Irina Petrache, MD - Indiana University School of Medicine - Professor of Medicine, Biochemistry, and Molecular Biology

Irina Petrache

MD

Indiana University School of Medicine

Professor of Medicine, Biochemistry, and Molecular Biology

Indianapolis, IN | United States

Main Specialties: Pulmonary Disease

Additional Specialties: Pulmonary and Critical Care Medicine

Irina Petrache, MD - Indiana University School of Medicine - Professor of Medicine, Biochemistry, and Molecular Biology

Irina Petrache

MD

Introduction

Primary Affiliation: Indiana University School of Medicine - Indianapolis, IN , United States

Specialties:

Additional Specialties:

Publications

62Publications

2480Reads

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1983PubMed Central Citations

Transient and persistent metabolomic changes in plasma following chronic cigarette smoke exposure in a mouse model.

PLoS One 2014 9;9(7):e101855. Epub 2014 Jul 9.

Integrated Department of Immunology, National Jewish Health and University of Colorado School of Medicine, Denver, Colorado, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0101855PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090193PMC
January 2016
75 Reads
8 Citations
3.234 Impact Factor

Human adipose-derived stem cells ameliorate cigarette smoke-induced murine myelosuppression via secretion of TSG-6.

Stem Cells 2015 Feb;33(2):468-78

Department of Cellular & Integrative Physiology, Herman B Wells Center for Pediatric Research, Indiana University, Indianapolis, Indiana, USA; Indiana Center for Vascular Biology and Medicine, VC-CAST Signature Center, Department of Medicine, Herman B Wells Center for Pediatric Research, Indiana University, Indianapolis, Indiana, USA; VA Center for Regenerative Medicine Indianapolis, "Richard L. Roudebush" VA Medical Center, Indianapolis, Indiana, USA.

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http://dx.doi.org/10.1002/stem.1851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618797PMC
February 2015
84 Reads
9 Citations
6.523 Impact Factor

Impact of alginate-producing Pseudomonas aeruginosa on alveolar macrophage apoptotic cell clearance.

J Cyst Fibros 2015 Jan 12;14(1):70-77. Epub 2014 Jul 12.

Department of Medicine, School of Medicine, Indiana University Purdue University Indianapolis, Indianapolis, IN.

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http://dx.doi.org/10.1016/j.jcf.2014.06.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637177PMC
January 2015
22 Reads
5 Citations
3.480 Impact Factor

Active trafficking of alpha 1 antitrypsin across the lung endothelium.

PLoS One 2014 17;9(4):e93979. Epub 2014 Apr 17.

Department of Medicine, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America; "Richard L. Roudebush" Veteran Affairs Medical Center, Indianapolis, Indiana, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0093979PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990572PMC
January 2015
52 Reads
11 Citations
3.234 Impact Factor

Overexpression of type VI collagen in neoplastic lung tissues.

Oncol Rep 2014 Nov 22;32(5):1897-904. Epub 2014 Aug 22.

Department of Biology, Indiana University-Purdue University Indianapolis School of Science, Indianapolis, IN, USA.

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http://dx.doi.org/10.3892/or.2014.3438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203334PMC
November 2014
46 Reads
3 Citations
2.191 Impact Factor

Cathepsin E promotes pulmonary emphysema via mitochondrial fission.

Am J Pathol 2014 Oct;184(10):2730-41

Section of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, Connecticut. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2014.06.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188869PMC
October 2014
14 Reads
4 Citations
4.591 Impact Factor

Vertebral erosion: an uncommon complication of tracheal tubes.

Am J Respir Crit Care Med 2014 Jul;190(2):e4

1 Departments of Medicine and Radiology, Indiana University, Indianapolis, Indiana; and.

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http://dx.doi.org/10.1164/rccm.201309-1610IMDOI Listing
July 2014
39 Reads
13.000 Impact Factor

Progress in solving the sex hormone paradox in pulmonary hypertension.

Am J Physiol Lung Cell Mol Physiol 2014 Jul 9;307(1):L7-26. Epub 2014 May 9.

Division of Pulmonary, Allergy, Critical Care, Occupational and Sleep Medicine, and Richard L. Roudebush VA Medical Center; Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana; and.

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http://ajplung.physiology.org/content/ajplung/307/1/L7.full.
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http://ajplung.physiology.org/lookup/doi/10.1152/ajplung.003
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http://dx.doi.org/10.1152/ajplung.00337.2013DOI Listing
July 2014
109 Reads
33 Citations
4.080 Impact Factor

Selective endothelin-A receptor blockade attenuates endotoxin-induced pulmonary hypertension and pulmonary vascular dysfunction.

