Publications by authors named "Irwin D Bernstein"

70Publications

Clonal Analysis of Embryonic Hematopoietic Stem Cell Precursors Using Single Cell Index Sorting Combined with Endothelial Cell Niche Co-culture.

J Vis Exp 2018 05 8(135). Epub 2018 May 8.

Clinical Research Division, Fred Hutchinson Cancer Research Center; Department of Pediatrics, Division of Pediatric Hematology/Oncology, University of Washington School of Medicine.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3791/56973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101165PMC
May 2018

Gemtuzumab ozogamicin for acute myeloid leukemia.

Blood 2017 11 11;130(22):2373-2376. Epub 2017 Oct 11.

Fred Hutchinson Cancer Research Center, Seattle, WA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2017-09-797712DOI Listing
November 2017

CD33 Splicing Polymorphism Determines Gemtuzumab Ozogamicin Response in De Novo Acute Myeloid Leukemia: Report From Randomized Phase III Children's Oncology Group Trial AAML0531.

J Clin Oncol 2017 Aug 23;35(23):2674-2682. Epub 2017 Jun 23.

Jatinder K. Lamba, Lata Chauhan, and Miyoung Shin, University of Florida, Gainesville, FL; Michael R. Loken, Hematologics Inc; Rhonda E. Ries, Irwin D. Bernstein, and Soheil Meshinchi, Fred Hutchinson Cancer Research Center; Roland B. Walter and Soheil Meshinchi, University of Washington, Seattle, WA; Jessica A. Pollard, Maine Medical Center, Portland, ME; Jessica A. Pollard, Tufts University, Boston, MA; Yi-Cheng Wang, Children's Oncology Group, Monrovia; Todd A. Alonzo, University of Southern California, Los Angeles, CA; Richard Aplenc, Children's Hospital of Philadelphia, Philadelphia, PA; Betsy A. Hirsch, University of Minnesota, Minneapolis, MN; Susana C. Raimondi, St Jude Children's Research Hospital, Memphis, TN; and Alan S. Gamis, Children's Mercy Hospitals and Clinics, Kansas City, MO.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JCO.2016.71.2513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549451PMC
August 2017

A Common Origin for B-1a and B-2 Lymphocytes in Clonal Pre- Hematopoietic Stem Cells.

Stem Cell Reports 2017 06 4;8(6):1563-1572. Epub 2017 May 4.

Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, D2-373, Seattle, WA 98109, USA; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98105, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stemcr.2017.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469918PMC
June 2017

Engineered Murine HSCs Reconstitute Multi-lineage Hematopoiesis and Adaptive Immunity.

Cell Rep 2016 12;17(12):3178-3192

Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Howard Hughes Medical Institute, Children's Hospital Boston, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2016.11.077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247798PMC
December 2016

Asynchronous combinatorial action of four regulatory factors activates Bcl11b for T cell commitment.

Nat Immunol 2016 08 4;17(8):956-65. Epub 2016 Jul 4.

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ni.3514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955789PMC
August 2016

Infusion of a non-HLA-matched ex-vivo expanded cord blood progenitor cell product after intensive acute myeloid leukaemia chemotherapy: a phase 1 trial.

Lancet Haematol 2016 Jul 7;3(7):e330-9. Epub 2016 Jun 7.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Department of Medical Oncology, University of Washington, Seattle, WA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S2352-3026(16)30023-0DOI Listing
July 2016

CD33 Expression and Its Association With Gemtuzumab Ozogamicin Response: Results From the Randomized Phase III Children's Oncology Group Trial AAML0531.

J Clin Oncol 2016 Mar 19;34(7):747-55. Epub 2016 Jan 19.

Jessica A. Pollard, Maine Medical Center, Portland, ME; and Tufts University, Boston, MA; Michael Loken, Hematologics; Irwin D. Bernstein and Soheil Meshinchi, Fred Hutchinson Cancer Research Center; Irwin D. Bernstein and Soheil Meshinchi, University of Washington, Seattle, WA; Robert B. Gerbing and Todd A. Alonzo, Children's Oncology Group, Arcadia; Todd A. Alonzo, Keck School of Medicine of University of Southern California, Los Angeles, CA; Susana C. Raimondi, St Jude Children's Research Hospital, Memphis, TN; Betsy Hirsch, University of Minnesota Cancer Center, Minneapolis, MN; Richard Aplenc, Children's Hospital of Philadelphia, Philadelphia, PA; and Alan S. Gamis, Children's Mercy Hospitals and Clinics, Kansas City, MO.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JCO.2015.62.6846DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872025PMC
March 2016

Notch ligand Delta-like 1 promotes in vivo vasculogenesis in human cord blood-derived endothelial colony forming cells.

Cytotherapy 2015 May 2;17(5):579-92. Epub 2015 Jan 2.

Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA; Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, USA; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S14653249140088
Publisher Site
http://dx.doi.org/10.1016/j.jcyt.2014.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915927PMC
May 2015

Induction of multipotential hematopoietic progenitors from human pluripotent stem cells via respecification of lineage-restricted precursors.

