Publications by authors named "Irina Mirkina"

18Publications

Assessing the function of pneumococcal neuraminidases NanA, NanB and NanC in in vitro and in vivo lung infection models using monoclonal antibodies.

Authors:
Philipp Janesch Harald Rouha Adriana Badarau Lukas Stulik Irina Mirkina Marisa Caccamo Katharina Havlicek Barbara Maierhofer Susanne Weber Karin Groß Jacqueline Steinhäuser Manuel Zerbs Cecilia Varga Ivana Dolezilkova Sabine Maier Gerhild Zauner Nels Nielson Christine A Power Eszter Nagy

Virulence 2018 ;9(1):1521-1538

a Arsanis Biosciences , Vienna , Austria.

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April 2019

Disarming Staphylococcus aureus from destroying human cells by simultaneously neutralizing six cytotoxins with two human monoclonal antibodies.

Authors:
Harald Rouha Susanne Weber Philipp Janesch Barbara Maierhofer Karin Gross Ivana Dolezilkova Irina Mirkina Zehra C Visram Stefan Malafa Lukas Stulik Adriana Badarau Eszter Nagy

Virulence 2018 01 26;9(1):231-247. Epub 2017 Dec 26.

a Arsanis Biosciences, Helmut-Qualtinger-Gasse 2, Campus Vienna Biocenter , Vienna , Austria.

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January 2018

Multiple Modes of Action of a Monoclonal Antibody against Multidrug-Resistant Escherichia coli Sequence Type 131-30.

Authors:
Luis M Guachalla Katharina Hartl Cecília Varga Lukas Stulik Irina Mirkina Stefan Malafa Eszter Nagy Gábor Nagy Valéria Szijártó

Antimicrob Agents Chemother 2017 11 24;61(11). Epub 2017 Oct 24.

Arsanis Biosciences GmbH, Vienna, Austria

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November 2017

Endotoxin neutralization by an O-antigen specific monoclonal antibody: A potential novel therapeutic approach against Klebsiella pneumoniae ST258.

Authors:
Valéria Szijártó Luis M Guachalla Katharina Hartl Cecília Varga Adriana Badarau Irina Mirkina Zehra C Visram Lukas Stulik Christine A Power Eszter Nagy Gábor Nagy

Virulence 2017 10 19;8(7):1203-1215. Epub 2017 Jan 19.

a Arsanis Biosciences GmbH , Vienna , Austria.

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October 2017

Context matters: The importance of dimerization-induced conformation of the LukGH leukocidin of Staphylococcus aureus for the generation of neutralizing antibodies.

Authors:
Adriana Badarau Harald Rouha Stefan Malafa Michael B Battles Laura Walker Nels Nielson Ivana Dolezilkova Astrid Teubenbacher Srijib Banerjee Barbara Maierhofer Susanne Weber Lukas Stulik Derek T Logan Martin Welin Irina Mirkina Clara Pleban Gerhild Zauner Karin Gross Michaela Jägerhofer Zoltán Magyarics Eszter Nagy

MAbs 2016 10 28;8(7):1347-1360. Epub 2016 Jul 28.

a Arsanis Biosciences , Campus Vienna Biocenter, Vienna , Austria.

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October 2016

Bactericidal monoclonal antibodies specific to the lipopolysaccharide O antigen from multidrug-resistant Escherichia coli clone ST131-O25b:H4 elicit protection in mice.

Authors:
Valéria Szijártó Luis M Guachalla Zehra C Visram Katharina Hartl Cecília Varga Irina Mirkina Jakub Zmajkovic Adriana Badarau Gerhild Zauner Clara Pleban Zoltán Magyarics Eszter Nagy Gábor Nagy

Antimicrob Agents Chemother 2015 16;59(6):3109-16. Epub 2015 Mar 16.

Arsanis Biosciences GmbH, Vienna, Austria

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February 2016

Five birds, one stone: neutralization of α-hemolysin and 4 bi-component leukocidins of Staphylococcus aureus with a single human monoclonal antibody.

Authors:
Harald Rouha Adriana Badarau Zehra C Visram Michael B Battles Bianka Prinz Zoltán Magyarics Gábor Nagy Irina Mirkina Lukas Stulik Manuel Zerbs Michaela Jägerhofer Barbara Maierhofer Astrid Teubenbacher Ivana Dolezilkova Karin Gross Srijib Banerjee Gerhild Zauner Stefan Malafa Jakub Zmajkovic Sabine Maier Robert Mabry Eric Krauland K Dane Wittrup Tillman U Gerngross Eszter Nagy

MAbs 2015 ;7(1):243-54

a Arsanis Biosciences ; Vienna , Austria.

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September 2015

Phenotyping of human melanoma cells reveals a unique composition of receptor targets and a subpopulation co-expressing ErbB4, EPO-R and NGF-R.

Authors:
Irina Mirkina Emir Hadzijusufovic Clemens Krepler Mario Mikula Diana Mechtcheriakova Sabine Strommer Alexander Stella Erika Jensen-Jarolim Christoph Höller Volker Wacheck Hubert Pehamberger Peter Valent

PLoS One 2014 29;9(1):e84417. Epub 2014 Jan 29.

Ludwig Boltzmann Cluster Oncology, Medical University of Vienna, Vienna, Austria ; Division of Hematology & Hemostaseology, Department of Medicine I, Medical University of Vienna, Vienna, Austria.

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September 2014

5-azacytidine and decitabine exert proapoptotic effects on neoplastic mast cells: role of FAS-demethylation and FAS re-expression, and synergism with FAS-ligand.