Pulm Circ 2014 Jun;4(2):300-10

Department of Medicine, Division of Pulmonary, Allergy, Critical Care, Occupational and Sleep Medicine, Indiana University, Indianapolis, Indiana, USA ; Center for Immunobiology, Indiana University, Indianapolis, Indiana, USA ; Roudebush Veterans Affairs Medical Center, Indianapolis, Indiana, USA.

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http://dx.doi.org/10.1086/675993DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070772PMC
June 2014
46 Reads
1 Citation

Smoking exposure induces human lung endothelial cell adaptation to apoptotic stress.

Am J Respir Cell Mol Biol 2014 Mar;50(3):513-25

1 Department of Medicine, Division of Pulmonary, Allergy, Critical Care, and Occupational Medicine, Indiana University School of Medicine, Indianapolis, Indiana.

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http://dx.doi.org/10.1165/rcmb.2013-0023OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455468PMC
March 2014
43 Reads
10 Citations
3.985 Impact Factor

Effects of lipid interactions on model vesicle engulfment by alveolar macrophages.

Biophys J 2014 Feb;106(3):598-609

Department of Physics, Indiana University Purdue University Indianapolis, Indianapolis, Indiana. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2013.12.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944992PMC
February 2014
33 Reads
2 Citations
3.972 Impact Factor

HIV envelope protein gp120-induced apoptosis in lung microvascular endothelial cells by concerted upregulation of EMAP II and its receptor, CXCR3.

Am J Physiol Lung Cell Mol Physiol 2014 Feb 6;306(4):L372-82. Epub 2013 Dec 6.

Indiana University School of Medicine, Cellular and Integrative Physiology, Indianapolis, IN 46202.

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http://dx.doi.org/10.1152/ajplung.00193.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920224PMC
February 2014
21 Reads
8 Citations
4.080 Impact Factor

MSPrep--summarization, normalization and diagnostics for processing of mass spectrometry-based metabolomic data.

Bioinformatics 2014 Jan 29;30(1):133-4. Epub 2013 Oct 29.

Department of Biostatistics and Informatics, University of Colorado School of Public Health, Aurora, CO, Department of Immunology, National Jewish Health Center, Denver, CO, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN and Department of Pulmonary Medicine, National Jewish Health Center, Denver, CO, USA.

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http://dx.doi.org/10.1093/bioinformatics/btt589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866554PMC
January 2014
18 Reads
15 Citations
4.981 Impact Factor

The involvement of sphingolipids in chronic obstructive pulmonary diseases.

Handb Exp Pharmacol 2013 (216):247-64

Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.

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http://dx.doi.org/10.1007/978-3-7091-1511-4_12DOI Listing
July 2013
31 Reads
6 Citations

α₁-Antitrypsin modulates lung endothelial cell inflammatory responses to TNF-α.

Am J Respir Cell Mol Biol 2013 Jul;49(1):143-50

Division of Pulmonary, Allergy, Critical Care, and Occupational Medicine, Center for Immunobiology, Indiana University, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1165/rcmb.2012-0515OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727880PMC
July 2013
21 Reads
19 Citations
3.985 Impact Factor

Cigarette smoke exposure inhibits contact hypersensitivity via the generation of platelet-activating factor agonists.

J Immunol 2013 Mar 25;190(5):2447-54. Epub 2013 Jan 25.

Department of Dermatology, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.4049/jimmunol.1202699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3577966PMC
March 2013
35 Reads
17 Citations
4.922 Impact Factor

RTP801 is required for ceramide-induced cell-specific death in the murine lung.

Am J Respir Cell Mol Biol 2013 Jan 28;48(1):87-93. Epub 2012 Sep 28.

Department of Biochemistry and Molecular Biology, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1165/rcmb.2012-0254OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547084PMC
January 2013
44 Reads
11 Citations
3.985 Impact Factor

In vivo knockdown of intersectin-1s alters endothelial cell phenotype and causes microvascular remodeling in the mouse lungs.

Apoptosis 2013 Jan;18(1):57-76

Department of Pharmacology, Rush University, 1735 W. Harrison St., Chicago, IL 60612, USA.

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http://dx.doi.org/10.1007/s10495-012-0762-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543613PMC
January 2013
9 Reads
11 Citations
3.685 Impact Factor

Cigarette smoke-induced CXCR3 receptor up-regulation mediates endothelial apoptosis.

Am J Respir Cell Mol Biol 2012 Dec 30;47(6):807-14. Epub 2012 Aug 30.

Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1165/rcmb.2012-0132OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547093PMC
December 2012
33 Reads
8 Citations
3.985 Impact Factor

Pathogenesis of chronic obstructive pulmonary disease.

