after treatment when we compared four different biological agents.

Conclusions: It was seen that NLR, PLR, MPV and CRP values decreased independently of the type of the biological agent used in our study. Therefore, we think that these parameters can be used to evaluate the effects of biological agent treatment on systemic inflammation in psoriasis patients and to monitor the course of the disease.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.5114/ada.2020.94838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262800PMC
April 2020

Potential role of anti-interleukin-17 in COVID-19 treatment.

Dermatol Ther 2020 Jul 20;33(4):e13715. Epub 2020 Jun 20.

Department of Internal Medicine, University of Health Sciences Gazi Yaşargil Trainning and Research Hospital, Diyarbakır, Turkey.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/dth.13715DOI Listing
July 2020

Spontaneous resolution of human papillomavirus infection in a patient with psoriasis given secukinumab.

Int J Dermatol 2020 Jul 2;59(7):e256-e257. Epub 2020 May 2.

Department of Dermatology, Şanlıurfa Education and Research Hospital, Şanlıurfa, Turkey.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/ijd.14910DOI Listing
July 2020

Systemic isotretinoin therapy in the era of COVID-19.

Dermatol Ther 2020 Jul 20;33(4):e13482. Epub 2020 May 20.

Department of Dermatology, University of Rome G. Marconi, Rome, Italy.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/dth.13482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261989PMC
July 2020

First clinical picture of a very rare disease: Primary cutaneous adenomyoepithelioma.

J Cosmet Dermatol 2020 Sep 12;19(9):2444-2446. Epub 2020 Apr 12.

Department of Dermatology, Van Training and Research Hospital, University of Health Sciences, Van, Turkey.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/jocd.13408DOI Listing
September 2020

Clinical features and etiology of patients with erythema ab igne: A retrospective multicenter study.

Authors:
Murat Ozturk Isa An

J Cosmet Dermatol 2020 Jul 7;19(7):1774-1779. Epub 2019 Nov 7.

Department of Dermatology, Sanlıurfa Training and Research Hospital, Sanlıurfa, Turkey.

Objective: The aim of this study was to investigate the demographic and clinical features, etiology of patients with erythema ab igne (EAI) who presented to our clinics.

Materials And Methods: The present study was conducted on 71 patients who were admitted to our dermatology clinics between April 2018 and June 2019 and were diagnosed with EAI by clinical or histopathological examination. Age, gender, localization of lesions, and etiologic causes of lesions were recorded.

Results: Of the 71 patients, 48 (67.6%) were women and 23 (32.4%) were men. The mean age of the patients was 28.6 ± 10.4 years. Most of the lesions were localized (60.6%, n = 43) on the anterior aspect of both legs. Among the etiological reasons, 53 (74.6%) patients had exposure to heater, 14 (19.7%) patients had exposure to stove, 2 (2.8%) patients had laptop use, 1 (1.4%) patient had tandoor contact, and 1 (1.4%) patient had exposure to hot water bag. One patient was diagnosed with bullous EAI.

Conclusion: In conclusion, EAI was also more common in females and lower extremities, which is in accordance with the literature. However, the mean age of occurrence in our study is younger when compared with that in the literature. One case of EAI due to the use of tandoor in our study has not been reported previously. It should be kept in mind that bullous EAI may develop in patients with diabetes mellitus.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/jocd.13210DOI Listing
July 2020

Do blood groups play a role in etiology of rosacea?

Authors:
Murat Ozturk Isa An

J Cosmet Dermatol 2020 Feb 5;19(2):400-403. Epub 2019 Sep 5.

Department of Dermatology, Sanliurfa Education and Research Hospital, Sanliurfa, Turkey.

Background: The pathogenesis of rosacea is not fully understood. The innate immune system is impaired in patients with rosacea. This leads to abnormal inflammatory cytokine release. It has been proposed that the molecular mechanism for the role of the ABO antigenic system in human diseases may arise from its relationship with the von Willebrand factor and several pro-inflammatory and adhesion molecules. To our knowledge, the relationship between ABO-Rh groups and rosacea has not been investigated previously.