Authors:
Viviane Ghanim Harald Herrmann Gerwin Heller Barbara Peter Emir Hadzijusufovic Katharina Blatt Karina Schuch Sabine Cerny-Reiterer Irina Mirkina Heidrun Karlic Winfried F Pickl Sabine Zöchbauer-Müller Peter Valent

Blood 2012 May 21;119(18):4242-52. Epub 2012 Mar 21.

Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Waehringer Guertel 18-20, Vienna, Austria

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May 2012

The PI3-kinase/mTOR-targeting drug NVP-BEZ235 inhibits growth and IgE-dependent activation of human mast cells and basophils.

Authors:
Katharina Blatt Harald Herrmann Irina Mirkina Emir Hadzijusufovic Barbara Peter Sabine Strommer Gregor Hoermann Matthias Mayerhofer Konrad Hoetzenecker Walter Klepetko Viviane Ghanim Katharina Marth Thorsten Füreder Volker Wacheck Rudolf Valenta Peter Valent

PLoS One 2012 27;7(1):e29925. Epub 2012 Jan 27.

Division of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria.

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July 2012

Polo-like kinase-1 as a novel target in neoplastic mast cells: demonstration of growth-inhibitory effects of small interfering RNA and the Polo-like kinase-1 targeting drug BI 2536.

Authors:
Barbara Peter Karoline V Gleixner Sabine Cerny-Reiterer Harald Herrmann Viviane Winter Emir Hadzijusufovic Veronika Ferenc Karina Schuch Irina Mirkina Hans-Peter Horny Winfried F Pickl Leonhard Müllauer Michael Willmann Peter Valent

Haematologica 2011 May 17;96(5):672-80. Epub 2011 Jan 17.

Department of Internal Medicine I, Division of Hematology & Hemostaseology, Medical University of Vienna, Austria.

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May 2011

Phenotypic heterogeneity, novel diagnostic markers, and target expression profiles in normal and neoplastic human mast cells.

Authors:
Peter Valent Sabine Cerny-Reiterer Harald Herrmann Irina Mirkina Tracy I George Karl Sotlar Wolfgang R Sperr Hans-Peter Horny

Best Pract Res Clin Haematol 2010 Sep 12;23(3):369-78. Epub 2010 Aug 12.

Ludwig Boltzmann Cluster Oncology, Vienna, Austria.

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September 2010

[Tumor stem cell research - basis and challenge for diagnosis and therapy].

Authors:
Heidrun Karlic Harald Herrmann Axel Schulenburg Thomas W Grunt Sylvia Laffer Irina Mirkina Rainer Hubmann Medhat Shehata Brigitte Marian Edgar Selzer Michael Pfeilstöcker Elisabeth Pittermann Ulrich Jäger Hubert Pehamberger Christoph Zielinski Peter Valent

Wien Klin Wochenschr 2010 Jul 22;122(13-14):423-36. Epub 2010 Jul 22.

Ludwig Boltzmann Cluster Oncology (LBI for Leukemia Research), Hanusch Hospital, Vienna, Austria.

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July 2010

Evidence for PI3K-dependent CXCR3 agonist-induced degranulation of human cord blood-derived mast cells.

Authors:
Ian Willox Irina Mirkina John Westwick Stephen G Ward

Mol Immunol 2010 Aug 2;47(14):2367-77. Epub 2010 Jun 2.

Inflammatory Cell Biology Laboratory, Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK.

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August 2010

H1-receptor antagonists terfenadine and loratadine inhibit spontaneous growth of neoplastic mast cells.

Authors:
Emir Hadzijusufovic Barbara Peter Karoline V Gleixner Karina Schuch Winfried F Pickl Tuddow Thaiwong Vilma Yuzbasiyan-Gurkan Irina Mirkina Michael Willmann Peter Valent

Exp Hematol 2010 Oct 1;38(10):896-907. Epub 2010 Jun 1.

Department for Companion Animals and Horses, Clinic for Internal Medicine and Infectious Diseases, University of Veterinary Medicine Vienna, Vienna, Austria.

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October 2010

Neoplastic stem cells: current concepts and clinical perspectives.

Authors:
Axel Schulenburg Kira Brämswig Harald Herrmann Heidrun Karlic Irina Mirkina Rainer Hubmann Sylvia Laffer Brigitte Marian Medhat Shehata Clemens Krepler Hubert Pehamberger Thomas Grunt Ulrich Jäger Christoph C Zielinski Peter Valent

Crit Rev Oncol Hematol 2010 Nov 25;76(2):79-98. Epub 2010 Feb 25.

Bone Marrow Transplantation Unit, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria.

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November 2010

Identification of proapoptotic Bim as a tumor suppressor in neoplastic mast cells: role of KIT D816V and effects of various targeted drugs.

Authors:
Karl J Aichberger Karoline V Gleixner Irina Mirkina Sabine Cerny-Reiterer Barbara Peter Veronika Ferenc Michael Kneidinger Christian Baumgartner Matthias Mayerhofer Alexander Gruze Winfried F Pickl Christian Sillaber Peter Valent

Blood 2009 Dec 22;114(26):5342-51. Epub 2009 Oct 22.

Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria.

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December 2009

Inhibition of human cord blood-derived mast cell responses by anti-Fc epsilon RI mAb 15/1 versus anti-IgE Omalizumab.

Authors:
Irina Mirkina Tamás Schweighoffer Franz Kricek

Immunol Lett 2007 Apr 1;109(2):120-8. Epub 2007 Mar 1.

Novartis Institutes for BioMedical Research, Brunnerstrasse 59, A-1235 Vienna, Austria.

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April 2007