J Clin Invest 2012 Aug 1;122(8):2749-55. Epub 2012 Aug 1.

Program in Translational Lung Research, Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado, School of Medicine, Denver, CO, USA.

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http://dx.doi.org/10.1172/JCI60324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408733PMC
August 2012
11 Reads
98 Citations
13.215 Impact Factor

LC3 as a potential therapeutic target in hypoxia-induced pulmonary hypertension.

Autophagy 2012 Jul 25;8(7):1146-7. Epub 2012 May 25.

Division of Pulmonary, Allergy, Critical Care, Occupational and Sleep Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.

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http://dx.doi.org/10.4161/auto.20520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429553PMC
July 2012
22 Reads
8 Citations
11.753 Impact Factor

17β-Estradiol attenuates hypoxic pulmonary hypertension via estrogen receptor-mediated effects.

Am J Respir Crit Care Med 2012 May 1;185(9):965-80. Epub 2012 Mar 1.

Division of Pulmonary, Allergy, Critical Care and Occupational Medicine, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

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http://www.atsjournals.org/doi/abs/10.1164/rccm.201107-1293O
Publisher Site
http://dx.doi.org/10.1164/rccm.201107-1293OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359941PMC
May 2012
16 Reads
47 Citations
13.000 Impact Factor

Mechanisms of lung endothelial barrier disruption induced by cigarette smoke: role of oxidative stress and ceramides.

Am J Physiol Lung Cell Mol Physiol 2011 Dec 26;301(6):L836-46. Epub 2011 Aug 26.

Department of Medicine, Indiana University School of Medicine, Indianapolis, 46202-5120, USA.

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http://dx.doi.org/10.1152/ajplung.00385.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3233827PMC
December 2011
108 Reads
40 Citations
4.080 Impact Factor

Involvement of ceramide in cell death responses in the pulmonary circulation.

Proc Am Thorac Soc 2011 Nov;8(6):492-6

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Indiana University, Indianapolis, Indiana, USA.

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http://dx.doi.org/10.1513/pats.201104-034MWDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359077PMC
November 2011
6 Reads
14 Citations

Dihydroceramide-based response to hypoxia.

J Biol Chem 2011 Nov 13;286(44):38069-78. Epub 2011 Sep 13.

Department of Medicine, Indiana University, Indianapolis, Indiana 46202, USA.

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http://dx.doi.org/10.1074/jbc.M111.297994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207482PMC
November 2011
54 Reads
21 Citations
4.573 Impact Factor

Two-photon imaging within the murine thorax without respiratory and cardiac motion artifact.

Am J Pathol 2011 Jul 7;179(1):75-82. Epub 2011 May 7.

Center for Immunobiology, Indiana University, Indianapolis, Indiana, USA.

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http://dx.doi.org/10.1016/j.ajpath.2011.03.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3123791PMC
July 2011
37 Reads
26 Citations
4.591 Impact Factor

Lung endothelial monocyte-activating protein 2 is a mediator of cigarette smoke-induced emphysema in mice.

J Clin Invest 2011 Jun 16;121(6):2470-9. Epub 2011 May 16.

Indiana Center for Vascular Biology and Medicine and Department of Cellular and Integrative Physiology, Indiana University, Indianapolis, Indiana 46202, USA.

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http://dx.doi.org/10.1172/JCI43881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104742PMC
June 2011
36 Reads
30 Citations
13.215 Impact Factor

Periostin regulates goblet cell metaplasia in a model of allergic airway inflammation.

J Immunol 2011 Apr 14;186(8):4959-66. Epub 2011 Mar 14.

Department of Pediatrics, Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.4049/jimmunol.1002359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074384PMC
April 2011
48 Reads
21 Citations
4.922 Impact Factor

Adipose stem cell treatment in mice attenuates lung and systemic injury induced by cigarette smoking.

Am J Respir Crit Care Med 2011 Jan 13;183(2):215-25. Epub 2010 Aug 13.

Division of Pulmonary and Critical Care Medicine, Indiana University, Indianapolis, IN 46202-5120, USA.

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http://dx.doi.org/10.1164/rccm.201001-0126OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040390PMC
January 2011
41 Reads
60 Citations
13.000 Impact Factor

Lung disease associated with alpha1-antitrypsin deficiency.

Proc Am Thorac Soc 2010 Nov;7(6):381-6

Program in Translational Lung Research, Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado at Denver, Aurora, Colorado, USA.