Materials And Methods: One hundred and fourteen patients with rosacea and 258 healthy individuals who had blood group record were included in this study. The results were analyzed statistically.

Results: In terms of ABO blood groups, 54 (47.4%) patients had A, 14 (12.3%) patients had B, 7 (6.1%) patients had AB, and 39 (34.2%) patients had O blood groups in the patient group. In the control group, 109 (42.2%) individuals had A, 45 (17.5%) individuals had B, 29 (11.2%) individuals had AB, and 75 (29.1%) individuals had O blood group. There was no significant difference between the groups (P > .05). In terms of Rh groups, 103 (90.4%) patients were Rh (+) and 11 (9.6%) patients were Rh (-). In the control group, 220 (85.3%) individuals were Rh (+) and 38 (14.7%) were Rh (-). There was no significant difference between the groups (P > .05).

Conclusion: We did not find a relationship between blood groups and rosacea. But, we think this is an interesting hypothesis. To clarify this possible relationship, comprehensive and further studies are needed in different races and geographic regions.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/jocd.13143DOI Listing
February 2020

Immunohistochemical evaluation of the effect of acitretin and systemic steroid treatments on Ki-67, Bcl-2, and COX-2 levels in cutaneous lichen planus patients.

Int J Dermatol 2019 Dec 19;58(12):1444-1450. Epub 2019 Jun 19.

Department of Dermatology, Sanliurfa Education and Research Hospital, Sanliurfa, Turkey.

Background: Lichen planus (LP) is an inflammatory disease that affects skin, hair follicles, mucous membranes, and nails. Ki-67 is an antigen associated with the proliferation of cells in all stages of cell cycle except G0. Bcl-2 is a protooncogene that protects cells from apoptosis. COX-2 is an antiapoptotic protein that increases in inflammation. The infiltration of T cells in LP seems to be responsible in the apoptosis of the basal keratinocytes.

Objective: The purpose of this study was to investigate the effects of prednisolone and acitretin treatments on Ki-67, Bcl-2, and COX-2 expression and apoptosis in patients with LP and the role of Ki-67, Bcl-2, and COX-2 proteins in LP.

Methods: Fifty-eight patients with clinically and histopathologically diagnosed LP who had not been treated with systemic treatment before and 15 healthy volunteers were evaluated prospectively. Pretreatment and posttreatment biopsies were immunohistochemically stained with Ki-67, Bcl-2, and COX-2. The percentage of the stained cells were calculated and recorded.

Results: Although the percentage of staining with Ki-67 and Bcl-2 after treatment with prednisolone and acitretin decreased significantly (P < 0.05) in both groups, there was no significant difference between groups (P > 0.05). COX-2 decreased but was not statistically significant.

Conclusions: With this study in cutaneous lichen planus, prednisolone and acitretin treatments reduced Bcl-2 and Ki-67 levels and did not effect COX-2 levels. It should be clarified whether these results can be obtained with any treatment effective in cutaneous lichen planus.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/ijd.14543DOI Listing
December 2019

Phytocontact dermatitis due to : Report of three cases.

North Clin Istanb 2019 7;6(1):81-84. Epub 2018 Aug 7.

Department of Dermatology, Dicle University Faculty of Medicine, Diyarbakir, Turkey.

() is a member of the Ranunculaceae family and is often used by advanced age women living in rural areas for the topical treatment of arthralgia, myalgia, hemorrhoid, and warts. Protoanemonin is a substance found in the fresh leaves of the plants from the Ranunculaceae family and leads to contact dermatitis. In this report, we present three cases that developed phytocontact dermatitis caused by the topical use of as an alternative treatment method for arthralgia and palmoplantar psoriasis.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.14744/nci.2018.93695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526994PMC
August 2018

The effect of pentavalent antimonial compounds used in the treatment of cutaneous leishmaniasis on hemogram and biochemical parameters.

