Irina Elcheva

Irina Elcheva

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Irina Elcheva

Irina Elcheva

Publications by authors named "Irina Elcheva"

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13Publications

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A novel hiPSC-derived system for hematoendothelial and myeloid blood toxicity screens identifies compounds promoting and inhibiting endothelial-to-hematopoietic transition.

Toxicol In Vitro 2019 Aug 9;61:104622. Epub 2019 Aug 9.

Division of Pediatric Hematology and Oncology, Department of Pediatrics, Pennsylvania State University, College of Medicine, Hershey, PA 17033, USA.

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http://dx.doi.org/10.1016/j.tiv.2019.104622DOI Listing
August 2019

Extracellular vesicle-dependent effect of RNA-binding protein IGF2BP1 on melanoma metastasis.

Oncogene 2019 05 1;38(21):4182-4196. Epub 2019 Apr 1.

Division of Pediatric Hematology/Oncology, Department of Pediatrics, Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA.

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http://www.nature.com/articles/s41388-019-0797-3
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http://dx.doi.org/10.1038/s41388-019-0797-3DOI Listing
May 2019

The Post-GWAS Era: How to Validate the Contribution of Gene Variants in Lupus.

Curr Rheumatol Rep 2019 Jan 23;21(1). Epub 2019 Jan 23.

Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, H107, 500 University Drive, Hershey, PA, 17033-0850, USA.

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http://dx.doi.org/10.1007/s11926-019-0801-5DOI Listing
January 2019

Application of small molecule CHIR99021 leads to the loss of hemangioblast progenitor and increased hematopoiesis of human pluripotent stem cells.

Exp Hematol 2018 09 5;65:38-48.e1. Epub 2018 Jun 5.

Institute of Theoretical and Experimental Biophysics, Pushchino, Moscow Region, Russian Federation; Department of Pathology, Developmental Biology Program, Stanley Manne Children's Research Institute, Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2018.05.007DOI Listing
September 2018

Metabo-miR: miR-211 Regulates Mitochondrial Energy Metabolism in Vitiligo.

J Invest Dermatol 2017 09;137(9):1828-1830

Division of Pediatric Hematology/Oncology, Department of Pediatrics, Pennsylvania State University, College of Medicine, Hershey, Pennsylvania, USA.

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http://dx.doi.org/10.1016/j.jid.2017.06.012DOI Listing
September 2017

Cytokine-free directed differentiation of human pluripotent stem cells efficiently produces hemogenic endothelium with lymphoid potential.

Stem Cell Res Ther 2017 03 17;8(1):67. Epub 2017 Mar 17.

Department of Pathology, Developmental Biology Program, Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

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http://dx.doi.org/10.1186/s13287-017-0519-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356295PMC
March 2017

Direct Induction of Hemogenic Endothelium and Blood by Overexpression of Transcription Factors in Human Pluripotent Stem Cells.

J Vis Exp 2015 Dec 3(106):e52910. Epub 2015 Dec 3.

Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health;

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http://dx.doi.org/10.3791/52910DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692773PMC
December 2015

Direct induction of haematoendothelial programs in human pluripotent stem cells by transcriptional regulators.

Nat Commun 2014 Jul 14;5:4372. Epub 2014 Jul 14.

1] National Primate Research Center, University of Wisconsin Graduate School, 1220 Capitol Court, Madison, Wisconsin 53715, USA [2] Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53707-7365, USA [3] Department of Pathology and Laboratory Medicine, University of Wisconsin Medical School, 600 Highland Avenue, Madison, Wisconsin 53792, USA.

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http://dx.doi.org/10.1038/ncomms5372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107340PMC
July 2014

Role of β-TrCP ubiquitin ligase receptor in UVB mediated responses in skin.

Arch Biochem Biophys 2011 Apr 25;508(2):178-84. Epub 2010 Dec 25.

Department of Dermatology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00039861100052
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http://dx.doi.org/10.1016/j.abb.2010.12.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150842PMC
April 2011

CRD-BP protects the coding region of betaTrCP1 mRNA from miR-183-mediated degradation.

Mol Cell 2009 Jul;35(2):240-6

Department of Dermatology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA.

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http://dx.doi.org/10.1016/j.molcel.2009.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742352PMC
July 2009

Gli2 is targeted for ubiquitination and degradation by beta-TrCP ubiquitin ligase.

J Biol Chem 2006 Jul 1;281(28):19320-6. Epub 2006 May 1.

Department of Dermatology, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA.

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http://dx.doi.org/10.1074/jbc.M513203200DOI Listing
July 2006

CRD-BP mediates stabilization of betaTrCP1 and c-myc mRNA in response to beta-catenin signalling.

Nature 2006 Jun;441(7095):898-901

Department of Dermatology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706, USA.

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http://dx.doi.org/10.1038/nature04839DOI Listing
June 2006