Irmela Jeremias

Irmela Jeremias

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Irmela Jeremias

Irmela Jeremias

Publications by authors named "Irmela Jeremias"

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45Publications

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The Cytotoxic Natural Product Vioprolide A Targets Nucleolar Protein 14, Which Is Essential for Ribosome Biogenesis.

Angew Chem Int Ed Engl 2020 Jan 12;59(4):1595-1600. Epub 2019 Dec 12.

Center for Integrated Protein Science (CIPSM), Department Chemie, Technische Universität München (TUM), Lichtenbergstrasse 4, 85747, Garching, Germany.

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http://dx.doi.org/10.1002/anie.201911158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004033PMC
January 2020

Deep Learning Reveals Cancer Metastasis and Therapeutic Antibody Targeting in the Entire Body.

Cell 2019 Dec;179(7):1661-1676.e19

Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Zentrum München, 85764 Neuherberg, Germany; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig Maximilian University of Munich (LMU), 81377 Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.11.013DOI Listing
December 2019

Characteristics and Therapeutic Targeting of Minimal Residual Disease in Childhood Acute Lymphoblastic Leukemia.

Adv Exp Med Biol 2018;1100:127-139

Department of Pediatrics I, Pediatric Hematology/Oncology, ALL-BFM Study Group, University Hospital Schleswig-Holstein, Kiel, Germany.

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http://link.springer.com/10.1007/978-3-319-97746-1_8
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http://dx.doi.org/10.1007/978-3-319-97746-1_8DOI Listing
July 2019

JMJD1C-mediated metabolic dysregulation contributes to HOXA9-dependent leukemogenesis.

Leukemia 2019 06 8;33(6):1400-1410. Epub 2019 Jan 8.

Cancer and Stem Cell Biology Group, Children's Cancer Institute, University of New South Wales, Sydney, NSW 2052, Australia.

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http://www.nature.com/articles/s41375-018-0354-z
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http://dx.doi.org/10.1038/s41375-018-0354-zDOI Listing
June 2019

Tumor Cell Dormancy-Triggered by the Niche.

Dev Cell 2019 05;49(3):311-312

Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Munich, Germany; German Cancer Consortium (DKTK), Partner Site, Munich, Germany; Department of Pediatrics, Dr. von Hauner Childrens Hospital, Ludwig Maximilian University, Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2019.04.022DOI Listing
May 2019

Frequent and reliable engraftment of certain adult primary acute lymphoblastic leukemias in mice.

Leuk Lymphoma 2019 03 20;60(3):848-851. Epub 2018 Sep 20.

a Research Unit Apoptosis in Hematopoietic Stem Cells (AHS), Helmholtz Center Munich , German Research Center for Environmental Health , Munich , Germany.

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http://dx.doi.org/10.1080/10428194.2018.1509314DOI Listing
March 2019

A rare subgroup of leukemia stem cells harbors relapse-inducing potential in acute lymphoblastic leukemia.

Exp Hematol 2019 01 24;69:1-10. Epub 2018 Sep 24.

Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Center Munich, German Center for Environmental Health (HMGU), Munich, Germany; Department of Pediatrics, Dr. von Hauner Childrens Hospital, Ludwig Maximilians University, Munich, Germany; German Consortium for Translational Cancer Research (DKTK), Partnering Site Munich, Munich, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0301472X183080
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http://dx.doi.org/10.1016/j.exphem.2018.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542675PMC
January 2019

Characterization of Rare, Dormant, and Therapy-Resistant Cells in Acute Lymphoblastic Leukemia.

Cancer Cell 2016 Dec 1;30(6):849-862. Epub 2016 Dec 1.

Department of Gene Vectors, Helmholtz Zentrum München, German Center for Environmental Health (HMGU), 81377 Munich, Germany; German Consortium for Translational Cancer Research (DKTK), Partnering Site, Munich, 81377 Munich, Germany; Department of Pediatrics, Dr. von Hauner Children's Hospital, Ludwig Maximilians University München, 80337 Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156313PMC
December 2016

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice.