Cutan Ocul Toxicol 2019 Sep 16;38(3):294-297. Epub 2019 May 16.

c Department of Physiology, Harran University Medical Faculty , Sanlıurfa , Turkey.

: The aim of this study was to analyze the effect of pentavalent antimonials used in the treatment of cutaneous leishmaniasis (CL) on hemogram and biochemical parameters. : The study consisted of 168 patients diagnosed with CL after microscopic examination and treated with either systemic sodium stibogluconate (SSG) or meglumine antimonate (MA) 20 mg/kg/day for 14 days. The patients were divided into two groups as SSG and MA patients. Neutrophil count, leukocyte count, lymphocyte count, hemoglobin concentration, platelet count, amylase, lipase, alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood urea nitrogen and serum creatinine levels were compared before and on the 14th day of the treatment. : There was a statistically significant decrease in the neutrophil, lymphocyte, leukocyte, platelet counts, and hemoglobin and blood urea nitrogen levels on the 14th day of the treatment when compared to the pre-treatment values. A statistically significant increase was found in the ALT, AST, amylase and lipase levels. No significant change was found in the serum creatinine levels. : According to the results of our study, pentavalent antimonials given standard doses in the treatment of CL can lead to an increase in the pancreatic enzymes and transaminases and bone marrow suppression. We do not recommend any change in the treatment if these conditions are not corroborated by clinical findings.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1080/15569527.2019.1610887DOI Listing
September 2019

Phytodermatitis in East and southeast of Turkey: A prospective study.

Authors:
Isa An Murat Ozturk

Cutan Ocul Toxicol 2019 Jun 17;38(2):176-181. Epub 2019 Feb 17.

b Department of Dermatology , Health Sciences Universty Van Training and Research Hospital , Van , Turkey.

Objective: Some plants may cause cutaneous side effects called phytodermatitis due to skin contact. Plants that cause phytodermatitis vary according to countries and regions. The aim of this study was to examine the phytodermatitis cases seen in Turkey's east and southeast and compare them with phytodermatitis cases seen previously in the literature in these provinces and to revise the literature.

Material And Methods: In this study, 34 patients with phytodermatitis were prospectively evaluated. The demographic and clinical characteristics of the patients such as age, sex, affected areas, dermatitis type, and plant name were recorded.

Results: Phytophotodermatitis (PPD) developed in 7 (20,5%) of 34 patients. PPDs occured after contact of Heracleum persicum, Ferula orientalis and Chaerophyllum macropodum Boiss. Two (5.8%) patients developed allergic contact dermatitis due to Xanthium strumarium. Irritant contact dermatitis (ICD) developed in 25 patients (73.5%). ICD was most frequently associated with Tragopogon porrifolius (8 patients). In other patients, ICD was developed due to Ranunculus arvensis, Mentha pulegium, Euphorbia helioscopia, Heracleum persicum, Malva sylvestris, Mandragora autumnalis, Plantago major, and Rheum ribes.

Conclusion: In our study, we determined the cases of PPD caused by F. orientalis and Chaerophyllum macropodum Boiss, which were not previously described in the literature, and ICD which was caused by R. ribes. Clinicians should be aware that cutaneous reactions due to these plants may develop. Our study is the first comprehensive and prospective study on phytodermatitis in Turkey. More studies are needed to determine causes and prevalance of phytodermatitis in Turkey.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1080/15569527.2018.1561711DOI Listing
June 2019

Bullous Pemphigoid Induced by Metamizole in a Pediatric Patient.

Indian J Dermatol 2018 Sep-Oct;63(5):415-417

Department of Pathology, Dicle University Medical Faculty, Diyarbakir, Turkey.