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http://dx.doi.org/10.1513/pats.201002-020AWDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136958PMC
November 2010
25 Reads
17 Citations

Safety and efficacy of alpha-1-antitrypsin augmentation therapy in the treatment of patients with alpha-1-antitrypsin deficiency.

Biologics 2009 13;3:193-204. Epub 2009 Jul 13.

Department of Medicine, Indiana, University School of Medicine, Indianapolis, Indiana, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726081PMC
February 2010
93 Reads
16 Citations

A monoclonal rat anti-mouse EMAP II antibody that functionally neutralizes pro- and mature-EMAP II in vitro.

J Immunol Methods 2009 Oct 14;350(1-2):22-8. Epub 2009 Aug 14.

Department of Cellular and Integrative Physiology, Indiana Center for Vascular Biology & Medicine, IU School of Medicine, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1016/j.jim.2009.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778252PMC
October 2009
23 Reads
5 Citations
2.005 Impact Factor

Mechanism of alpha-1 antitrypsin endocytosis by lung endothelium.

FASEB J 2009 Sep 7;23(9):3149-58. Epub 2009 May 7.

Department of Medicine, Division of Pulmonary, Allergy, Critical Care and Occupational Medicine, Indiana University, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1096/fj.09-129304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735364PMC
September 2009
70 Reads
15 Citations
5.043 Impact Factor

Spinal ceramide and neuronal apoptosis in morphine antinociceptive tolerance.

Neurosci Lett 2009 Sep 23;463(1):49-53. Epub 2009 Jul 23.

Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 South Grand Blvd, St. Louis, MO 63104, USA.

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http://dx.doi.org/10.1016/j.neulet.2009.07.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754041PMC
September 2009
20 Reads
7 Citations
2.060 Impact Factor

CFTR regulation of intracellular pH and ceramides is required for lung endothelial cell apoptosis.

Am J Respir Cell Mol Biol 2009 Sep 23;41(3):314-23. Epub 2009 Jan 23.

Section of Pulmonology and Critical Care, Department of Pediatrics, Indiana University, Indianapolis, Indiana 46202-5120, USA.

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http://dx.doi.org/10.1165/rcmb.2008-0264OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742751PMC
September 2009
45 Reads
12 Citations
3.985 Impact Factor

Type V collagen-induced oral tolerance plus low-dose cyclosporine prevents rejection of MHC class I and II incompatible lung allografts.

J Immunol 2009 Jul;183(1):237-45

Department of Medicine, Center for Immunobiology, Indiana University School of Medicine, Indianapolis, 46202, USA.

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http://dx.doi.org/10.4049/jimmunol.0804028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997997PMC
July 2009
35 Reads
15 Citations
4.922 Impact Factor

Spinal ceramide modulates the development of morphine antinociceptive tolerance via peroxynitrite-mediated nitroxidative stress and neuroimmune activation.

J Pharmacol Exp Ther 2009 Apr 25;329(1):64-75. Epub 2008 Nov 25.

Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Saint Louis University School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.1124/jpet.108.146290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670603PMC
April 2009
13 Reads
29 Citations
3.972 Impact Factor

Tissue transglutaminase protects epithelial ovarian cancer cells from cisplatin-induced apoptosis by promoting cell survival signaling.

Carcinogenesis 2008 Oct 29;29(10):1893-900. Epub 2008 Jul 29.

Department of Medicine, Richard L. Roudebush Veterans Affairs Medical Center, Indiana University School of Medicine, 535 Barnhill Drive, RT 473, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1093/carcin/bgn158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2556973PMC
October 2008
41 Reads
39 Citations
5.334 Impact Factor

Targeted induction of lung endothelial cell apoptosis causes emphysema-like changes in the mouse.

J Biol Chem 2008 Oct 21;283(43):29447-60. Epub 2008 Aug 21.

University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1074/jbc.M804595200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570855PMC
October 2008
34 Reads
51 Citations
4.573 Impact Factor

Superoxide dismutase protects against apoptosis and alveolar enlargement induced by ceramide.

Am J Physiol Lung Cell Mol Physiol 2008 Jul 25;295(1):L44-53. Epub 2008 Apr 25.

Division of Pulmonary, Allergy, Critical Care, and Occupational Medicine, Indiana University, Indianapolis, Indiana 46202-5120, USA.

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http://dx.doi.org/10.1152/ajplung.00448.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2494787PMC
July 2008
45 Reads
30 Citations
4.080 Impact Factor

Apoptotic sphingolipid signaling by ceramides in lung endothelial cells.

Am J Respir Cell Mol Biol 2008 Jun 10;38(6):639-46. Epub 2008 Jan 10.

Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1165/rcmb.2007-0274OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2396244PMC
June 2008
23 Reads
25 Citations
3.985 Impact Factor

Molecular multitasking in the airspace: alpha1-antitrypsin takes on thrombin and plasmin.

Am J Respir Cell Mol Biol 2007 Aug 31;37(2):130-4. Epub 2007 May 31.

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http://dx.doi.org/10.1165/rcmb.2007-0163TRDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976548PMC
August 2007
9 Reads
5 Citations
3.985 Impact Factor

Role of lung maintenance program in the heterogeneity of lung destruction in emphysema.

Proc Am Thorac Soc 2006 Nov;3(8):673-9

Division of Cardiopulmonary Pathology, Department of Pathology, Ross Research Building, Room 519, 720 Rutland Avenue, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1513/pats.200605-124SFDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2647653PMC
November 2006
28 Reads
33 Citations

alpha-1 antitrypsin inhibits caspase-3 activity, preventing lung endothelial cell apoptosis.

Am J Pathol 2006 Oct;169(4):1155-66

Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1780181PMC
http://dx.doi.org/10.2353/ajpath.2006.060058DOI Listing
October 2006
54 Reads
84 Citations
4.591 Impact Factor

Ceramide causes pulmonary cell apoptosis and emphysema: a role for sphingolipid homeostasis in the maintenance of alveolar cells.

Proc Am Thorac Soc 2006 Aug;3(6):510

Division of Pulmonary, Allergy, Critical Care and Occupational Medicine, Indiana University School of Medicine, Indianapolis, 46202, USA.

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http://dx.doi.org/10.1513/pats.200603-071MSDOI Listing
August 2006
17 Reads
9 Citations

State of the art. Cellular and molecular mechanisms of alveolar destruction in emphysema: an evolutionary perspective.

Proc Am Thorac Soc 2006 Aug;3(6):503-10

Department of Pathology, Division of Cardiopulmonary Pathology, Ross Research Building, Ross 519, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1513/pats.200603-054MSDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2647641PMC
August 2006
20 Reads
56 Citations

A novel antiapoptotic role for alpha1-antitrypsin in the prevention of pulmonary emphysema.

Am J Respir Crit Care Med 2006 Jun 2;173(11):1222-8. Epub 2006 Mar 2.

Division of Pulmonary and Critical Care, Department of Medicine, John Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1164/rccm.200512-1842OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662968PMC
June 2006
47 Reads
64 Citations
13.000 Impact Factor

Pulmonary ischemia induces lung remodeling and angiogenesis.

J Appl Physiol (1985) 2006 Feb 6;100(2):587-93. Epub 2005 Oct 6.

Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1152/japplphysiol.00029.2005DOI Listing
February 2006
18 Reads
12 Citations

Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice.

Nat Med 2005 May 24;11(5):491-8. Epub 2005 Apr 24.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, 5501 Hopkins Bayview Circle, JHAAC, 4B.65, Baltimore, Maryland 21224, USA.

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http://dx.doi.org/10.1038/nm1238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1352344PMC
May 2005
24 Reads
184 Citations
27.363 Impact Factor

Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice.

J Clin Invest 2004 Nov;114(9):1248-59

Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1172/JCI21146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC524225PMC
November 2004
42 Reads
312 Citations
13.215 Impact Factor

Central involvement of Rho family GTPases in TNF-alpha-mediated bovine pulmonary endothelial cell apoptosis.

Biochem Biophys Res Commun 2003 Jun;306(1):244-9

Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, 1830 Building, Room 527, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1016/s0006-291x(03)00945-8DOI Listing
June 2003
45 Reads
22 Citations
2.300 Impact Factor

The role of the microtubules in tumor necrosis factor-alpha-induced endothelial cell permeability.

Am J Respir Cell Mol Biol 2003 May;28(5):574-81

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://www.usahealthsystem.com/workfiles/com_docs/academicde
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http://www.atsjournals.org/doi/abs/10.1165/rcmb.2002-0075OC
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http://dx.doi.org/10.1165/rcmb.2002-0075OCDOI Listing
May 2003
25 Reads
79 Citations
3.985 Impact Factor

Apoptosis and emphysema: the missing link.

Am J Respir Cell Mol Biol 2003 May;28(5):551-4

Division of Cardiopulmonary Pathology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1165/rcmb.F269DOI Listing
May 2003
27 Reads
65 Citations
3.985 Impact Factor

Caspase-dependent cleavage of myosin light chain kinase (MLCK) is involved in TNF-alpha-mediated bovine pulmonary endothelial cell apoptosis.

FASEB J 2003 Mar;17(3):407-16

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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March 2003
59 Reads
32 Citations
5.043 Impact Factor

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