Authors:
Elizabeth C Townsend Mark A Murakami Alexandra Christodoulou Amanda L Christie Johannes Köster Tiffany A DeSouza Elizabeth A Morgan Scott P Kallgren Huiyun Liu Shuo-Chieh Wu Olivia Plana Joan Montero Kristen E Stevenson Prakash Rao Raga Vadhi Michael Andreeff Philippe Armand Karen K Ballen Patrizia Barzaghi-Rinaudo Sarah Cahill Rachael A Clark Vesselina G Cooke Matthew S Davids Daniel J DeAngelo David M Dorfman Hilary Eaton Benjamin L Ebert Julia Etchin Brant Firestone David C Fisher Arnold S Freedman Ilene A Galinsky Hui Gao Jacqueline S Garcia Francine Garnache-Ottou Timothy A Graubert Alejandro Gutierrez Ensar Halilovic Marian H Harris Zachary T Herbert Steven M Horwitz Giorgio Inghirami Andrew M Intlekofer Moriko Ito Shai Izraeli Eric D Jacobsen Caron A Jacobson Sébastien Jeay Irmela Jeremias Michelle A Kelliher Raphael Koch Marina Konopleva Nadja Kopp Steven M Kornblau Andrew L Kung Thomas S Kupper Nicole R LeBoeuf Ann S LaCasce Emma Lees Loretta S Li A Thomas Look Masato Murakami Markus Muschen Donna Neuberg Samuel Y Ng Oreofe O Odejide Stuart H Orkin Rachel R Paquette Andrew E Place Justine E Roderick Jeremy A Ryan Stephen E Sallan Brent Shoji Lewis B Silverman Robert J Soiffer David P Steensma Kimberly Stegmaier Richard M Stone Jerome Tamburini Aaron R Thorner Paul van Hummelen Martha Wadleigh Marion Wiesmann Andrew P Weng Jens U Wuerthner David A Williams Bruce M Wollison Andrew A Lane Anthony Letai Monica M Bertagnolli Jerome Ritz Myles Brown Henry Long Jon C Aster Margaret A Shipp James D Griffin David M Weinstock

Cancer Cell 2016 07 11;30(1):183. Epub 2016 Jul 11.

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http://dx.doi.org/10.1016/j.ccell.2016.06.008DOI Listing
July 2016

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice.

Authors:
Elizabeth C Townsend Mark A Murakami Alexandra Christodoulou Amanda L Christie Johannes Köster Tiffany A DeSouza Elizabeth A Morgan Scott P Kallgren Huiyun Liu Shuo-Chieh Wu Olivia Plana Joan Montero Kristen E Stevenson Prakash Rao Raga Vadhi Michael Andreeff Philippe Armand Karen K Ballen Patrizia Barzaghi-Rinaudo Sarah Cahill Rachael A Clark Vesselina G Cooke Matthew S Davids Daniel J DeAngelo David M Dorfman Hilary Eaton Benjamin L Ebert Julia Etchin Brant Firestone David C Fisher Arnold S Freedman Ilene A Galinsky Hui Gao Jacqueline S Garcia Francine Garnache-Ottou Timothy A Graubert Alejandro Gutierrez Ensar Halilovic Marian H Harris Zachary T Herbert Steven M Horwitz Giorgio Inghirami Andrew M Intlekofer Moriko Ito Shai Izraeli Eric D Jacobsen Caron A Jacobson Sébastien Jeay Irmela Jeremias Michelle A Kelliher Raphael Koch Marina Konopleva Nadja Kopp Steven M Kornblau Andrew L Kung Thomas S Kupper Nicole R LeBoeuf Ann S LaCasce Emma Lees Loretta S Li A Thomas Look Masato Murakami Markus Muschen Donna Neuberg Samuel Y Ng Oreofe O Odejide Stuart H Orkin Rachel R Paquette Andrew E Place Justine E Roderick Jeremy A Ryan Stephen E Sallan Brent Shoji Lewis B Silverman Robert J Soiffer David P Steensma Kimberly Stegmaier Richard M Stone Jerome Tamburini Aaron R Thorner Paul van Hummelen Martha Wadleigh Marion Wiesmann Andrew P Weng Jens U Wuerthner David A Williams Bruce M Wollison Andrew A Lane Anthony Letai Monica M Bertagnolli Jerome Ritz Myles Brown Henry Long Jon C Aster Margaret A Shipp James D Griffin David M Weinstock

Cancer Cell 2016 04;29(4):574-586

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, 450 Brookline Avenue, Dana 510B, MA 02215, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.03.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177991PMC
April 2016

An advanced preclinical mouse model for acute myeloid leukemia using patients' cells of various genetic subgroups and in vivo bioluminescence imaging.

PLoS One 2015 20;10(3):e0120925. Epub 2015 Mar 20.

Group Apoptosis, Department of Gene Vectors, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Oncology, Dr von Haunersches Kinderspital, Ludwig Maximilians-Universität (LMU), Munich, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0120925PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368518PMC
February 2016

Anti-leukemic effects of the V-ATPase inhibitor Archazolid A.

Oncotarget 2015 Dec;6(41):43508-28

Department of Pharmacy, Pharmaceutical Biology, Ludwig-Maximilians-University, Munich, Germany.