Bullous pemphigoid (BP) is an autoimmune bullous disease commonly seen in adult population but rarely encountered in the pediatric population. Although the exact etiology of BP remains unclear, various vaccines, infectious agents, and drug use have been blamed in the etiology of BP. Here, we present a 14-year-old patient who developed BP after using metamizole and whose diagnosis was clinically and histopathologically confirmed.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.4103/ijd.IJD_209_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124229PMC
September 2018

Multiple Eruptive Dermatofibromas in a Patient With Systemic Lupus Erythematosus Treated With Methylprednisolone.

Arch Rheumatol 2018 Jun 13;33(2):236-237. Epub 2017 Sep 13.

Department of Dermatology, Medical Faculty of Dicle University, Diyarbakır, Turkey.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.5606/ArchRheumatol.2018.6569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117143PMC
June 2018

Congenital Insensitivity to Pain and Anhydrosis Syndrome.

Authors:
Isa An Derya Ucmak

Indian Dermatol Online J 2018 May-Jun;9(3):211-212

Department of Dermatology, Dicle University Medical Faculty, Diyarbakır, Turkey.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.4103/idoj.IDOJ_86_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956878PMC
June 2018

Colchicine may be of therapeutic benefit in prurigo pigmentosa.

Pediatr Dermatol 2018 May 11;35(3):e202-e203. Epub 2018 Apr 11.

Department of Dermatology, İzmir Katip Çelebi University, İzmir, Turkey.

Prurigo pigmentosa (PP) is a rare inflammatory skin disease. Neutrophil-mediated inflammation is considered to be responsible for the etiopathogenesis of PP. We consider that colchicine may be an effective agent in the treatment of PP since it exerts an antiinflammatory effect by inhibiting neutrophil chemotaxis. Further studies are required to verify whether colchicine is an effective treatment option for PP.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/pde.13480DOI Listing
May 2018

Asymptomatic flesh-colored lobular nodule on the nose.

Dermatol Online J 2018 Feb 15;24(2). Epub 2018 Feb 15.

Department of Dermatology, Dicle University Medical Faculty, Diyarbakır, Turkey,.

Chondroid syringoma is a rare benign tumor of the skin appendages. Chondroid syringoma is mostly manifested by a slow-growing, painless, well defined subcutaneous or intradermal nodule. A 43-year-old man presented to our clinic with the complaint of an asymptomatic nodule on the dorsum of the nose for 8 months. The lesion was totally excised. Histopathological examination was notable for epithelial islets embedded in the chondroid matrix in the dermis. The patient was diagnosed with chondroid syringoma in light of the clinical and histopathological findings.
View Article and Find Full Text PDF

Download full-text PDF

Source
February 2018

SkIndia Quiz 43: Firm Asymptomatic Nodular Skin Lesion on the Nose.

Indian Dermatol Online J 2018 Jan-Feb;9(1):73-74

Department of Pathology, Dicle University Medical Faculty, Diyarbakır, Turkey.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.4103/idoj.IDOJ_123_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803954PMC
February 2018

SkIndia Quiz 41: Asymptomatic Skin-Colored Papule on the Scalp Skin.

Indian Dermatol Online J 2017 Sep-Oct;8(5):380-381

Department of Dermatology, Dicle University Medical Faculty, Diyarbakır, Turkey.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.4103/idoj.IDOJ_352_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621210PMC
October 2017

Bullous Hemorrhagic Dermatosis Induced by Enoxaparin.

Indian Dermatol Online J 2017 Sep-Oct;8(5):347-349

Department of Pathology, Dicle University Medical Faculty, Diyarbakır, Turkey.

Bullous hemorrhagic dermatosis induced by enoxaparin is a rare, self-limiting, cutaneous adverse reaction causing no complications. In this report, we present a case where bullous hemorrhagic dermatosis developed at a location distant from the site of injection after using enoxaparin for 5 days for pulmonary venous thrombosis.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.4103/idoj.IDOJ_355_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621195PMC
October 2017