Cell Stem Cell 2013 Oct;13(4):459-70

Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Manton Center for Orphan Disease Research, Howard Hughes Medical Institute, Children's Hospital Boston and Dana Farber Cancer Institute; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stem.2013.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888026PMC
October 2013

Notch-HES1 signaling axis controls hemato-endothelial fate decisions of human embryonic and induced pluripotent stem cells.

Blood 2013 Aug 3;122(7):1162-73. Epub 2013 Jun 3.

McMaster Stem Cell and Cancer Research Institute, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2012-12-471649DOI Listing
August 2013

Visualizing human ESC-derived hematopoiesis.

Blood 2013 Jan;121(5):717-8

Fred Hutchinson Cancer Research Center.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2012-12-469932DOI Listing
January 2013

Activation of Notch signaling during ex vivo expansion maintains donor muscle cell engraftment.

Stem Cells 2012 Oct;30(10):2212-20

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109-1024, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/stem.1181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448880PMC
October 2012

Engineering stem cell expansion.

Cell Stem Cell 2012 Feb;10(2):113-4

Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA 98109, USA.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S19345909120001
Publisher Site
http://dx.doi.org/10.1016/j.stem.2012.01.012DOI Listing
February 2012

Acute myeloid leukemia stem cells and CD33-targeted immunotherapy.

Blood 2012 Jun 27;119(26):6198-208. Epub 2012 Jan 27.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2011-11-325050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383202PMC
June 2012

SIRT1 is dispensable for function of hematopoietic stem cells in adult mice.

Blood 2012 Feb 4;119(8):1856-60. Epub 2012 Jan 4.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2011-09-377077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293640PMC
February 2012

Ex vivo expansion of human hematopoietic stem and progenitor cells.

Blood 2011 Jun 23;117(23):6083-90. Epub 2011 Mar 23.

Pediatric Oncology, Clinical Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2011-01-283606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3122936PMC
June 2011

Jagged2 acts as a Delta-like Notch ligand during early hematopoietic cell fate decisions.

Blood 2011 Apr 3;117(17):4449-59. Epub 2011 Mar 3.

Department of Clinical Chemistry, Microbiology and Immunology, Faculty of Medicine and Health Sciences, Ghent University, Ghent University Hospital, Ghent, Belgium.

View Article

Download full-text PDF

Source
http://www.bloodjournal.org/cgi/doi/10.1182/blood-2010-06-29
Publisher Site
http://dx.doi.org/10.1182/blood-2010-06-290049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673751PMC
April 2011

Notch2 governs the rate of generation of mouse long- and short-term repopulating stem cells.

J Clin Invest 2011 Mar;121(3):1207-16

Pediatric Oncology, Clinical Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/JCI43868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049401PMC
March 2011

Combination of HOXB4 and Delta-1 ligand improves expansion of cord blood cells.

Blood 2010 Dec 4;116(26):5859-66. Epub 2010 Oct 4.

Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2010-05-286062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031382PMC
December 2010

Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution.

Nat Med 2010 Feb 17;16(2):232-6. Epub 2010 Jan 17.

Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nm.2080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819359PMC
February 2010

Hematopoietic stem cell function and survival depend on c-Myc and N-Myc activity.

Cell Stem Cell 2008 Dec;3(6):611-24

Ecole Polytechnique Fédérale de Lausanne (EPFL), ISREC, Swiss Institute for Experimental Cancer Research, School of Life Science, CH-1066 Epalinges, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stem.2008.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635113PMC
December 2008

Loss of TLE1 and TLE4 from the del(9q) commonly deleted region in AML cooperates with AML1-ETO to affect myeloid cell proliferation and survival.

Blood 2008 Apr 7;111(8):4338-47. Epub 2008 Feb 7.

Department of Pediatrics, Division of Pediatric Hematology/Oncology, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2007-07-103291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2288729PMC
April 2008

Clinical strategies to enhance posttransplant immune reconstitution.

Biol Blood Marrow Transplant 2008 Jan;14(1 Suppl 1):94-9

Department of Pediatrics, Fred Hutchinson Cancer Center, 1100 Fairview Avenue, D2-373, Seattle, Washington 98109, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbmt.2007.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2744216PMC
January 2008

Phosphorylated ITIMs enable ubiquitylation of an inhibitory cell surface receptor.

Traffic 2008 Feb 18;9(2):267-79. Epub 2007 Dec 18.

Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109-1024, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1600-0854.2007.00682.xDOI Listing
February 2008

Notch target Hes5 ensures appropriate Notch induced T- versus B-cell choices in the thymus.

Blood 2008 Mar 29;111(5):2615-20. Epub 2007 Nov 29.

Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N., Seattle, WA 98109, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2007-03-079855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2254545PMC
March 2008

ITIM-dependent endocytosis of CD33-related Siglecs: role of intracellular domain, tyrosine phosphorylation, and the tyrosine phosphatases, Shp1 and Shp2.

J Leukoc Biol 2008 Jan 18;83(1):200-11. Epub 2007 Oct 18.

Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., D2-373, Seattle, WA 98109-1024, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1189/jlb.0607388DOI Listing
January 2008

The interaction of the Wnt and Notch pathways modulates natural killer versus T cell differentiation.

Stem Cells 2007 Oct 19;25(10):2488-97. Epub 2007 Jul 19.

Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., D2-373, Seattle, Washington 98109, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1634/stemcells.2007-0102DOI Listing
October 2007

Enhanced T-cell reconstitution by hematopoietic progenitors expanded ex vivo using the Notch ligand Delta1.

Blood 2007 Apr 9;109(8):3579-87. Epub 2007 Jan 9.

Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, USA.

View Article

Download full-text PDF

Source
http://www.bloodjournal.org/cgi/doi/10.1182/blood-2006-08-03
Publisher Site
http://dx.doi.org/10.1182/blood-2006-08-039842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1852253PMC
April 2007

Density of the Notch ligand Delta1 determines generation of B and T cell precursors from hematopoietic stem cells.

J Exp Med 2005 May 25;201(9):1361-6. Epub 2005 Apr 25.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

View Article

Download full-text PDF

Source
http://www.jem.org/lookup/doi/10.1084/jem.20042450
Publisher Site
http://dx.doi.org/10.1084/jem.20042450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213184PMC
May 2005

Influence of CD33 expression levels and ITIM-dependent internalization on gemtuzumab ozogamicin-induced cytotoxicity.

Blood 2005 Feb 28;105(3):1295-302. Epub 2004 Sep 28.

Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, D2-373, Seattle, WA 98109-1024, USA.

View Article

Download full-text PDF

Source
http://www.bloodjournal.org/cgi/doi/10.1182/blood-2004-07-27
Publisher Site
http://dx.doi.org/10.1182/blood-2004-07-2784DOI Listing
February 2005

Establishment of a pluripotent preleukaemic stem cell line by expression of the AML1-ETO fusion protein in Notch1-immortalized HSCN1cl10 cells.

Br J Haematol 2004 May;125(3):353-7

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1365-2141.2004.04914.xDOI Listing
May 2004

The peripheral benzodiazepine receptor ligand PK11195 overcomes different resistance mechanisms to sensitize AML cells to gemtuzumab ozogamicin.

Blood 2004 Jun 12;103(11):4276-84. Epub 2004 Feb 12.

Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, D1-100, PO Box 19024, Seattle, WA 98109-1024, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2003-11-3825DOI Listing
June 2004

Conditionally cleavable radioimmunoconjugates: a novel approach for the release of radioisotopes from radioimmunoconjugates.

Bioconjug Chem 2003 Sep-Oct;14(5):927-33

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/abs/10.1021/bc025655z
Publisher Site
http://dx.doi.org/10.1021/bc025655zDOI Listing
April 2004

Activating mutations of RTK/ras signal transduction pathway in pediatric acute myeloid leukemia.

Blood 2003 Aug 17;102(4):1474-9. Epub 2003 Apr 17.

Fred Hutchinson Cancer Research Center, Division of Clinical Research, D4-100, 1100 Fairview Ave N, PO Box 19024, Seattle, WA 98109-1024, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2003-01-0137DOI Listing
August 2003

Multidrug resistance protein attenuates gemtuzumab ozogamicin-induced cytotoxicity in acute myeloid leukemia cells.

Blood 2003 Aug 10;102(4):1466-73. Epub 2003 Apr 10.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2003-02-0396DOI Listing
August 2003

Immunophenotypic evidence of leukemia after induction therapy predicts relapse: results from a prospective Children's Cancer Group study of 252 patients with acute myeloid leukemia.

Blood 2003 May 27;101(9):3398-406. Epub 2002 Dec 27.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; the Department of Pediatrics, University of Washington, Seattle, WA 98109, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2002-10-3064DOI Listing
May 2003

Combined effects of Notch signaling and cytokines induce a multiple log increase in precursors with lymphoid and myeloid reconstituting ability.

Blood 2003 Mar 31;101(5):1784-9. Epub 2002 Oct 31.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

View Article

Download full-text PDF

Source
http://www.bloodjournal.org/cgi/doi/10.1182/blood-2002-06-18
Publisher Site
http://dx.doi.org/10.1182/blood-2002-06-1862DOI Listing
March 2003

Delta-1 enhances marrow and thymus repopulating ability of human CD34(+)CD38(-) cord blood cells.

J Clin Invest 2002 Oct;110(8):1165-74

Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N., Seattle, Washington 98195, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/JCI16167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC150801PMC
October 2002

CD33 as a target for selective ablation of acute myeloid leukemia.

Clin Lymphoma 2002 Mar;2 Suppl 1:S9-11

Pediatric Oncology, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA 98109, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3816/clm.2002.s.002DOI Listing
March 2002

Antibody-directed therapies for hematological malignancies.

Trends Mol Med 2002 Feb;8(2):69-76

Clinical Research Division, Fred Hutchinson Cancer Research Center, and Dept of Medicine, University of Washington, Seattle, WA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s1471-4914(02)02278-5DOI Listing
February 2002