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http://dx.doi.org/10.18632/oncotarget.6180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791247PMC
December 2015

TRAIL-receptor costimulation inhibits proximal TCR signaling and suppresses human T cell activation and proliferation.

J Immunol 2014 Oct 12;193(8):4021-31. Epub 2014 Sep 12.

Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, 89075 Ulm, Germany;

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1303242
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http://dx.doi.org/10.4049/jimmunol.1303242DOI Listing
October 2014

Activation of DNA damage response by antitumor therapy counteracts the activity of vinca alkaloids.

Anticancer Res 2013 Dec;33(12):5273-87

Helmholtz Center Munich, German Research Center for Environmental Health, Marchioninistrasse 25, D-81377 München, Germany.

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December 2013

Impact of the p53 status of tumor cells on extrinsic and intrinsic apoptosis signaling.

Cell Commun Signal 2013 Apr 17;11(1):27. Epub 2013 Apr 17.

Helmholtz Zentrum München, German Research Center for Environmental Health, Marchioninistrasse 25, Munich, D-81377, Germany.

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http://dx.doi.org/10.1186/1478-811X-11-27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641951PMC
April 2013

Glucocorticoids augment survival and proliferation of tumor cells.

Anticancer Res 2012 Oct;32(10):4251-61

Helmholtz Center Munich, German Research Center for Environmental Health, Munich, Germany.

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October 2012

Leukemia-initiating cells of patient-derived acute lymphoblastic leukemia xenografts are sensitive toward TRAIL.

Blood 2012 May 9;119(18):4224-7. Epub 2012 Mar 9.

Department of Gene Vectors, Helmholtz Zentrum München, German Research Center for Environmental Health, Marchioninistrasse 25, Munich, Germany.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2011-08-37
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http://dx.doi.org/10.1182/blood-2011-08-370114DOI Listing
May 2012

TCR-transgenic lymphocytes specific for HMMR/Rhamm limit tumor outgrowth in vivo.

Blood 2012 Apr 27;119(15):3440-9. Epub 2012 Feb 27.

Institute of Molecular Immunology, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany.

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http://dx.doi.org/10.1182/blood-2011-06-357939DOI Listing
April 2012

Efficient RNA interference in patients' acute lymphoblastic leukemia cells amplified as xenografts in mice.

Cell Commun Signal 2012 Mar 26;10(1). Epub 2012 Mar 26.

Department of Gene Vectors, Helmholtz Center Munich - German Research Center for Environmental Health, Marchioninistr, 25, 81377 Munich, Germany.

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http://dx.doi.org/10.1186/1478-811X-10-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349556PMC
March 2012

Optimized anti-tumor effects of anthracyclines plus Vinca alkaloids using a novel, mechanism-based application schedule.

Blood 2011 Dec 16;118(23):6123-31. Epub 2011 Sep 16.

Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany.

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http://dx.doi.org/10.1182/blood-2010-02-269811DOI Listing
December 2011

Important role of caspase-8 for chemosensitivity of ALL cells.

Clin Cancer Res 2011 Dec 18;17(24):7605-13. Epub 2011 Oct 18.

Helmholtz Center Munich–German Research Center for Environmental Health, Department of Gene Vectors, Marchioninistrasse 25, D-81377 Munich, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-0513DOI Listing
December 2011

Small molecule XIAP inhibitors sensitize childhood acute leukemia cells for CD95-induced apoptosis.

Int J Cancer 2010 May;126(9):2216-28

University Children's Hospital, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1002/ijc.24816DOI Listing
May 2010

CD95/Apo-1/Fas: independent cell death induced by doxorubicin in normal cultured cardiomyocytes.

Cancer Immunol Immunother 2005 Jul 10;54(7):655-62. Epub 2005 Feb 10.

Department of Hematology/Oncology, Dr. von Haunersches Kinderspital, Lindwurmstr 4, 80337 Munich, Germany.

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http://dx.doi.org/10.1007/s00262-004-0604-yDOI Listing
July 2005

Cooperation of betulinic acid and TRAIL to induce apoptosis in tumor cells.

Oncogene 2004 Oct;23(46):7611-20

University Children's Hospital, Prittwitzstr. 43, D-89075 Ulm, Germany.

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http://dx.doi.org/10.1038/sj.onc.1207970DOI Listing
October 2004

TRAIL induced survival and proliferation in cancer cells resistant towards TRAIL-induced apoptosis mediated by NF-kappaB.

Oncogene 2003 Jun;22(25):3842-52

Dr von Haunersches Kinderspital, Department of Hematology/Oncology, Lindwurmstr 4, Munich 80337, Germany.

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http://www.nature.com/articles/1206520
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http://dx.doi.org/10.1038/sj.onc.1206520DOI Listing
June 2003